Reviewed, UniProtKB/Swiss-Prot P48351 (CATA2_CUCPE)

Names and origin

Protein names

Recommended name:
    Catalase isozyme 2
    EC=1.11.1.6

Gene names

Name:

CAT2

Organism

Cucurbita pepo (Vegetable marrow) (Summer squash)

Taxonomic identifier

3663 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Cucurbitales › Cucurbitaceae › Cucurbita

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H(2)O(2) = O(2) + 2 H(2)O.
Cofactor	Heme group By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	PeroxisomeProbable.
Tissue specificity	High levels in green cotyledons, mature leaf, stem and green hypocotyl.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Peroxisome
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	Catalase isozyme 2		PRO_0000084936
Sites
	Active site	65	1	By similarity
	Active site	138	1	By similarity
	Metal binding	347	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48351-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 1D3C97F8E026D600	FASTA	492	56,953
	10 20 30 40 50 60 MDPYKYRPSS AYNTPFCTTN SGAPIWNNTA VMSVGERGPI LLEDYQLIEK IATFTRERIP 70 80 90 100 110 120 ERVVHARGAS AKGFFEVTHD VSDLSCADFL RAPGVQTPVI VRFSTVIHER VSPETVRDPR 130 140 150 160 170 180 GFAVKFYTRE GNFDLVGNNF PVFFVRDAMQ FPDVIRAFKP NPKSHLQESW RFLDFCSYHP 190 200 210 220 230 240 ESLLSFAWFY DDVGIPINYR HMEGFGVQAY SLINKAGKAR LVKFHWKPTC GVKSMLEEEA 250 260 270 280 290 300 IRVGGSNHSH ATQDLYESIA AGNFPEWRLY IQTIDYEDQN NYDFEPLDTT IAWPEDVVPL 310 320 330 340 350 360 RPVGRLVLNK NIDNFFAENE MLAFSMSLVP GIHYSDDKML QARSFAYADT QRHRLGPNYL 370 380 390 400 410 420 QLPVNAPKCP HHNNHHEGFM NFMHRDEEVN YFPSRYDACR HAEKYPMPPN VLSGKRERCV 430 440 450 460 470 480 IPKENHNFKQ AGDRYRSWAP DRQERFVNRF VEALSDSKVT HEVRNIWISY WTQADRSLGQ 490 KIASRMNARP NM

References

[1]	"cDNA cloning and differential gene expression of three catalases in pumpkin." Esaka M., Yamada N., Kitabayashi M., Setoguchi Y., Tsugeki R., Kondo M., Nishimura M. Plant Mol. Biol. 33:141-155(1997) [PubMed: 9037166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cotyledon.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D55646 mRNA. Translation: BAA09507.1.
PIR	T09754.
3D structure databases
HSSP	HSSP built from PDB template 1M7S based on UniProtKB P46206.
ModBase	Search...
Family and domain databases
InterPro	IPR002226. Catalase. IPR011614. Catalase_N. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
ProDom	PD000510. Catalase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA2_CUCPE

Accession

Primary (citable) accession number: P48351

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 25, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)