Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tissue alpha-L-fucosidase

Gene

FUCA1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei296May be important for catalysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51 1153

Protein family/group databases

CAZyiGH29 Glycoside Hydrolase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1
Short name:
Alpha-L-fucosidase 1
Gene namesi
Name:FUCA1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Involvement in diseasei

Defects in FUCA1 are the cause of fucosidosis. It is a lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001030727 – 465Tissue alpha-L-fucosidaseAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP48300
PRIDEiP48300

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000019256

Structurei

3D structure databases

ProteinModelPortaliP48300
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3340 Eukaryota
COG3669 LUCA
HOGENOMiHOG000029598
HOVERGENiHBG002155
InParanoidiP48300
KOiK01206

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR016286 FUC_metazoa-typ
IPR028755 FUCA1
IPR031919 Fucosidase_C
IPR000933 Glyco_hydro_29
IPR018526 Glyco_hydro_29_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10030 PTHR10030, 1 hit
PTHR10030:SF2 PTHR10030:SF2, 1 hit
PfamiView protein in Pfam
PF01120 Alpha_L_fucos, 1 hit
PF16757 Fucosidase_C, 1 hit
PIRSFiPIRSF001092 Alpha-L-fucosidase, 1 hit
PRINTSiPR00741 GLHYDRLASE29
SMARTiView protein in SMART
SM00812 Alpha_L_fucos, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00385 ALPHA_L_FUCOSIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPWAVGLGP PPPAVPLLLL LLLGAALVRA AAPPRRYTPD WQSLDSRPLP
60 70 80 90 100
DWFDKAKFGV FVHWGEFAVP AWGSEWFWWH WKGEGLPQYE QFMSENYPPG
110 120 130 140 150
FSYADFGPQF TARFFHPDTW ADLFQAAGAR YVVLTTKHHE GFTNWPSSVS
160 170 180 190 200
WNWNSNDVGP HRDLVGELGR ALRKRNIRYG LYHSLLEWFH PLYLLDKKNN
210 220 230 240 250
FKTQFFVRAK TMPELYDLVN RYEPDLIWSD GEWKCPDTYW NSTEFLSWLY
260 270 280 290 300
NDSPVKDHVV VNDRWGQNCS CHHGGYYNCQ DKYKPESLPD LKWEMCTSID
310 320 330 340 350
KVSWGYRRNM VMSDVASECE IISELVQTVS LGGNYLLNIG PTKDGLIVPI
360 370 380 390 400
FQERLLSIGK WLSINGEAIY ASKPWRVQLE KNTTSVWYTS RGMTVYAIFL
410 420 430 440 450
RWPENGVLSL KSPVTTSTTQ ITMLGIQKDL KWSTEPEGLL IYLPQLSLFT
460
LPVEFGWTIK LTGVE
Length:465
Mass (Da):53,757
Last modified:February 1, 1996 - v1
Checksum:i832BA3C3510341B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14 – 15AV → LPL in AAB17403 (PubMed:8661697).Curated2
Sequence conflicti14 – 15AV → LPL in AAB17401 (PubMed:8661697).Curated2
Sequence conflicti30 – 32AAA → GPP in AAB17403 (PubMed:8661697).Curated3
Sequence conflicti30 – 32AAA → GPP in AAB17401 (PubMed:8661697).Curated3
Sequence conflicti66E → V in AAB17403 (PubMed:8661697).Curated1
Sequence conflicti66E → V in AAB17401 (PubMed:8661697).Curated1
Sequence conflicti234K → E in AAB17403 (PubMed:8661697).Curated1
Sequence conflicti257D → G in CAA63197 (PubMed:8730282).Curated1
Sequence conflicti291L → H in AAB17403 (PubMed:8661697).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92671
, X92672, X92673, X92674, X92675, X92676, X92677, X92678 Genomic DNA Translation: CAA63362.1
X92448 mRNA Translation: CAA63197.1
U29765 mRNA Translation: AAB17403.1
U29766 Genomic DNA Translation: AAB17401.1
RefSeqiNP_001003250.1, NM_001003250.1
UniGeneiCfa.3785

Genome annotation databases

GeneIDi403929
KEGGicfa:403929

Entry informationi

Entry nameiFUCO_CANLF
AccessioniPrimary (citable) accession number: P48300
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health