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P48317 (GA45A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Growth arrest and DNA damage-inducible protein GADD45 alpha
Alternative name(s):
DNA damage-inducible transcript 1 protein
Short name=DDIT-1
Gene names
Name:Gadd45a
Synonyms:Ddit1, Gadd45
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity By similarity.

Subunit structure

Interacts with AURKA, PCNA, GADD45GIP1 and MAPK14 By similarity.

Subcellular location

Nucleus By similarity.

Induction

By various types of DNA damage and growth arrest.

Sequence similarities

Belongs to the GADD45 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Growth arrest and DNA damage-inducible protein GADD45 alpha
PRO_0000148333

Regions

Region1 – 1616Intrinsically disordered By similarity
Region105 – 11814Intrinsically disordered By similarity

Sequences

Sequence LengthMass (Da)Tools
P48317 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 6FB2956D27BE6BDE

FASTA16518,480
        10         20         30         40         50         60 
MTLEEFSAAE QKIERMDTVG DALEEVLSKA RSQRTITVGV YEAAKLLNVD PDNVVLCLLA 

        70         80         90        100        110        120 
ADEDDDRDVA LQIHFTLIRA FCCENDINIL RVSNPGRLAE LLLLENDKSP AESGGLAQTP 

       130        140        150        160 
DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPER 

« Hide

References

[1]"Cloning of the rat Gadd45 cDNA and its mRNA expression in the brain."
Yoshida T., Schneider E.L., Mori N.
Gene 151:253-255(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Brain.
[2]"Cloning of rat GADD45 gene and induction analysis following ionizing radiation in vivo."
Yoshida T., Okazaki T., Hughes P.E., Schneider E.L., Mori N.
FEBS Lett. 380:87-92(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L32591 mRNA. Translation: AAA96332.1.
L39010 Genomic DNA. Translation: AAB02030.1.
PIRS68690.
UniGeneRn.10250.

3D structure databases

ProteinModelPortalP48317.
SMRP48317. Positions 14-164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000007698.

PTM databases

PhosphoSiteP48317.

Proteomic databases

PRIDEP48317.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:2654. rat.

Organism-specific databases

RGD2654. Gadd45a.

Phylogenomic databases

eggNOGNOG75953.
HOGENOMHOG000013221.
HOVERGENHBG051684.
InParanoidP48317.
PhylomeDBP48317.

Gene expression databases

GenevestigatorP48317.

Family and domain databases

InterProIPR024824. GADD45.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PANTHERPTHR10411. PTHR10411. 1 hit.
PfamPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP48317.

Entry information

Entry nameGA45A_RAT
AccessionPrimary (citable) accession number: P48317
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families