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Protein

Interleukin-15

Gene

Il15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • cytokine receptor binding Source: InterPro

GO - Biological processi

  • aging Source: Ensembl
  • cell maturation Source: MGI
  • cellular response to vitamin D Source: Ensembl
  • extrathymic T cell selection Source: MGI
  • hyaluronan metabolic process Source: Ensembl
  • immune response Source: InterPro
  • inflammatory response Source: Ensembl
  • interleukin-15-mediated signaling pathway Source: MGI
  • lymph node development Source: MGI
  • natural killer cell differentiation Source: MGI
  • negative regulation of smooth muscle cell proliferation Source: Ensembl
  • NK T cell proliferation Source: MGI
  • positive regulation of immune response Source: MGI
  • positive regulation of interleukin-17 production Source: MGI
  • positive regulation of natural killer cell differentiation Source: MGI
  • positive regulation of natural killer cell proliferation Source: MGI
  • positive regulation of protein O-linked glycosylation Source: MGI
  • positive regulation of T cell proliferation Source: MGI
  • positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
  • regulation of defense response to virus by host Source: MGI
  • regulation of T cell differentiation Source: MGI
  • skeletal muscle atrophy Source: Ensembl
  • tyrosine phosphorylation of STAT protein Source: MGI

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-8983432. Interleukin-15 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-15
Short name:
IL-15
Gene namesi
Name:Il15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:103014. Il15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000001539930 – 48Sequence analysisAdd BLAST19
ChainiPRO_000001540049 – 162Interleukin-15Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 1331 Publication
Disulfide bondi90 ↔ 1361 Publication
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48346.
PRIDEiP48346.

PTM databases

PhosphoSitePlusiP48346.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031712.
CleanExiMM_IL15.
ExpressionAtlasiP48346. baseline and differential.
GenevisibleiP48346. MM.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • cytokine receptor binding Source: InterPro

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034148.

Structurei

Secondary structure

1162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi49 – 63Combined sources15
Helixi64 – 66Combined sources3
Beta strandi72 – 75Combined sources4
Helixi81 – 83Combined sources3
Helixi84 – 101Combined sources18
Helixi105 – 124Combined sources20
Helixi136 – 138Combined sources3
Beta strandi139 – 143Combined sources5
Helixi144 – 160Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PSMX-ray2.19A/B49-162[»]
ProteinModelPortaliP48346.
SMRiP48346.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48346.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ5D. Eukaryota.
ENOG41119SX. LUCA.
GeneTreeiENSGT00390000016264.
HOGENOMiHOG000113029.
HOVERGENiHBG006142.
InParanoidiP48346.
KOiK05433.
OMAiTSIQCYL.
OrthoDBiEOG091G0VGG.
PhylomeDBiP48346.
TreeFamiTF336199.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR020439. IL-15.
IPR003443. IL-15/IL-21_fam.
IPR020466. IL-15_mml.
PfamiView protein in Pfam
PF02372. IL15. 1 hit.
PRINTSiPR01947. INTLKN15MAML.
PR01930. INTRLEUKIN15.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILKPYMRN TSISCYLCFL LNSHFLTEAG IHVFILGCVS VGLPKTEANW
60 70 80 90 100
IDVRYDLEKI ESLIQSIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH
110 120 130 140 150
EYSNMTLNET VRNVLYLANS TLSSNKNVAE SGCKECEELE EKTFTEFLQS
160
FIRIVQMFIN TS
Length:162
Mass (Da):18,593
Last modified:February 1, 1996 - v1
Checksum:i68C971498CEBF296
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14332 mRNA. Translation: AAA75377.1.
BC023698 mRNA. Translation: AAH23698.1.
CCDSiCCDS40401.1.
PIRiI49124.
RefSeqiNP_001241676.1. NM_001254747.1.
NP_032383.1. NM_008357.2.
XP_006530768.1. XM_006530705.3.
XP_006530769.1. XM_006530706.3.
XP_006530770.1. XM_006530707.3.
XP_006530771.1. XM_006530708.3.
XP_006530772.1. XM_006530709.2.
XP_006530773.1. XM_006530710.2.
XP_006530774.1. XM_006530711.3.
XP_006530775.1. XM_006530712.3.
XP_006530776.1. XM_006530713.3.
XP_011246614.1. XM_011248312.2.
XP_011246615.1. XM_011248313.2.
XP_011246616.1. XM_011248314.2.
UniGeneiMm.4392.
Mm.490053.

Genome annotation databases

EnsembliENSMUST00000034148; ENSMUSP00000034148; ENSMUSG00000031712.
ENSMUST00000209363; ENSMUSP00000147848; ENSMUSG00000031712.
ENSMUST00000209573; ENSMUSP00000148256; ENSMUSG00000031712.
GeneIDi16168.
KEGGimmu:16168.
UCSCiuc009mjk.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiIL15_MOUSE
AccessioniPrimary (citable) accession number: P48346
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 27, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families