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P48302

- EDNRB_MOUSE

UniProt

P48302 - EDNRB_MOUSE

Protein

Endothelin B receptor

Gene

Ednrb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages.

    GO - Molecular functioni

    1. endothelin receptor activity Source: MGI
    2. peptide hormone binding Source: Ensembl
    3. protein binding Source: MGI

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular response to lipopolysaccharide Source: Ensembl
    3. cGMP-mediated signaling Source: Ensembl
    4. developmental pigmentation Source: MGI
    5. enteric nervous system development Source: BHF-UCL
    6. enteric smooth muscle cell differentiation Source: BHF-UCL
    7. epithelial fluid transport Source: Ensembl
    8. G-protein coupled receptor signaling pathway Source: MGI
    9. macrophage chemotaxis Source: Ensembl
    10. melanocyte differentiation Source: MGI
    11. negative regulation of apoptotic process Source: Ensembl
    12. negative regulation of cellular protein metabolic process Source: Ensembl
    13. negative regulation of neuron maturation Source: BHF-UCL
    14. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    15. neural crest cell migration Source: MGI
    16. peripheral nervous system development Source: MGI
    17. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    18. pigmentation Source: MGI
    19. positive regulation of cell proliferation Source: Ensembl
    20. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    21. positive regulation of penile erection Source: Ensembl
    22. positive regulation of protein phosphorylation Source: Ensembl
    23. positive regulation of renal sodium excretion Source: Ensembl
    24. positive regulation of urine volume Source: Ensembl
    25. posterior midgut development Source: MGI
    26. regulation of blood pressure Source: MGI
    27. regulation of epithelial cell proliferation Source: Ensembl
    28. regulation of fever generation Source: Ensembl
    29. regulation of pH Source: MGI
    30. regulation of sensory perception of pain Source: Ensembl
    31. response to organic cyclic compound Source: Ensembl
    32. response to pain Source: Ensembl
    33. sensory perception of pain Source: Ensembl
    34. vasodilation Source: Ensembl
    35. vein smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin B receptor
    Short name:
    ET-B
    Short name:
    ET-BR
    Alternative name(s):
    Endothelin receptor non-selective type
    Gene namesi
    Name:Ednrb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:102720. Ednrb.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane raft Source: Ensembl
    3. nuclear membrane Source: Ensembl
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 442416Endothelin B receptorPRO_0000012730Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi174 ↔ 255PROSITE-ProRule annotation
    Modified residuei305 – 3051PhosphoserineBy similarity
    Lipidationi402 – 4021S-palmitoyl cysteineSequence Analysis
    Lipidationi403 – 4031S-palmitoyl cysteineSequence Analysis
    Lipidationi405 – 4051S-palmitoyl cysteineSequence Analysis
    Modified residuei419 – 4191PhosphoserineBy similarity
    Modified residuei439 – 4391PhosphotyrosineBy similarity
    Modified residuei440 – 4401PhosphoserineBy similarity
    Modified residuei441 – 4411PhosphoserineBy similarity
    Modified residuei442 – 4421PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP48302.
    PRIDEiP48302.

    PTM databases

    PhosphoSiteiP48302.

