P48356 (LEPR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leptin receptor
Short name=LEP-R

Alternative name(s):
B219
OB receptor
Short name=OB-R
CD_antigen=CD295

Gene names

Name:	Lepr
Synonyms:	Db, Obr

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1162 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway. Isoform A may act to transport leptin to the cerebrospinal fluid By similarity. Isoform E could function as a transport protein.
Subunit structure	On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3. Interaction with SOCS3 inhibits JAK/STAT signaling.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Isoform E: Secreted Probable.
Tissue specificity	Isoform A: highest level of expression in lung and kidney, also present in kidney, heart, brain, spleen, liver, muscle, choroid plexus and hypothalamus. Isoform B: highest level of expression in hypothalamus and lower level in brain, testes and adipose tissue. Isoform E: expressed in adipose tissue, hypothalamus, heart, and testes.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. Ref.13 The box 1 motif is required for JAK interaction and/or activation. Ref.13
Post-translational modification	On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3. Phosphorylation on Tyr-1138 is required for STAT3 binding/activation. Ref.10 Ref.11 Phosphorylation of Tyr-985 is required for SOCS3 binding and SOCS3 mediated inhibition of leptin signaling, whereas phosphorylation of Tyr-1077 has a more accessory role.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains. Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Obesity
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cholesterol metabolic process Inferred from genetic interaction PubMed 15995171. Source: MGI cytokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC negative regulation of hydrolase activity Inferred from genetic interaction PubMed 15995171. Source: MGI
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement PubMed 9102398. Source: MGI
Molecular_function	cytokine receptor activity Inferred from electronic annotation. Source: InterPro transmembrane signaling receptor activity Traceable author statement PubMed 9102398. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BBS1	Q8NFJ9	3	EBI-6143588,EBI-1805484	From a different organism.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform B (identifier: P48356-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: P48356-2)

The sequence of this isoform differs from the canonical sequence as follows:
     890-894: PETFE → RTDTL
     895-1162: Missing.

Isoform C (identifier: P48356-3)

The sequence of this isoform differs from the canonical sequence as follows:
     890-892: PET → VTV
     893-1162: Missing.

Isoform D (identifier: P48356-4)

The sequence of this isoform differs from the canonical sequence as follows:
     890-900: PETFEHLFTKH → DISFHEVFIFR
     901-1162: Missing.

Isoform E (identifier: P48356-5)

