Endothelin B receptor precursor - Mus musculus (Mouse)

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P48302 (EDNRB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Endothelin B receptor
Short name=ET-B
Short name=ET-BR

Alternative name(s):
Endothelin receptor non-selective type

Gene names

Name:

Ednrb

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aging Inferred from electronic annotation. Source: Compara cGMP-mediated signaling Inferred from electronic annotation. Source: Compara cellular response to lipopolysaccharide Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara enteric nervous system development Inferred from direct assay PubMed 10021336. Source: BHF-UCL enteric smooth muscle cell differentiation Inferred from direct assay PubMed 10021336. Source: BHF-UCL epithelial fluid transport Inferred from electronic annotation. Source: Compara macrophage chemotaxis Inferred from electronic annotation. Source: Compara melanocyte differentiation Inferred from direct assay PubMed 9012511. Source: MGI negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of cellular protein metabolic process Inferred from electronic annotation. Source: Compara negative regulation of neuron maturation Inferred from direct assay PubMed 10021336. Source: BHF-UCL negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 10021336. Source: BHF-UCL neural crest cell migration Inferred from mutant phenotype PubMed 10591209. Source: MGI peripheral nervous system development Inferred from mutant phenotype PubMed 8582288. Source: MGI phospholipase C-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of penile erection Inferred from electronic annotation. Source: Compara positive regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara positive regulation of urine volume Inferred from electronic annotation. Source: Compara posterior midgut development Inferred from mutant phenotype PubMed 8582288. Source: MGI regulation of blood pressure Inferred from mutant phenotype PubMed 10626068. Source: MGI regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara regulation of pH Inferred from mutant phenotype PubMed 11413164. Source: MGI regulation of sensory perception of pain Inferred from electronic annotation. Source: Compara response to organic cyclic compound Inferred from electronic annotation. Source: Compara response to pain Inferred from electronic annotation. Source: Compara sensory perception of pain Inferred from electronic annotation. Source: Compara vasodilation Inferred from electronic annotation. Source: Compara vein smooth muscle contraction Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane raft Inferred from electronic annotation. Source: Compara nuclear membrane Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	endothelin receptor activity Inferred from direct assay PubMed 12441350. Source: MGI peptide hormone binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

Potential

Chain

27 – 442

416

Endothelin B receptor

PRO_0000012730

Regions

Topological domain

27 – 101

Extracellular Potential

Transmembrane

102 – 126

Helical; Name=1; Potential

Topological domain

127 – 137

Cytoplasmic Potential

Transmembrane

138 – 163

Helical; Name=2; Potential

Topological domain

164 – 175

Extracellular Potential

Transmembrane

176 – 197

Helical; Name=3; Potential

Topological domain

198 – 218

Cytoplasmic Potential

Transmembrane

219 – 243

Helical; Name=4; Potential

Topological domain

244 – 271

Extracellular Potential

Transmembrane

272 – 296

Helical; Name=5; Potential

Topological domain

297 – 324

Cytoplasmic Potential

Transmembrane

325 – 350

Helical; Name=6; Potential

Topological domain

351 – 362

Extracellular Potential

Transmembrane

363 – 389

Helical; Name=7; Potential

Topological domain

390 – 442

Cytoplasmic Potential

Amino acid modifications

Modified residue

305

Phosphoserine By similarity

Modified residue

419

Phosphoserine By similarity

Modified residue

439

Phosphotyrosine By similarity

Modified residue

440

Phosphoserine By similarity

Modified residue

441

Phosphoserine By similarity

Lipidation

402

S-palmitoyl cysteine Potential

Lipidation

403

S-palmitoyl cysteine Potential

Lipidation

405

S-palmitoyl cysteine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

174 ↔ 255

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P48302 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: ED28A676F854B3D1
Show »

FASTA

442

49,561

        10         20         30         40         50         60 
MQSPASRCGR ALVALLLACG FLGVWGEKRG FPPAQATLSL LGTKEVMTPP TKTSWTRGSN 

        70         80         90        100        110        120 
SSLMRSSAPA EVTKGGRGAG VPPRSFPPPC QRNIEISKTF KYINTIVSCL VFVLGIIGNS 

       130        140        150        160        170        180 
TLLRIIYKNK CMRNGPNILI ASLALGDLLH IIIDIPINTY KLLAEDWPFG AEMCKLVPFI 

       190        200        210        220        230        240 
QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF 

       250        260        270        280        290        300 
DMITSDYKGK PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA VFYTLMTCEM 

       310        320        330        340        350        360 
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY DQSNPHRCEL 

       370        380        390        400        410        420 
LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQTFEE KQSLEEKQSC 

       430        440 
LKFKANDHGY DNFRSSNKYS SS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice." Hosoda K., Hammer R.E., Richardson J.A., Baynash A.G., Cheung J.C., Giaid A., Yanagisawa M. Cell 79:1267-1276(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum, Head and Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32329 mRNA. Translation: AAB60508.1. AK076426 mRNA. Translation: BAC36337.1. AK082103 mRNA. Translation: BAC38409.1. AK083415 mRNA. Translation: BAC38908.1. AK085532 mRNA. Translation: BAC39465.1. BC026553 mRNA. Translation: AAH26553.1.
IPI	IPI00110848.
RefSeq	NP_001129533.1. NM_001136061.2. NP_001263225.1. NM_001276296.1. NP_031930.1. NM_007904.4.
UniGene	Mm.229532.
3D structure databases
ProteinModelPortal	P48302.
SMR	P48302. Positions 97-398.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P48302.
Proteomic databases
PaxDb	P48302.
PRIDE	P48302.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000022718; ENSMUSP00000022718; ENSMUSG00000022122. ENSMUST00000172237; ENSMUSP00000126057; ENSMUSG00000022122.
GeneID	13618.
KEGG	mmu:13618.
UCSC	uc007uww.2. mouse.
Organism-specific databases
CTD	1910.
MGI	MGI:102720. Ednrb.
Phylogenomic databases
eggNOG	NOG278704.
GeneTree	ENSGT00690000101856.
HOGENOM	HOG000272623.
HOVERGEN	HBG051443.
InParanoid	P48302.
KO	K04198.
OMA	LHIVIDI.
OrthoDB	EOG45HRX3.
Gene expression databases
Bgee	P48302.
CleanEx	MM_EDNRB.
Genevestigator	P48302.
GermOnline	ENSMUSG00000022122. Mus musculus.
Family and domain databases
InterPro	IPR000499. Endthln_rcpt. IPR001112. ETB_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00571. ENDOTHELINBR. PR00366. ENDOTHELINR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P48302.
ChEMBL	CHEMBL1681617.
ChiTaRS	EDNRB. mouse.
NextBio	284288.
SOURCE	Search...

Entry information

Entry name

EDNRB_MOUSE

Accession

Primary (citable) accession number: P48302
Secondary accession number(s): Q542M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents