P48301 (TEAD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 91.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Transcriptional enhancer factor TEF-4 Alternative name(s): ETEF-1 Embryonic TEA domain-containing factor Short name=ETF TEA domain family member 2 Short name=TEAD-2 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 445 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction By similarity. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. |
| Subunit structure | Interacts with YAP1 and WWTR1/TAZ By similarity. |
| Subcellular location | |
| Tissue specificity | Highest expression in brain. High levels also found in lung, testis and ovarian follicle cells. Lower levels in heart and spleen. |
| Developmental stage | In the embryo, levels fall after fertilization until the 2-4 cell stage and then increase rapidly. |
| Sequence similarities | Contains 1 TEA DNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Ligand | DNA-binding |
| Molecular function | Activator |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | negative regulation of cell death Inferred from genetic interaction. Source: UniProtKB neural tube closureInferred from mutant phenotype. Source: MGI positive regulation of transcription from RNA polymerase II promoterInferred from direct assay. Source: MGI |
| Cellular component | transcription factor complex Inferred from direct assay. Source: MGI |
| Molecular function | DNA binding Inferred from direct assay Ref.1. Source: MGI protein bindingInferred from physical interaction. Source: MGI sequence-specific distal enhancer binding RNA polymerase II transcription factor activityInferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 445 | 445 | Transcriptional enhancer factor TEF-4 | PRO_0000205933 | |||||
Regions | |||||||||
| DNA binding | 40 – 107 | 68 | TEA | ||||||
| Region | 172 – 445 | 274 | Transcriptional activation Potential | ||||||
| Compositional bias | 152 – 216 | 65 | Pro-rich | ||||||
Experimental info | |||||||||
| Sequence conflict | 289 | 1 | Y → F in CAA64216. Ref.3 | ||||||
Sequences
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References
| [1] | "Molecular characterization of cDNA encoding a novel protein related to transcriptional enhancer factor-1 from neural precursor cells." Yasunami M., Suzuki K., Houtani T., Sugimoto T., Ohkubo H. J. Biol. Chem. 270:18649-18654(1995) [PubMed: 7629195] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR. Tissue: Head. |
| [2] | "Structural organization and chromosomal assignment of the mouse embryonic TEA domain-containing factor (ETF) gene." Suzuki K., Yasunami M., Matsuda Y., Maeda T., Kobayashi H., Terasaki H., Ohkubo H. Genomics 36:263-270(1996) [PubMed: 8812452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6. |
| [3] | "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain." Jacquemin P., Hwang J.-J., Martial J.A., Dolle P., Davidson I. J. Biol. Chem. 271:21775-21785(1996) [PubMed: 8702974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse." Kaneko K.J., Cullinan E.B., Latham K.E., Depamphilis M.L. Development 124:1963-1973(1997) [PubMed: 9169843] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Carcinoma. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D50563 mRNA. Translation: BAA09126.1. D83596 Genomic DNA. Translation: BAA12018.1. X94442 mRNA. Translation: CAA64216.1. Y10026 mRNA. Translation: CAA71135.1. |
| IPI | IPI00110847. |
| PIR | A57400. |
| RefSeq | NP_035695.1. NM_011565.2. |
| UniGene | Mm.3019. |
3D structure databases | |
| ProteinModelPortal | P48301. |
| SMR | P48301. Positions 40-115, 221-444. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P48301. |
PTM databases | |
| PhosphoSite | P48301. |
Proteomic databases | |
| PRIDE | P48301. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000033060; ENSMUSP00000033060; ENSMUSG00000030796. ENSMUST00000107801; ENSMUSP00000103431; ENSMUSG00000030796. |
| GeneID | 21677. |
| KEGG | mmu:21677. |
Organism-specific databases | |
| CTD | 8463. |
| MGI | MGI:104904. Tead2. |
Phylogenomic databases | |
| eggNOG | roNOG11312. |
| HOGENOM | HBG402953. |
| HOVERGEN | HBG056905. |
| InParanoid | P48301. |
| OMA | MTLTCSS. |
| OrthoDB | EOG483D4Q. |
| PhylomeDB | P48301. |
Gene expression databases | |
| ArrayExpress | P48301. |
| Bgee | P48301. |
| CleanEx | MM_TEAD2. |
| Genevestigator | P48301. |
| GermOnline | ENSMUSG00000030796. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000818. TEA/ATTS. IPR016361. TEF. [Graphical view] |
| KO | K09449. |
| PANTHER | PTHR11834. TEA/ATTS. 1 hit. |
| Pfam | PF01285. TEA. 1 hit. [Graphical view] |
| PIRSF | PIRSF002603. TEF. 1 hit. |
| PRINTS | PR00065. TEADOMAIN. |
| SMART | SM00426. TEA. 1 hit. [Graphical view] |
| PROSITE | PS00554. TEA_1. 1 hit. PS51088. TEA_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 300972. |
| SOURCE | Search... |
Entry information
| Entry name | TEAD2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P48301 Secondary accession number(s): Q62297 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with