The sequence of this isoform differs from the canonical sequence as follows:
     797-805: DNFIPIEKY → GMCTVLFMD
     806-1162: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 1162	1141	Leptin receptor		PRO_0000010906
Regions
	Topological domain	22 – 839	818	Extracellular Potential
	Transmembrane	840 – 860	21	Helical; Potential
	Topological domain	861 – 1162	302	Cytoplasmic Potential
	Domain	236 – 328	93	Fibronectin type-III 1
	Domain	329 – 427	99	Ig-like
	Domain	535 – 629	95	Fibronectin type-III 2
	Domain	637 – 729	93	Fibronectin type-III 3
	Domain	735 – 827	93	Fibronectin type-III 4
	Region	465 – 482	18	Leptin-binding By similarity
	Region	891 – 896	6	Required for JAK2 activation
	Motif	620 – 624	5	WSXWS motif
	Motif	869 – 877	9	Box 1 motif
Amino acid modifications
	Modified residue	985	1	Phosphotyrosine; by JAK2 Ref.10
	Modified residue	1077	1	Phosphotyrosine Ref.10
	Modified residue	1138	1	Phosphotyrosine; by JAK2
	Glycosylation	41	1	N-linked (GlcNAc...) Potential
	Glycosylation	56	1	N-linked (GlcNAc...) Potential
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Glycosylation	98	1	N-linked (GlcNAc...) Potential
	Glycosylation	187	1	N-linked (GlcNAc...) Potential
	Glycosylation	275	1	N-linked (GlcNAc...) Potential
	Glycosylation	345	1	N-linked (GlcNAc...) Potential
	Glycosylation	431	1	N-linked (GlcNAc...) Potential
	Glycosylation	514	1	N-linked (GlcNAc...) Potential
	Glycosylation	622	1	N-linked (GlcNAc...) Potential
	Glycosylation	657	1	N-linked (GlcNAc...) Potential
	Glycosylation	668	1	N-linked (GlcNAc...) Potential
	Glycosylation	686	1	N-linked (GlcNAc...) Potential
	Glycosylation	695	1	N-linked (GlcNAc...) Potential
	Glycosylation	698	1	N-linked (GlcNAc...) Potential
	Glycosylation	726	1	N-linked (GlcNAc...) Potential
	Disulfide bond	37 ↔ 90		By similarity
	Disulfide bond	89 ↔ 99		By similarity
	Disulfide bond	131 ↔ 142		By similarity
	Disulfide bond	186 ↔ 195		By similarity
	Disulfide bond	188 ↔ 193		By similarity
	Disulfide bond	350 ↔ 410		By similarity
	Disulfide bond	411 ↔ 416		By similarity
	Disulfide bond	434 ↔ 445		By similarity
	Disulfide bond	471 ↔ 526		By similarity
	Disulfide bond	486 ↔ 496		By similarity
Natural variations
	Alternative sequence	797 – 805	9	DNFIPIEKY → GMCTVLFMD in isoform E.		VSP_001703
	Alternative sequence	806 – 1162	357	Missing in isoform E.		VSP_001704
	Alternative sequence	890 – 900	11	PETFEHLFTKH → DISFHEVFIFR in isoform D.		VSP_001701
	Alternative sequence	890 – 894	5	PETFE → RTDTL in isoform A.		VSP_001697
	Alternative sequence	890 – 892	3	PET → VTV in isoform C.		VSP_001699
	Alternative sequence	893 – 1162	270	Missing in isoform C.		VSP_001700
	Alternative sequence	895 – 1162	268	Missing in isoform A.		VSP_001698
	Alternative sequence	901 – 1162	262	Missing in isoform D.		VSP_001702
	Natural variant	541	1	V → I in strain: NZO.
	Natural variant	600	1	D → N in strain: KK Obese. Ref.8
	Natural variant	651	1	V → I in strain: NZO.
	Natural variant	1044	1	T → I in strain: NZO.
Experimental info
	Mutagenesis	985	1	Y → L: No change in EPO-induced JAK2 activation and EPO-induced tyrosine phosphorylation. No phosphorylation; when associated with S-1138. No phosphorylation; when associated with both S-1138 and F-1077. No change in STAT3 activation. No PTPN11 binding. No SOCS3 binding nor inhibition of signaling. Greatly reduced ERK/FOS activation. Ref.11 Ref.12
	Mutagenesis	1077	1	Y → F: No effect on EPO-induced tyrosine phosphorylation. Ref.11
	Mutagenesis	1138	1	Y → S: No change in EPO-induced JAK2 activation and EPO-induced tyrosine phosphorylation. No phosphorylation; when associated with L-985. No phosphorylation; when associated with L-985 and F-1077. No STAT3 activation. No change in SOCS3 binding nor signaling inhibition. No effect on ERK/FOS activation. Ref.11 Ref.12
	Sequence conflict	140	1	F → I in AAC52705. Ref.5
	Sequence conflict	140	1	F → I in AAC52706. Ref.5
	Sequence conflict	140	1	F → I in AAC52707. Ref.5
