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Protein

Leptin receptor

Gene

Lepr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for hormone LEP/leptin (Probable) (PubMed:11861497). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS (PubMed:10799542, PubMed:25383904, PubMed:11923481, PubMed:11861497). In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:10660043, PubMed:12594516). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25383904, PubMed:11923481). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis (PubMed:12594516). Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus (PubMed:25383904). Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (PubMed:9732873).1 Publication7 Publications
Isoform A: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:17620316, PubMed:20223942). Does not induce phosphorylation of and activate STAT3 (PubMed:11923481, PubMed:20223942).3 Publications
Isoform E: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.1 Publication

GO - Molecular functioni

  • leptin receptor activity Source: UniProtKB
  • transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  • angiogenesis Source: UniProtKB
  • bone growth Source: UniProtKB
  • cholesterol metabolic process Source: MGI
  • energy homeostasis Source: UniProtKB
  • glucose homeostasis Source: UniProtKB
  • leptin-mediated signaling pathway Source: UniProtKB
  • negative regulation of autophagy Source: UniProtKB
  • negative regulation of gluconeogenesis Source: MGI
  • negative regulation of hydrolase activity Source: MGI
  • phagocytosis Source: UniProtKB
  • regulation of bone remodeling Source: UniProtKB
  • regulation of energy homeostasis Source: UniProtKB
  • regulation of feeding behavior Source: UniProtKB
  • regulation of metabolic process Source: MGI
  • response to leptin Source: UniProtKB
  • sexual reproduction Source: UniProtKB
  • signal transduction Source: MGI
  • T cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-2586551. Signaling by Leptin.
R-MMU-2586552. Signaling by Leptin.

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin receptor
Short name:
LEP-R
Alternative name(s):
B219
OB receptor
Short name:
OB-R
CD_antigen: CD295
Gene namesi
Name:Lepr
Synonyms:Db, Obr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104993. Lepr.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Basolateral cell membrane By similarity
Isoform E :
  • Secreted 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 839ExtracellularSequence analysisAdd BLAST818
Transmembranei840 – 860HelicalSequence analysisAdd BLAST21
Topological domaini861 – 1162CytoplasmicSequence analysisAdd BLAST302

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Mutants are hyperphagic, obese, infertile, diabetic and have impaired growth (PubMed:12594516). Have wet brain weight significantly lower than controls. Brain uptake of leptin is also reduced (PubMed:11861497). Animals have an increased bone formation leading to high bone mass (PubMed:10660043). Have impaired T-cell immunity, Th2 responses are favoured in mutants (PubMed:9732873). Conditional knockout in parabrachial nucleus CCK-expressing neurons, treated with 2-deoxyglucose, have increased levels of glucagon, corticosterone and epinephrin concentrations compared to wild-types (PubMed:25383904).5 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi891E → A: No effect on STAT3 phosphorylation. 1 Publication1
Mutagenesisi894E → A: No effect on STAT3 phosphorylation. 1 Publication1
Mutagenesisi896 – 897LF → AA: Abrogates STAT3 phosphorylation. 1 Publication2
Mutagenesisi899 – 900KH → AA: No effect on STAT3 phosphorylation. 1 Publication2
Mutagenesisi902E → A: No effect on STAT3 phosphorylation. 1 Publication1
Mutagenesisi908P → A: No effect on STAT3 phosphorylation. 1 Publication1
Mutagenesisi985Y → L: No change in EPO-induced JAK2 activation and EPO-induced tyrosine phosphorylation. No phosphorylation; when associated with S-1138. No phosphorylation; when associated with both S-1138 and F-1077. No change in STAT3 activation. No PTPN11 binding. No SOCS3 binding nor inhibition of signaling. Greatly reduced ERK/FOS activation. Mutants are hyperphagic, obese and hyperglycaemic, females show a defect in lactation. 3 Publications1
Mutagenesisi1077Y → F: No effect on EPO-induced tyrosine phosphorylation. 1 Publication1
Mutagenesisi1138Y → S: No change in EPO-induced JAK2 activation and EPO-induced tyrosine phosphorylation. No phosphorylation; when associated with L-985. No phosphorylation; when associated with L-985 and F-1077. No STAT3 activation. No change in SOCS3 binding nor signaling inhibition. No effect on ERK/FOS activation. 2 Publications1

