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Protein

Endothelin B receptor

Gene

Ednrb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages.

GO - Molecular functioni

  1. endothelin receptor activity Source: MGI
  2. peptide hormone binding Source: MGI

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular response to lipopolysaccharide Source: Ensembl
  3. cGMP-mediated signaling Source: Ensembl
  4. developmental pigmentation Source: MGI
  5. endothelin receptor signaling pathway Source: MGI
  6. enteric nervous system development Source: BHF-UCL
  7. enteric smooth muscle cell differentiation Source: BHF-UCL
  8. epithelial fluid transport Source: Ensembl
  9. G-protein coupled receptor signaling pathway Source: MGI
  10. macrophage chemotaxis Source: MGI
  11. melanocyte differentiation Source: MGI
  12. negative regulation of apoptotic process Source: Ensembl
  13. negative regulation of cellular protein metabolic process Source: MGI
  14. negative regulation of neuron maturation Source: BHF-UCL
  15. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  16. neural crest cell migration Source: MGI
  17. peripheral nervous system development Source: MGI
  18. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  19. pigmentation Source: MGI
  20. positive regulation of cell proliferation Source: Ensembl
  21. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  22. positive regulation of penile erection Source: Ensembl
  23. positive regulation of protein phosphorylation Source: Ensembl
  24. positive regulation of renal sodium excretion Source: Ensembl
  25. positive regulation of urine volume Source: Ensembl
  26. posterior midgut development Source: MGI
  27. regulation of blood pressure Source: MGI
  28. regulation of epithelial cell proliferation Source: Ensembl
  29. regulation of fever generation Source: Ensembl
  30. regulation of pH Source: MGI
  31. regulation of sensory perception of pain Source: Ensembl
  32. response to organic cyclic compound Source: Ensembl
  33. response to pain Source: Ensembl
  34. sensory perception of pain Source: Ensembl
  35. vasoconstriction Source: MGI
  36. vasodilation Source: Ensembl
  37. vein smooth muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin B receptor
Short name:
ET-B
Short name:
ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene namesi
Name:Ednrb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:102720. Ednrb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 10175ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12625Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini127 – 13711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 16326Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini164 – 17512ExtracellularSequence AnalysisAdd
BLAST
Transmembranei176 – 19722Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini198 – 21821CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei219 – 24325Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini244 – 27128ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29625Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini297 – 32428CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei325 – 35026Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini351 – 36212ExtracellularSequence AnalysisAdd
BLAST
Transmembranei363 – 38927Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini390 – 44253CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane raft Source: Ensembl
  3. nuclear membrane Source: Ensembl
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 442416Endothelin B receptorPRO_0000012730Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi174 ↔ 255PROSITE-ProRule annotation
Modified residuei305 – 3051PhosphoserineBy similarity
Lipidationi402 – 4021S-palmitoyl cysteineSequence Analysis
Lipidationi403 – 4031S-palmitoyl cysteineSequence Analysis
Lipidationi405 – 4051S-palmitoyl cysteineSequence Analysis
Modified residuei419 – 4191PhosphoserineBy similarity
Modified residuei439 – 4391PhosphotyrosineBy similarity
Modified residuei440 – 4401PhosphoserineBy similarity
Modified residuei441 – 4411PhosphoserineBy similarity
Modified residuei442 – 4421PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP48302.
PaxDbiP48302.
PRIDEiP48302.

PTM databases

PhosphoSiteiP48302.

Expressioni

Gene expression databases

BgeeiP48302.
CleanExiMM_EDNRB.
GenevestigatoriP48302.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP48302.
SMRiP48302. Positions 97-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278704.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP48302.
KOiK04198.
OMAiTAEIMTP.
OrthoDBiEOG7HHWS4.
PhylomeDBiP48302.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSPASRCGR ALVALLLACG FLGVWGEKRG FPPAQATLSL LGTKEVMTPP
60 70 80 90 100
TKTSWTRGSN SSLMRSSAPA EVTKGGRGAG VPPRSFPPPC QRNIEISKTF
110 120 130 140 150
KYINTIVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH
160 170 180 190 200
IIIDIPINTY KLLAEDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY
210 220 230 240 250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DMITSDYKGK
260 270 280 290 300
PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA VFYTLMTCEM
310 320 330 340 350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY
360 370 380 390 400
DQSNPHRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC
410 420 430 440
LCCWCQTFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS
Length:442
Mass (Da):49,561
Last modified:February 1, 1996 - v1
Checksum:iED28A676F854B3D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32329 mRNA. Translation: AAB60508.1.
AK076426 mRNA. Translation: BAC36337.1.
AK082103 mRNA. Translation: BAC38409.1.
AK083415 mRNA. Translation: BAC38908.1.
AK085532 mRNA. Translation: BAC39465.1.
BC026553 mRNA. Translation: AAH26553.1.
CCDSiCCDS27317.1.
RefSeqiNP_001129533.1. NM_001136061.2.
NP_001263225.1. NM_001276296.1.
NP_031930.1. NM_007904.4.
XP_006518578.1. XM_006518515.2.
UniGeneiMm.229532.

Genome annotation databases

EnsembliENSMUST00000022718; ENSMUSP00000022718; ENSMUSG00000022122.
ENSMUST00000172237; ENSMUSP00000126057; ENSMUSG00000022122.
GeneIDi13618.
KEGGimmu:13618.
UCSCiuc007uww.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32329 mRNA. Translation: AAB60508.1.
AK076426 mRNA. Translation: BAC36337.1.
AK082103 mRNA. Translation: BAC38409.1.
AK083415 mRNA. Translation: BAC38908.1.
AK085532 mRNA. Translation: BAC39465.1.
BC026553 mRNA. Translation: AAH26553.1.
CCDSiCCDS27317.1.
RefSeqiNP_001129533.1. NM_001136061.2.
NP_001263225.1. NM_001276296.1.
NP_031930.1. NM_007904.4.
XP_006518578.1. XM_006518515.2.
UniGeneiMm.229532.

3D structure databases

ProteinModelPortaliP48302.
SMRiP48302. Positions 97-402.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP48302.
ChEMBLiCHEMBL1681617.
GuidetoPHARMACOLOGYi220.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP48302.

Proteomic databases

MaxQBiP48302.
PaxDbiP48302.
PRIDEiP48302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022718; ENSMUSP00000022718; ENSMUSG00000022122.
ENSMUST00000172237; ENSMUSP00000126057; ENSMUSG00000022122.
GeneIDi13618.
KEGGimmu:13618.
UCSCiuc007uww.2. mouse.

Organism-specific databases

CTDi1910.
MGIiMGI:102720. Ednrb.

Phylogenomic databases

eggNOGiNOG278704.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP48302.
KOiK04198.
OMAiTAEIMTP.
OrthoDBiEOG7HHWS4.
PhylomeDBiP48302.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiEdnrb. mouse.
NextBioi284288.
PROiP48302.
SOURCEiSearch...

Gene expression databases

BgeeiP48302.
CleanExiMM_EDNRB.
GenevestigatoriP48302.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice."
    Hosoda K., Hammer R.E., Richardson J.A., Baynash A.G., Cheung J.C., Giaid A., Yanagisawa M.
    Cell 79:1267-1276(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Head and Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiEDNRB_MOUSE
AccessioniPrimary (citable) accession number: P48302
Secondary accession number(s): Q542M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 1, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.