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Protein

Sphingosine 1-phosphate receptor 1

Gene

S1pr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • G-protein coupled receptor binding Source: Ensembl
  • sphingolipid binding Source: RGD
  • sphingosine-1-phosphate receptor activity Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton reorganization Source: UniProtKB
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
  • angiogenesis Source: UniProtKB-KW
  • blood vessel maturation Source: UniProtKB
  • brain development Source: Ensembl
  • cardiac muscle tissue growth involved in heart morphogenesis Source: UniProtKB
  • cell migration Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • endothelial cell differentiation Source: RGD
  • G-protein coupled receptor signaling pathway Source: RGD
  • heart trabecula morphogenesis Source: UniProtKB
  • lamellipodium assembly Source: UniProtKB
  • leukocyte chemotaxis Source: Ensembl
  • negative regulation of stress fiber assembly Source: RGD
  • neuron differentiation Source: RGD
  • positive regulation of cell migration Source: RGD
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
  • positive regulation of GTPase activity Source: RGD
  • positive regulation of positive chemotaxis Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: RGD
  • regulation of bone mineralization Source: UniProtKB
  • regulation of bone resorption Source: UniProtKB
  • regulation of cell adhesion Source: Ensembl
  • sphingosine-1-phosphate signaling pathway Source: UniProtKB
  • T cell migration Source: UniProtKB
  • transmission of nerve impulse Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processAngiogenesis, Chemotaxis

Enzyme and pathway databases

ReactomeiR-RNO-418594 G alpha (i) signalling events
R-RNO-419408 Lysosphingolipid and LPA receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 1
Short name:
S1P receptor 1
Short name:
S1P1
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 1
Sphingosine 1-phosphate receptor Edg-1
Short name:
S1P receptor Edg-1
CD_antigen: CD363
Gene namesi
Name:S1pr1
Synonyms:Edg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi61958 S1pr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularBy similarityAdd BLAST47
Transmembranei48 – 69Helical; Name=1By similarityAdd BLAST22
Topological domaini70 – 83CytoplasmicBy similarityAdd BLAST14
Transmembranei84 – 105Helical; Name=2By similarityAdd BLAST22
Topological domaini106 – 117ExtracellularBy similarityAdd BLAST12
Transmembranei118 – 139Helical; Name=3By similarityAdd BLAST22
Topological domaini140 – 161CytoplasmicBy similarityAdd BLAST22
Transmembranei162 – 183Helical; Name=4By similarityAdd BLAST22
Topological domaini184 – 197ExtracellularBy similarityAdd BLAST14
Transmembranei198 – 225Helical; Name=5By similarityAdd BLAST28
Topological domaini226 – 258CytoplasmicBy similarityAdd BLAST33
Transmembranei259 – 279Helical; Name=6By similarityAdd BLAST21
Topological domaini280 – 290ExtracellularBy similarityAdd BLAST11
Transmembranei291 – 311Helical; Name=7By similarityAdd BLAST21
Topological domaini312 – 383CytoplasmicBy similarityAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1914263

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694141 – 383Sphingosine 1-phosphate receptor 1Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11N6-acetyllysineBy similarity1
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi185 ↔ 192PROSITE-ProRule annotation
Modified residuei237PhosphothreonineBy similarity1
Disulfide bondi283 ↔ 288PROSITE-ProRule annotation
Lipidationi329S-palmitoyl cysteineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei354PhosphoserineSequence analysis1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP48303
PRIDEiP48303

PTM databases

iPTMnetiP48303
PhosphoSitePlusiP48303
SwissPalmiP48303
UniCarbKBiP48303

Expressioni

Developmental stagei

First detected at embryonic day 15. At postnatal day 14 detected in skin, spleen, liver, kidney, heart, testicle, lung and brain. At adulthood is most abundant in brain.1 Publication

Gene expression databases

BgeeiENSRNOG00000013683
GenevisibleiP48303 RN

Interactioni

Subunit structurei

Interacts with GNAI1 and GNAI3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052627

Chemistry databases

BindingDBiP48303

Structurei

3D structure databases

ProteinModelPortaliP48303
SMRiP48303
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 122Sphingosine 1-phosphate bindingBy similarity2
Regioni266 – 270Sphingosine 1-phosphate bindingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIA7 Eukaryota
ENOG410XQD3 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiP48303
KOiK04288
OMAiCFIACWA
OrthoDBiEOG091G0DD4
PhylomeDBiP48303
TreeFamiTF330052

Family and domain databases

InterProiView protein in InterPro
IPR000987 EDG1_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004061 S1P_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00642 EDG1RECEPTOR
PR00237 GPCRRHODOPSN
PR01523 S1PRECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P48303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSTSIPVV KALRSQVSDY GNYDIIVRHY NYTGKLNIGV EKDHGIKLTS
60 70 80 90 100
VVFILICCLI ILENIFVLLT IWKTKKFHRP MYYFIGNLAL SDLLAGVAYT
110 120 130 140 150
ANLLLSGATT YKLTPAQWFL REGSMFVALS ASVFSLLAIA IERYITMLKM
160 170 180 190 200
KLHNGSNSSR SFLLISACWV ISLILGGLPI MGWNCISSLS SCSTVLPLYH
210 220 230 240 250
KHYILFCTTV FTLLLLSIVI LYCRIYSLVR TRSRRLTFRK NISKASRSSE
260 270 280 290 300
KSLALLKTVI IVLSVFIACW APLFILLLLD VGCKAKTCDI LYKAEYFLVL
310 320 330 340 350
AVLNSGTNPI IYTLTNKEMR RAFIRIISCC KCPNGDSAGK FKRPIIPGME
360 370 380
FSRSKSDNSS HPQKDDGDNP ETIMSSGNVN SSS
Length:383
Mass (Da):42,746
Last modified:February 1, 1996 - v1
Checksum:i090BA6AEE09DB4F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10303 mRNA Translation: AAA83418.1
BC097938 mRNA Translation: AAH97938.1
PIRiI53870
RefSeqiNP_058997.1, NM_017301.2
XP_008759681.1, XM_008761459.2
UniGeneiRn.109455

Genome annotation databases

EnsembliENSRNOT00000018318; ENSRNOP00000052627; ENSRNOG00000013683
GeneIDi29733
KEGGirno:29733
UCSCiRGD:61958 rat

Similar proteinsi

Entry informationi

Entry nameiS1PR1_RAT
AccessioniPrimary (citable) accession number: P48303
Secondary accession number(s): Q4V7F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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