Keywords - Diseasei

Obesity

Chemistry databases

GuidetoPHARMACOLOGYi1712.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001090622 – 1162Leptin receptorAdd BLAST1141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 90By similarity
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi89 ↔ 99By similarity
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi131 ↔ 142By similarity
Disulfide bondi186 ↔ 195By similarity
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi188 ↔ 193By similarity
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi350 ↔ 410By similarity
Disulfide bondi411 ↔ 416By similarity
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi434 ↔ 445By similarity
Disulfide bondi471 ↔ 526By similarity
Disulfide bondi486 ↔ 496By similarity
Glycosylationi514N-linked (GlcNAc...)Sequence analysis1
Glycosylationi622N-linked (GlcNAc...)Sequence analysis1
Glycosylationi657N-linked (GlcNAc...)Sequence analysis1
Glycosylationi668N-linked (GlcNAc...)Sequence analysis1
Glycosylationi686N-linked (GlcNAc...)Sequence analysis1
Glycosylationi695N-linked (GlcNAc...)Sequence analysis1
Glycosylationi698N-linked (GlcNAc...)Sequence analysis1
Glycosylationi726N-linked (GlcNAc...)Sequence analysis1
Modified residuei880PhosphoserineCombined sources1
Modified residuei985Phosphotyrosine; by JAK22 Publications1
Modified residuei1077Phosphotyrosine1 Publication1
Modified residuei1138Phosphotyrosine; by JAK21 Publication1

Post-translational modificationi

On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1138 is required for STAT3 binding/activation. Phosphorylation of Tyr-1077 has a more accessory role.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP48356.
PaxDbiP48356.
PeptideAtlasiP48356.
PRIDEiP48356.

PTM databases

iPTMnetiP48356.
PhosphoSitePlusiP48356.

Expressioni

Tissue specificityi

Isoform A: highest level of expression in lung and kidney, also present in heart, brain, spleen, liver, muscle, choroid plexus and hypothalamus. Isoform B: highest levels of expression in hypothalamus and lower levels in brain, testes and adipose tissue. Expressed by neurons of the parabrachial nucleus (PubMed:25383904). Expressed by peripheral blood mononuclear cells and CD4+ T-cells (PubMed:9732873). Isoform E: expressed in adipose tissue, liver, hypothalamus, cerebral microvessels, heart, and testes (PubMed:17620316).3 Publications

Gene expression databases

BgeeiENSMUSG00000057722.
CleanExiMM_LEPR.
ExpressionAtlasiP48356. baseline and differential.
GenevisibleiP48356. MM.

Interactioni

Subunit structurei

Present as a mixture of monomers and dimers (Probable). The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity) (PubMed:11018044, PubMed:11923481). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (PubMed:11018044).By similarity1 Publication2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BBS1Q8NFJ93EBI-6143588,EBI-1805484From a different organism.
Plcg1Q620772EBI-2257257,EBI-300133

Protein-protein interaction databases

BioGridi201139. 3 interactors.
DIPiDIP-42763N.
IntActiP48356. 10 interactors.
MINTiMINT-2569396.
STRINGi10090.ENSMUSP00000037385.

Structurei

3D structure databases

ProteinModelPortaliP48356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 331Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini329 – 427Ig-likeAdd BLAST99
Domaini537 – 632Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini637 – 729Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST93
Domaini738 – 832Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni465 – 482Leptin-bindingBy similarityAdd BLAST18
Regioni891 – 896Required for JAK2 activation1 Publication6
Regioni896 – 904Required for STAT3 phosphorylation1 Publication9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi620 – 624WSXWS motif5
Motifi869 – 877Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.1 Publication
The box 1 motif is required for JAK interaction and/or activation.1 Publication

