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Protein

Lithostathine-1-beta

Gene

REG1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiI63.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Lithostathine-1-beta
Alternative name(s):
Pancreatic stone protein 2
Short name:
PSP-2
Regenerating islet-derived protein 1-beta
Short name:
REG-1-beta
Regenerating protein I beta
Gene namesi
Name:REG1B
Synonyms:PSPS2, REGL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:9952. REG1B.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34319.

Polymorphism and mutation databases

BioMutaiREG1B.
DMDMi1346460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 166144Lithostathine-1-betaPRO_0000017425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271O-linked (GalNAc...)1 Publication
Disulfide bondi36 ↔ 47PROSITE-ProRule annotation
Disulfide bondi64 ↔ 162PROSITE-ProRule annotation
Disulfide bondi137 ↔ 154PROSITE-ProRule annotation

Post-translational modificationi

All O-linked glycans consist of Gal-GlcNAc-Gal-GalNAc tetrasaccharide core and get elongated (microheterogeneity).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48304.
PRIDEiP48304.

PTM databases

PhosphoSiteiP48304.

Expressioni

Gene expression databases

BgeeiP48304.
CleanExiHS_REG1B.
ExpressionAtlasiP48304. baseline and differential.
GenevisibleiP48304. HS.

Organism-specific databases

HPAiHPA045549.
HPA045579.

Interactioni

Protein-protein interaction databases

BioGridi111900. 3 interactions.
IntActiP48304. 2 interactions.
MINTiMINT-1421294.
STRINGi9606.ENSP00000303206.

Structurei

3D structure databases

ProteinModelPortaliP48304.
SMRiP48304. Positions 36-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 164131C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiP48304.
OMAiQTNSFFM.
PhylomeDBiP48304.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTNSFFML ISSLMFLSLS QGQESQTELP NPRISCPEGT NAYRSYCYYF
60 70 80 90 100
NEDPETWVDA DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SSTDDSNVWI
110 120 130 140 150
GLHDPKKNRR WHWSSGSLVS YKSWDTGSPS SANAGYCASL TSCSGFKKWK
160
DESCEKKFSF VCKFKN
Length:166
Mass (Da):18,665
Last modified:February 1, 1996 - v1
Checksum:iD1DC20E11AE5DDE8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091R → H.
Corresponds to variant rs7586984 [ dbSNP | Ensembl ].
VAR_050121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08010 Genomic DNA. Translation: AAA18204.1.
D17291 Genomic DNA. Translation: BAA04124.1.
D16816 mRNA. Translation: BAA04091.1.
BC027895 mRNA. Translation: AAH27895.1.
CCDSiCCDS1963.1.
PIRiS34591. RGHU1B.
RefSeqiNP_006498.1. NM_006507.3.
UniGeneiHs.4158.
Hs.708865.

Genome annotation databases

EnsembliENST00000305089; ENSP00000303206; ENSG00000172023.
GeneIDi5968.
KEGGihsa:5968.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Lithostathine A

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08010 Genomic DNA. Translation: AAA18204.1.
D17291 Genomic DNA. Translation: BAA04124.1.
D16816 mRNA. Translation: BAA04091.1.
BC027895 mRNA. Translation: AAH27895.1.
CCDSiCCDS1963.1.
PIRiS34591. RGHU1B.
RefSeqiNP_006498.1. NM_006507.3.
UniGeneiHs.4158.
Hs.708865.

3D structure databases

ProteinModelPortaliP48304.
SMRiP48304. Positions 36-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111900. 3 interactions.
IntActiP48304. 2 interactions.
MINTiMINT-1421294.
STRINGi9606.ENSP00000303206.

Protein family/group databases

MEROPSiI63.002.

PTM databases

PhosphoSiteiP48304.

Polymorphism and mutation databases

BioMutaiREG1B.
DMDMi1346460.

Proteomic databases

PaxDbiP48304.
PRIDEiP48304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305089; ENSP00000303206; ENSG00000172023.
GeneIDi5968.
KEGGihsa:5968.

Organism-specific databases

CTDi5968.
GeneCardsiREG1B.
HGNCiHGNC:9952. REG1B.
HPAiHPA045549.
HPA045579.
MIMi167771. gene.
neXtProtiNX_P48304.
PharmGKBiPA34319.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiP48304.
OMAiQTNSFFM.
PhylomeDBiP48304.

Miscellaneous databases

GeneWikiiREG1B.
GenomeRNAii5968.
NextBioi23234.
PROiP48304.
SOURCEiSearch...

Gene expression databases

BgeeiP48304.
CleanExiHS_REG1B.
ExpressionAtlasiP48304. baseline and differential.
GenevisibleiP48304. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A gene homologous to the reg gene is expressed in the human pancreas."
    Bartoli C., Gharib B., Giorgi D., Sansonetti A., Dagorn J.-C., Berge-Lefranc U.
    FEBS Lett. 327:289-293(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Isolation, structural determination and expression of a novel reg gene, human regI beta."
    Moriizumi S., Watanabe T., Unno M., Nakagawara K., Suzuki Y., Miyashita H., Yonekura H., Okamoto H.
    Biochim. Biophys. Acta 1217:199-202(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Pancreas.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  4. "The glycan moiety of human pancreatic lithostathine. Structure characterization and possible pathophysiological implications."
    De Reggi M., Capon C., Gharib B., Wieruszeski J.-M., Michel R., Fournet B.
    Eur. J. Biochem. 230:503-510(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT THR-27.

Entry informationi

Entry nameiREG1B_HUMAN
AccessioniPrimary (citable) accession number: P48304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 16, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.