Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tissue factor pathway inhibitor 2

Gene

TFPI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei46 – 472Reactive bondBy similarity
Sitei107 – 1082Reactive bondBy similarity
Sitei168 – 1692Reactive bondBy similarity

GO - Molecular functioni

  • extracellular matrix structural constituent Source: ProtInc
  • serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Protein family/group databases

MEROPSiI02.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor pathway inhibitor 2
Short name:
TFPI-2
Alternative name(s):
Placental protein 5
Short name:
PP5
Gene namesi
Name:TFPI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11761. TFPI2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: HPA
  • proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36476.

Polymorphism and mutation databases

DMDMi1351226.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22222 PublicationsAdd
BLAST
Chaini23 – 235213Tissue factor pathway inhibitor 2PRO_0000016876Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 86PROSITE-ProRule annotation1 Publication
Disulfide bondi45 ↔ 69PROSITE-ProRule annotation1 Publication
Disulfide bondi61 ↔ 82PROSITE-ProRule annotation1 Publication
Disulfide bondi96 ↔ 149PROSITE-ProRule annotation
Disulfide bondi106 ↔ 130PROSITE-ProRule annotation
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence analysis
Disulfide bondi122 ↔ 145PROSITE-ProRule annotation
Disulfide bondi158 ↔ 208PROSITE-ProRule annotation
Disulfide bondi167 ↔ 191PROSITE-ProRule annotation
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence analysis
Disulfide bondi183 ↔ 204PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP48307.
PaxDbiP48307.
PeptideAtlasiP48307.
PRIDEiP48307.

PTM databases

iPTMnetiP48307.

Miscellaneous databases

PMAP-CutDBP48307.

Expressioni

Tissue specificityi

Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.

Gene expression databases

BgeeiP48307.
CleanExiHS_TFPI2.
ExpressionAtlasiP48307. baseline and differential.
GenevisibleiP48307. HS.

Organism-specific databases

HPAiCAB010142.
HPA049158.
HPA054479.

Interactioni

Subunit structurei

Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.1 Publication

Protein-protein interaction databases

BioGridi113693. 2 interactions.
IntActiP48307. 2 interactions.
MINTiMINT-1187323.
STRINGi9606.ENSP00000222543.

Structurei

Secondary structure

1
235
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 364Combined sources
Beta strandi49 – 557Combined sources
Turni56 – 594Combined sources
Beta strandi60 – 667Combined sources
Beta strandi76 – 783Combined sources
Helixi79 – 857Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZR0X-ray1.80B/D28-90[»]
ProteinModelPortaliP48307.
SMRiP48307. Positions 28-211.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48307.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 8651BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 14954BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd
BLAST
Domaini158 – 20851BPTI/Kunitz inhibitor 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi213 – 2175Poly-Lys

Domaini

This inhibitor contains three inhibitory domains.

Sequence similaritiesi

Contains 3 BPTI/Kunitz inhibitor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
InParanoidiP48307.
OMAiDRYTQSC.
OrthoDBiEOG73FQKT.
PhylomeDBiP48307.
TreeFamiTF315349.

Family and domain databases

Gene3Di4.10.410.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 3 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 3 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P48307-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPARPLGLS ILLLFLTEAA LGDAAQEPTG NNAEICLLPL DYGPCRALLL
60 70 80 90 100
RYYYDRYTQS CRQFLYGGCE GNANNFYTWE ACDDACWRIE KVPKVCRLQV
110 120 130 140 150
SVDDQCEGST EKYFFNLSSM TCEKFFSGGC HRNRIENRFP DEATCMGFCA
160 170 180 190 200
PKKIPSFCYS PKDEGLCSAN VTRYYFNPRY RTCDAFTYTG CGGNDNNFVS
210 220 230
REDCKRACAK ALKKKKKMPK LRFASRIRKI RKKQF
Length:235
Mass (Da):26,934
Last modified:February 1, 1996 - v1
Checksum:i975ABA5C53F7C65F
GO
Isoform 2 (identifier: P48307-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-40: Missing.

Note: No experimental confirmation available.
Show »
Length:224
Mass (Da):25,796
Checksum:iF586328C31344765
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231D → A AA sequence (PubMed:3276312).Curated
Sequence conflicti23 – 231D → G AA sequence (PubMed:7872799).Curated
Sequence conflicti36 – 361C → I AA sequence (PubMed:7872799).Curated
Sequence conflicti42 – 421Y → R AA sequence (PubMed:7872799).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021V → A.
Corresponds to variant rs1804202 [ dbSNP | Ensembl ].
VAR_012005
Natural varianti231 – 2311R → Q.
Corresponds to variant rs12669450 [ dbSNP | Ensembl ].
VAR_050064

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei30 – 4011Missing in isoform 2. 1 PublicationVSP_056031Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29992 mRNA. Translation: BAA06272.1.
L27624 mRNA. Translation: AAA20094.1.
AF217542 Genomic DNA. Translation: AAK13254.1.
AY691946 mRNA. Translation: AAU04568.1.
AK092499 mRNA. Translation: BAC03906.1.
AK313260 mRNA. Translation: BAG36070.1.
AC002076 Genomic DNA. Translation: AAS02022.1.
CH236949 Genomic DNA. Translation: EAL24140.1.
CH471091 Genomic DNA. Translation: EAW76809.1.
CH471091 Genomic DNA. Translation: EAW76811.1.
BC005330 mRNA. Translation: AAH05330.1.
CCDSiCCDS5632.1. [P48307-1]
PIRiA54951.
S71593.
RefSeqiNP_001257932.1. NM_001271003.1. [P48307-2]
NP_006519.1. NM_006528.3. [P48307-1]
UniGeneiHs.438231.

