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P48317

- GA45A_RAT

UniProt

P48317 - GA45A_RAT

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Protein

Growth arrest and DNA damage-inducible protein GADD45 alpha

Gene

Gadd45a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity By similarity.By similarity

GO - Biological processi

  1. cell cycle arrest Source: UniProtKB-KW
  2. cellular response to DNA damage stimulus Source: RGD
  3. G2/M transition of mitotic cell cycle Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 alpha
Alternative name(s):
DNA damage-inducible transcript 1 protein
Short name:
DDIT-1
Gene namesi
Name:Gadd45a
Synonyms:Ddit1, Gadd45
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2654. Gadd45a.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Growth arrest and DNA damage-inducible protein GADD45 alphaPRO_0000148333Add
BLAST

Proteomic databases

PRIDEiP48317.

PTM databases

PhosphoSiteiP48317.

Expressioni

Inductioni

By various types of DNA damage and growth arrest.

Gene expression databases

GenevestigatoriP48317.

Interactioni

Subunit structurei

Interacts with AURKA, PCNA, GADD45GIP1 and MAPK14.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007698.

Structurei

3D structure databases

ProteinModelPortaliP48317.
SMRiP48317. Positions 14-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1616Intrinsically disorderedBy similarityAdd
BLAST
Regioni105 – 11814Intrinsically disorderedBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the GADD45 family.Curated

Phylogenomic databases

eggNOGiNOG75953.
HOGENOMiHOG000013221.
HOVERGENiHBG051684.
InParanoidiP48317.
PhylomeDBiP48317.

Family and domain databases

InterProiIPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PANTHERiPTHR10411. PTHR10411. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.

Sequencei

Sequence statusi: Complete.

P48317-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLEEFSAAE QKIERMDTVG DALEEVLSKA RSQRTITVGV YEAAKLLNVD
60 70 80 90 100
PDNVVLCLLA ADEDDDRDVA LQIHFTLIRA FCCENDINIL RVSNPGRLAE
110 120 130 140 150
LLLLENDKSP AESGGLAQTP DLHCVLVTNP HSSQWKDPAL SQLICFCRES
160
RYMDQWVPVI NLPER
Length:165
Mass (Da):18,480
Last modified:February 1, 1996 - v1
Checksum:i6FB2956D27BE6BDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L32591 mRNA. Translation: AAA96332.1.
L39010 Genomic DNA. Translation: AAB02030.1.
PIRiS68690.
UniGeneiRn.10250.

Genome annotation databases

UCSCiRGD:2654. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L32591 mRNA. Translation: AAA96332.1 .
L39010 Genomic DNA. Translation: AAB02030.1 .
PIRi S68690.
UniGenei Rn.10250.

3D structure databases

ProteinModelPortali P48317.
SMRi P48317. Positions 14-164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000007698.

PTM databases

PhosphoSitei P48317.

Proteomic databases

PRIDEi P48317.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2654. rat.

Organism-specific databases

RGDi 2654. Gadd45a.

Phylogenomic databases

eggNOGi NOG75953.
HOGENOMi HOG000013221.
HOVERGENi HBG051684.
InParanoidi P48317.
PhylomeDBi P48317.

Miscellaneous databases

PROi P48317.

Gene expression databases

Genevestigatori P48317.

Family and domain databases

InterProi IPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view ]
PANTHERi PTHR10411. PTHR10411. 1 hit.
Pfami PF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view ]
SUPFAMi SSF55315. SSF55315. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of the rat Gadd45 cDNA and its mRNA expression in the brain."
    Yoshida T., Schneider E.L., Mori N.
    Gene 151:253-255(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  2. "Cloning of rat GADD45 gene and induction analysis following ionizing radiation in vivo."
    Yoshida T., Okazaki T., Hughes P.E., Schneider E.L., Mori N.
    FEBS Lett. 380:87-92(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGA45A_RAT
AccessioniPrimary (citable) accession number: P48317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3