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P48301

- TEAD2_MOUSE

UniProt

P48301 - TEAD2_MOUSE

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Protein

Transcriptional enhancer factor TEF-4

Gene

Tead2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi40 – 10768TEAPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. embryonic heart tube morphogenesis Source: MGI
  2. hippo signaling Source: InterPro
  3. lateral mesoderm development Source: MGI
  4. negative regulation of cell death Source: UniProtKB
  5. neural tube closure Source: MGI
  6. notochord development Source: MGI
  7. paraxial mesoderm development Source: MGI
  8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  9. transcription from RNA polymerase II promoter Source: GOC
  10. vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_198602. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional enhancer factor TEF-4
Alternative name(s):
ETEF-1
Embryonic TEA domain-containing factor
Short name:
ETF
TEA domain family member 2
Short name:
TEAD-2
Gene namesi
Name:Tead2
Synonyms:Etdf, Etf, Tef4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:104904. Tead2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Transcriptional enhancer factor TEF-4PRO_0000205933Add
BLAST

Proteomic databases

MaxQBiP48301.
PRIDEiP48301.

PTM databases

PhosphoSiteiP48301.

Expressioni

Tissue specificityi

Highest expression in brain. High levels also found in lung, testis and ovarian follicle cells. Lower levels in heart and spleen.

Developmental stagei

In the embryo, levels fall after fertilization until the 2-4 cell stage and then increase rapidly.

Gene expression databases

BgeeiP48301.
CleanExiMM_TEAD2.
ExpressionAtlasiP48301. baseline and differential.
GenevestigatoriP48301.

Interactioni

Subunit structurei

Interacts with YAP1 and WWTR1/TAZ.By similarity

Protein-protein interaction databases

BioGridi204099. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP48301.
SMRiP48301. Positions 40-115, 221-444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni172 – 445274Transcriptional activationSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi152 – 21665Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 TEA DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG246992.
HOGENOMiHOG000253933.
HOVERGENiHBG056905.
InParanoidiP48301.
KOiK09448.
OMAiGSGTPWN.
OrthoDBiEOG7288RP.
PhylomeDBiP48301.
TreeFamiTF313443.

Family and domain databases

InterProiIPR000818. TEA/ATTS.
IPR016361. TEF.
[Graphical view]
PANTHERiPTHR11834. PTHR11834. 1 hit.
PfamiPF01285. TEA. 1 hit.
[Graphical view]
PIRSFiPIRSF002603. TEF. 1 hit.
PRINTSiPR00065. TEADOMAIN.
SMARTiSM00426. TEA. 1 hit.
[Graphical view]
PROSITEiPS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48301-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDPRTGAPL DDGGGWTGSE EGSEEGTGGS EGVGGDGSPD AEGVWSPDIE
60 70 80 90 100
QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV
110 120 130 140 150
SSHIQVLARR KSREIQSKLK DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL
160 170 180 190 200
GPSGPQATEL FQFWSGSSGP PWNVPDVKPF SQAPFSVSLT PPASDLPGYE
210 220 230 240 250
PPPALSPLPP PAPSPPAWQA RALGTARLQL IEFSAFVEPP DAVDSFQRHL
260 270 280 290 300
FVHISQQCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV
310 320 330 340 350
KFWADLNWGP SAEEAGSSGG GGGFYGVSSQ YESRELMTLT CSSKVCSFGK
360 370 380 390 400
QVVEKVETER AQLEDGRFVY RLLRSPMCEY LVNFLHKLRQ LPERYMMNSV
410 420 430 440
LENFTILQVV TNRDTQELLL CTAYVFEVST SERGAQYHIY RLVRD
Length:445
Mass (Da):49,041
Last modified:February 1, 1996 - v1
Checksum:i237BC27A8BF9877C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2891Y → F in CAA64216. (PubMed:8702974)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50563 mRNA. Translation: BAA09126.1.
D83596 Genomic DNA. Translation: BAA12018.1.
X94442 mRNA. Translation: CAA64216.1.
Y10026 mRNA. Translation: CAA71135.1.
CCDSiCCDS21236.1.
PIRiA57400.
RefSeqiNP_001272427.1. NM_001285498.1.
NP_035695.1. NM_011565.2.
XP_006540840.1. XM_006540777.1.
UniGeneiMm.3019.