	Sequence conflict	720	1	A → T in CAA71343. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform B [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 0E1E75B076BA60A2	FASTA	1,162	130,789
	10 20 30 40 50 60 MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP AGAPNNASAL 70 80 90 100 110 120 KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS ALTDNTEGKT LASVVKASVF 130 140 150 160 170 180 RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN PFKNYDSKVH LLYDLPEVID DSPLPPLKDS 190 200 210 220 230 240 FQTVQCNCSL RGCECHVPVP RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL 250 260 270 280 290 300 GLHMEVTDDG NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS 310 320 330 340 350 360 SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC IYKNENQIIS 370 380 390 400 410 420 SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY 430 440 450 460 470 480 AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT 490 500 510 520 530 540 SEPKNCVLQR DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN 550 560 570 580 590 600 VKAEITVNTG LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD 610 620 630 640 650 660 LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD VTKKERNVTL 670 680 690 700 710 720 LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT FLWTEPAHTV TVLAVNSLGA 730 740 750 760 770 780 SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS CVILSWTLSP DDYSLLYLVI EWKILNEDDG 790 800 810 820 830 840 MKWLRIPSNV KKFYIHDNFI PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL 850 860 870 880 890 900 YVIVPIIISS CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKP ETFEHLFTKH 910 920 930 940 950 960 AESVIFGPLL LEPEPISEEI SVDTAWKNKD EMVPAAMVSL LLTTPDPESS SICISDQCNS 970 980 990 1000 1010 1020 ANFSGSQSTQ VTCEDECQRQ PSVKYATLVS NDKLVETDEE QGFIHSPVSN CISSNHSPLR 1030 1040 1050 1060 1070 1080 QSFSSSSWET EAQTFFLLSD QQPTMISPQL SFSGLDELLE LEGSFPEENH REKSVCYLGV 1090 1100 1110 1120 1130 1140 TSVNRRESGV LLTGEAGILC TFPAQCLFSD IRILQERCSH FVENNLSLGT SGENFVPYMP 1150 1160 QFQTCSTHSH KIMENKMCDL TV
	Isoform A [UniParc]. Checksum: DF9A7A0E5AC75A53	FASTA	894	101,058
	10 20 30 40 50 60 MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP AGAPNNASAL 70 80 90 100 110 120 KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS ALTDNTEGKT LASVVKASVF 130 140 150 160 170 180 RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN PFKNYDSKVH LLYDLPEVID DSPLPPLKDS 190 200 210 220 230 240 FQTVQCNCSL RGCECHVPVP RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL 250 260 270 280 290 300 GLHMEVTDDG NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS 310 320 330 340 350 360 SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC IYKNENQIIS 370 380 390 400 410 420 SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY 430 440 450 460 470 480 AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT 490 500 510 520 530 540 SEPKNCVLQR DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN 550 560 570 580 590 600 VKAEITVNTG LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD 610 620 630 640 650 660 LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD VTKKERNVTL 670 680 690 700 710 720 LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT FLWTEPAHTV TVLAVNSLGA 730 740 750 760 770 780 SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS CVILSWTLSP DDYSLLYLVI EWKILNEDDG 790 800 810 820 830 840 MKWLRIPSNV KKFYIHDNFI PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL 850 860 870 880 890 YVIVPIIISS CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKR TDTL
	Isoform C [UniParc]. Checksum: 726E5C075A53C9F3	FASTA	892	100,771
	10 20 30 40 50 60 MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP AGAPNNASAL 70 80 90 100 110 120 KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS ALTDNTEGKT LASVVKASVF 130 140 150 160 170 180 RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN PFKNYDSKVH LLYDLPEVID DSPLPPLKDS 190 200 210 220 230 240 FQTVQCNCSL RGCECHVPVP RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL 250 260 270 280 290 300 GLHMEVTDDG NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS 310 320 330 340 350 360 SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC IYKNENQIIS 370 380 390 400 410 420 SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY 430 440 450 460 470 480 AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT 490 500 510 520 530 540 SEPKNCVLQR DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN 550 560 570 580 590 600 VKAEITVNTG LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD 610 620 630 640 650 660 LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD VTKKERNVTL 670 680 690 700 710 720 LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT FLWTEPAHTV TVLAVNSLGA 730 740 750 760 770 780 SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS CVILSWTLSP DDYSLLYLVI EWKILNEDDG 790 800 810 820 830 840 MKWLRIPSNV KKFYIHDNFI PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL 850 860 870 880 890 YVIVPIIISS CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKV TV
	Isoform D [UniParc]. Checksum: 7370A3C7BB5E7942	FASTA	900	101,863
	10 20 30 40 50 60 MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP AGAPNNASAL 70 80 90 100 110 120 KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS ALTDNTEGKT LASVVKASVF 130 140 150 160 170 180 RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN PFKNYDSKVH LLYDLPEVID DSPLPPLKDS 190 200 210 220 230 240 FQTVQCNCSL RGCECHVPVP RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL 250 260 270 280 290 300 GLHMEVTDDG NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS 310 320 330 340 350 360 SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC IYKNENQIIS 370 380 390 400 410 420 SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY 430 440 450 460 470 480 AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT 490 500 510 520 530 540 SEPKNCVLQR DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN 550 560 570 580 590 600 VKAEITVNTG LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD 610 620 630 640 650 660 LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD VTKKERNVTL 670 680 690 700 710 720 LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT FLWTEPAHTV TVLAVNSLGA 730 740 750 760 770 780 SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS CVILSWTLSP DDYSLLYLVI EWKILNEDDG 790 800 810 820 830 840 MKWLRIPSNV KKFYIHDNFI PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL 850 860 870 880 890 900 YVIVPIIISS CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKD ISFHEVFIFR
	Isoform E [UniParc]. Checksum: 591B5DE008BDB898	FASTA	805	90,887
	10 20 30 40 50 60 MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP AGAPNNASAL 70 80 90 100 110 120 KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS ALTDNTEGKT LASVVKASVF 130 140 150 160 170 180 RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN PFKNYDSKVH LLYDLPEVID DSPLPPLKDS 190 200 210 220 230 240 FQTVQCNCSL RGCECHVPVP RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL 250 260 270 280 290 300 GLHMEVTDDG NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS 310 320 330 340 350 360 SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC IYKNENQIIS 370 380 390 400 410 420 SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY 430 440 450 460 470 480 AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT 490 500 510 520 530 540 SEPKNCVLQR DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN 550 560 570 580 590 600 VKAEITVNTG LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD 610 620 630 640 650 660 LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD VTKKERNVTL 670 680 690 700 710 720 LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT FLWTEPAHTV TVLAVNSLGA 730 740 750 760 770 780 SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS CVILSWTLSP DDYSLLYLVI EWKILNEDDG 790 800 MKWLRIPSNV KKFYIHGMCT VLFMD

