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P48317

- GA45A_RAT

UniProt

P48317 - GA45A_RAT

Protein

Growth arrest and DNA damage-inducible protein GADD45 alpha

Gene

Gadd45a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity By similarity.By similarity

    GO - Biological processi

    1. cell cycle arrest Source: UniProtKB-KW
    2. cellular response to DNA damage stimulus Source: RGD
    3. G2/M transition of mitotic cell cycle Source: RGD

    Keywords - Biological processi

    Cell cycle, DNA damage, Growth arrest

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth arrest and DNA damage-inducible protein GADD45 alpha
    Alternative name(s):
    DNA damage-inducible transcript 1 protein
    Short name:
    DDIT-1
    Gene namesi
    Name:Gadd45a
    Synonyms:Ddit1, Gadd45
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2654. Gadd45a.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 165165Growth arrest and DNA damage-inducible protein GADD45 alphaPRO_0000148333Add
    BLAST

    Proteomic databases

    PRIDEiP48317.

    PTM databases

    PhosphoSiteiP48317.

    Expressioni

    Inductioni

    By various types of DNA damage and growth arrest.

    Gene expression databases

    GenevestigatoriP48317.

    Interactioni

    Subunit structurei

    Interacts with AURKA, PCNA, GADD45GIP1 and MAPK14.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000007698.

    Structurei

    3D structure databases

    ProteinModelPortaliP48317.
    SMRiP48317. Positions 14-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 1616Intrinsically disorderedBy similarityAdd
    BLAST
    Regioni105 – 11814Intrinsically disorderedBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GADD45 family.Curated

    Phylogenomic databases

    eggNOGiNOG75953.
    HOGENOMiHOG000013221.
    HOVERGENiHBG051684.
    InParanoidiP48317.
    PhylomeDBiP48317.

    Family and domain databases

    InterProiIPR024824. GADD45.
    IPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    [Graphical view]
    PANTHERiPTHR10411. PTHR10411. 1 hit.
    PfamiPF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view]
    SUPFAMiSSF55315. SSF55315. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P48317-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLEEFSAAE QKIERMDTVG DALEEVLSKA RSQRTITVGV YEAAKLLNVD    50
    PDNVVLCLLA ADEDDDRDVA LQIHFTLIRA FCCENDINIL RVSNPGRLAE 100
    LLLLENDKSP AESGGLAQTP DLHCVLVTNP HSSQWKDPAL SQLICFCRES 150
    RYMDQWVPVI NLPER 165
    Length:165
    Mass (Da):18,480
    Last modified:February 1, 1996 - v1
    Checksum:i6FB2956D27BE6BDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32591 mRNA. Translation: AAA96332.1.
    L39010 Genomic DNA. Translation: AAB02030.1.
    PIRiS68690.
    UniGeneiRn.10250.

    Genome annotation databases

    UCSCiRGD:2654. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32591 mRNA. Translation: AAA96332.1 .
    L39010 Genomic DNA. Translation: AAB02030.1 .
    PIRi S68690.
    UniGenei Rn.10250.

    3D structure databases

    ProteinModelPortali P48317.
    SMRi P48317. Positions 14-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000007698.

    PTM databases

    PhosphoSitei P48317.

    Proteomic databases

    PRIDEi P48317.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2654. rat.

    Organism-specific databases

    RGDi 2654. Gadd45a.

    Phylogenomic databases

    eggNOGi NOG75953.
    HOGENOMi HOG000013221.
    HOVERGENi HBG051684.
    InParanoidi P48317.
    PhylomeDBi P48317.

    Miscellaneous databases

    PROi P48317.

    Gene expression databases

    Genevestigatori P48317.

    Family and domain databases

    InterProi IPR024824. GADD45.
    IPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    [Graphical view ]
    PANTHERi PTHR10411. PTHR10411. 1 hit.
    Pfami PF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55315. SSF55315. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the rat Gadd45 cDNA and its mRNA expression in the brain."
      Yoshida T., Schneider E.L., Mori N.
      Gene 151:253-255(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.
    2. "Cloning of rat GADD45 gene and induction analysis following ionizing radiation in vivo."
      Yoshida T., Okazaki T., Hughes P.E., Schneider E.L., Mori N.
      FEBS Lett. 380:87-92(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiGA45A_RAT
    AccessioniPrimary (citable) accession number: P48317
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3