Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P48346

- IL15_MOUSE

UniProt

P48346 - IL15_MOUSE

Protein

Interleukin-15

Gene

Il15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    GO - Biological processi

    1. aging Source: Ensembl
    2. cell maturation Source: MGI
    3. cellular response to vitamin D Source: Ensembl
    4. extrathymic T cell selection Source: MGI
    5. hyaluronan metabolic process Source: Ensembl
    6. immune response Source: InterPro
    7. inflammatory response Source: Ensembl
    8. lymph node development Source: MGI
    9. natural killer cell differentiation Source: MGI
    10. negative regulation of smooth muscle cell proliferation Source: Ensembl
    11. NK T cell proliferation Source: MGI
    12. positive regulation of immune response Source: MGI
    13. positive regulation of interleukin-17 production Source: Ensembl
    14. positive regulation of natural killer cell differentiation Source: MGI
    15. positive regulation of natural killer cell proliferation Source: MGI
    16. positive regulation of T cell proliferation Source: MGI
    17. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
    18. regulation of defense response to virus by host Source: MGI
    19. regulation of T cell differentiation Source: MGI
    20. skeletal muscle atrophy Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-15
    Short name:
    IL-15
    Gene namesi
    Name:Il15
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:103014. Il15.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: MGI
    3. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Propeptidei30 – 4819Sequence AnalysisPRO_0000015399Add
    BLAST
    Chaini49 – 162114Interleukin-15PRO_0000015400Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 1331 Publication
    Disulfide bondi90 ↔ 1361 Publication
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP48346.

    PTM databases

    PhosphoSiteiP48346.

    Expressioni

    Gene expression databases

    ArrayExpressiP48346.
    BgeeiP48346.
    CleanExiMM_IL15.
    GenevestigatoriP48346.

    Structurei

    Secondary structure

    1
    162
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi49 – 6315
    Helixi64 – 663
    Beta strandi72 – 754
    Helixi81 – 833
    Helixi84 – 10118
    Helixi105 – 12420
    Helixi136 – 1383
    Beta strandi139 – 1435
    Helixi144 – 16017

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PSMX-ray2.19A/B49-162[»]
    ProteinModelPortaliP48346.
    SMRiP48346. Positions 46-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP48346.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-15/IL-21 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44071.
    HOGENOMiHOG000113029.
    HOVERGENiHBG006142.
    InParanoidiP48346.
    KOiK05433.
    OMAiRSTSIQC.
    OrthoDBiEOG77Q4ZF.
    PhylomeDBiP48346.
    TreeFamiTF336199.

    Family and domain databases

    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR020439. IL-15.
    IPR003443. IL-15/IL-21_fam.
    IPR020466. IL-15_mml.
    [Graphical view]
    PfamiPF02372. IL15. 1 hit.
    [Graphical view]
    PRINTSiPR01947. INTLKN15MAML.
    PR01930. INTRLEUKIN15.
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48346-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILKPYMRN TSISCYLCFL LNSHFLTEAG IHVFILGCVS VGLPKTEANW    50
    IDVRYDLEKI ESLIQSIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH 100
    EYSNMTLNET VRNVLYLANS TLSSNKNVAE SGCKECEELE EKTFTEFLQS 150
    FIRIVQMFIN TS 162
    Length:162
    Mass (Da):18,593
    Last modified:February 1, 1996 - v1
    Checksum:i68C971498CEBF296
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14332 mRNA. Translation: AAA75377.1.
    BC023698 mRNA. Translation: AAH23698.1.
    CCDSiCCDS40401.1.
    PIRiI49124.
    RefSeqiNP_001241676.1. NM_001254747.1.
    NP_032383.1. NM_008357.2.
    XP_006530768.1. XM_006530705.1.
    XP_006530769.1. XM_006530706.1.
    XP_006530770.1. XM_006530707.1.
    XP_006530771.1. XM_006530708.1.
    XP_006530772.1. XM_006530709.1.
    XP_006530773.1. XM_006530710.1.
    XP_006530774.1. XM_006530711.1.
    XP_006530775.1. XM_006530712.1.
    XP_006530776.1. XM_006530713.1.
    UniGeneiMm.4392.
    Mm.490053.

    Genome annotation databases

    EnsembliENSMUST00000034148; ENSMUSP00000034148; ENSMUSG00000031712.
    GeneIDi16168.
    KEGGimmu:16168.
    UCSCiuc009mjk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14332 mRNA. Translation: AAA75377.1 .
    BC023698 mRNA. Translation: AAH23698.1 .
    CCDSi CCDS40401.1.
    PIRi I49124.
    RefSeqi NP_001241676.1. NM_001254747.1.
    NP_032383.1. NM_008357.2.
    XP_006530768.1. XM_006530705.1.
    XP_006530769.1. XM_006530706.1.
    XP_006530770.1. XM_006530707.1.
    XP_006530771.1. XM_006530708.1.
    XP_006530772.1. XM_006530709.1.
    XP_006530773.1. XM_006530710.1.
    XP_006530774.1. XM_006530711.1.
    XP_006530775.1. XM_006530712.1.
    XP_006530776.1. XM_006530713.1.
    UniGenei Mm.4392.
    Mm.490053.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PSM X-ray 2.19 A/B 49-162 [» ]
    ProteinModelPortali P48346.
    SMRi P48346. Positions 46-162.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P48346.

    Proteomic databases

    PRIDEi P48346.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034148 ; ENSMUSP00000034148 ; ENSMUSG00000031712 .
    GeneIDi 16168.
    KEGGi mmu:16168.
    UCSCi uc009mjk.2. mouse.

    Organism-specific databases

    CTDi 3600.
    MGIi MGI:103014. Il15.

    Phylogenomic databases

    eggNOGi NOG44071.
    HOGENOMi HOG000113029.
    HOVERGENi HBG006142.
    InParanoidi P48346.
    KOi K05433.
    OMAi RSTSIQC.
    OrthoDBi EOG77Q4ZF.
    PhylomeDBi P48346.
    TreeFami TF336199.

    Miscellaneous databases

    EvolutionaryTracei P48346.
    NextBioi 289003.
    PROi P48346.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48346.
    Bgeei P48346.
    CleanExi MM_IL15.
    Genevestigatori P48346.

    Family and domain databases

    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR020439. IL-15.
    IPR003443. IL-15/IL-21_fam.
    IPR020466. IL-15_mml.
    [Graphical view ]
    Pfami PF02372. IL15. 1 hit.
    [Graphical view ]
    PRINTSi PR01947. INTLKN15MAML.
    PR01930. INTRLEUKIN15.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: WC/REJ X C57BL/6J.
      Tissue: Bone marrow.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    3. "Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation."
      Olsen S.K., Ota N., Kishishita S., Kukimoto-Niino M., Murayama K., Uchiyama H., Toyama M., Terada T., Shirouzu M., Kanagawa O., Yokoyama S.
      J. Biol. Chem. 282:37191-37204(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 42-162 IN COMPLEX WITH IL15RA, DISULFIDE BONDS.

    Entry informationi

    Entry nameiIL15_MOUSE
    AccessioniPrimary (citable) accession number: P48346
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3