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKH4. Eukaryota.
ENOG4110JZP. LUCA.
GeneTreeiENSGT00730000111209.
HOVERGENiHBG000140.
InParanoidiP48356.
KOiK05062.
OMAiNWNIQCW.
OrthoDBiEOG091G00QX.
PhylomeDBiP48356.
TreeFamiTF106501.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 6 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015752. Lep_receptor.
[Graphical view]
PANTHERiPTHR23036:SF109. PTHR23036:SF109. 3 hits.
PfamiPF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 3 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: P48356-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP
60 70 80 90 100
AGAPNNASAL KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS
110 120 130 140 150
ALTDNTEGKT LASVVKASVF RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN
160 170 180 190 200
PFKNYDSKVH LLYDLPEVID DSPLPPLKDS FQTVQCNCSL RGCECHVPVP
210 220 230 240 250
RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL GLHMEVTDDG
260 270 280 290 300
NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS
310 320 330 340 350
SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC
360 370 380 390 400
IYKNENQIIS SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR
410 420 430 440 450
GKFTYDAVYC CNEQACHHRY AELYVIDVNI NISCETDGYL TKMTCRWSPS
460 470 480 490 500
TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT SEPKNCVLQR DGFYECVFQP
510 520 530 540 550
IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN VKAEITVNTG
560 570 580 590 600
LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD
610 620 630 640 650
LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD
660 670 680 690 700
VTKKERNVTL LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT
710 720 730 740 750
FLWTEPAHTV TVLAVNSLGA SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS
760 770 780 790 800
CVILSWTLSP DDYSLLYLVI EWKILNEDDG MKWLRIPSNV KKFYIHDNFI
810 820 830 840 850
PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL YVIVPIIISS
860 870 880 890 900
CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKP ETFEHLFTKH
910 920 930 940 950
AESVIFGPLL LEPEPISEEI SVDTAWKNKD EMVPAAMVSL LLTTPDPESS
960 970 980 990 1000
SICISDQCNS ANFSGSQSTQ VTCEDECQRQ PSVKYATLVS NDKLVETDEE
1010 1020 1030 1040 1050
QGFIHSPVSN CISSNHSPLR QSFSSSSWET EAQTFFLLSD QQPTMISPQL
1060 1070 1080 1090 1100
SFSGLDELLE LEGSFPEENH REKSVCYLGV TSVNRRESGV LLTGEAGILC
1110 1120 1130 1140 1150
TFPAQCLFSD IRILQERCSH FVENNLSLGT SGENFVPYMP QFQTCSTHSH
1160
KIMENKMCDL TV
Length:1,162
Mass (Da):130,789
Last modified:February 1, 1996 - v1
Checksum:i0E1E75B076BA60A2
GO
Isoform A (identifier: P48356-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-894: PETFE → RTDTL
     895-1162: Missing.

Show »
Length:894
Mass (Da):101,058
Checksum:iDF9A7A0E5AC75A53
GO
Isoform C (identifier: P48356-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-892: PET → VTV
     893-1162: Missing.

Show »
Length:892
Mass (Da):100,771
Checksum:i726E5C075A53C9F3
GO
Isoform D (identifier: P48356-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-900: PETFEHLFTKH → DISFHEVFIFR
     901-1162: Missing.

Show »
Length:900
Mass (Da):101,863
Checksum:i7370A3C7BB5E7942
GO
Isoform E (identifier: P48356-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-805: DNFIPIEKY → GMCTVLFMD
     806-1162: Missing.

Show »
Length:805
Mass (Da):90,887
Checksum:i591B5DE008BDB898
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140F → I in AAC52705 (PubMed:8692797).Curated1
Sequence conflicti140F → I in AAC52706 (PubMed:8692797).Curated1
Sequence conflicti140F → I in AAC52707 (PubMed:8692797).Curated1
Sequence conflicti720A → T in CAA71343 (PubMed:9322935).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti541V → I in strain: NZO. 1
Natural varianti600D → N in strain: KK Obese. 1 Publication1
Natural varianti651V → I in strain: NZO. 1
Natural varianti1044T → I in strain: NZO. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001703797 – 805DNFIPIEKY → GMCTVLFMD in isoform E. 1 Publication9
Alternative sequenceiVSP_001704806 – 1162Missing in isoform E. 1 PublicationAdd BLAST357
Alternative sequenceiVSP_001701890 – 900PETFEHLFTKH → DISFHEVFIFR in isoform D. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_001697890 – 894PETFE → RTDTL in isoform A. 3 Publications5
Alternative sequenceiVSP_001699890 – 892PET → VTV in isoform C. 2 Publications3
Alternative sequenceiVSP_001700893 – 1162Missing in isoform C. 2 PublicationsAdd BLAST270
Alternative sequenceiVSP_001698895 – 1162Missing in isoform A. 3 PublicationsAdd BLAST268
Alternative sequenceiVSP_001702901 – 1162Missing in isoform D. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42467 mRNA. Translation: AAA93014.1.
U46135 mRNA. Translation: AAC52408.1.
U49106 mRNA. Translation: AAC52420.1.
U49107 mRNA. Translation: AAC52421.1.
U49108 mRNA. Translation: AAC52422.1.
U49109 mRNA. Translation: AAC52423.1.
U49110 mRNA. Translation: AAC52424.1.
U52915 mRNA. Translation: AAC52599.1.
U58861 mRNA. Translation: AAC52705.1.
U58862 mRNA. Translation: AAC52706.1.
U58863 mRNA. Translation: AAC52707.1.
Y10298 mRNA. Translation: CAA71343.1.
AF039456
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455 Genomic DNA. Translation: AAB95334.1.
AF039461
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA. Translation: AAB95333.1. Different termination.
AF039459
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458 Genomic DNA. Translation: AAB95335.1.
AF039460
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA. Translation: AAB95332.1.
Y10296 mRNA. Translation: CAA71342.1.
AF098792 Genomic DNA. Translation: AAD13218.1.
CCDSiCCDS18397.1. [P48356-3]
CCDS51239.1. [P48356-2]
CCDS51240.1. [P48356-1]
PIRiS68437.
S68438.
S68439.
S68440.
S68441.
RefSeqiNP_001116371.1. NM_001122899.1. [P48356-2]
NP_034834.1. NM_010704.2. [P48356-3]
NP_666258.2. NM_146146.2. [P48356-1]
UniGeneiMm.259282.

