Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P48356

- LEPR_MOUSE

UniProt

P48356 - LEPR_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leptin receptor

Gene

Lepr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway.
Isoform A may act to transport leptin to the cerebrospinal fluid.By similarity
Isoform E could function as a transport protein.

GO - Molecular functioni

  1. cytokine receptor activity Source: InterPro
  2. transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  1. cholesterol metabolic process Source: MGI
  2. negative regulation of gluconeogenesis Source: MGI
  3. negative regulation of hydrolase activity Source: MGI
  4. regulation of metabolic process Source: MGI
  5. signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_169390. Signaling by Leptin.
REACT_188529. Signaling by Leptin.

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin receptor
Short name:
LEP-R
Alternative name(s):
B219
OB receptor
Short name:
OB-R
CD_antigen: CD295
Gene namesi
Name:Lepr
Synonyms:Db, Obr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:104993. Lepr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 839818ExtracellularSequence AnalysisAdd
BLAST
Transmembranei840 – 86021HelicalSequence AnalysisAdd
BLAST
Topological domaini861 – 1162302CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. integral component of plasma membrane Source: MGI
  3. plasma membrane Source: Reactome
  4. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi985 – 9851Y → L: No change in EPO-induced JAK2 activation and EPO-induced tyrosine phosphorylation. No phosphorylation; when associated with S-1138. No phosphorylation; when associated with both S-1138 and F-1077. No change in STAT3 activation. No PTPN11 binding. No SOCS3 binding nor inhibition of signaling. Greatly reduced ERK/FOS activation. 2 Publications
Mutagenesisi1077 – 10771Y → F: No effect on EPO-induced tyrosine phosphorylation. 1 Publication
Mutagenesisi1138 – 11381Y → S: No change in EPO-induced JAK2 activation and EPO-induced tyrosine phosphorylation. No phosphorylation; when associated with L-985. No phosphorylation; when associated with L-985 and F-1077. No STAT3 activation. No change in SOCS3 binding nor signaling inhibition. No effect on ERK/FOS activation. 2 Publications

Keywords - Diseasei

Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 11621141Leptin receptorPRO_0000010906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 90By similarity
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi89 ↔ 99By similarity
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi131 ↔ 142By similarity
Disulfide bondi186 ↔ 195By similarity
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi188 ↔ 193By similarity
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi350 ↔ 410By similarity
Disulfide bondi411 ↔ 416By similarity
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi434 ↔ 445By similarity
Disulfide bondi471 ↔ 526By similarity
Disulfide bondi486 ↔ 496By similarity
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi657 – 6571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi668 – 6681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi686 – 6861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi695 – 6951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi698 – 6981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi726 – 7261N-linked (GlcNAc...)Sequence Analysis
Modified residuei985 – 9851Phosphotyrosine; by JAK22 Publications
Modified residuei1077 – 10771Phosphotyrosine1 Publication
Modified residuei1138 – 11381Phosphotyrosine; by JAK21 Publication

Post-translational modificationi

On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3. Phosphorylation on Tyr-1138 is required for STAT3 binding/activation.2 Publications
Phosphorylation of Tyr-985 is required for SOCS3 binding and SOCS3 mediated inhibition of leptin signaling, whereas phosphorylation of Tyr-1077 has a more accessory role.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP48356.
PRIDEiP48356.

PTM databases

PhosphoSiteiP48356.

Expressioni

Tissue specificityi

Isoform A: highest level of expression in lung and kidney, also present in kidney, heart, brain, spleen, liver, muscle, choroid plexus and hypothalamus. Isoform B: highest level of expression in hypothalamus and lower level in brain, testes and adipose tissue. Isoform E: expressed in adipose tissue, hypothalamus, heart, and testes.

Gene expression databases

BgeeiP48356.
CleanExiMM_LEPR.
ExpressionAtlasiP48356. baseline and differential.
GenevestigatoriP48356.

