P48299 (EDN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endothelin-3
Short name=ET-3

Alternative name(s):
Preproendothelin-3
Short name=PPET3

Gene names

Name:

Edn3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Endothelins are endothelium-derived vasoconstrictor peptides.
Subcellular location	Secreted.
Sequence similarities	Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Vasoactive Vasoconstrictor
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell surface receptor signaling pathway Inferred from electronic annotation. Source: Compara inositol phosphate-mediated signaling Inferred from electronic annotation. Source: Compara melanocyte differentiation Inferred from direct assay PubMed 9012511. Source: MGI neural crest cell migration Inferred from mutant phenotype PubMed 9624616. Source: MGI neuron differentiation Inferred from mutant phenotype PubMed 9624616. Source: MGI neutrophil chemotaxis Inferred from electronic annotation. Source: Compara peptide hormone secretion Inferred from electronic annotation. Source: Compara positive regulation of MAP kinase activity Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from direct assay PubMed 11401406. Source: MGI positive regulation of heart rate Inferred from electronic annotation. Source: Compara positive regulation of hormone secretion Inferred from electronic annotation. Source: Compara positive regulation of leukocyte chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of mitosis Inferred from electronic annotation. Source: Compara regulation of cell migration Inferred from mutant phenotype PubMed 14138974. Source: MGI regulation of developmental pigmentation Inferred from mutant phenotype PubMed 14138974. Source: MGI regulation of systemic arterial blood pressure by endothelin Inferred from electronic annotation. Source: Compara regulation of vasoconstriction Inferred from electronic annotation. Source: InterPro vein smooth muscle contraction Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Propeptide	17 – 94	78			PRO_0000008114
	Peptide	97 – 117	21	Endothelin-3		PRO_0000008115
	Propeptide	118 – 214	97			PRO_0000008116
Regions
	Region	159 – 173	15	Endothelin-like
Sites
	Site	117 – 118	2	Cleavage; by KEL By similarity
Amino acid modifications
	Disulfide bond	97 ↔ 111		By similarity
	Disulfide bond	99 ↔ 107		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48299 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 8911260872D6A713	FASTA	214	23,322
	10 20 30 40 50 60 MEPGLWLLLG LTVTSAAGLV PCPQSGDSGR ASVSQGPPEA GSERGCEETV AGPGERIVSP 70 80 90 100 110 120 TVALPAQPES AGQERAPGRS GKQEDKGLPA HHRPRRCTCF TYKDKECVYY CHLDIIWINT 130 140 150 160 170 180 PEQTVPYGLS NYRESLRGKR SLGPVPESSQ PSPWTRLRCT CMGADDKACA HFCARTRDVT 190 200 210 SYSGRAERPA AEEMRETGGP RQRLMSRTDK AHRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons." Baynash A.G., Hosoda K., Giaid A., Richardson J.A., Emoto N., Hammer R.E., Yanagisawa M. Cell 79:1277-1285(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Head and Spinal cord.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32330 mRNA. Translation: AAB60509.1. AK048006 mRNA. Translation: BAC33211.1. AK049775 mRNA. Translation: BAC33915.1. AK079150 mRNA. Translation: BAC37561.1.
IPI	IPI00110015.
PIR	I49351.
RefSeq	NP_031929.1. NM_007903.3.
UniGene	Mm.9478.
3D structure databases
ProteinModelPortal	P48299.
ModBase	Search...
Proteomic databases
PRIDE	P48299.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000029030; ENSMUSP00000029030; ENSMUSG00000027524.
GeneID	13616.
KEGG	mmu:13616.
Organism-specific databases
CTD	1908.
MGI	MGI:95285. Edn3.
Phylogenomic databases
eggNOG	NOG41573.
GeneTree	ENSGT00530000063310.
HOGENOM	HOG000231110.
HOVERGEN	HBG051442.
InParanoid	P48299.
KO	K05227.
OMA	DCEETVA.
OrthoDB	EOG4Z62PG.
Gene expression databases
ArrayExpress	P48299.
Bgee	P48299.
CleanEx	MM_EDN3.
Genevestigator	P48299.
GermOnline	ENSMUSG00000027524. Mus musculus.
Family and domain databases
InterPro	IPR020475. Bibrotoxin/Sarafotoxin-D. IPR019764. Endothelin_toxin_CS. IPR001928. Endothln-like_toxin. [Graphical view]
Pfam	PF00322. Endothelin. 1 hit. [Graphical view]
PRINTS	PR00365. ENDOTHELIN.
SMART	SM00272. END. 2 hits. [Graphical view]
PROSITE	PS00270. ENDOTHELIN. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	284280.
SOURCE	Search...

Entry information

Entry name

EDN3_MOUSE

Accession

Primary (citable) accession number: P48299
Secondary accession number(s): Q543L0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program