Genome annotation databases

EnsembliENST00000222543; ENSP00000222543; ENSG00000105825. [P48307-1]
GeneIDi7980.
KEGGihsa:7980.
UCSCiuc003umy.2. human. [P48307-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29992 mRNA. Translation: BAA06272.1.
L27624 mRNA. Translation: AAA20094.1.
AF217542 Genomic DNA. Translation: AAK13254.1.
AY691946 mRNA. Translation: AAU04568.1.
AK092499 mRNA. Translation: BAC03906.1.
AK313260 mRNA. Translation: BAG36070.1.
AC002076 Genomic DNA. Translation: AAS02022.1.
CH236949 Genomic DNA. Translation: EAL24140.1.
CH471091 Genomic DNA. Translation: EAW76809.1.
CH471091 Genomic DNA. Translation: EAW76811.1.
BC005330 mRNA. Translation: AAH05330.1.
CCDSiCCDS5632.1. [P48307-1]
PIRiA54951.
S71593.
RefSeqiNP_001257932.1. NM_001271003.1. [P48307-2]
NP_006519.1. NM_006528.3. [P48307-1]
UniGeneiHs.438231.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZR0X-ray1.80B/D28-90[»]
ProteinModelPortaliP48307.
SMRiP48307. Positions 28-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113693. 2 interactions.
IntActiP48307. 2 interactions.
MINTiMINT-1187323.
STRINGi9606.ENSP00000222543.

Protein family/group databases

MEROPSiI02.013.

PTM databases

iPTMnetiP48307.

Polymorphism and mutation databases

DMDMi1351226.

Proteomic databases

MaxQBiP48307.
PaxDbiP48307.
PeptideAtlasiP48307.
PRIDEiP48307.

Protocols and materials databases

DNASUi7980.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222543; ENSP00000222543; ENSG00000105825. [P48307-1]
GeneIDi7980.
KEGGihsa:7980.
UCSCiuc003umy.2. human. [P48307-1]

Organism-specific databases

CTDi7980.
GeneCardsiTFPI2.
HGNCiHGNC:11761. TFPI2.
HPAiCAB010142.
HPA049158.
HPA054479.
MIMi600033. gene.
neXtProtiNX_P48307.
PharmGKBiPA36476.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
InParanoidiP48307.
OMAiDRYTQSC.
OrthoDBiEOG73FQKT.
PhylomeDBiP48307.
TreeFamiTF315349.

Miscellaneous databases

EvolutionaryTraceiP48307.
GeneWikiiTFPI2.
GenomeRNAii7980.
PMAP-CutDBP48307.
PROiP48307.
SOURCEiSearch...

Gene expression databases

BgeeiP48307.
CleanExiHS_TFPI2.
ExpressionAtlasiP48307. baseline and differential.
GenevisibleiP48307. HS.

Family and domain databases

Gene3Di4.10.410.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 3 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 3 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2."
    Miyagi Y., Koshikawa N., Yasumitsu H., Miyagi E., Hirahara F., Aoki I., Misugi K., Umeda M., Miyazaki K.
    J. Biochem. 116:939-942(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
    Tissue: Placenta.
  2. "Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor."
    Sprecher C.A., Kisiel W., Mathewes S., Foster D.C.
    Proc. Natl. Acad. Sci. U.S.A. 91:3353-3357(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene."
    Kamei S., Kazama Y., Kuijper J.L., Foster D.C., Kisiel W.
    Biochim. Biophys. Acta 1517:430-435(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Xu Y., Li T., Du G.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  10. "Novel extracellular matrix-associated serine proteinase inhibitors from human skin fibroblasts."
    Rao C.N., Liu Y.Y., Peavey C.L., Woodley D.T.
    Arch. Biochem. Biophys. 317:311-314(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-42, FUNCTION.
    Tissue: Fibroblast.
  11. Cited for: PROTEIN SEQUENCE OF 23-35; 47-53 AND 133-146.
    Tissue: Placenta.
  12. Erratum
    Buetzow R., Huhtala M.-L., Bohn H., Virtanen I., Seppaelae M.
    Biochem. Biophys. Res. Commun. 151:630-631(1988)
  13. "Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin. Implications for KD1 specificity of inhibition."
    Schmidt A.E., Chand H.S., Cascio D., Kisiel W., Bajaj S.P.
    J. Biol. Chem. 280:27832-27838(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 28-90 IN COMPLEX WITH BOVINE TRYPSIN, DISULFIDE BONDS.
  14. "Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function."
    Katayama K., Yamaguchi M., Noguchi K., Sugimoto Y.
    Cancer Lett. 345:124-131(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPP2R3C.

Entry informationi

Entry nameiTFPI2_HUMAN
AccessioniPrimary (citable) accession number: P48307
Secondary accession number(s): Q66ME8, Q8NAK6, Q9UC86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 6, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.