    Expressioni

    Gene expression databases

    BgeeiP48302.
    CleanExiMM_EDNRB.
    GenevestigatoriP48302.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP48302.
    SMRiP48302. Positions 97-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 10175ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 13711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 17512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini198 – 21821CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini244 – 27128ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 32428CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini351 – 36212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini390 – 44253CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei102 – 12625Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 16326Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei176 – 19722Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 24325Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29625Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei325 – 35026Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei363 – 38927Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG278704.
    GeneTreeiENSGT00690000101856.
    HOGENOMiHOG000272623.
    HOVERGENiHBG051443.
    InParanoidiP48302.
    KOiK04198.
    OMAiLHIVIDI.
    OrthoDBiEOG7HHWS4.
    PhylomeDBiP48302.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000499. Endthln_rcpt.
    IPR001112. ETB_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00571. ENDOTHELINBR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48302-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSPASRCGR ALVALLLACG FLGVWGEKRG FPPAQATLSL LGTKEVMTPP    50
    TKTSWTRGSN SSLMRSSAPA EVTKGGRGAG VPPRSFPPPC QRNIEISKTF 100
    KYINTIVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH 150
    IIIDIPINTY KLLAEDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY 200
    RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DMITSDYKGK 250
    PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA VFYTLMTCEM 300
    LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY 350
    DQSNPHRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC 400
    LCCWCQTFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS 442
    Length:442
    Mass (Da):49,561
    Last modified:February 1, 1996 - v1
    Checksum:iED28A676F854B3D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32329 mRNA. Translation: AAB60508.1.
    AK076426 mRNA. Translation: BAC36337.1.
    AK082103 mRNA. Translation: BAC38409.1.
    AK083415 mRNA. Translation: BAC38908.1.
    AK085532 mRNA. Translation: BAC39465.1.
    BC026553 mRNA. Translation: AAH26553.1.
    CCDSiCCDS27317.1.
    RefSeqiNP_001129533.1. NM_001136061.2.
    NP_001263225.1. NM_001276296.1.
    NP_031930.1. NM_007904.4.
    XP_006518578.1. XM_006518515.1.
    UniGeneiMm.229532.

    Genome annotation databases

    EnsembliENSMUST00000022718; ENSMUSP00000022718; ENSMUSG00000022122.
    ENSMUST00000172237; ENSMUSP00000126057; ENSMUSG00000022122.
    GeneIDi13618.
    KEGGimmu:13618.
    UCSCiuc007uww.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32329 mRNA. Translation: AAB60508.1 .
    AK076426 mRNA. Translation: BAC36337.1 .
    AK082103 mRNA. Translation: BAC38409.1 .
    AK083415 mRNA. Translation: BAC38908.1 .
    AK085532 mRNA. Translation: BAC39465.1 .
    BC026553 mRNA. Translation: AAH26553.1 .
    CCDSi CCDS27317.1.
    RefSeqi NP_001129533.1. NM_001136061.2.
    NP_001263225.1. NM_001276296.1.
    NP_031930.1. NM_007904.4.
    XP_006518578.1. XM_006518515.1.
    UniGenei Mm.229532.

    3D structure databases

    ProteinModelPortali P48302.
    SMRi P48302. Positions 97-402.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P48302.
    ChEMBLi CHEMBL1681617.
    GuidetoPHARMACOLOGYi 220.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P48302.

    Proteomic databases

    PaxDbi P48302.
    PRIDEi P48302.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022718 ; ENSMUSP00000022718 ; ENSMUSG00000022122 .
    ENSMUST00000172237 ; ENSMUSP00000126057 ; ENSMUSG00000022122 .
    GeneIDi 13618.
    KEGGi mmu:13618.
    UCSCi uc007uww.2. mouse.

    Organism-specific databases

    CTDi 1910.
    MGIi MGI:102720. Ednrb.

    Phylogenomic databases

    eggNOGi NOG278704.
    GeneTreei ENSGT00690000101856.
    HOGENOMi HOG000272623.
    HOVERGENi HBG051443.
    InParanoidi P48302.
    KOi K04198.
    OMAi LHIVIDI.
    OrthoDBi EOG7HHWS4.
    PhylomeDBi P48302.
    TreeFami TF331292.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    ChiTaRSi EDNRB. mouse.
    NextBioi 284288.
    PROi P48302.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48302.
    CleanExi MM_EDNRB.
    Genevestigatori P48302.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000499. Endthln_rcpt.
    IPR001112. ETB_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00571. ENDOTHELINBR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice."
      Hosoda K., Hammer R.E., Richardson J.A., Baynash A.G., Cheung J.C., Giaid A., Yanagisawa M.
      Cell 79:1267-1276(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum, Head and Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiEDNRB_MOUSE
    AccessioniPrimary (citable) accession number: P48302
    Secondary accession number(s): Q542M3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3