Reviewed, UniProtKB/Swiss-Prot P48302 (EDNRB_MOUSE)

Names and origin

Protein names

Recommended name:
    Endothelin B receptor
      Short name=ET-B
Alternative name(s):
    Endothelin receptor non-selective type

Gene names

Name:

Ednrb

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from direct assay. Source: MGI melanocyte differentiation Inferred from direct assay. Source: MGI neural crest cell migration Inferred from mutant phenotype. Source: MGI peripheral nervous system development Inferred from mutant phenotype. Source: MGI posterior midgut development Inferred from mutant phenotype. Source: MGI regulation of blood pressure Inferred from mutant phenotype. Source: MGI regulation of pH Inferred from mutant phenotype. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	endothelin-B receptor activity Inferred from direct assay. Source: MGI protein binding Inferred from physical interaction. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 442	416	Endothelin B receptor		PRO_0000012730
Regions
	Topological domain	27 – 101	75	Extracellular Potential
	Transmembrane	102 – 126	25	1 Potential
	Topological domain	127 – 137	11	Cytoplasmic Potential
	Transmembrane	138 – 163	26	2 Potential
	Topological domain	164 – 175	12	Extracellular Potential
	Transmembrane	176 – 197	22	3 Potential
	Topological domain	198 – 218	21	Cytoplasmic Potential
	Transmembrane	219 – 243	25	4 Potential
	Topological domain	244 – 271	28	Extracellular Potential
	Transmembrane	272 – 296	25	5 Potential
	Topological domain	297 – 324	28	Cytoplasmic Potential
	Transmembrane	325 – 350	26	6 Potential
	Topological domain	351 – 362	12	Extracellular Potential
	Transmembrane	363 – 389	27	7 Potential
	Topological domain	390 – 442	53	Cytoplasmic Potential
Amino acid modifications
	Lipidation	402	1	S-palmitoyl cysteine Potential
	Lipidation	403	1	S-palmitoyl cysteine Potential
	Lipidation	405	1	S-palmitoyl cysteine Potential
	Glycosylation	60	1	N-linked (GlcNAc...) Potential
	Disulfide bond	174 ↔ 255		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48302-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: ED28A676F854B3D1	FASTA	442	49,561
	10 20 30 40 50 60 MQSPASRCGR ALVALLLACG FLGVWGEKRG FPPAQATLSL LGTKEVMTPP TKTSWTRGSN 70 80 90 100 110 120 SSLMRSSAPA EVTKGGRGAG VPPRSFPPPC QRNIEISKTF KYINTIVSCL VFVLGIIGNS 130 140 150 160 170 180 TLLRIIYKNK CMRNGPNILI ASLALGDLLH IIIDIPINTY KLLAEDWPFG AEMCKLVPFI 190 200 210 220 230 240 QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF 250 260 270 280 290 300 DMITSDYKGK PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA VFYTLMTCEM 310 320 330 340 350 360 LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY DQSNPHRCEL 370 380 390 400 410 420 LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQTFEE KQSLEEKQSC 430 440 LKFKANDHGY DNFRSSNKYS SS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice." Hosoda K., Hammer R.E., Richardson J.A., Baynash A.G., Cheung J.C., Giaid A., Yanagisawa M. Cell 79:1267-1276(1994) [PubMed: 8001159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum, Head and Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U32329 mRNA. Translation: AAB60508.1. AK076426 mRNA. Translation: BAC36337.1. AK082103 mRNA. Translation: BAC38409.1. AK083415 mRNA. Translation: BAC38908.1. AK085532 mRNA. Translation: BAC39465.1. BC026553 mRNA. Translation: AAH26553.1.
IPI	IPI00110848.
RefSeq	NP_001129533.1. NP_031930.1.
UniGene	Mm.229532
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P48302.
Proteomic databases
PRIDE	P48302.
Genome annotation databases
Ensembl	ENSMUSG00000022122. Mus musculus. [Contig view]
GeneID	13618.
KEGG	mmu:13618.
Organism-specific databases
MGI	MGI:102720. Ednrb.
Phylogenomic databases
HOGENOM	P48302.
HOVERGEN	P48302.
OMA	P48302. WGEERGF.
Gene expression databases
ArrayExpress	P48302.
Bgee	P48302.
CleanEx	MM_EDNRB.
GermOnline	ENSMUSG00000022122. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR000499. Endthln_rcpt. IPR001112. ETB_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19264:SF69. Endthln_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00571. ENDOTHELINBR. PR00366. ENDOTHELINR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	284288.
SOURCE	Search...

Entry information

Entry name

EDNRB_MOUSE

Accession

Primary (citable) accession number: P48302
Secondary accession number(s): Q542M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)