References

[1]	"Identification and expression cloning of a leptin receptor, OB-R." Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K.J., Smutko J.S., Mays G.G., Woolf E.A., Monroe C.A., Tepper R.I. Cell 83:1263-1271(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). Tissue: Choroid plexus.
[2]	"Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice." Chen H., Charlat O., Tartaglia L.A., Woolf E.A., Weng X., Ellis S.J., Lakey N.D., Culpepper J., Moore K.J., Breitbart R.E., Duyk G.M., Tepper R.I., Morgenstern J.P. Cell 84:491-495(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). Strain: C57BL/KsJ. Tissue: Hypothalamus.
[3]	"Abnormal splicing of the leptin receptor in diabetic mice." Lee G.-H., Proenca R., Montez J.M., Carroll K.M., Darvishzadeh J.G., Lee J.I., Friedman J.M. Nature 379:632-635(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D AND E). Strain: C57BL/Ks. Tissue: Hypothalamus.
[4]	"Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction." Cioffi J.A., Shafer A.W., Zupancic T.J., Smith-Gbur J., Mikhail A., Platika D., Snodgrass H.R. Nat. Med. 2:585-589(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C). Strain: BALB/c. Tissue: Liver.
[5]	"Defective STAT signaling by the leptin receptor in diabetic mice." Ghilardi N., Ziegler S., Wiestner A., Stoffel R., Heim M.H., Skoda R.C. Proc. Natl. Acad. Sci. U.S.A. 93:6231-6235(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B). Strain: FVB/N. Tissue: Spleen.
[6]	"Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse." Igel M., Becker W., Herberg L., Joost H.G. Endocrinology 138:4234-4239(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). Strain: NZO. Tissue: Hypothalamus.
[7]	"Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts." Chua S.C., Koutras I.K., Han L., Liu S.M., Kay J., Young S.J., Chung W.K., Leibel R.L. Genomics 45:264-270(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A; B; C AND E). Strain: 129/J.
[8]	"Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain." Igel M., Taylor B.A., Phillips S.J., Becker W., Herberg L., Joost H.G. J. Endocrinol. 21:337-345(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), VARIANT ASN-600. Strain: KK Obese. Tissue: Hypothalamus.
[9]	"Murine leptin receptor genomic exon 18b and surrounding sequence." Banks A.S., Myers M.G. Jr. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 890-1162 (ISOFORM B). Strain: 129.
[10]	"Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor." Eyckerman S., Broekaert D., Verhee A., Vandekerckhove J., Tavernier J. FEBS Lett. 486:33-37(2000) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT TYR-985 AND TYR-1077.
[11]	"Activation of downstream signals by the long form of the leptin receptor." Banks A.S., Davis S.M., Bates S.H., Myers M.G. Jr. J. Biol. Chem. 275:14563-14572(2000) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION, STAT3 ACTIVATION, ERK/FOS ACTIVATION, MUTAGENESIS OF TYR-985; TYR-1077 AND TYR-1138.
[12]	"SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985." Bjorbaek C., Lavery H.J., Bates S.H., Olson R.K., Davis S.M., Flier J.S., Myers M.G. Jr. J. Biol. Chem. 275:40649-40657(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SOCS3, MUTAGENESIS OF TYR-985 AND TYR-1138.
[13]	"Regulation of Jak kinases by intracellular leptin receptor sequences." Kloek C., Haq A.K., Dunn S.L., Lavery H.J., Banks A.S., Myers M.G. Jr. J. Biol. Chem. 277:41547-41555(2002) [PubMed] [Europe PMC] [Abstract] Cited for: DOMAIN JAK2 ACTIVATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U42467 mRNA. Translation: AAA93014.1. U46135 mRNA. Translation: AAC52408.1. U49106 mRNA. Translation: AAC52420.1. U49107 mRNA. Translation: AAC52421.1. U49108 mRNA. Translation: AAC52422.1. U49109 mRNA. Translation: AAC52423.1. U49110 mRNA. Translation: AAC52424.1. U52915 mRNA. Translation: AAC52599.1. U58861 mRNA. Translation: AAC52705.1. U58862 mRNA. Translation: AAC52706.1. U58863 mRNA. Translation: AAC52707.1. Y10298 mRNA. Translation: CAA71343.1. AF039456 , AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455 Genomic DNA. Translation: AAB95334.1. AF039461 , AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA. Translation: AAB95333.1. Different termination. AF039459 , AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458 Genomic DNA. Translation: AAB95335.1. AF039460 , AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA. Translation: AAB95332.1. Y10296 mRNA. Translation: CAA71342.1. AF098792 Genomic DNA. Translation: AAD13218.1.
IPI	IPI00229997. IPI00229998. IPI00229999. IPI00230000. IPI00230203.
PIR	S68437. S68438. S68439. S68440. S68441.
RefSeq	NP_001116371.1. NM_001122899.1. NP_034834.1. NM_010704.2. NP_666258.2. NM_146146.2.
UniGene	Mm.259282.
3D structure databases
ProteinModelPortal	P48356.
SMR	P48356. Positions 220-323, 359-830.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-42763N.
IntAct	P48356. 3 interactions.
MINT	MINT-2569396.
PTM databases
PhosphoSite	P48356.
Proteomic databases
PaxDb	P48356.
PRIDE	P48356.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000037552; ENSMUSP00000037385; ENSMUSG00000057722. ENSMUST00000102777; ENSMUSP00000099838; ENSMUSG00000057722. ENSMUST00000106921; ENSMUSP00000102534; ENSMUSG00000057722.
GeneID	16847.
KEGG	mmu:16847.
UCSC	uc008twa.1. mouse.
Organism-specific databases
CTD	3953.
MGI	MGI:104993. Lepr.
Phylogenomic databases
eggNOG	NOG29456.
GeneTree	ENSGT00550000074436.
HOVERGEN	HBG000140.
InParanoid	P48356.
KO	K05062.
OMA	LKLFICY.
OrthoDB	EOG469QT5.
Gene expression databases
ArrayExpress	P48356.
Bgee	P48356.
CleanEx	MM_LEPR.
Genevestigator	P48356.
GermOnline	ENSMUSG00000057722. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR003961. Fibronectin_type3. IPR003529. Hematopoietin_rcpt_Gp130_CS. IPR003531. Hempt_rcpt_S_F1_CS. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR010457. IgC2-like_lig-bd. IPR015752. Lep_receptor. [Graphical view]
PANTHER	PTHR23036:SF11. PTHR23036:SF11. 1 hit.
Pfam	PF06328. Lep_receptor_Ig. 1 hit. [Graphical view]
SMART	SM00060. FN3. 4 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 4 hits.
PROSITE	PS50853. FN3. 4 hits. PS01353. HEMATOPO_REC_L_F2. 1 hit. PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	290776.
SOURCE	Search...

Entry information

Entry name

LEPR_MOUSE

Accession

Primary (citable) accession number: P48356
Secondary accession number(s): O35686 , O54986, Q61215, Q64309, Q9QWG3, Q9QWV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 132 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program