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Protein

Interleukin-15

Gene

Il15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

GO - Molecular functioni

  • cytokine activity Source: MGI

GO - Biological processi

  • aging Source: Ensembl
  • cell maturation Source: MGI
  • cellular response to vitamin D Source: Ensembl
  • extrathymic T cell selection Source: MGI
  • hyaluronan metabolic process Source: Ensembl
  • immune response Source: GO_Central
  • inflammatory response Source: Ensembl
  • lymph node development Source: MGI
  • natural killer cell differentiation Source: MGI
  • negative regulation of smooth muscle cell proliferation Source: Ensembl
  • NK T cell proliferation Source: MGI
  • positive regulation of immune response Source: MGI
  • positive regulation of interleukin-17 production Source: MGI
  • positive regulation of natural killer cell differentiation Source: MGI
  • positive regulation of natural killer cell proliferation Source: MGI
  • positive regulation of protein O-linked glycosylation Source: MGI
  • positive regulation of T cell proliferation Source: MGI
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  • regulation of defense response to virus by host Source: MGI
  • regulation of T cell differentiation Source: MGI
  • signal transduction Source: GO_Central
  • skeletal muscle atrophy Source: Ensembl
  • tyrosine phosphorylation of Stat5 protein Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-15
Short name:
IL-15
Gene namesi
Name:Il15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:103014. Il15.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: Ensembl
  • cytoplasm Source: MGI
  • extracellular space Source: GO_Central
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Propeptidei30 – 4819Sequence AnalysisPRO_0000015399Add
BLAST
Chaini49 – 162114Interleukin-15PRO_0000015400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 1331 Publication
Disulfide bondi90 ↔ 1361 Publication
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP48346.

PTM databases

PhosphoSiteiP48346.

Expressioni

Gene expression databases

BgeeiP48346.
CleanExiMM_IL15.
ExpressionAtlasiP48346. baseline and differential.
GenevisibleiP48346. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034148.

Structurei

Secondary structure

1
162
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi49 – 6315Combined sources
Helixi64 – 663Combined sources
Beta strandi72 – 754Combined sources
Helixi81 – 833Combined sources
Helixi84 – 10118Combined sources
Helixi105 – 12420Combined sources
Helixi136 – 1383Combined sources
Beta strandi139 – 1435Combined sources
Helixi144 – 16017Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PSMX-ray2.19A/B49-162[»]
ProteinModelPortaliP48346.
SMRiP48346. Positions 46-162.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48346.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44071.
HOGENOMiHOG000113029.
HOVERGENiHBG006142.
InParanoidiP48346.
KOiK05433.
OMAiRSTSIQC.
OrthoDBiEOG77Q4ZF.
PhylomeDBiP48346.
TreeFamiTF336199.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020439. IL-15.
IPR003443. IL-15/IL-21_fam.
IPR020466. IL-15_mml.
[Graphical view]
PfamiPF02372. IL15. 1 hit.
[Graphical view]
PRINTSiPR01947. INTLKN15MAML.
PR01930. INTRLEUKIN15.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILKPYMRN TSISCYLCFL LNSHFLTEAG IHVFILGCVS VGLPKTEANW
60 70 80 90 100
IDVRYDLEKI ESLIQSIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH
110 120 130 140 150
EYSNMTLNET VRNVLYLANS TLSSNKNVAE SGCKECEELE EKTFTEFLQS
160
FIRIVQMFIN TS
Length:162
Mass (Da):18,593
Last modified:February 1, 1996 - v1
Checksum:i68C971498CEBF296
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14332 mRNA. Translation: AAA75377.1.
BC023698 mRNA. Translation: AAH23698.1.
CCDSiCCDS40401.1.
PIRiI49124.
RefSeqiNP_001241676.1. NM_001254747.1.
NP_032383.1. NM_008357.2.
XP_006530768.1. XM_006530705.2.
XP_006530769.1. XM_006530706.2.
XP_006530770.1. XM_006530707.2.
XP_006530771.1. XM_006530708.2.
XP_006530772.1. XM_006530709.1.
XP_006530773.1. XM_006530710.1.
XP_006530774.1. XM_006530711.2.
XP_006530775.1. XM_006530712.2.
XP_006530776.1. XM_006530713.2.
UniGeneiMm.4392.
Mm.490053.

Genome annotation databases

EnsembliENSMUST00000034148; ENSMUSP00000034148; ENSMUSG00000031712.
GeneIDi16168.
KEGGimmu:16168.
UCSCiuc009mjk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14332 mRNA. Translation: AAA75377.1.
BC023698 mRNA. Translation: AAH23698.1.
CCDSiCCDS40401.1.
PIRiI49124.
RefSeqiNP_001241676.1. NM_001254747.1.
NP_032383.1. NM_008357.2.
XP_006530768.1. XM_006530705.2.
XP_006530769.1. XM_006530706.2.
XP_006530770.1. XM_006530707.2.
XP_006530771.1. XM_006530708.2.
XP_006530772.1. XM_006530709.1.
XP_006530773.1. XM_006530710.1.
XP_006530774.1. XM_006530711.2.
XP_006530775.1. XM_006530712.2.
XP_006530776.1. XM_006530713.2.
UniGeneiMm.4392.
Mm.490053.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PSMX-ray2.19A/B49-162[»]
ProteinModelPortaliP48346.
SMRiP48346. Positions 46-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034148.

PTM databases

PhosphoSiteiP48346.

Proteomic databases

PRIDEiP48346.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034148; ENSMUSP00000034148; ENSMUSG00000031712.
GeneIDi16168.
KEGGimmu:16168.
UCSCiuc009mjk.2. mouse.

Organism-specific databases

CTDi3600.
MGIiMGI:103014. Il15.

Phylogenomic databases

eggNOGiNOG44071.
HOGENOMiHOG000113029.
HOVERGENiHBG006142.
InParanoidiP48346.
KOiK05433.
OMAiRSTSIQC.
OrthoDBiEOG77Q4ZF.
PhylomeDBiP48346.
TreeFamiTF336199.

Miscellaneous databases

EvolutionaryTraceiP48346.
NextBioi289003.
PROiP48346.
SOURCEiSearch...

Gene expression databases

BgeeiP48346.
CleanExiMM_IL15.
ExpressionAtlasiP48346. baseline and differential.
GenevisibleiP48346. MM.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020439. IL-15.
IPR003443. IL-15/IL-21_fam.
IPR020466. IL-15_mml.
[Graphical view]
PfamiPF02372. IL15. 1 hit.
[Graphical view]
PRINTSiPR01947. INTLKN15MAML.
PR01930. INTRLEUKIN15.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: WC/REJ X C57BL/6J.
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. "Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation."
    Olsen S.K., Ota N., Kishishita S., Kukimoto-Niino M., Murayama K., Uchiyama H., Toyama M., Terada T., Shirouzu M., Kanagawa O., Yokoyama S.
    J. Biol. Chem. 282:37191-37204(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 42-162 IN COMPLEX WITH IL15RA, DISULFIDE BONDS.

Entry informationi

Entry nameiIL15_MOUSE
AccessioniPrimary (citable) accession number: P48346
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.