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Protein

Transcriptional enhancer factor TEF-4

Gene

Tead2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 114TEAPROSITE-ProRule annotationAdd BLAST77

GO - Molecular functioni

GO - Biological processi

  • cellular response to retinoic acid Source: MGI
  • embryonic heart tube morphogenesis Source: MGI
  • hippo signaling Source: MGI
  • lateral mesoderm development Source: MGI
  • negative regulation of cell death Source: UniProtKB
  • neural tube closure Source: MGI
  • notochord development Source: MGI
  • paraxial mesoderm development Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • protein-containing complex assembly Source: MGI
  • regulation of stem cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • vasculogenesis Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-MMU-8951671 RUNX3 regulates YAP1-mediated transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional enhancer factor TEF-4
Alternative name(s):
ETEF-1
Embryonic TEA domain-containing factor
Short name:
ETF
TEA domain family member 2
Short name:
TEAD-2
Gene namesi
Name:Tead2
Synonyms:Etdf, Etf, Tef4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:104904 Tead2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059331 – 445Transcriptional enhancer factor TEF-4Add BLAST445

Proteomic databases

PaxDbiP48301
PRIDEiP48301

PTM databases

iPTMnetiP48301
PhosphoSitePlusiP48301

Expressioni

Tissue specificityi

Highest expression in brain. High levels also found in lung, testis and ovarian follicle cells. Lower levels in heart and spleen.

Developmental stagei

In the embryo, levels fall after fertilization until the 2-4 cell stage and then increase rapidly.

Gene expression databases

BgeeiENSMUSG00000030796
CleanExiMM_TEAD2
ExpressionAtlasiP48301 baseline and differential
GenevisibleiP48301 MM

Interactioni

Subunit structurei

Interacts with YAP1 and WWTR1/TAZ.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204099, 3 interactors
CORUMiP48301
STRINGi10090.ENSMUSP00000033060

Structurei

3D structure databases

ProteinModelPortaliP48301
SMRiP48301
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 445Transcriptional activationSequence analysisAdd BLAST274

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi152 – 216Pro-richAdd BLAST65

Phylogenomic databases

eggNOGiKOG3841 Eukaryota
ENOG410XQMP LUCA
GeneTreeiENSGT00390000008670
HOGENOMiHOG000253933
HOVERGENiHBG056905
InParanoidiP48301
KOiK09448
OMAiQMGEPRA
OrthoDBiEOG091G08YE
PhylomeDBiP48301
TreeFamiTF313443

Family and domain databases

Gene3Di1.10.10.1610, 1 hit
InterProiView protein in InterPro
IPR000818 TEA/ATTS_dom
IPR038096 TEA/ATTS_sf
IPR016361 TEF_metazoa
PfamiView protein in Pfam
PF01285 TEA, 1 hit
PIRSFiPIRSF002603 TEF, 1 hit
PRINTSiPR00065 TEADOMAIN
SMARTiView protein in SMART
SM00426 TEA, 1 hit
PROSITEiView protein in PROSITE
PS00554 TEA_1, 1 hit
PS51088 TEA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P48301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDPRTGAPL DDGGGWTGSE EGSEEGTGGS EGVGGDGSPD AEGVWSPDIE
60 70 80 90 100
QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV
110 120 130 140 150
SSHIQVLARR KSREIQSKLK DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL
160 170 180 190 200
GPSGPQATEL FQFWSGSSGP PWNVPDVKPF SQAPFSVSLT PPASDLPGYE
210 220 230 240 250
PPPALSPLPP PAPSPPAWQA RALGTARLQL IEFSAFVEPP DAVDSFQRHL
260 270 280 290 300
FVHISQQCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV
310 320 330 340 350
KFWADLNWGP SAEEAGSSGG GGGFYGVSSQ YESRELMTLT CSSKVCSFGK
360 370 380 390 400
QVVEKVETER AQLEDGRFVY RLLRSPMCEY LVNFLHKLRQ LPERYMMNSV
410 420 430 440
LENFTILQVV TNRDTQELLL CTAYVFEVST SERGAQYHIY RLVRD
Length:445
Mass (Da):49,041
Last modified:February 1, 1996 - v1
Checksum:i237BC27A8BF9877C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289Y → F in CAA64216 (PubMed:8702974).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50563 mRNA Translation: BAA09126.1
D83596 Genomic DNA Translation: BAA12018.1
X94442 mRNA Translation: CAA64216.1
Y10026 mRNA Translation: CAA71135.1
CCDSiCCDS21236.1
PIRiA57400
RefSeqiNP_001272427.1, NM_001285498.1
NP_035695.1, NM_011565.2
XP_006540840.1, XM_006540777.2
UniGeneiMm.3019

Genome annotation databases

EnsembliENSMUST00000033060; ENSMUSP00000033060; ENSMUSG00000030796
ENSMUST00000107801; ENSMUSP00000103431; ENSMUSG00000030796
GeneIDi21677
KEGGimmu:21677
UCSCiuc009gud.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTEAD2_MOUSE
AccessioniPrimary (citable) accession number: P48301
Secondary accession number(s): Q62297
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health