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Reviewed, UniProtKB/Swiss-Prot P48302 (EDNRB_MOUSE)

Last modified June 16, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Endothelin B receptor
      Short name=ET-B
Alternative name(s):
    Endothelin receptor non-selective type
Gene names
Name: Ednrb
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 442416Endothelin B receptor
PRO_0000012730

Regions

Topological domain27 – 10175Extracellular Potential
Transmembrane102 – 126251 Potential
Topological domain127 – 13711Cytoplasmic Potential
Transmembrane138 – 163262 Potential
Topological domain164 – 17512Extracellular Potential
Transmembrane176 – 197223 Potential
Topological domain198 – 21821Cytoplasmic Potential
Transmembrane219 – 243254 Potential
Topological domain244 – 27128Extracellular Potential
Transmembrane272 – 296255 Potential
Topological domain297 – 32428Cytoplasmic Potential
Transmembrane325 – 350266 Potential
Topological domain351 – 36212Extracellular Potential
Transmembrane363 – 389277 Potential
Topological domain390 – 44253Cytoplasmic Potential

Amino acid modifications

Lipidation4021S-palmitoyl cysteine Potential
Lipidation4031S-palmitoyl cysteine Potential
Lipidation4051S-palmitoyl cysteine Potential
Glycosylation601N-linked (GlcNAc...) Potential
Disulfide bond174 ↔ 255 By similarity

Sequences

Sequence LengthMass (Da)Tools
P48302-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: ED28A676F854B3D1

FASTA44249,561
        10         20         30         40         50         60 
MQSPASRCGR ALVALLLACG FLGVWGEKRG FPPAQATLSL LGTKEVMTPP TKTSWTRGSN 

        70         80         90        100        110        120 
SSLMRSSAPA EVTKGGRGAG VPPRSFPPPC QRNIEISKTF KYINTIVSCL VFVLGIIGNS 

       130        140        150        160        170        180 
TLLRIIYKNK CMRNGPNILI ASLALGDLLH IIIDIPINTY KLLAEDWPFG AEMCKLVPFI 

       190        200        210        220        230        240 
QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF 

       250        260        270        280        290        300 
DMITSDYKGK PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA VFYTLMTCEM 

       310        320        330        340        350        360 
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY DQSNPHRCEL 

       370        380        390        400        410        420 
LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQTFEE KQSLEEKQSC 

       430        440 
LKFKANDHGY DNFRSSNKYS SS 

« Hide

References

« Hide 'large scale' references
[1]"Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice."
Hosoda K., Hammer R.E., Richardson J.A., Baynash A.G., Cheung J.C., Giaid A., Yanagisawa M.
Cell 79:1267-1276(1994) [PubMed: 8001159] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum, Head and Kidney.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

U32329 mRNA. Translation: AAB60508.1.
AK076426 mRNA. Translation: BAC36337.1.
AK082103 mRNA. Translation: BAC38409.1.
AK083415 mRNA. Translation: BAC38908.1.
AK085532 mRNA. Translation: BAC39465.1.
BC026553 mRNA. Translation: AAH26553.1.
IPIIPI00110848.
RefSeqNP_001129533.1.
NP_031930.1.
UniGeneMm.229532

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP48302.

Proteomic databases

PRIDEP48302.

Genome annotation databases

EnsemblENSMUSG00000022122. Mus musculus. [Contig view]
GeneID13618.
KEGGmmu:13618.

Organism-specific databases

MGIMGI:102720. Ednrb.

Phylogenomic databases

HOGENOMP48302.
HOVERGENP48302.
OMAP48302. WGEERGF.

Gene expression databases

ArrayExpressP48302.
BgeeP48302.
CleanExMM_EDNRB.
GermOnlineENSMUSG00000022122. Mus musculus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PANTHERPTHR19264:SF69. Endthln_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio284288.
SOURCESearch...

Entry information

Entry nameEDNRB_MOUSE
AccessionPrimary (citable) accession number: P48302
Secondary accession number(s): Q542M3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 16, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents