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P48302 (EDNRB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin B receptor

Short name=ET-B
Short name=ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene names
Name:Ednrb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 12441350. Source: MGI

aging

Inferred from electronic annotation. Source: Ensembl

cGMP-mediated signaling

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

developmental pigmentation

Inferred from mutant phenotype PubMed 15322542. Source: MGI

enteric nervous system development

Inferred from direct assay PubMed 10021336. Source: BHF-UCL

enteric smooth muscle cell differentiation

Inferred from direct assay PubMed 10021336. Source: BHF-UCL

epithelial fluid transport

Inferred from electronic annotation. Source: Ensembl

macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

melanocyte differentiation

Inferred from direct assay PubMed 9012511. Source: MGI

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cellular protein metabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron maturation

Inferred from direct assay PubMed 10021336. Source: BHF-UCL

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10021336. Source: BHF-UCL

neural crest cell migration

Inferred from mutant phenotype PubMed 10591209. Source: MGI

peripheral nervous system development

Inferred from mutant phenotype PubMed 8582288. Source: MGI

phospholipase C-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

pigmentation

Inferred from mutant phenotype PubMed 2379821. Source: MGI

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of penile erection

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of urine volume

Inferred from electronic annotation. Source: Ensembl

posterior midgut development

Inferred from mutant phenotype PubMed 8582288. Source: MGI

regulation of blood pressure

Inferred from mutant phenotype PubMed 10626068. Source: MGI

regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of fever generation

Inferred from electronic annotation. Source: Ensembl

regulation of pH

Inferred from mutant phenotype PubMed 11413164. Source: MGI

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

response to pain

Inferred from electronic annotation. Source: Ensembl

sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

vasodilation

Inferred from electronic annotation. Source: Ensembl

vein smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane raft

Inferred from electronic annotation. Source: Ensembl

nuclear membrane

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionendothelin receptor activity

Inferred from direct assay PubMed 12441350. Source: MGI

peptide hormone binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 12441350. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 442416Endothelin B receptor
PRO_0000012730

Regions

Topological domain27 – 10175Extracellular Potential
Transmembrane102 – 12625Helical; Name=1; Potential
Topological domain127 – 13711Cytoplasmic Potential
Transmembrane138 – 16326Helical; Name=2; Potential
Topological domain164 – 17512Extracellular Potential
Transmembrane176 – 19722Helical; Name=3; Potential
Topological domain198 – 21821Cytoplasmic Potential
Transmembrane219 – 24325Helical; Name=4; Potential
Topological domain244 – 27128Extracellular Potential
Transmembrane272 – 29625Helical; Name=5; Potential
Topological domain297 – 32428Cytoplasmic Potential
Transmembrane325 – 35026Helical; Name=6; Potential
Topological domain351 – 36212Extracellular Potential
Transmembrane363 – 38927Helical; Name=7; Potential
Topological domain390 – 44253Cytoplasmic Potential

Amino acid modifications

Modified residue3051Phosphoserine By similarity
Modified residue4191Phosphoserine By similarity
Modified residue4391Phosphotyrosine By similarity
Modified residue4401Phosphoserine By similarity
Modified residue4411Phosphoserine By similarity
Modified residue4421Phosphoserine By similarity
Lipidation4021S-palmitoyl cysteine Potential
Lipidation4031S-palmitoyl cysteine Potential
Lipidation4051S-palmitoyl cysteine Potential
Glycosylation601N-linked (GlcNAc...) Potential
Disulfide bond174 ↔ 255 By similarity

Sequences

Sequence LengthMass (Da)Tools
P48302 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: ED28A676F854B3D1

FASTA44249,561
        10         20         30         40         50         60 
MQSPASRCGR ALVALLLACG FLGVWGEKRG FPPAQATLSL LGTKEVMTPP TKTSWTRGSN 

        70         80         90        100        110        120 
SSLMRSSAPA EVTKGGRGAG VPPRSFPPPC QRNIEISKTF KYINTIVSCL VFVLGIIGNS 

       130        140        150        160        170        180 
TLLRIIYKNK CMRNGPNILI ASLALGDLLH IIIDIPINTY KLLAEDWPFG AEMCKLVPFI 

       190        200        210        220        230        240 
QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF 

       250        260        270        280        290        300 
DMITSDYKGK PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA VFYTLMTCEM 

       310        320        330        340        350        360 
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY DQSNPHRCEL 

       370        380        390        400        410        420 
LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQTFEE KQSLEEKQSC 

       430        440 
LKFKANDHGY DNFRSSNKYS SS 

« Hide

References

« Hide 'large scale' references
[1]"Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice."
Hosoda K., Hammer R.E., Richardson J.A., Baynash A.G., Cheung J.C., Giaid A., Yanagisawa M.
Cell 79:1267-1276(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum, Head and Kidney.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U32329 mRNA. Translation: AAB60508.1.
AK076426 mRNA. Translation: BAC36337.1.
AK082103 mRNA. Translation: BAC38409.1.
AK083415 mRNA. Translation: BAC38908.1.
AK085532 mRNA. Translation: BAC39465.1.
BC026553 mRNA. Translation: AAH26553.1.
CCDSCCDS27317.1.
RefSeqNP_001129533.1. NM_001136061.2.
NP_001263225.1. NM_001276296.1.
NP_031930.1. NM_007904.4.
XP_006518578.1. XM_006518515.1.
UniGeneMm.229532.

3D structure databases

ProteinModelPortalP48302.
SMRP48302. Positions 97-402.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP48302.
ChEMBLCHEMBL1681617.
GuidetoPHARMACOLOGY220.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP48302.

Proteomic databases

PaxDbP48302.
PRIDEP48302.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022718; ENSMUSP00000022718; ENSMUSG00000022122.
ENSMUST00000172237; ENSMUSP00000126057; ENSMUSG00000022122.
GeneID13618.
KEGGmmu:13618.
UCSCuc007uww.2. mouse.

Organism-specific databases

CTD1910.
MGIMGI:102720. Ednrb.

Phylogenomic databases

eggNOGNOG278704.
GeneTreeENSGT00690000101856.
HOGENOMHOG000272623.
HOVERGENHBG051443.
InParanoidP48302.
KOK04198.
OMALHIVIDI.
OrthoDBEOG7HHWS4.
PhylomeDBP48302.
TreeFamTF331292.

Gene expression databases

BgeeP48302.
CleanExMM_EDNRB.
GenevestigatorP48302.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSEDNRB. mouse.
NextBio284288.
PROP48302.
SOURCESearch...

Entry information

Entry nameEDNRB_MOUSE
AccessionPrimary (citable) accession number: P48302
Secondary accession number(s): Q542M3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries