P48317 (GA45A_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 alpha

Alternative name(s):
DNA damage-inducible transcript 1 protein
Short name=DDIT-1

Gene names

Name:	Gadd45a
Synonyms:	Ddit1, Gadd45

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity By similarity.
Subunit structure	Interacts with AURKA, PCNA, GADD45GIP1 and MAPK14 By similarity.
Subcellular location	Nucleus By similarity.
Induction	By various types of DNA damage and growth arrest.
Sequence similarities	Belongs to the GADD45 family.

Ontologies

Keywords
Biological process	Cell cycle DNA damage Growth arrest
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G2/M transition of mitotic cell cycle Inferred from expression pattern PubMed 11964479. Source: RGD cell cycle arrest Inferred from electronic annotation. Source: UniProtKB-KW response to DNA damage stimulus Traceable author statement PubMed 11964479. Source: RGD
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Growth arrest and DNA damage-inducible protein GADD45 alpha		PRO_0000148333
Regions
	Region	1 – 16	16	Intrinsically disordered By similarity
	Region	105 – 118	14	Intrinsically disordered By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48317 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 6FB2956D27BE6BDE	FASTA	165	18,480
	10 20 30 40 50 60 MTLEEFSAAE QKIERMDTVG DALEEVLSKA RSQRTITVGV YEAAKLLNVD PDNVVLCLLA 70 80 90 100 110 120 ADEDDDRDVA LQIHFTLIRA FCCENDINIL RVSNPGRLAE LLLLENDKSP AESGGLAQTP 130 140 150 160 DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPER

References

[1]	"Cloning of the rat Gadd45 cDNA and its mRNA expression in the brain." Yoshida T., Schneider E.L., Mori N. Gene 151:253-255(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain.
[2]	"Cloning of rat GADD45 gene and induction analysis following ionizing radiation in vivo." Yoshida T., Okazaki T., Hughes P.E., Schneider E.L., Mori N. FEBS Lett. 380:87-92(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L32591 mRNA. Translation: AAA96332.1. L39010 Genomic DNA. Translation: AAB02030.1.
IPI	IPI00189831.
PIR	S68690.
UniGene	Rn.10250.
3D structure databases
ProteinModelPortal	P48317.
SMR	P48317. Positions 14-164.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000007698.
PTM databases
PhosphoSite	P48317.
Proteomic databases
PRIDE	P48317.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:2654. rat.
Organism-specific databases
RGD	2654. Gadd45a.
Phylogenomic databases
eggNOG	NOG75953.
HOGENOM	HOG000013221.
HOVERGEN	HBG051684.
InParanoid	P48317.
OrthoDB	EOG41NTN5.
Gene expression databases
ArrayExpress	P48317.
Genevestigator	P48317.
GermOnline	ENSRNOG00000005615. Rattus norvegicus.
Family and domain databases
InterPro	IPR024824. GADD45. IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45. [Graphical view]
PANTHER	PTHR10411. PTHR10411. 1 hit.
Pfam	PF01248. Ribosomal_L7Ae. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GA45A_RAT

Accession

Primary (citable) accession number: P48317

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program