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P48318 (DCE1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate decarboxylase 1

EC=4.1.1.15
Alternative name(s):
67 kDa glutamic acid decarboxylase
Short name=GAD-67
Glutamate decarboxylase 67 kDa isoform
Gene names
Name:Gad1
Synonyms:Gad67
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the production of GABA.

Catalytic activity

L-glutamate = 4-aminobutanoate + CO2.

Cofactor

Pyridoxal phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the group II decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Glutamate decarboxylase 1
PRO_0000146964

Regions

Region189 – 1913Substrate binding By similarity

Sites

Binding site5661Substrate By similarity

Amino acid modifications

Modified residue4041N6-(pyridoxal phosphate)lysine By similarity

Experimental info

Sequence conflict1331R → H in CAA90277. Ref.1
Sequence conflict2341E → K in S67453. Ref.5
Sequence conflict2581S → T in CAA90277. Ref.1
Sequence conflict3601D → S in CAA90277. Ref.1
Sequence conflict4611F → N in CAA90277. Ref.1
Sequence conflict5541G → A in CAA90277. Ref.1
Sequence conflict5751T → S in CAA90277. Ref.1
Sequence conflict5831I → T in CAA90277. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P48318 [UniParc].

Last modified December 13, 2002. Version 2.
Checksum: 82D1AAF216F25100

FASTA59366,648
        10         20         30         40         50         60 
MASSTPSPAT SSNAGADPNT TNLRPTTYDT WCGVAHGCTR KLGLKICGFL QRTNSLEEKS 

        70         80         90        100        110        120 
RLVSAFRERQ SSKNLLSCEN SDQGARFRRT ETDFSNLFAQ DLLPAKNGEE QTAQFLLEVV 

       130        140        150        160        170        180 
DILLNYVRKT FDRSTKVLDF HHPHQLLEGM EGFNLELSDH PESLEQILVD CRDTLKYGVR 

       190        200        210        220        230        240 
TGHPRFFNQL STGLDIIGLA GEWLTSTANT NMFTYEIAPV FVLMEQITLK KMREIVGWSN 

       250        260        270        280        290        300 
KDGDGIFSPG GAISNMYSIM AARYKYFPEV KTKGMAAVPK LVLFTSEHSH YSIKKAGAAL 

       310        320        330        340        350        360 
GFGTDNVILI KCNERGKIIP ADLEAKILDA KQKGYVPLYV NATAGTTVYG AFDPIQEIAD 

       370        380        390        400        410        420 
ICEKYNLWLH VDAAWGGGLL MSRKHRHKLS GIERANSVTW NPHKMMGVLL QCSAILVKEK 

       430        440        450        460        470        480 
GILQGCNQMC AGYLFQPDKQ YDVSYDTGDK AIQCGRHVDI FKFWLMWKAK GTVGFENQIN 

       490        500        510        520        530        540 
KCLELADYLY AKIKNREEFE MVFDGEPEHT NVCFWYIPQS LRGVPDSPER REKLHRVAPK 

       550        560        570        580        590 
IKALMMESGT TMVGYQPQGD KANFFRMVIS NPAATQSDID FLIEEIERLG QDL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular identification of the 62 kd form of glutamic acid decarboxylase from the mouse."
Katarova Z., Szabo G., Mugnaini E., Greenspan R.
Eur. J. Neurosci. 2:190-202(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]Aust G., Steinbrenner H., Thamm B., Rost A.K., Seissler J.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[3]"High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ILS and ISS.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Retina.
[5]"Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic beta-cells and other peripheral tissues of mouse and rat."
Faulkner-Jones B.E., Cram D.S., Kun J., Harrison L.C.
Endocrinology 133:2962-2972(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 198-403.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49976 mRNA. Translation: CAA90277.1.
Y12257 mRNA. Translation: CAA72934.1.
AF483492 mRNA. Translation: AAL90766.1.
AF483493 mRNA. Translation: AAL90767.1.
BC027059 mRNA. Translation: AAH27059.1.
S67453 mRNA. No translation available.
PIRS61534.
RefSeqNP_032103.2. NM_008077.4.
XP_006498828.1. XM_006498765.1.
XP_006498829.1. XM_006498766.1.
UniGeneMm.272120.

3D structure databases

ProteinModelPortalP48318.
SMRP48318. Positions 92-592.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP48318. 2 interactions.
MINTMINT-4092862.

PTM databases

PhosphoSiteP48318.

Proteomic databases

PaxDbP48318.
PRIDEP48318.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000094934; ENSMUSP00000092539; ENSMUSG00000070880.
GeneID14415.
KEGGmmu:14415.
UCSCuc008jzk.1. mouse.

Organism-specific databases

CTD2571.
MGIMGI:95632. Gad1.

Phylogenomic databases

eggNOGCOG0076.
HOGENOMHOG000005382.
HOVERGENHBG004980.
InParanoidP48318.
KOK01580.
OMATNLRPPG.
OrthoDBEOG7H1JM3.
PhylomeDBP48318.
TreeFamTF314688.

Gene expression databases

ArrayExpressP48318.
BgeeP48318.
CleanExMM_GAD1.
GenevestigatorP48318.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
PROSITEPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285997.
PROP48318.
SOURCESearch...

Entry information

Entry nameDCE1_MOUSE
AccessionPrimary (citable) accession number: P48318
Secondary accession number(s): O08685
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 13, 2002
Last modified: April 16, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot