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P48301

- TEAD2_MOUSE

UniProt

P48301 - TEAD2_MOUSE

Protein

Transcriptional enhancer factor TEF-4

Gene

Tead2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction By similarity. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi40 – 10768TEAPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. embryonic heart tube morphogenesis Source: MGI
    2. hippo signaling Source: InterPro
    3. lateral mesoderm development Source: MGI
    4. negative regulation of cell death Source: UniProtKB
    5. neural tube closure Source: MGI
    6. notochord development Source: MGI
    7. paraxial mesoderm development Source: MGI
    8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    9. transcription from RNA polymerase II promoter Source: GOC
    10. vasculogenesis Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_198602. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional enhancer factor TEF-4
    Alternative name(s):
    ETEF-1
    Embryonic TEA domain-containing factor
    Short name:
    ETF
    TEA domain family member 2
    Short name:
    TEAD-2
    Gene namesi
    Name:Tead2
    Synonyms:Etdf, Etf, Tef4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:104904. Tead2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Transcriptional enhancer factor TEF-4PRO_0000205933Add
    BLAST

    Proteomic databases

    PRIDEiP48301.

    PTM databases

    PhosphoSiteiP48301.

    Expressioni

    Tissue specificityi

    Highest expression in brain. High levels also found in lung, testis and ovarian follicle cells. Lower levels in heart and spleen.

    Developmental stagei

    In the embryo, levels fall after fertilization until the 2-4 cell stage and then increase rapidly.

    Gene expression databases

    BgeeiP48301.
    CleanExiMM_TEAD2.
    GenevestigatoriP48301.

    Interactioni

    Subunit structurei

    Interacts with YAP1 and WWTR1/TAZ.By similarity

    Protein-protein interaction databases

    BioGridi204099. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP48301.
    SMRiP48301. Positions 40-115, 221-444.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni172 – 445274Transcriptional activationSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi152 – 21665Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 TEA DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG246992.
    HOGENOMiHOG000253933.
    HOVERGENiHBG056905.
    InParanoidiP48301.
    KOiK09448.
    OMAiGSGTPWN.
    OrthoDBiEOG7288RP.
    PhylomeDBiP48301.
    TreeFamiTF313443.

    Family and domain databases

    InterProiIPR000818. TEA/ATTS.
    IPR016361. TEF.
    [Graphical view]
    PANTHERiPTHR11834. PTHR11834. 1 hit.
    PfamiPF01285. TEA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002603. TEF. 1 hit.
    PRINTSiPR00065. TEADOMAIN.
    SMARTiSM00426. TEA. 1 hit.
    [Graphical view]
    PROSITEiPS00554. TEA_1. 1 hit.
    PS51088. TEA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48301-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDPRTGAPL DDGGGWTGSE EGSEEGTGGS EGVGGDGSPD AEGVWSPDIE    50
    QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV 100
    SSHIQVLARR KSREIQSKLK DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL 150
    GPSGPQATEL FQFWSGSSGP PWNVPDVKPF SQAPFSVSLT PPASDLPGYE 200
    PPPALSPLPP PAPSPPAWQA RALGTARLQL IEFSAFVEPP DAVDSFQRHL 250
    FVHISQQCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV 300
    KFWADLNWGP SAEEAGSSGG GGGFYGVSSQ YESRELMTLT CSSKVCSFGK 350
    QVVEKVETER AQLEDGRFVY RLLRSPMCEY LVNFLHKLRQ LPERYMMNSV 400
    LENFTILQVV TNRDTQELLL CTAYVFEVST SERGAQYHIY RLVRD 445
    Length:445
    Mass (Da):49,041
    Last modified:February 1, 1996 - v1
    Checksum:i237BC27A8BF9877C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti289 – 2891Y → F in CAA64216. (PubMed:8702974)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50563 mRNA. Translation: BAA09126.1.
    D83596 Genomic DNA. Translation: BAA12018.1.
    X94442 mRNA. Translation: CAA64216.1.
    Y10026 mRNA. Translation: CAA71135.1.
    CCDSiCCDS21236.1.
    PIRiA57400.
    RefSeqiNP_001272427.1. NM_001285498.1.
    NP_035695.1. NM_011565.2.
    XP_006540840.1. XM_006540777.1.
    UniGeneiMm.3019.

    Genome annotation databases

    EnsembliENSMUST00000033060; ENSMUSP00000033060; ENSMUSG00000030796.
    ENSMUST00000107801; ENSMUSP00000103431; ENSMUSG00000030796.
    GeneIDi21677.
    KEGGimmu:21677.
    UCSCiuc009gud.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50563 mRNA. Translation: BAA09126.1 .
    D83596 Genomic DNA. Translation: BAA12018.1 .
    X94442 mRNA. Translation: CAA64216.1 .
    Y10026 mRNA. Translation: CAA71135.1 .
    CCDSi CCDS21236.1.
    PIRi A57400.
    RefSeqi NP_001272427.1. NM_001285498.1.
    NP_035695.1. NM_011565.2.
    XP_006540840.1. XM_006540777.1.
    UniGenei Mm.3019.

    3D structure databases

    ProteinModelPortali P48301.
    SMRi P48301. Positions 40-115, 221-444.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204099. 3 interactions.

    PTM databases

    PhosphoSitei P48301.

    Proteomic databases

    PRIDEi P48301.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033060 ; ENSMUSP00000033060 ; ENSMUSG00000030796 .
    ENSMUST00000107801 ; ENSMUSP00000103431 ; ENSMUSG00000030796 .
    GeneIDi 21677.
    KEGGi mmu:21677.
    UCSCi uc009gud.1. mouse.

    Organism-specific databases

    CTDi 8463.
    MGIi MGI:104904. Tead2.

    Phylogenomic databases

    eggNOGi NOG246992.
    HOGENOMi HOG000253933.
    HOVERGENi HBG056905.
    InParanoidi P48301.
    KOi K09448.
    OMAi GSGTPWN.
    OrthoDBi EOG7288RP.
    PhylomeDBi P48301.
    TreeFami TF313443.

    Enzyme and pathway databases

    Reactomei REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_198602. PPARA activates gene expression.

    Miscellaneous databases

    ChiTaRSi TEAD2. mouse.
    NextBioi 300972.
    PROi P48301.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48301.
    CleanExi MM_TEAD2.
    Genevestigatori P48301.

    Family and domain databases

    InterProi IPR000818. TEA/ATTS.
    IPR016361. TEF.
    [Graphical view ]
    PANTHERi PTHR11834. PTHR11834. 1 hit.
    Pfami PF01285. TEA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002603. TEF. 1 hit.
    PRINTSi PR00065. TEADOMAIN.
    SMARTi SM00426. TEA. 1 hit.
    [Graphical view ]
    PROSITEi PS00554. TEA_1. 1 hit.
    PS51088. TEA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of cDNA encoding a novel protein related to transcriptional enhancer factor-1 from neural precursor cells."
      Yasunami M., Suzuki K., Houtani T., Sugimoto T., Ohkubo H.
      J. Biol. Chem. 270:18649-18654(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Head.
    2. "Structural organization and chromosomal assignment of the mouse embryonic TEA domain-containing factor (ETF) gene."
      Suzuki K., Yasunami M., Matsuda Y., Maeda T., Kobayashi H., Terasaki H., Ohkubo H.
      Genomics 36:263-270(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.
    3. "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain."
      Jacquemin P., Hwang J.-J., Martial J.A., Dolle P., Davidson I.
      J. Biol. Chem. 271:21775-21785(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse."
      Kaneko K.J., Cullinan E.B., Latham K.E., Depamphilis M.L.
      Development 124:1963-1973(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Carcinoma.

    Entry informationi

    Entry nameiTEAD2_MOUSE
    AccessioniPrimary (citable) accession number: P48301
    Secondary accession number(s): Q62297
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3