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P48299

- EDN3_MOUSE

UniProt

P48299 - EDN3_MOUSE

Protein

Endothelin-3

Gene

Edn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Endothelins are endothelium-derived vasoconstrictor peptides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei117 – 1182Cleavage; by KELBy similarity

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: Ensembl
    2. inositol phosphate-mediated signaling Source: Ensembl
    3. melanocyte differentiation Source: MGI
    4. neural crest cell migration Source: MGI
    5. neuron differentiation Source: MGI
    6. neutrophil chemotaxis Source: Ensembl
    7. peptide hormone secretion Source: Ensembl
    8. positive regulation of cell proliferation Source: MGI
    9. positive regulation of heart rate Source: Ensembl
    10. positive regulation of hormone secretion Source: Ensembl
    11. positive regulation of leukocyte chemotaxis Source: Ensembl
    12. positive regulation of MAP kinase activity Source: Ensembl
    13. positive regulation of mitosis Source: Ensembl
    14. regulation of cell migration Source: MGI
    15. regulation of developmental pigmentation Source: MGI
    16. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
    17. regulation of vasoconstriction Source: InterPro
    18. vein smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-3
    Short name:
    ET-3
    Alternative name(s):
    Preproendothelin-3
    Short name:
    PPET3
    Gene namesi
    Name:Edn3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:95285. Edn3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Propeptidei17 – 9478PRO_0000008114Add
    BLAST
    Peptidei97 – 11721Endothelin-3PRO_0000008115Add
    BLAST
    Propeptidei118 – 21497PRO_0000008116Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi97 ↔ 111By similarity
    Disulfide bondi99 ↔ 107By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP48299.

    Expressioni

    Gene expression databases

    ArrayExpressiP48299.
    BgeeiP48299.
    CleanExiMM_EDN3.
    GenevestigatoriP48299.

    Structurei

    3D structure databases

    ProteinModelPortaliP48299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni159 – 17315Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41573.
    GeneTreeiENSGT00530000063310.
    HOGENOMiHOG000231110.
    HOVERGENiHBG051442.
    InParanoidiP48299.
    KOiK05227.
    OMAiHHRSRRC.
    OrthoDBiEOG7PCJHP.
    PhylomeDBiP48299.
    TreeFamiTF333184.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48299-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPGLWLLLG LTVTSAAGLV PCPQSGDSGR ASVSQGPPEA GSERGCEETV    50
    AGPGERIVSP TVALPAQPES AGQERAPGRS GKQEDKGLPA HHRPRRCTCF 100
    TYKDKECVYY CHLDIIWINT PEQTVPYGLS NYRESLRGKR SLGPVPESSQ 150
    PSPWTRLRCT CMGADDKACA HFCARTRDVT SYSGRAERPA AEEMRETGGP 200
    RQRLMSRTDK AHRP 214
    Length:214
    Mass (Da):23,322
    Last modified:February 1, 1996 - v1
    Checksum:i8911260872D6A713
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32330 mRNA. Translation: AAB60509.1.
    AK048006 mRNA. Translation: BAC33211.1.
    AK049775 mRNA. Translation: BAC33915.1.
    AK079150 mRNA. Translation: BAC37561.1.
    CCDSiCCDS17156.1.
    PIRiI49351.
    RefSeqiNP_031929.1. NM_007903.4.
    UniGeneiMm.9478.

    Genome annotation databases

    EnsembliENSMUST00000029030; ENSMUSP00000029030; ENSMUSG00000027524.
    GeneIDi13616.
    KEGGimmu:13616.
    UCSCiuc008ofi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32330 mRNA. Translation: AAB60509.1 .
    AK048006 mRNA. Translation: BAC33211.1 .
    AK049775 mRNA. Translation: BAC33915.1 .
    AK079150 mRNA. Translation: BAC37561.1 .
    CCDSi CCDS17156.1.
    PIRi I49351.
    RefSeqi NP_031929.1. NM_007903.4.
    UniGenei Mm.9478.

    3D structure databases

    ProteinModelPortali P48299.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P48299.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029030 ; ENSMUSP00000029030 ; ENSMUSG00000027524 .
    GeneIDi 13616.
    KEGGi mmu:13616.
    UCSCi uc008ofi.1. mouse.

    Organism-specific databases

    CTDi 1908.
    MGIi MGI:95285. Edn3.

    Phylogenomic databases

    eggNOGi NOG41573.
    GeneTreei ENSGT00530000063310.
    HOGENOMi HOG000231110.
    HOVERGENi HBG051442.
    InParanoidi P48299.
    KOi K05227.
    OMAi HHRSRRC.
    OrthoDBi EOG7PCJHP.
    PhylomeDBi P48299.
    TreeFami TF333184.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 284280.
    PROi P48299.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48299.
    Bgeei P48299.
    CleanExi MM_EDN3.
    Genevestigatori P48299.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons."
      Baynash A.G., Hosoda K., Giaid A., Richardson J.A., Emoto N., Hammer R.E., Yanagisawa M.
      Cell 79:1277-1285(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head and Spinal cord.

    Entry informationi

    Entry nameiEDN3_MOUSE
    AccessioniPrimary (citable) accession number: P48299
    Secondary accession number(s): Q543L0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3