Interactioni

Subunit structurei

On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3. Interaction with SOCS3 inhibits JAK/STAT signaling.

Binary interactionsi

WithEntry#Exp.IntActNotes
BBS1Q8NFJ93EBI-6143588,EBI-1805484From a different organism.
Plcg1Q620772EBI-2257257,EBI-300133

Protein-protein interaction databases

BioGridi201139. 3 interactions.
DIPiDIP-42763N.
IntActiP48356. 10 interactions.
MINTiMINT-2569396.

Structurei

3D structure databases

ProteinModelPortaliP48356.
SMRiP48356. Positions 127-328, 359-830.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini238 – 33194Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini329 – 42799Ig-likeAdd
BLAST
Domaini537 – 63296Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini637 – 72993Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini738 – 83295Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni465 – 48218Leptin-bindingBy similarityAdd
BLAST
Regioni891 – 8966Required for JAK2 activation

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi620 – 6245WSXWS motif
Motifi869 – 8779Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.1 Publication
The box 1 motif is required for JAK interaction and/or activation.1 Publication

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG29456.
GeneTreeiENSGT00730000111209.
HOVERGENiHBG000140.
InParanoidiP48356.
KOiK05062.
OMAiSWAQGLN.
OrthoDBiEOG7034GB.
PhylomeDBiP48356.
TreeFamiTF106501.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015752. Lep_receptor.
[Graphical view]
PANTHERiPTHR23036:SF11. PTHR23036:SF11. 1 hit.
PfamiPF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 3 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform B (identifier: P48356-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP
60 70 80 90 100
AGAPNNASAL KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS
110 120 130 140 150
ALTDNTEGKT LASVVKASVF RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN
160 170 180 190 200
PFKNYDSKVH LLYDLPEVID DSPLPPLKDS FQTVQCNCSL RGCECHVPVP
210 220 230 240 250
RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL GLHMEVTDDG
260 270 280 290 300
NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS
310 320 330 340 350
SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC
360 370 380 390 400
IYKNENQIIS SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR
410 420 430 440 450
GKFTYDAVYC CNEQACHHRY AELYVIDVNI NISCETDGYL TKMTCRWSPS
460 470 480 490 500
TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT SEPKNCVLQR DGFYECVFQP
510 520 530 540 550
IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN VKAEITVNTG
560 570 580 590 600
LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD
610 620 630 640 650
LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD
660 670 680 690 700
VTKKERNVTL LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT
710 720 730 740 750
FLWTEPAHTV TVLAVNSLGA SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS
760 770 780 790 800
CVILSWTLSP DDYSLLYLVI EWKILNEDDG MKWLRIPSNV KKFYIHDNFI
810 820 830 840 850
PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL YVIVPIIISS
860 870 880 890 900
CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKP ETFEHLFTKH
910 920 930 940 950
AESVIFGPLL LEPEPISEEI SVDTAWKNKD EMVPAAMVSL LLTTPDPESS
960 970 980 990 1000
SICISDQCNS ANFSGSQSTQ VTCEDECQRQ PSVKYATLVS NDKLVETDEE
1010 1020 1030 1040 1050
QGFIHSPVSN CISSNHSPLR QSFSSSSWET EAQTFFLLSD QQPTMISPQL
1060 1070 1080 1090 1100
SFSGLDELLE LEGSFPEENH REKSVCYLGV TSVNRRESGV LLTGEAGILC
1110 1120 1130 1140 1150
TFPAQCLFSD IRILQERCSH FVENNLSLGT SGENFVPYMP QFQTCSTHSH
1160
KIMENKMCDL TV
Length:1,162
Mass (Da):130,789
Last modified:February 1, 1996 - v1
Checksum:i0E1E75B076BA60A2
GO
Isoform A (identifier: P48356-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-894: PETFE → RTDTL
     895-1162: Missing.

Show »
Length:894
Mass (Da):101,058
Checksum:iDF9A7A0E5AC75A53
GO
Isoform C (identifier: P48356-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-892: PET → VTV
     893-1162: Missing.

