Reviewed, UniProtKB/Swiss-Prot P48301 (TEAD2_MOUSE)

Names and origin

Protein names

Recommended name:
    Transcriptional enhancer factor TEF-4
Alternative name(s):
    TEA domain family member 2
      Short name=TEAD-2
    Embryonic TEA domain-containing factor
      Short name=ETF
    ETEF-1

Gene names

Name:	Tead2
Synonyms:	Etdf, Etf, Tef4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Putative transcription factor that binds to the SPH and GT-IIC "enhansons" (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Subcellular location	Nucleus.
Tissue specificity	Highest expression in brain. High levels also found in lung, testis and ovarian follicle cells. Lower levels in heart and spleen.
Developmental stage	In the embryo, levels fall after fertilization until the 2-4 cell stage and then increase rapidly.
Sequence similarities	Contains 1 TEA DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
Gene Ontology (GO)
Biological process	positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	transcription factor complex Inferred from direct assay. Source: MGI
Molecular function	transcription activator activity Inferred from genetic interaction. Source: MGI transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Transcriptional enhancer factor TEF-4		PRO_0000205933
Regions
	DNA binding	40 – 107	68	TEA
	Region	172 – 445	274	Transcriptional activation Potential
	Compositional bias	152 – 216	65	Pro-rich
Experimental info
	Sequence conflict	289	1	Y → F in CAA64216. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P48301-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 237BC27A8BF9877C	FASTA	445	49,041
	10 20 30 40 50 60 MGDPRTGAPL DDGGGWTGSE EGSEEGTGGS EGVGGDGSPD AEGVWSPDIE QSFQEALAIY 70 80 90 100 110 120 PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR KSREIQSKLK 130 140 150 160 170 180 DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL GPSGPQATEL FQFWSGSSGP PWNVPDVKPF 190 200 210 220 230 240 SQAPFSVSLT PPASDLPGYE PPPALSPLPP PAPSPPAWQA RALGTARLQL IEFSAFVEPP 250 260 270 280 290 300 DAVDSFQRHL FVHISQQCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV 310 320 330 340 350 360 KFWADLNWGP SAEEAGSSGG GGGFYGVSSQ YESRELMTLT CSSKVCSFGK QVVEKVETER 370 380 390 400 410 420 AQLEDGRFVY RLLRSPMCEY LVNFLHKLRQ LPERYMMNSV LENFTILQVV TNRDTQELLL 430 440 CTAYVFEVST SERGAQYHIY RLVRD

References

[1]	"Molecular characterization of cDNA encoding a novel protein related to transcriptional enhancer factor-1 from neural precursor cells." Yasunami M., Suzuki K., Houtani T., Sugimoto T., Ohkubo H. J. Biol. Chem. 270:18649-18654(1995) [PubMed: 7629195] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR. Tissue: Head.
[2]	"Structural organization and chromosomal assignment of the mouse embryonic TEA domain-containing factor (ETF) gene." Suzuki K., Yasunami M., Matsuda Y., Maeda T., Kobayashi H., Terasaki H., Ohkubo H. Genomics 36:263-270(1996) [PubMed: 8812452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6.
[3]	"A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain." Jacquemin P., Hwang J.-J., Martial J.A., Dolle P., Davidson I. J. Biol. Chem. 271:21775-21785(1996) [PubMed: 8702974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse." Kaneko K.J., Cullinan E.B., Latham K.E., Depamphilis M.L. Development 124:1963-1973(1997) [PubMed: 9169843] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D50563 mRNA. Translation: BAA09126.1. D83596 Genomic DNA. Translation: BAA12018.1. X94442 mRNA. Translation: CAA64216.1. Y10026 mRNA. Translation: CAA71135.1.
IPI	IPI00110847.
PIR	A57400.
RefSeq	NP_035695.1.
UniGene	Mm.3019
3D structure databases
SMR	P48301. Positions 40-115.
ModBase	Search...
Proteomic databases
PRIDE	P48301.
Genome annotation databases
Ensembl	ENSMUSG00000030796. Mus musculus. [Contig view]
GeneID	21677.
KEGG	mmu:21677.
Organism-specific databases
MGI	MGI:104904. Tead2.
Phylogenomic databases
HOGENOM	P48301.
HOVERGEN	P48301.
OMA	P48301. EVSTSER.
Gene expression databases
ArrayExpress	P48301.
Bgee	P48301.
CleanEx	MM_TEAD2.
GermOnline	ENSMUSG00000030796. Mus musculus.
Family and domain databases
InterPro	IPR000818. TEA/ATTS. IPR016361. TEF. [Graphical view]
PANTHER	PTHR11834. TEA/ATTS. 1 hit.
Pfam	PF01285. TEA. 1 hit. [Graphical view]
PIRSF	PIRSF002603. TEF. 1 hit.
PRINTS	PR00065. TEADOMAIN.
SMART	SM00426. TEA. 1 hit. [Graphical view]
PROSITE	PS00554. TEA_1. 1 hit. PS51088. TEA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	300972.
SOURCE	Search...

Entry information

Entry name

TEAD2_MOUSE

Accession

Primary (citable) accession number: P48301
Secondary accession number(s): Q62297

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)