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Protein

Endothelin-3

Gene

Edn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei117 – 1182Cleavage; by KELBy similarity

GO - Molecular functioni

  1. hormone activity Source: MGI

GO - Biological processi

  1. cell surface receptor signaling pathway Source: MGI
  2. cellular calcium ion homeostasis Source: MGI
  3. cellular magnesium ion homeostasis Source: MGI
  4. inositol phosphate-mediated signaling Source: MGI
  5. melanocyte differentiation Source: MGI
  6. neural crest cell migration Source: MGI
  7. neuron differentiation Source: MGI
  8. neutrophil chemotaxis Source: MGI
  9. peptide hormone secretion Source: MGI
  10. positive regulation of cell proliferation Source: MGI
  11. positive regulation of heart rate Source: MGI
  12. positive regulation of hormone secretion Source: MGI
  13. positive regulation of leukocyte chemotaxis Source: MGI
  14. positive regulation of MAP kinase activity Source: MGI
  15. positive regulation of mitosis Source: MGI
  16. positive regulation of potassium ion transmembrane transport Source: MGI
  17. regulation of cell migration Source: MGI
  18. regulation of developmental pigmentation Source: MGI
  19. regulation of systemic arterial blood pressure by endothelin Source: MGI
  20. regulation of vasoconstriction Source: InterPro
  21. vasoconstriction Source: MGI
  22. vein smooth muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-3
Short name:
ET-3
Alternative name(s):
Preproendothelin-3
Short name:
PPET3
Gene namesi
Name:Edn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:95285. Edn3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Propeptidei17 – 9478PRO_0000008114Add
BLAST
Peptidei97 – 11721Endothelin-3PRO_0000008115Add
BLAST
Propeptidei118 – 21497PRO_0000008116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi97 ↔ 111By similarity
Disulfide bondi99 ↔ 107By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP48299.

Expressioni

Gene expression databases

BgeeiP48299.
CleanExiMM_EDN3.
ExpressionAtlasiP48299. baseline and differential.
GenevestigatoriP48299.

Structurei

3D structure databases

ProteinModelPortaliP48299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni159 – 17315Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41573.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiP48299.
KOiK05227.
OMAiHHRSRRC.
OrthoDBiEOG7PCJHP.
PhylomeDBiP48299.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGLWLLLG LTVTSAAGLV PCPQSGDSGR ASVSQGPPEA GSERGCEETV
60 70 80 90 100
AGPGERIVSP TVALPAQPES AGQERAPGRS GKQEDKGLPA HHRPRRCTCF
110 120 130 140 150
TYKDKECVYY CHLDIIWINT PEQTVPYGLS NYRESLRGKR SLGPVPESSQ
160 170 180 190 200
PSPWTRLRCT CMGADDKACA HFCARTRDVT SYSGRAERPA AEEMRETGGP
210
RQRLMSRTDK AHRP
Length:214
Mass (Da):23,322
Last modified:February 1, 1996 - v1
Checksum:i8911260872D6A713
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32330 mRNA. Translation: AAB60509.1.
AK048006 mRNA. Translation: BAC33211.1.
AK049775 mRNA. Translation: BAC33915.1.
AK079150 mRNA. Translation: BAC37561.1.
CCDSiCCDS17156.1.
PIRiI49351.
RefSeqiNP_031929.1. NM_007903.4.
UniGeneiMm.9478.

Genome annotation databases

EnsembliENSMUST00000029030; ENSMUSP00000029030; ENSMUSG00000027524.
GeneIDi13616.
KEGGimmu:13616.
UCSCiuc008ofi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32330 mRNA. Translation: AAB60509.1.
AK048006 mRNA. Translation: BAC33211.1.
AK049775 mRNA. Translation: BAC33915.1.
AK079150 mRNA. Translation: BAC37561.1.
CCDSiCCDS17156.1.
PIRiI49351.
RefSeqiNP_031929.1. NM_007903.4.
UniGeneiMm.9478.

3D structure databases

ProteinModelPortaliP48299.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP48299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029030; ENSMUSP00000029030; ENSMUSG00000027524.
GeneIDi13616.
KEGGimmu:13616.
UCSCiuc008ofi.1. mouse.

Organism-specific databases

CTDi1908.
MGIiMGI:95285. Edn3.

Phylogenomic databases

eggNOGiNOG41573.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiP48299.
KOiK05227.
OMAiHHRSRRC.
OrthoDBiEOG7PCJHP.
PhylomeDBiP48299.
TreeFamiTF333184.

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi284280.
PROiP48299.
SOURCEiSearch...

Gene expression databases

BgeeiP48299.
CleanExiMM_EDN3.
ExpressionAtlasiP48299. baseline and differential.
GenevestigatoriP48299.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons."
    Baynash A.G., Hosoda K., Giaid A., Richardson J.A., Emoto N., Hammer R.E., Yanagisawa M.
    Cell 79:1277-1285(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Spinal cord.

Entry informationi

Entry nameiEDN3_MOUSE
AccessioniPrimary (citable) accession number: P48299
Secondary accession number(s): Q543L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.