Show »
Length:892
Mass (Da):100,771
Checksum:i726E5C075A53C9F3
GO
Isoform D (identifier: P48356-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-900: PETFEHLFTKH → DISFHEVFIFR
     901-1162: Missing.

Show »
Length:900
Mass (Da):101,863
Checksum:i7370A3C7BB5E7942
GO
Isoform E (identifier: P48356-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-805: DNFIPIEKY → GMCTVLFMD
     806-1162: Missing.

Show »
Length:805
Mass (Da):90,887
Checksum:i591B5DE008BDB898
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1401F → I in AAC52705. (PubMed:8692797)Curated
Sequence conflicti140 – 1401F → I in AAC52706. (PubMed:8692797)Curated
Sequence conflicti140 – 1401F → I in AAC52707. (PubMed:8692797)Curated
Sequence conflicti720 – 7201A → T in CAA71343. (PubMed:9322935)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti541 – 5411V → I in strain: NZO.
Natural varianti600 – 6001D → N in strain: KK Obese. 1 Publication
Natural varianti651 – 6511V → I in strain: NZO.
Natural varianti1044 – 10441T → I in strain: NZO.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei797 – 8059DNFIPIEKY → GMCTVLFMD in isoform E. 1 PublicationVSP_001703
Alternative sequencei806 – 1162357Missing in isoform E. 1 PublicationVSP_001704Add
BLAST
Alternative sequencei890 – 90011PETFEHLFTKH → DISFHEVFIFR in isoform D. 1 PublicationVSP_001701Add
BLAST
Alternative sequencei890 – 8945PETFE → RTDTL in isoform A. 3 PublicationsVSP_001697
Alternative sequencei890 – 8923PET → VTV in isoform C. 2 PublicationsVSP_001699
Alternative sequencei893 – 1162270Missing in isoform C. 2 PublicationsVSP_001700Add
BLAST
Alternative sequencei895 – 1162268Missing in isoform A. 3 PublicationsVSP_001698Add
BLAST
Alternative sequencei901 – 1162262Missing in isoform D. 1 PublicationVSP_001702Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42467 mRNA. Translation: AAA93014.1.
U46135 mRNA. Translation: AAC52408.1.
U49106 mRNA. Translation: AAC52420.1.
U49107 mRNA. Translation: AAC52421.1.
U49108 mRNA. Translation: AAC52422.1.
U49109 mRNA. Translation: AAC52423.1.
U49110 mRNA. Translation: AAC52424.1.
U52915 mRNA. Translation: AAC52599.1.
U58861 mRNA. Translation: AAC52705.1.
U58862 mRNA. Translation: AAC52706.1.
U58863 mRNA. Translation: AAC52707.1.
Y10298 mRNA. Translation: CAA71343.1.
AF039456
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455 Genomic DNA. Translation: AAB95334.1.
AF039461
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA. Translation: AAB95333.1. Different termination.
AF039459
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458 Genomic DNA. Translation: AAB95335.1.
AF039460
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA. Translation: AAB95332.1.
Y10296 mRNA. Translation: CAA71342.1.
AF098792 Genomic DNA. Translation: AAD13218.1.
CCDSiCCDS18397.1. [P48356-3]
CCDS51239.1. [P48356-2]
CCDS51240.1. [P48356-1]
PIRiS68437.
S68438.
S68439.
S68440.
S68441.
RefSeqiNP_001116371.1. NM_001122899.1. [P48356-2]
NP_034834.1. NM_010704.2. [P48356-3]
NP_666258.2. NM_146146.2. [P48356-1]
UniGeneiMm.259282.

