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Protein

Prefoldin subunit 3

Gene

PAC10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Miscellaneous

Present with 6550 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • tubulin binding Source: SGD

GO - Biological processi

  • microtubule-based process Source: GO_Central
  • protein folding Source: InterPro
  • tubulin complex assembly Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-30790-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 3
Alternative name(s):
Genes involved in microtubule biogenesis protein 2
Gim complex subunit 2
Short name:
GimC subunit 2
Gene namesi
Name:PAC10
Synonyms:GIM2, PFD3
Ordered Locus Names:YGR078C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR078C
SGDiS000003310 PAC10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001536591 – 199Prefoldin subunit 3Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP48363
PaxDbiP48363
PRIDEiP48363

PTM databases

iPTMnetiP48363

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • tubulin binding Source: SGD

Protein-protein interaction databases

BioGridi33320, 641 interactors
DIPiDIP-6837N
IntActiP48363, 151 interactors
MINTiP48363
STRINGi4932.YGR078C

Structurei

3D structure databases

ProteinModelPortaliP48363
SMRiP48363
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000018904
HOGENOMiHOG000184744
InParanoidiP48363
OMAiQITVMEV
OrthoDBiEOG092C4ZF5

Family and domain databases

InterProiView protein in InterPro
IPR016655 PFD3
IPR004127 Prefoldin_subunit_alpha
PANTHERiPTHR12409 PTHR12409, 1 hit
PfamiView protein in Pfam
PF02996 Prefoldin, 1 hit
PIRSFiPIRSF016396 Prefoldin_subunit_3, 1 hit

Sequencei

Sequence statusi: Complete.

P48363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLFNSTEK NARGIPQAPF IENVNEIIKD PSDFELCFNK FQERLSKYKF
60 70 80 90 100
MQESKLATIK QLKTRIPDLE NTLKICQSLR NHSDEGDESD EPILLHYQLN
110 120 130 140 150
DTLYTKAQVD IPEDRADLKV GLWLGADVML EYPIDEAIEL LKKKLADSEQ
160 170 180 190
SLTVSTEDVE FLRENITTME VNCARLYNWD VQRRQDLKQA QEGTKNLKI
Length:199
Mass (Da):23,115
Last modified:February 1, 1996 - v1
Checksum:i884D7449C7AD6233
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29137 Genomic DNA Translation: AAA70038.1
Z72863 Genomic DNA Translation: CAA97080.1
AY557774 Genomic DNA Translation: AAS56100.1
BK006941 Genomic DNA Translation: DAA08171.1
PIRiS59741
RefSeqiNP_011592.3, NM_001181207.3

Genome annotation databases

EnsemblFungiiYGR078C; YGR078C; YGR078C
GeneIDi852969
KEGGisce:YGR078C

Similar proteinsi

Entry informationi

Entry nameiPFD3_YEAST
AccessioniPrimary (citable) accession number: P48363
Secondary accession number(s): D6VUL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health