Genome annotation databases

EnsembliENSMUST00000033060; ENSMUSP00000033060; ENSMUSG00000030796.
ENSMUST00000107801; ENSMUSP00000103431; ENSMUSG00000030796.
GeneIDi21677.
KEGGimmu:21677.
UCSCiuc009gud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50563 mRNA. Translation: BAA09126.1 .
D83596 Genomic DNA. Translation: BAA12018.1 .
X94442 mRNA. Translation: CAA64216.1 .
Y10026 mRNA. Translation: CAA71135.1 .
CCDSi CCDS21236.1.
PIRi A57400.
RefSeqi NP_001272427.1. NM_001285498.1.
NP_035695.1. NM_011565.2.
XP_006540840.1. XM_006540777.1.
UniGenei Mm.3019.

3D structure databases

ProteinModelPortali P48301.
SMRi P48301. Positions 40-115, 221-444.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204099. 3 interactions.

PTM databases

PhosphoSitei P48301.

Proteomic databases

MaxQBi P48301.
PRIDEi P48301.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033060 ; ENSMUSP00000033060 ; ENSMUSG00000030796 .
ENSMUST00000107801 ; ENSMUSP00000103431 ; ENSMUSG00000030796 .
GeneIDi 21677.
KEGGi mmu:21677.
UCSCi uc009gud.1. mouse.

Organism-specific databases

CTDi 8463.
MGIi MGI:104904. Tead2.

Phylogenomic databases

eggNOGi NOG246992.
HOGENOMi HOG000253933.
HOVERGENi HBG056905.
InParanoidi P48301.
KOi K09448.
OMAi GSGTPWN.
OrthoDBi EOG7288RP.
PhylomeDBi P48301.
TreeFami TF313443.

Enzyme and pathway databases

Reactomei REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_198602. PPARA activates gene expression.

Miscellaneous databases

ChiTaRSi TEAD2. mouse.
NextBioi 300972.
PROi P48301.
SOURCEi Search...

Gene expression databases

Bgeei P48301.
CleanExi MM_TEAD2.
ExpressionAtlasi P48301. baseline and differential.
Genevestigatori P48301.

Family and domain databases

InterProi IPR000818. TEA/ATTS.
IPR016361. TEF.
[Graphical view ]
PANTHERi PTHR11834. PTHR11834. 1 hit.
Pfami PF01285. TEA. 1 hit.
[Graphical view ]
PIRSFi PIRSF002603. TEF. 1 hit.
PRINTSi PR00065. TEADOMAIN.
SMARTi SM00426. TEA. 1 hit.
[Graphical view ]
PROSITEi PS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of cDNA encoding a novel protein related to transcriptional enhancer factor-1 from neural precursor cells."
    Yasunami M., Suzuki K., Houtani T., Sugimoto T., Ohkubo H.
    J. Biol. Chem. 270:18649-18654(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Head.
  2. "Structural organization and chromosomal assignment of the mouse embryonic TEA domain-containing factor (ETF) gene."
    Suzuki K., Yasunami M., Matsuda Y., Maeda T., Kobayashi H., Terasaki H., Ohkubo H.
    Genomics 36:263-270(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  3. "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain."
    Jacquemin P., Hwang J.-J., Martial J.A., Dolle P., Davidson I.
    J. Biol. Chem. 271:21775-21785(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse."
    Kaneko K.J., Cullinan E.B., Latham K.E., Depamphilis M.L.
    Development 124:1963-1973(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Carcinoma.

Entry informationi

Entry nameiTEAD2_MOUSE
AccessioniPrimary (citable) accession number: P48301
Secondary accession number(s): Q62297
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3