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P48316

- GA45A_MOUSE

UniProt

P48316 - GA45A_MOUSE

Protein

Growth arrest and DNA damage-inducible protein GADD45 alpha

Gene

Gadd45a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity.1 Publication

    GO - Molecular functioni

    1. core promoter binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. activation of MAPKKK activity Source: Ensembl
    2. cell cycle arrest Source: UniProtKB-KW
    3. cellular response to ionizing radiation Source: Ensembl
    4. cellular response to mechanical stimulus Source: Ensembl
    5. centrosome cycle Source: MGI
    6. negative regulation of protein kinase activity Source: MGI
    7. positive regulation of apoptotic process Source: Ensembl
    8. positive regulation of JNK cascade Source: Ensembl
    9. positive regulation of p38MAPK cascade Source: Ensembl
    10. positive regulation of reactive oxygen species metabolic process Source: Ensembl
    11. regulation of cell cycle Source: MGI
    12. signal transduction in response to DNA damage Source: Ensembl

    Keywords - Biological processi

    Cell cycle, DNA damage, Growth arrest

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth arrest and DNA damage-inducible protein GADD45 alpha
    Alternative name(s):
    DNA damage-inducible transcript 1 protein
    Short name:
    DDIT-1
    Gene namesi
    Name:Gadd45a
    Synonyms:Ddit1, Gadd45
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:107799. Gadd45a.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 165165Growth arrest and DNA damage-inducible protein GADD45 alphaPRO_0000148332Add
    BLAST

    Proteomic databases

    PRIDEiP48316.

    PTM databases

    PhosphoSiteiP48316.

    Expressioni

    Inductioni

    By various types of DNA damage and growth arrest.

    Gene expression databases

    ArrayExpressiP48316.
    BgeeiP48316.
    CleanExiMM_GADD45A.
    GenevestigatoriP48316.

    Interactioni

    Subunit structurei

    Interacts with AURKA, GADD45GIP1 and PCNA By similarity. Interacts with MAPK14.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi199077. 2 interactions.
    IntActiP48316. 1 interaction.
    STRINGi10090.ENSMUSP00000044034.

    Structurei

    3D structure databases

    ProteinModelPortaliP48316.
    SMRiP48316. Positions 1-165.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 1616Intrinsically disorderedBy similarityAdd
    BLAST
    Regioni105 – 11814Intrinsically disorderedBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GADD45 family.Curated

    Phylogenomic databases

    eggNOGiNOG75953.
    HOGENOMiHOG000013221.
    HOVERGENiHBG051684.
    InParanoidiP48316.
    KOiK04402.
    OMAiHCVLVTS.
    OrthoDBiEOG7J1819.
    PhylomeDBiP48316.
    TreeFamiTF300196.

    Family and domain databases

    InterProiIPR024824. GADD45.
    IPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    [Graphical view]
    PANTHERiPTHR10411. PTHR10411. 1 hit.
    PfamiPF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view]
    SUPFAMiSSF55315. SSF55315. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P48316-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLEEFSAAE QKTERMDTVG DALEEVLSKA RSQRTITVGV YEAAKLLNVD    50
    PDNVVLCLLA ADEDDDRDVA LQIHFTLIRA FCCENDINIL RVSNPGRLAE 100
    LLLLENDAGP AESGGAAQTP DLHCVLVTNP HSSQWKDPAL SQLICFCRES 150
    RYMDQWVPVI NLPER 165
    Length:165
    Mass (Da):18,339
    Last modified:February 1, 1996 - v1
    Checksum:iC96BAB354A84770F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28177 mRNA. Translation: AAA37656.1.
    U00937 Unassigned DNA. Translation: AAC27351.1.
    BC011141 mRNA. Translation: AAH11141.1.
    CCDSiCCDS20217.1.
    PIRiB56535.
    RefSeqiNP_031862.1. NM_007836.1.
    UniGeneiMm.72235.

    Genome annotation databases

    EnsembliENSMUST00000043098; ENSMUSP00000044034; ENSMUSG00000036390.
    GeneIDi13197.
    KEGGimmu:13197.
    UCSCiuc009cfc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28177 mRNA. Translation: AAA37656.1 .
    U00937 Unassigned DNA. Translation: AAC27351.1 .
    BC011141 mRNA. Translation: AAH11141.1 .
    CCDSi CCDS20217.1.
    PIRi B56535.
    RefSeqi NP_031862.1. NM_007836.1.
    UniGenei Mm.72235.

    3D structure databases

    ProteinModelPortali P48316.
    SMRi P48316. Positions 1-165.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199077. 2 interactions.
    IntActi P48316. 1 interaction.
    STRINGi 10090.ENSMUSP00000044034.

    PTM databases

    PhosphoSitei P48316.

    Proteomic databases

    PRIDEi P48316.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043098 ; ENSMUSP00000044034 ; ENSMUSG00000036390 .
    GeneIDi 13197.
    KEGGi mmu:13197.
    UCSCi uc009cfc.1. mouse.

    Organism-specific databases

    CTDi 1647.
    MGIi MGI:107799. Gadd45a.

    Phylogenomic databases

    eggNOGi NOG75953.
    HOGENOMi HOG000013221.
    HOVERGENi HBG051684.
    InParanoidi P48316.
    KOi K04402.
    OMAi HCVLVTS.
    OrthoDBi EOG7J1819.
    PhylomeDBi P48316.
    TreeFami TF300196.

    Miscellaneous databases

    NextBioi 283332.
    PROi P48316.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48316.
    Bgeei P48316.
    CleanExi MM_GADD45A.
    Genevestigatori P48316.

    Family and domain databases

    InterProi IPR024824. GADD45.
    IPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    [Graphical view ]
    PANTHERi PTHR10411. PTHR10411. 1 hit.
    Pfami PF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55315. SSF55315. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth."
      Zhan Q., Lord K.A., Alamo I. Jr., Hollander M.C., Carrier F., Ron D., Kohn K.W., Hoffman B., Liebermann D.A., Fornace A.J. Jr.
      Mol. Cell. Biol. 14:2361-2371(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
      Tissue: Liver.
    2. "Cloning and characteristics of murine genes coding for the human GADD45 analog -- a protein induced in response to DNA damage."
      Alimzhanov M.B., Kuprash D.V., Turetskaya R.L., Osipovich O.A., Borodulina O.R., Osovskaia V.S., Chumakov R.M., Nedospasov S.A.
      Dokl. Akad. Nauk 333:788-791(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/Sv.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    4. "The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway."
      Salvador J.M., Mittelstadt P.R., Belova G.I., Fornace A.J. Jr., Ashwell J.D.
      Nat. Immunol. 6:396-402(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAPK14, FUNCTION.

    Entry informationi

    Entry nameiGA45A_MOUSE
    AccessioniPrimary (citable) accession number: P48316
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3