Genome annotation databases

EnsembliENSMUST00000037552; ENSMUSP00000037385; ENSMUSG00000057722. [P48356-1]
ENSMUST00000102777; ENSMUSP00000099838; ENSMUSG00000057722. [P48356-3]
ENSMUST00000106921; ENSMUSP00000102534; ENSMUSG00000057722. [P48356-2]
GeneIDi16847.
KEGGimmu:16847.
UCSCiuc008tvx.2. mouse. [P48356-1]
uc008twa.1. mouse. [P48356-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42467 mRNA. Translation: AAA93014.1 .
U46135 mRNA. Translation: AAC52408.1 .
U49106 mRNA. Translation: AAC52420.1 .
U49107 mRNA. Translation: AAC52421.1 .
U49108 mRNA. Translation: AAC52422.1 .
U49109 mRNA. Translation: AAC52423.1 .
U49110 mRNA. Translation: AAC52424.1 .
U52915 mRNA. Translation: AAC52599.1 .
U58861 mRNA. Translation: AAC52705.1 .
U58862 mRNA. Translation: AAC52706.1 .
U58863 mRNA. Translation: AAC52707.1 .
Y10298 mRNA. Translation: CAA71343.1 .
AF039456
, AF039443 , AF039444 , AF039445 , AF039446 , AF039447 , AF039448 , AF039449 , AF039450 , AF039451 , AF039452 , AF039453 , AF039454 , AF039455 Genomic DNA. Translation: AAB95334.1 .
AF039461
, AF039443 , AF039444 , AF039445 , AF039446 , AF039447 , AF039448 , AF039449 , AF039450 , AF039451 , AF039452 , AF039453 , AF039454 , AF039455 , AF039456 , AF039457 , AF039458 , AF039459 Genomic DNA. Translation: AAB95333.1 . Different termination.
AF039459
, AF039443 , AF039444 , AF039445 , AF039446 , AF039447 , AF039448 , AF039449 , AF039450 , AF039451 , AF039452 , AF039453 , AF039454 , AF039455 , AF039456 , AF039457 , AF039458 Genomic DNA. Translation: AAB95335.1 .
AF039460
, AF039443 , AF039444 , AF039445 , AF039446 , AF039447 , AF039448 , AF039449 , AF039450 , AF039451 , AF039452 , AF039453 , AF039454 , AF039455 , AF039456 , AF039457 , AF039458 , AF039459 Genomic DNA. Translation: AAB95332.1 .
Y10296 mRNA. Translation: CAA71342.1 .
AF098792 Genomic DNA. Translation: AAD13218.1 .
CCDSi CCDS18397.1. [P48356-3 ]
CCDS51239.1. [P48356-2 ]
CCDS51240.1. [P48356-1 ]
PIRi S68437.
S68438.
S68439.
S68440.
S68441.
RefSeqi NP_001116371.1. NM_001122899.1. [P48356-2 ]
NP_034834.1. NM_010704.2. [P48356-3 ]
NP_666258.2. NM_146146.2. [P48356-1 ]
UniGenei Mm.259282.

3D structure databases

ProteinModelPortali P48356.
SMRi P48356. Positions 127-328, 359-830.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201139. 3 interactions.
DIPi DIP-42763N.
IntActi P48356. 10 interactions.
MINTi MINT-2569396.

PTM databases

PhosphoSitei P48356.

Proteomic databases

PaxDbi P48356.
PRIDEi P48356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037552 ; ENSMUSP00000037385 ; ENSMUSG00000057722 . [P48356-1 ]
ENSMUST00000102777 ; ENSMUSP00000099838 ; ENSMUSG00000057722 . [P48356-3 ]
ENSMUST00000106921 ; ENSMUSP00000102534 ; ENSMUSG00000057722 . [P48356-2 ]
GeneIDi 16847.
KEGGi mmu:16847.
UCSCi uc008tvx.2. mouse. [P48356-1 ]
uc008twa.1. mouse. [P48356-5 ]

Organism-specific databases

CTDi 3953.
MGIi MGI:104993. Lepr.

Phylogenomic databases

eggNOGi NOG29456.
GeneTreei ENSGT00730000111209.
HOVERGENi HBG000140.
InParanoidi P48356.
KOi K05062.
OMAi SWAQGLN.
OrthoDBi EOG7034GB.
PhylomeDBi P48356.
TreeFami TF106501.

Enzyme and pathway databases

Reactomei REACT_169390. Signaling by Leptin.
REACT_188529. Signaling by Leptin.

Miscellaneous databases

NextBioi 290776.
PROi P48356.
SOURCEi Search...

Gene expression databases

Bgeei P48356.
CleanExi MM_LEPR.
ExpressionAtlasi P48356. baseline and differential.
Genevestigatori P48356.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015752. Lep_receptor.
[Graphical view ]
PANTHERi PTHR23036:SF11. PTHR23036:SF11. 1 hit.
Pfami PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 4 hits.
PROSITEi PS50853. FN3. 3 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Tissue: Choroid plexus.
  2. "Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice."
    Chen H., Charlat O., Tartaglia L.A., Woolf E.A., Weng X., Ellis S.J., Lakey N.D., Culpepper J., Moore K.J., Breitbart R.E., Duyk G.M., Tepper R.I., Morgenstern J.P.
    Cell 84:491-495(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
    Strain: C57BL/KsJ.
    Tissue: Hypothalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D AND E).
    Strain: C57BL/Ks.
    Tissue: Hypothalamus.
  4. "Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction."
    Cioffi J.A., Shafer A.W., Zupancic T.J., Smith-Gbur J., Mikhail A., Platika D., Snodgrass H.R.
    Nat. Med. 2:585-589(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C).
    Strain: BALB/c.
    Tissue: Liver.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
    Strain: FVB/N.
    Tissue: Spleen.
  6. "Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse."
    Igel M., Becker W., Herberg L., Joost H.G.
    Endocrinology 138:4234-4239(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
    Strain: NZO.
    Tissue: Hypothalamus.
  7. "Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts."
    Chua S.C., Koutras I.K., Han L., Liu S.M., Kay J., Young S.J., Chung W.K., Leibel R.L.
    Genomics 45:264-270(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A; B; C AND E).
    Strain: 129/J.
  8. "Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain."
    Igel M., Taylor B.A., Phillips S.J., Becker W., Herberg L., Joost H.G.
    J. Endocrinol. 21:337-345(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), VARIANT ASN-600.
    Strain: KK Obese.
    Tissue: Hypothalamus.
  9. "Murine leptin receptor genomic exon 18b and surrounding sequence."
    Banks A.S., Myers M.G. Jr.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 890-1162 (ISOFORM B).
    Strain: 129.
  10. "Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor."
    Eyckerman S., Broekaert D., Verhee A., Vandekerckhove J., Tavernier J.
    FEBS Lett. 486:33-37(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-985 AND TYR-1077.
  11. "Activation of downstream signals by the long form of the leptin receptor."
    Banks A.S., Davis S.M., Bates S.H., Myers M.G. Jr.
    J. Biol. Chem. 275:14563-14572(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-985 AND TYR-1138, STAT3 ACTIVATION, ERK/FOS ACTIVATION, MUTAGENESIS OF TYR-985; TYR-1077 AND TYR-1138.
  12. "SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985."
    Bjorbaek C., Lavery H.J., Bates S.H., Olson R.K., Davis S.M., Flier J.S., Myers M.G. Jr.
    J. Biol. Chem. 275:40649-40657(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SOCS3, MUTAGENESIS OF TYR-985 AND TYR-1138.
  13. "Regulation of Jak kinases by intracellular leptin receptor sequences."
    Kloek C., Haq A.K., Dunn S.L., Lavery H.J., Banks A.S., Myers M.G. Jr.
    J. Biol. Chem. 277:41547-41555(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN JAK2 ACTIVATION.

Entry informationi

Entry nameiLEPR_MOUSE
AccessioniPrimary (citable) accession number: P48356
Secondary accession number(s): O35686
, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3