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P48319

- DCE1_PIG

UniProt

P48319 - DCE1_PIG

Protein

Glutamate decarboxylase 1

Gene

GAD1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the production of GABA.

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.

    Cofactori

    Pyridoxal phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei567 – 5671SubstrateBy similarity

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. carboxylic acid metabolic process Source: InterPro
    2. neurotransmitter biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Neurotransmitter biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_207345. GABA synthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylase 1 (EC:4.1.1.15)
    Alternative name(s):
    67 kDa glutamic acid decarboxylase
    Short name:
    GAD-67
    Glutamate decarboxylase 67 kDa isoform
    Gene namesi
    Name:GAD1
    Synonyms:GAD67
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 15

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. cell cortex Source: Ensembl
    3. mitochondrion Source: Ensembl
    4. presynaptic active zone Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594Glutamate decarboxylase 1PRO_0000146966Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei405 – 4051N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP48319.
    SMRiP48319. Positions 93-593.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni190 – 1923Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00730000110441.
    HOVERGENiHBG004980.
    KOiK01580.
    OMAiEYLYTKI.
    OrthoDBiEOG7H1JM3.
    TreeFamiTF314688.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48319-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSTPSSSA TSSNAGPDPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF    50
    LQRTNSLEEK SRLVSAFKER QSSKNLLSCE NSDRDGRFRR TETDFSNLFA 100
    RDLLPAKNGE EQTVQFLLEV VDILLNYVRK TFDRSTKVLD FHHPHQLLEG 150
    MEGFNLELSD HPESLEQILV DCRDTLKYGV RTGHPRFFNQ LSTGLDIIGL 200
    AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS NKDGDGIFSP 250
    GGAISNMYSI MAARYKYFPE VKTKGMAAVP KLVLFTSEHS HYSIKKAGAA 300
    LGFGTDNVIL IKCNERGKII PADLEAKILE AKQKGYIPLY VNATAGTTVY 350
    GAFDPIQEIA DICEKYNLWL HVDAAWGGGL LMSRKHRHKL SGIERADSVT 400
    WNPHKMMGVL LQCSAILVKE KGILQGCNQM CAGYLFQPDK QYDVSYDTGD 450
    KAIQCGRHVD IFKFWLMWKA KGTVGFENQI NKCLELAEYL YAKIKNREEF 500
    EMVFDGEPEH TNVCFWYIPQ SLRGVPDSPE RREKLHRVAP KIKALMMESG 550
    TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL 594
    Length:594
    Mass (Da):66,895
    Last modified:February 1, 1996 - v1
    Checksum:i42C7954A537862AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31849 mRNA. Translation: BAA06636.1.
    PIRiJC4065.
    RefSeqiNP_999059.1. NM_213894.1.
    UniGeneiSsc.14526.

    Genome annotation databases

    EnsembliENSSSCT00000026586; ENSSSCP00000023541; ENSSSCG00000022233.
    GeneIDi396928.
    KEGGissc:396928.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31849 mRNA. Translation: BAA06636.1 .
    PIRi JC4065.
    RefSeqi NP_999059.1. NM_213894.1.
    UniGenei Ssc.14526.

    3D structure databases

    ProteinModelPortali P48319.
    SMRi P48319. Positions 93-593.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000026586 ; ENSSSCP00000023541 ; ENSSSCG00000022233 .
    GeneIDi 396928.
    KEGGi ssc:396928.

    Organism-specific databases

    CTDi 2571.

    Phylogenomic databases

    GeneTreei ENSGT00730000110441.
    HOVERGENi HBG004980.
    KOi K01580.
    OMAi EYLYTKI.
    OrthoDBi EOG7H1JM3.
    TreeFami TF314688.

    Enzyme and pathway databases

    Reactomei REACT_207345. GABA synthesis.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences of two porcine glutamic acid decarboxylases (65- and 67-kDa GAD)."
      Suzuki R., Asami N., Amann E., Wagatsuma M.
      Gene 152:257-260(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiDCE1_PIG
    AccessioniPrimary (citable) accession number: P48319
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3