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Protein

Growth arrest and DNA damage-inducible protein GADD45 alpha

Gene

Gadd45a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity.1 Publication

GO - Molecular functioni

  • core promoter binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, Growth arrest

Enzyme and pathway databases

ReactomeiR-MMU-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 alpha
Alternative name(s):
DNA damage-inducible transcript 1 protein
Short name:
DDIT-1
Gene namesi
Name:Gadd45a
Synonyms:Ddit1, Gadd45
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107799. Gadd45a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483321 – 165Growth arrest and DNA damage-inducible protein GADD45 alphaAdd BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48316.
PRIDEiP48316.

PTM databases

PhosphoSitePlusiP48316.

Expressioni

Inductioni

By various types of DNA damage and growth arrest.

Gene expression databases

BgeeiENSMUSG00000036390.
CleanExiMM_GADD45A.
ExpressionAtlasiP48316. baseline and differential.
GenevisibleiP48316. MM.

Interactioni

Subunit structurei

Interacts with AURKA, GADD45GIP1 and PCNA (By similarity). Interacts with MAPK14.By similarity1 Publication

Protein-protein interaction databases

BioGridi199077. 6 interactors.
IntActiP48316. 1 interactor.
STRINGi10090.ENSMUSP00000044034.

Structurei

3D structure databases

ProteinModelPortaliP48316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 16Intrinsically disorderedBy similarityAdd BLAST16
Regioni105 – 118Intrinsically disorderedBy similarityAdd BLAST14

Sequence similaritiesi

Belongs to the GADD45 family.Curated

Phylogenomic databases

eggNOGiENOG410IFHI. Eukaryota.
ENOG4111M8M. LUCA.
GeneTreeiENSGT00390000016506.
HOGENOMiHOG000013221.
HOVERGENiHBG051684.
InParanoidiP48316.
KOiK04402.
OMAiNPHASQW.
OrthoDBiEOG091G0RHU.
PhylomeDBiP48316.
TreeFamiTF300196.

Family and domain databases

InterProiIPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PANTHERiPTHR10411. PTHR10411. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.

Sequencei

Sequence statusi: Complete.

P48316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEEFSAAE QKTERMDTVG DALEEVLSKA RSQRTITVGV YEAAKLLNVD
60 70 80 90 100
PDNVVLCLLA ADEDDDRDVA LQIHFTLIRA FCCENDINIL RVSNPGRLAE
110 120 130 140 150
LLLLENDAGP AESGGAAQTP DLHCVLVTNP HSSQWKDPAL SQLICFCRES
160
RYMDQWVPVI NLPER
Length:165
Mass (Da):18,339
Last modified:February 1, 1996 - v1
Checksum:iC96BAB354A84770F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28177 mRNA. Translation: AAA37656.1.
U00937 Unassigned DNA. Translation: AAC27351.1.
BC011141 mRNA. Translation: AAH11141.1.
CCDSiCCDS20217.1.
PIRiB56535.
RefSeqiNP_031862.1. NM_007836.1.
UniGeneiMm.72235.

Genome annotation databases

EnsembliENSMUST00000043098; ENSMUSP00000044034; ENSMUSG00000036390.
GeneIDi13197.
KEGGimmu:13197.
UCSCiuc009cfc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28177 mRNA. Translation: AAA37656.1.
U00937 Unassigned DNA. Translation: AAC27351.1.
BC011141 mRNA. Translation: AAH11141.1.
CCDSiCCDS20217.1.
PIRiB56535.
RefSeqiNP_031862.1. NM_007836.1.
UniGeneiMm.72235.

3D structure databases

ProteinModelPortaliP48316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199077. 6 interactors.
IntActiP48316. 1 interactor.
STRINGi10090.ENSMUSP00000044034.

PTM databases

PhosphoSitePlusiP48316.

Proteomic databases

PaxDbiP48316.
PRIDEiP48316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043098; ENSMUSP00000044034; ENSMUSG00000036390.
GeneIDi13197.
KEGGimmu:13197.
UCSCiuc009cfc.1. mouse.

Organism-specific databases

CTDi1647.
MGIiMGI:107799. Gadd45a.

Phylogenomic databases

eggNOGiENOG410IFHI. Eukaryota.
ENOG4111M8M. LUCA.
GeneTreeiENSGT00390000016506.
HOGENOMiHOG000013221.
HOVERGENiHBG051684.
InParanoidiP48316.
KOiK04402.
OMAiNPHASQW.
OrthoDBiEOG091G0RHU.
PhylomeDBiP48316.
TreeFamiTF300196.

Enzyme and pathway databases

ReactomeiR-MMU-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.

Miscellaneous databases

PROiP48316.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036390.
CleanExiMM_GADD45A.
ExpressionAtlasiP48316. baseline and differential.
GenevisibleiP48316. MM.

Family and domain databases

InterProiIPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PANTHERiPTHR10411. PTHR10411. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGA45A_MOUSE
AccessioniPrimary (citable) accession number: P48316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.