Genome annotation databases

EnsembliENSMUST00000037552; ENSMUSP00000037385; ENSMUSG00000057722. [P48356-1]
ENSMUST00000102777; ENSMUSP00000099838; ENSMUSG00000057722. [P48356-3]
ENSMUST00000106921; ENSMUSP00000102534; ENSMUSG00000057722. [P48356-2]
GeneIDi16847.
KEGGimmu:16847.
UCSCiuc008tvx.2. mouse. [P48356-1]
uc008twa.1. mouse. [P48356-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42467 mRNA. Translation: AAA93014.1.
U46135 mRNA. Translation: AAC52408.1.
U49106 mRNA. Translation: AAC52420.1.
U49107 mRNA. Translation: AAC52421.1.
U49108 mRNA. Translation: AAC52422.1.
U49109 mRNA. Translation: AAC52423.1.
U49110 mRNA. Translation: AAC52424.1.
U52915 mRNA. Translation: AAC52599.1.
U58861 mRNA. Translation: AAC52705.1.
U58862 mRNA. Translation: AAC52706.1.
U58863 mRNA. Translation: AAC52707.1.
Y10298 mRNA. Translation: CAA71343.1.
AF039456
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455 Genomic DNA. Translation: AAB95334.1.
AF039461
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA. Translation: AAB95333.1. Different termination.
AF039459
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458 Genomic DNA. Translation: AAB95335.1.
AF039460
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA. Translation: AAB95332.1.
Y10296 mRNA. Translation: CAA71342.1.
AF098792 Genomic DNA. Translation: AAD13218.1.
CCDSiCCDS18397.1. [P48356-3]
CCDS51239.1. [P48356-2]
CCDS51240.1. [P48356-1]
PIRiS68437.
S68438.
S68439.
S68440.
S68441.
RefSeqiNP_001116371.1. NM_001122899.1. [P48356-2]
NP_034834.1. NM_010704.2. [P48356-3]
NP_666258.2. NM_146146.2. [P48356-1]
UniGeneiMm.259282.

3D structure databases

ProteinModelPortaliP48356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201139. 3 interactors.
DIPiDIP-42763N.
IntActiP48356. 10 interactors.
MINTiMINT-2569396.
STRINGi10090.ENSMUSP00000037385.

Chemistry databases

GuidetoPHARMACOLOGYi1712.

PTM databases

iPTMnetiP48356.
PhosphoSitePlusiP48356.

Proteomic databases

MaxQBiP48356.
PaxDbiP48356.
PeptideAtlasiP48356.
PRIDEiP48356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037552; ENSMUSP00000037385; ENSMUSG00000057722. [P48356-1]
ENSMUST00000102777; ENSMUSP00000099838; ENSMUSG00000057722. [P48356-3]
ENSMUST00000106921; ENSMUSP00000102534; ENSMUSG00000057722. [P48356-2]
GeneIDi16847.
KEGGimmu:16847.
UCSCiuc008tvx.2. mouse. [P48356-1]
uc008twa.1. mouse. [P48356-5]

Organism-specific databases

CTDi3953.
MGIiMGI:104993. Lepr.

Phylogenomic databases

eggNOGiENOG410IKH4. Eukaryota.
ENOG4110JZP. LUCA.
GeneTreeiENSGT00730000111209.
HOVERGENiHBG000140.
InParanoidiP48356.
KOiK05062.
OMAiNWNIQCW.
OrthoDBiEOG091G00QX.
PhylomeDBiP48356.
TreeFamiTF106501.

Enzyme and pathway databases

ReactomeiR-MMU-2586551. Signaling by Leptin.
R-MMU-2586552. Signaling by Leptin.

Miscellaneous databases

PROiP48356.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057722.
CleanExiMM_LEPR.
ExpressionAtlasiP48356. baseline and differential.
GenevisibleiP48356. MM.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 6 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015752. Lep_receptor.
[Graphical view]
PANTHERiPTHR23036:SF109. PTHR23036:SF109. 3 hits.
PfamiPF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 3 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEPR_MOUSE
AccessioniPrimary (citable) accession number: P48356
Secondary accession number(s): O35686
, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 168 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.