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Protein

Endothelin B receptor

Gene

Ednrb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages.

GO - Molecular functioni

  • endothelin receptor activity Source: MGI
  • peptide hormone binding Source: MGI

GO - Biological processi

  • aging Source: Ensembl
  • cellular response to lipopolysaccharide Source: Ensembl
  • cGMP-mediated signaling Source: Ensembl
  • developmental pigmentation Source: MGI
  • endothelin receptor signaling pathway Source: MGI
  • enteric nervous system development Source: BHF-UCL
  • enteric smooth muscle cell differentiation Source: BHF-UCL
  • epithelial fluid transport Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: MGI
  • macrophage chemotaxis Source: MGI
  • melanocyte differentiation Source: MGI
  • negative regulation of apoptotic process Source: Ensembl
  • negative regulation of cellular protein metabolic process Source: MGI
  • negative regulation of neuron maturation Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • neural crest cell migration Source: MGI
  • peripheral nervous system development Source: MGI
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  • pigmentation Source: MGI
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • positive regulation of penile erection Source: Ensembl
  • positive regulation of protein phosphorylation Source: Ensembl
  • positive regulation of renal sodium excretion Source: Ensembl
  • positive regulation of urine volume Source: Ensembl
  • posterior midgut development Source: MGI
  • regulation of blood pressure Source: MGI
  • regulation of epithelial cell proliferation Source: Ensembl
  • regulation of fever generation Source: Ensembl
  • regulation of pH Source: MGI
  • regulation of sensory perception of pain Source: Ensembl
  • response to organic cyclic compound Source: Ensembl
  • response to pain Source: Ensembl
  • sensory perception of pain Source: Ensembl
  • vasoconstriction Source: MGI
  • vasodilation Source: Ensembl
  • vein smooth muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin B receptor
Short name:
ET-B
Short name:
ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene namesi
Name:Ednrb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:102720. Ednrb.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 101ExtracellularSequence analysisAdd BLAST75
Transmembranei102 – 126Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini127 – 137CytoplasmicSequence analysisAdd BLAST11
Transmembranei138 – 163Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini164 – 175ExtracellularSequence analysisAdd BLAST12
Transmembranei176 – 197Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini198 – 218CytoplasmicSequence analysisAdd BLAST21
Transmembranei219 – 243Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini244 – 271ExtracellularSequence analysisAdd BLAST28
Transmembranei272 – 296Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini297 – 324CytoplasmicSequence analysisAdd BLAST28
Transmembranei325 – 350Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini351 – 362ExtracellularSequence analysisAdd BLAST12
Transmembranei363 – 389Helical; Name=7Sequence analysisAdd BLAST27
Topological domaini390 – 442CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1681617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001273027 – 442Endothelin B receptorAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi174 ↔ 255PROSITE-ProRule annotation
Modified residuei305PhosphoserineBy similarity1
Lipidationi402S-palmitoyl cysteineSequence analysis1
Lipidationi403S-palmitoyl cysteineSequence analysis1
Lipidationi405S-palmitoyl cysteineSequence analysis1
Modified residuei419PhosphoserineBy similarity1
Modified residuei439PhosphotyrosineBy similarity1
Modified residuei440PhosphoserineBy similarity1
Modified residuei441PhosphoserineBy similarity1
Modified residuei442PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP48302.
PaxDbiP48302.
PRIDEiP48302.

PTM databases

iPTMnetiP48302.
PhosphoSitePlusiP48302.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022122.
CleanExiMM_EDNRB.
GenevisibleiP48302. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022718.

Chemistry databases

BindingDBiP48302.

Structurei

3D structure databases

ProteinModelPortaliP48302.
SMRiP48302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP48302.
KOiK04198.
OMAiTAEIMTP.
OrthoDBiEOG091G0CJV.
PhylomeDBiP48302.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSPASRCGR ALVALLLACG FLGVWGEKRG FPPAQATLSL LGTKEVMTPP
60 70 80 90 100
TKTSWTRGSN SSLMRSSAPA EVTKGGRGAG VPPRSFPPPC QRNIEISKTF
110 120 130 140 150
KYINTIVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH
160 170 180 190 200
IIIDIPINTY KLLAEDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY
210 220 230 240 250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DMITSDYKGK
260 270 280 290 300
PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA VFYTLMTCEM
310 320 330 340 350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY
360 370 380 390 400
DQSNPHRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC
410 420 430 440
LCCWCQTFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS
Length:442
Mass (Da):49,561
Last modified:February 1, 1996 - v1
Checksum:iED28A676F854B3D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32329 mRNA. Translation: AAB60508.1.
AK076426 mRNA. Translation: BAC36337.1.
AK082103 mRNA. Translation: BAC38409.1.
AK083415 mRNA. Translation: BAC38908.1.
AK085532 mRNA. Translation: BAC39465.1.
BC026553 mRNA. Translation: AAH26553.1.
CCDSiCCDS27317.1.
RefSeqiNP_001129533.1. NM_001136061.2.
NP_001263225.1. NM_001276296.1.
NP_031930.1. NM_007904.4.
XP_006518578.1. XM_006518515.2.
UniGeneiMm.229532.

Genome annotation databases

EnsembliENSMUST00000022718; ENSMUSP00000022718; ENSMUSG00000022122.
ENSMUST00000172237; ENSMUSP00000126057; ENSMUSG00000022122.
GeneIDi13618.
KEGGimmu:13618.
UCSCiuc007uww.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32329 mRNA. Translation: AAB60508.1.
AK076426 mRNA. Translation: BAC36337.1.
AK082103 mRNA. Translation: BAC38409.1.
AK083415 mRNA. Translation: BAC38908.1.
AK085532 mRNA. Translation: BAC39465.1.
BC026553 mRNA. Translation: AAH26553.1.
CCDSiCCDS27317.1.
RefSeqiNP_001129533.1. NM_001136061.2.
NP_001263225.1. NM_001276296.1.
NP_031930.1. NM_007904.4.
XP_006518578.1. XM_006518515.2.
UniGeneiMm.229532.

3D structure databases

ProteinModelPortaliP48302.
SMRiP48302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022718.

Chemistry databases

BindingDBiP48302.
ChEMBLiCHEMBL1681617.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP48302.
PhosphoSitePlusiP48302.

Proteomic databases

MaxQBiP48302.
PaxDbiP48302.
PRIDEiP48302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022718; ENSMUSP00000022718; ENSMUSG00000022122.
ENSMUST00000172237; ENSMUSP00000126057; ENSMUSG00000022122.
GeneIDi13618.
KEGGimmu:13618.
UCSCiuc007uww.3. mouse.

Organism-specific databases

CTDi1910.
MGIiMGI:102720. Ednrb.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP48302.
KOiK04198.
OMAiTAEIMTP.
OrthoDBiEOG091G0CJV.
PhylomeDBiP48302.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiEdnrb. mouse.
PROiP48302.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022122.
CleanExiMM_EDNRB.
GenevisibleiP48302. MM.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDNRB_MOUSE
AccessioniPrimary (citable) accession number: P48302
Secondary accession number(s): Q542M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.