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P48346 (IL15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-15

Short name=IL-15
Gene names
Name:Il15
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-15/IL-21 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNK T cell proliferation

Inferred from mutant phenotype PubMed 10704459. Source: MGI

aging

Inferred from electronic annotation. Source: Ensembl

cell maturation

Inferred from genetic interaction PubMed 17318811. Source: MGI

cellular response to vitamin D

Inferred from electronic annotation. Source: Ensembl

extrathymic T cell selection

Inferred from mutant phenotype PubMed 10704459. Source: MGI

hyaluronan metabolic process

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: Ensembl

lymph node development

Inferred from mutant phenotype PubMed 10704459. Source: MGI

natural killer cell differentiation

Inferred from genetic interaction PubMed 17318811. Source: MGI

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell proliferation

Inferred from mutant phenotype PubMed 10704459. Source: MGI

positive regulation of immune response

Inferred from mutant phenotype PubMed 10704459. Source: MGI

positive regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell differentiation

Inferred from direct assay PubMed 14607906. Source: MGI

positive regulation of natural killer cell proliferation

Inferred from direct assay PubMed 14607906. Source: MGI

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from electronic annotation. Source: Ensembl

regulation of T cell differentiation

Inferred from mutant phenotype PubMed 10704459. Source: MGI

regulation of defense response to virus by host

Inferred from mutant phenotype PubMed 10704459. Source: MGI

skeletal muscle atrophy

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 11737071. Source: MGI

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 14607906. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Propeptide30 – 4819 Potential
PRO_0000015399
Chain49 – 162114Interleukin-15
PRO_0000015400

Amino acid modifications

Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1081N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential
Disulfide bond83 ↔ 133 Ref.3
Disulfide bond90 ↔ 136 Ref.3

Secondary structure

............... 162
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P48346 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 68C971498CEBF296

FASTA16218,593
        10         20         30         40         50         60 
MKILKPYMRN TSISCYLCFL LNSHFLTEAG IHVFILGCVS VGLPKTEANW IDVRYDLEKI 

        70         80         90        100        110        120 
ESLIQSIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH EYSNMTLNET VRNVLYLANS 

       130        140        150        160 
TLSSNKNVAE SGCKECEELE EKTFTEFLQS FIRIVQMFIN TS 

« Hide

References

« Hide 'large scale' references
[1]"Chromosomal assignment and genomic structure of IL15."
Anderson D.M., Johnson L., Glaccum M.B., Copeland N.G., Gilbert D.J., Jenkins N.A., Valentine V., Kirstein M.N., Shapiro D.N., Morris S.W., Grabstein K., Cosman D.
Genomics 25:701-706(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: WC/REJ X C57BL/6J.
Tissue: Bone marrow.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
[3]"Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation."
Olsen S.K., Ota N., Kishishita S., Kukimoto-Niino M., Murayama K., Uchiyama H., Toyama M., Terada T., Shirouzu M., Kanagawa O., Yokoyama S.
J. Biol. Chem. 282:37191-37204(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 42-162 IN COMPLEX WITH IL15RA, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U14332 mRNA. Translation: AAA75377.1.
BC023698 mRNA. Translation: AAH23698.1.
PIRI49124.
RefSeqNP_001241676.1. NM_001254747.1.
NP_032383.1. NM_008357.2.
XP_006530768.1. XM_006530705.1.
XP_006530769.1. XM_006530706.1.
XP_006530770.1. XM_006530707.1.
XP_006530771.1. XM_006530708.1.
XP_006530772.1. XM_006530709.1.
XP_006530773.1. XM_006530710.1.
XP_006530774.1. XM_006530711.1.
XP_006530775.1. XM_006530712.1.
XP_006530776.1. XM_006530713.1.
UniGeneMm.4392.
Mm.490053.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2PSMX-ray2.19A/B49-162[»]
ProteinModelPortalP48346.
SMRP48346. Positions 46-162.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP48346.

Proteomic databases

PRIDEP48346.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034148; ENSMUSP00000034148; ENSMUSG00000031712.
GeneID16168.
KEGGmmu:16168.
UCSCuc009mjk.2. mouse.

Organism-specific databases

CTD3600.
MGIMGI:103014. Il15.

Phylogenomic databases

eggNOGNOG44071.
HOGENOMHOG000113029.
HOVERGENHBG006142.
InParanoidP48346.
KOK05433.
OMARSTSIQC.
OrthoDBEOG77Q4ZF.
PhylomeDBP48346.
TreeFamTF336199.

Gene expression databases

ArrayExpressP48346.
BgeeP48346.
CleanExMM_IL15.
GenevestigatorP48346.

Family and domain databases

InterProIPR009079. 4_helix_cytokine-like_core.
IPR020439. IL-15.
IPR003443. IL-15/IL-21_fam.
IPR020466. IL-15_mml.
[Graphical view]
PfamPF02372. IL15. 1 hit.
[Graphical view]
PRINTSPR01947. INTLKN15MAML.
PR01930. INTRLEUKIN15.
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP48346.
NextBio289003.
PROP48346.
SOURCESearch...

Entry information

Entry nameIL15_MOUSE
AccessionPrimary (citable) accession number: P48346
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot