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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

Gene

NDUFB4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

GO - Biological processi

  • response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Alternative name(s):
Complex I-B15
Short name:
CI-B15
NADH-ubiquinone oxidoreductase B15 subunit
Gene namesi
Name:NDUFB4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei86 – 105HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001187992 – 129NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei26PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP48305.
PRIDEiP48305.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.

Protein-protein interaction databases

IntActiP48305. 2 interactors.
STRINGi9913.ENSBTAP00000021123.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35m33-129[»]
5LDWelectron microscopy4.27m33-129[»]
5LDXelectron microscopy5.60m33-129[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB4 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZUV. Eukaryota.
ENOG4112CXK. LUCA.
HOGENOMiHOG000060241.
HOVERGENiHBG001159.
InParanoidiP48305.
KOiK03960.

Family and domain databases

InterProiIPR009866. NADH_UbQ_OxRdtase_NDUFB4_su.
[Graphical view]
PANTHERiPTHR15469. PTHR15469. 1 hit.
PfamiPF07225. NDUF_B4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPKYEASR LSSLPTTLDP AEYDISSETR KAQAERLAIR SRLKREYQLQ
60 70 80 90 100
YYDPSRRGVI EDPALVRWTY ARSANIYPNF RPNTKTSLLG ALFGIGPLVF
110 120
WYYVFKTDRD RKEKLIQEGK LDRTFNISY
Length:129
Mass (Da):15,184
Last modified:January 23, 2007 - v2
Checksum:iF5DA3419E80D9125
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64898 mRNA. Translation: CAA46107.1.
BC103187 mRNA. Translation: AAI03188.1.
PIRiS28237.
RefSeqiNP_787016.1. NM_175822.2.
UniGeneiBt.49223.
Bt.60768.

Genome annotation databases

GeneIDi327706.
KEGGibta:327706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64898 mRNA. Translation: CAA46107.1.
BC103187 mRNA. Translation: AAI03188.1.
PIRiS28237.
RefSeqiNP_787016.1. NM_175822.2.
UniGeneiBt.49223.
Bt.60768.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35m33-129[»]
5LDWelectron microscopy4.27m33-129[»]
5LDXelectron microscopy5.60m33-129[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP48305. 2 interactors.
STRINGi9913.ENSBTAP00000021123.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP48305.
PRIDEiP48305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi327706.
KEGGibta:327706.

Organism-specific databases

CTDi4710.

Phylogenomic databases

eggNOGiENOG410IZUV. Eukaryota.
ENOG4112CXK. LUCA.
HOGENOMiHOG000060241.
HOVERGENiHBG001159.
InParanoidiP48305.
KOiK03960.

Family and domain databases

InterProiIPR009866. NADH_UbQ_OxRdtase_NDUFB4_su.
[Graphical view]
PANTHERiPTHR15469. PTHR15469. 1 hit.
PfamiPF07225. NDUF_B4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB4_BOVIN
AccessioniPrimary (citable) accession number: P48305
Secondary accession number(s): Q54A31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.