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Protein

Probable NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

ARH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an electron transfer protein. Essential for viability.1 Publication

Miscellaneous

Present with 1600 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei26FAD; via amide nitrogenBy similarity1
Binding sitei48FADBy similarity1
Binding sitei56FAD; via amide nitrogenBy similarity1
Binding sitei100FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei235NADPBy similarity1
Binding sitei407FAD; via amide nitrogenBy similarity1
Binding sitei414NADP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi177 – 180NADPBy similarity4
Nucleotide bindingi223 – 224NADPBy similarity2
Nucleotide bindingi414 – 416FADBy similarity3

GO - Molecular functioni

  • NADPH-adrenodoxin reductase activity Source: SGD

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
  • ubiquinone biosynthetic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciMetaCyc:YDR376W-MONOMER
YEAST:YDR376W-MONOMER
ReactomeiR-SCE-2395516 Electron transport from NADPH to Ferredoxin

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADPH:adrenodoxin oxidoreductase, mitochondrial (EC:1.18.1.6)
Short name:
AR
Short name:
Adrenodoxin reductase
Alternative name(s):
Ferredoxin--NADP(+) reductase
Short name:
Ferredoxin reductase
Gene namesi
Name:ARH1
Ordered Locus Names:YDR376W
ORF Names:D9481.5
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR376W
SGDiS000002784 ARH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Lethality in aerobic growth conditions and also during fermentation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000019425? – 493Probable NADPH:adrenodoxin oxidoreductase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP48360
PaxDbiP48360
PRIDEiP48360

Interactioni

Protein-protein interaction databases

BioGridi32435, 50 interactors
DIPiDIP-1201N
IntActiP48360, 2 interactors
MINTiP48360
STRINGi4932.YDR376W

Structurei

3D structure databases

ProteinModelPortaliP48360
SMRiP48360
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000013574
HOGENOMiHOG000249250
InParanoidiP48360
KOiK18914
OMAiWGLRFFR
OrthoDBiEOG092C2YAM

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR021163 Ferredox_Rdtase_adrenod
PIRSFiPIRSF000362 FNR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVQIRHIS SQINRKTVSI VGSGPSGFYT AYHLLKKSPI PLNVTIWEKL
60 70 80 90 100
PVPFGLSRYG VAPDHPEVKN CEETFTTCAE EFSSPTNQKH KFSFVGGITI
110 120 130 140 150
GKEILLKELL DNQDAVILSY GCTGDRKLNI PGELGTKGVF SSREFVNWYN
160 170 180 190 200
GHPDFAKDKR FTDFDWSKVS KVGIIGNGNV ALDITRVLIS NQIDEIWENT
210 220 230 240 250
DISSLALNLL RRAPVKDVKL IARRDFVHSK FTNKELRELW ELEKYGIRGR
260 270 280 290 300
IDPKFFQKEM FDPSKYDRAF NRRVEMCSEY LKPFNERSKK NYKKAPPPSS
310 320 330 340 350
GYDKFWELDY LKTPLKINRD DFGAINSLSL CNNRLNEDNS LQPLKDVNNI
360 370 380 390 400
MTYKVDLLIT SLGYAGVPMP EFSKLSIGFD KDHIANKQGR VLTSSGEIFP
410 420 430 440 450
HLYASGWIRK GSQGVIASTM QDAFEVGDRV IQDLVVSGAL SLENSIDLSN
460 470 480 490
IKHTTWKDWE RINKKELLRG KKEHKTRSKF LTFEELWNGV EGI
Length:493
Mass (Da):56,237
Last modified:February 1, 1996 - v1
Checksum:i9B0600BEA5A18CF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33H → Y in AAC49500 (PubMed:8890749).Curated1
Sequence conflicti132G → S in AAA69523 (PubMed:9818721).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28038 Genomic DNA Translation: AAA69523.1
U38689 Genomic DNA Translation: AAC49500.1
U28373 Genomic DNA Translation: AAB64812.1
S47189 Genomic DNA Translation: AAC09006.1
BK006938 Genomic DNA Translation: DAA12218.1
PIRiS61171
RefSeqiNP_010664.3, NM_001180684.3

Genome annotation databases

EnsemblFungiiYDR376W; YDR376W; YDR376W
GeneIDi851982
KEGGisce:YDR376W

Similar proteinsi

Entry informationi

Entry nameiADRO_YEAST
AccessioniPrimary (citable) accession number: P48360
Secondary accession number(s): D6VT08, P32840
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 25, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health