Reviewed,
UniProtKB/Swiss-Prot P48301 (TEAD2_MOUSE)
Last modified
June 16, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Transcriptional enhancer factor TEF-4 Alternative name(s): TEA domain family member 2 Short name=TEAD-2 Embryonic TEA domain-containing factor Short name=ETF ETEF-1 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 445 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Putative transcription factor that binds to the SPH and GT-IIC "enhansons" (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. |
| Subcellular location | |
| Tissue specificity | Highest expression in brain. High levels also found in lung, testis and ovarian follicle cells. Lower levels in heart and spleen. |
| Developmental stage | In the embryo, levels fall after fertilization until the 2-4 cell stage and then increase rapidly. |
| Sequence similarities | Contains 1 TEA DNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Ligand | DNA-binding |
| Molecular function | Activator |
| Gene Ontology (GO) | |
| Biological process | positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction. Source: MGI transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | transcription factor complex Inferred from direct assay. Source: MGI |
| Molecular function | transcription activator activity Inferred from genetic interaction. Source: MGI transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 445 | 445 | Transcriptional enhancer factor TEF-4 | PRO_0000205933 | |||||
Regions | |||||||||
| DNA binding | 40 – 107 | 68 | TEA | ||||||
| Region | 172 – 445 | 274 | Transcriptional activation Potential | ||||||
| Compositional bias | 152 – 216 | 65 | Pro-rich | ||||||
Experimental info | |||||||||
| Sequence conflict | 289 | 1 | Y → F in CAA64216. Ref.3 | ||||||
Sequences
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References
| [1] | "Molecular characterization of cDNA encoding a novel protein related to transcriptional enhancer factor-1 from neural precursor cells." Yasunami M., Suzuki K., Houtani T., Sugimoto T., Ohkubo H. J. Biol. Chem. 270:18649-18654(1995) [PubMed: 7629195] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR. Tissue: Head. |
| [2] | "Structural organization and chromosomal assignment of the mouse embryonic TEA domain-containing factor (ETF) gene." Suzuki K., Yasunami M., Matsuda Y., Maeda T., Kobayashi H., Terasaki H., Ohkubo H. Genomics 36:263-270(1996) [PubMed: 8812452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6. |
| [3] | "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain." Jacquemin P., Hwang J.-J., Martial J.A., Dolle P., Davidson I. J. Biol. Chem. 271:21775-21785(1996) [PubMed: 8702974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse." Kaneko K.J., Cullinan E.B., Latham K.E., Depamphilis M.L. Development 124:1963-1973(1997) [PubMed: 9169843] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Carcinoma. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D50563 mRNA. Translation: BAA09126.1. D83596 Genomic DNA. Translation: BAA12018.1. X94442 mRNA. Translation: CAA64216.1. Y10026 mRNA. Translation: CAA71135.1. | |
| IPI | IPI00110847. |
| PIR | A57400. |
| RefSeq | NP_035695.1. |
| UniGene | Mm.3019 |
3D structure databases | |
| SMR | P48301. Positions 40-115. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P48301. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000030796. Mus musculus. [Contig view] |
| GeneID | 21677. |
| KEGG | mmu:21677. |
Organism-specific databases | |
| MGI | MGI:104904. Tead2. |
Phylogenomic databases | |
| HOGENOM | P48301. |
| HOVERGEN | P48301. |
| OMA | P48301. EVSTSER. |
Gene expression databases | |
| ArrayExpress | P48301. |
| Bgee | P48301. |
| CleanEx | MM_TEAD2. |
| GermOnline | ENSMUSG00000030796. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000818. TEA/ATTS. IPR016361. TEF. [Graphical view] |
| PANTHER | PTHR11834. TEA/ATTS. 1 hit. |
| Pfam | PF01285. TEA. 1 hit. [Graphical view] |
| PIRSF | PIRSF002603. TEF. 1 hit. |
| PRINTS | PR00065. TEADOMAIN. |
| SMART | SM00426. TEA. 1 hit. [Graphical view] |
| PROSITE | PS00554. TEA_1. 1 hit. PS51088. TEA_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 300972. |
| SOURCE | Search... |
Entry information
| Entry name | TEAD2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P48301 Secondary accession number(s): Q62297 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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