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Protein

Glutamate decarboxylase 1

Gene

Gad1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the production of GABA.

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei566SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • gamma-aminobutyric acid biosynthetic process Source: Ensembl
  • locomotory exploration behavior Source: MGI
  • response to drug Source: Ensembl
  • social behavior Source: MGI

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processNeurotransmitter biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.15 3474
ReactomeiR-MMU-888568 GABA synthesis
R-MMU-888590 GABA synthesis, release, reuptake and degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase 1 (EC:4.1.1.15)
Alternative name(s):
67 kDa glutamic acid decarboxylase
Short name:
GAD-67
Glutamate decarboxylase 67 kDa isoform
Gene namesi
Name:Gad1
Synonyms:Gad67
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95632 Gad1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469641 – 593Glutamate decarboxylase 1Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineCombined sources1
Modified residuei404N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48318
PeptideAtlasiP48318
PRIDEiP48318

PTM databases

iPTMnetiP48318
PhosphoSitePlusiP48318
SwissPalmiP48318

Expressioni

Gene expression databases

BgeeiENSMUSG00000070880
CleanExiMM_GAD1
ExpressionAtlasiP48318 baseline and differential
GenevisibleiP48318 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP48318, 3 interactors
MINTiP48318
STRINGi10090.ENSMUSP00000092539

Structurei

3D structure databases

ProteinModelPortaliP48318
SMRiP48318
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 191Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0629 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
HOGENOMiHOG000005382
HOVERGENiHBG004980
InParanoidiP48318
KOiK01580
OMAiFHKHFFQ
OrthoDBiEOG091G07ZU
PhylomeDBiP48318
TreeFamiTF314688

Family and domain databases

Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

Sequencei

Sequence statusi: Complete.

P48318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTPSPAT SSNAGADPNT TNLRPTTYDT WCGVAHGCTR KLGLKICGFL
60 70 80 90 100
QRTNSLEEKS RLVSAFRERQ SSKNLLSCEN SDQGARFRRT ETDFSNLFAQ
110 120 130 140 150
DLLPAKNGEE QTAQFLLEVV DILLNYVRKT FDRSTKVLDF HHPHQLLEGM
160 170 180 190 200
EGFNLELSDH PESLEQILVD CRDTLKYGVR TGHPRFFNQL STGLDIIGLA
210 220 230 240 250
GEWLTSTANT NMFTYEIAPV FVLMEQITLK KMREIVGWSN KDGDGIFSPG
260 270 280 290 300
GAISNMYSIM AARYKYFPEV KTKGMAAVPK LVLFTSEHSH YSIKKAGAAL
310 320 330 340 350
GFGTDNVILI KCNERGKIIP ADLEAKILDA KQKGYVPLYV NATAGTTVYG
360 370 380 390 400
AFDPIQEIAD ICEKYNLWLH VDAAWGGGLL MSRKHRHKLS GIERANSVTW
410 420 430 440 450
NPHKMMGVLL QCSAILVKEK GILQGCNQMC AGYLFQPDKQ YDVSYDTGDK
460 470 480 490 500
AIQCGRHVDI FKFWLMWKAK GTVGFENQIN KCLELADYLY AKIKNREEFE
510 520 530 540 550
MVFDGEPEHT NVCFWYIPQS LRGVPDSPER REKLHRVAPK IKALMMESGT
560 570 580 590
TMVGYQPQGD KANFFRMVIS NPAATQSDID FLIEEIERLG QDL
Length:593
Mass (Da):66,648
Last modified:December 13, 2002 - v2
Checksum:i82D1AAF216F25100
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133R → H in CAA90277 (PubMed:12106047).Curated1
Sequence conflicti234E → K in S67453 (PubMed:8243324).Curated1
Sequence conflicti258S → T in CAA90277 (PubMed:12106047).Curated1
Sequence conflicti360D → S in CAA90277 (PubMed:12106047).Curated1
Sequence conflicti461F → N in CAA90277 (PubMed:12106047).Curated1
Sequence conflicti554G → A in CAA90277 (PubMed:12106047).Curated1
Sequence conflicti575T → S in CAA90277 (PubMed:12106047).Curated1
Sequence conflicti583I → T in CAA90277 (PubMed:12106047).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49976 mRNA Translation: CAA90277.1
Y12257 mRNA Translation: CAA72934.1
AF483492 mRNA Translation: AAL90766.1
AF483493 mRNA Translation: AAL90767.1
BC027059 mRNA Translation: AAH27059.1
S67453 mRNA No translation available.
CCDSiCCDS16108.1
PIRiS61534
RefSeqiNP_032103.2, NM_008077.5
XP_006498828.1, XM_006498765.3
XP_006498829.1, XM_006498766.3
UniGeneiMm.272120

Genome annotation databases

EnsembliENSMUST00000094934; ENSMUSP00000092539; ENSMUSG00000070880
GeneIDi14415
KEGGimmu:14415
UCSCiuc008jzk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDCE1_MOUSE
AccessioniPrimary (citable) accession number: P48318
Secondary accession number(s): O08685
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 13, 2002
Last modified: March 28, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health