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Protein

Protein HLJ1

Gene

HLJ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATPase activator activity Source: SGD

GO - Biological processi

  • ER-associated ubiquitin-dependent protein catabolic process Source: SGD
  • positive regulation of ATPase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-32851-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HLJ1
Gene namesi
Name:HLJ1
Ordered Locus Names:YMR161W
ORF Names:YM8520.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR161W.
SGDiS000004771. HLJ1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Protein HLJ1PRO_0000071120Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP48353.

PTM databases

iPTMnetiP48353.

Interactioni

Protein-protein interaction databases

BioGridi35338. 103 interactions.
IntActiP48353. 2 interactions.
MINTiMINT-4498163.

Structurei

3D structure databases

ProteinModelPortaliP48353.
SMRiP48353. Positions 21-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 8770JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00840000129767.
HOGENOMiHOG000233608.
InParanoidiP48353.
KOiK09518.
OMAiSKDKHEF.
OrthoDBiEOG73FQZP.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFTEDQEKI ALEILSKDKH EFYEILKVDR KATDSEIKKA YRKLAIKLHP
60 70 80 90 100
DKNSHPKAGE AFKVINRAFE VLSNEEKRSI YDRIGRDPDD RQMPSRGAAS
110 120 130 140 150
GFRGSAGGSP MGGGFEDMFF NSRFGGQRAG PPEDIFDFLF NAGGSPFGAS
160 170 180 190 200
PFGPSASTFS FGGPGGFRVY TNNRGGSPFM RQQPRSRQQQ QQAEENAVNS
210 220
QLKNMLVLFI IFIVLPMIKD YLFS
Length:224
Mass (Da):25,008
Last modified:February 1, 1996 - v1
Checksum:iA9BFED9BD242C2DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19358 Genomic DNA. Translation: AAA75025.1.
Z49705 Genomic DNA. Translation: CAA89797.1.
BK006946 Genomic DNA. Translation: DAA10057.1.
PIRiS54519.
RefSeqiNP_013884.1. NM_001182665.1.

Genome annotation databases

EnsemblFungiiYMR161W; YMR161W; YMR161W.
GeneIDi855196.
KEGGisce:YMR161W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19358 Genomic DNA. Translation: AAA75025.1.
Z49705 Genomic DNA. Translation: CAA89797.1.
BK006946 Genomic DNA. Translation: DAA10057.1.
PIRiS54519.
RefSeqiNP_013884.1. NM_001182665.1.

3D structure databases

ProteinModelPortaliP48353.
SMRiP48353. Positions 21-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35338. 103 interactions.
IntActiP48353. 2 interactions.
MINTiMINT-4498163.

PTM databases

iPTMnetiP48353.

Proteomic databases

MaxQBiP48353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR161W; YMR161W; YMR161W.
GeneIDi855196.
KEGGisce:YMR161W.

Organism-specific databases

EuPathDBiFungiDB:YMR161W.
SGDiS000004771. HLJ1.

Phylogenomic databases

GeneTreeiENSGT00840000129767.
HOGENOMiHOG000233608.
InParanoidiP48353.
KOiK09518.
OMAiSKDKHEF.
OrthoDBiEOG73FQZP.

Enzyme and pathway databases

BioCyciYEAST:G3O-32851-MONOMER.

Miscellaneous databases

NextBioi978673.
PROiP48353.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "HLJ1, a Saccharomyces cerevisiae homolog of Escherichia coli dnaJ with a high-copy lethal phenotype."
    Stepanek P., Guha S., Volkert F.C.
    Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHLJ1_YEAST
AccessioniPrimary (citable) accession number: P48353
Secondary accession number(s): D6VZY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1840 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.