Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

ARH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei26FAD; via amide nitrogenBy similarity1
Binding sitei48FADBy similarity1
Binding sitei56FAD; via amide nitrogenBy similarity1
Binding sitei100FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei235NADPBy similarity1
Binding sitei407FAD; via amide nitrogenBy similarity1
Binding sitei414NADP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi177 – 180NADPBy similarity4
Nucleotide bindingi223 – 224NADPBy similarity2
Nucleotide bindingi414 – 416FADBy similarity3

GO - Molecular functioni

  • NADPH-adrenodoxin reductase activity Source: SGD

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
  • ubiquinone biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciMetaCyc:YDR376W-MONOMER.
YEAST:YDR376W-MONOMER.
ReactomeiR-SCE-2395516. Electron transport from NADPH to Ferredoxin.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADPH:adrenodoxin oxidoreductase, mitochondrial (EC:1.18.1.6)
Short name:
AR
Short name:
Adrenodoxin reductase
Alternative name(s):
Ferredoxin--NADP(+) reductase
Short name:
Ferredoxin reductase
Gene namesi
Name:ARH1
Ordered Locus Names:YDR376W
ORF Names:D9481.5
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR376W.
SGDiS000002784. ARH1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: SGD
  • mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000019425? – 493Probable NADPH:adrenodoxin oxidoreductase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP48360.
PRIDEiP48360.

Interactioni

Protein-protein interaction databases

BioGridi32435. 6 interactors.
DIPiDIP-1201N.
IntActiP48360. 2 interactors.
MINTiMINT-383441.

Structurei

3D structure databases

ProteinModelPortaliP48360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000013574.
HOGENOMiHOG000249250.
InParanoidiP48360.
KOiK18914.
OMAiGWQRIDK.
OrthoDBiEOG092C2YAM.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
3.50.50.60. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR021163. Ferredox_Rdtase_adrenod.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFiPIRSF000362. FNR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVQIRHIS SQINRKTVSI VGSGPSGFYT AYHLLKKSPI PLNVTIWEKL
60 70 80 90 100
PVPFGLSRYG VAPDHPEVKN CEETFTTCAE EFSSPTNQKH KFSFVGGITI
110 120 130 140 150
GKEILLKELL DNQDAVILSY GCTGDRKLNI PGELGTKGVF SSREFVNWYN
160 170 180 190 200
GHPDFAKDKR FTDFDWSKVS KVGIIGNGNV ALDITRVLIS NQIDEIWENT
210 220 230 240 250
DISSLALNLL RRAPVKDVKL IARRDFVHSK FTNKELRELW ELEKYGIRGR
260 270 280 290 300
IDPKFFQKEM FDPSKYDRAF NRRVEMCSEY LKPFNERSKK NYKKAPPPSS
310 320 330 340 350
GYDKFWELDY LKTPLKINRD DFGAINSLSL CNNRLNEDNS LQPLKDVNNI
360 370 380 390 400
MTYKVDLLIT SLGYAGVPMP EFSKLSIGFD KDHIANKQGR VLTSSGEIFP
410 420 430 440 450
HLYASGWIRK GSQGVIASTM QDAFEVGDRV IQDLVVSGAL SLENSIDLSN
460 470 480 490
IKHTTWKDWE RINKKELLRG KKEHKTRSKF LTFEELWNGV EGI
Length:493
Mass (Da):56,237
Last modified:February 1, 1996 - v1
Checksum:i9B0600BEA5A18CF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33H → Y in AAC49500 (PubMed:8890749).Curated1
Sequence conflicti132G → S in AAA69523 (PubMed:9818721).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28038 Genomic DNA. Translation: AAA69523.1.
U38689 Genomic DNA. Translation: AAC49500.1.
U28373 Genomic DNA. Translation: AAB64812.1.
S47189 Genomic DNA. Translation: AAC09006.1.
BK006938 Genomic DNA. Translation: DAA12218.1.
PIRiS61171.
RefSeqiNP_010664.3. NM_001180684.3.

Genome annotation databases

EnsemblFungiiYDR376W; YDR376W; YDR376W.
GeneIDi851982.
KEGGisce:YDR376W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28038 Genomic DNA. Translation: AAA69523.1.
U38689 Genomic DNA. Translation: AAC49500.1.
U28373 Genomic DNA. Translation: AAB64812.1.
S47189 Genomic DNA. Translation: AAC09006.1.
BK006938 Genomic DNA. Translation: DAA12218.1.
PIRiS61171.
RefSeqiNP_010664.3. NM_001180684.3.

3D structure databases

ProteinModelPortaliP48360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32435. 6 interactors.
DIPiDIP-1201N.
IntActiP48360. 2 interactors.
MINTiMINT-383441.

Proteomic databases

MaxQBiP48360.
PRIDEiP48360.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR376W; YDR376W; YDR376W.
GeneIDi851982.
KEGGisce:YDR376W.

Organism-specific databases

EuPathDBiFungiDB:YDR376W.
SGDiS000002784. ARH1.

Phylogenomic databases

GeneTreeiENSGT00390000013574.
HOGENOMiHOG000249250.
InParanoidiP48360.
KOiK18914.
OMAiGWQRIDK.
OrthoDBiEOG092C2YAM.

Enzyme and pathway databases

BioCyciMetaCyc:YDR376W-MONOMER.
YEAST:YDR376W-MONOMER.
ReactomeiR-SCE-2395516. Electron transport from NADPH to Ferredoxin.

Miscellaneous databases

PROiP48360.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
3.50.50.60. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR021163. Ferredox_Rdtase_adrenod.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFiPIRSF000362. FNR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADRO_YEAST
AccessioniPrimary (citable) accession number: P48360
Secondary accession number(s): D6VT08, P32840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.