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P48299 (EDN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin-3

Short name=ET-3
Alternative name(s):
Preproendothelin-3
Short name=PPET3
Gene names
Name:Edn3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Endothelins are endothelium-derived vasoconstrictor peptides.

Subcellular location

Secreted.

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionVasoactive
Vasoconstrictor
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell surface receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

inositol phosphate-mediated signaling

Inferred from electronic annotation. Source: Ensembl

melanocyte differentiation

Inferred from direct assay PubMed 9012511. Source: MGI

neural crest cell migration

Inferred from mutant phenotype PubMed 9624616. Source: MGI

neuron differentiation

Inferred from mutant phenotype PubMed 9624616. Source: MGI

neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

peptide hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAP kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from direct assay PubMed 11401406. Source: MGI

positive regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

positive regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of leukocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitosis

Inferred from electronic annotation. Source: Ensembl

regulation of cell migration

Inferred from mutant phenotype PubMed 14138974. Source: MGI

regulation of developmental pigmentation

Inferred from mutant phenotype PubMed 14138974. Source: MGI

regulation of systemic arterial blood pressure by endothelin

Inferred from electronic annotation. Source: Ensembl

regulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

vein smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Propeptide17 – 9478
PRO_0000008114
Peptide97 – 11721Endothelin-3
PRO_0000008115
Propeptide118 – 21497
PRO_0000008116

Regions

Region159 – 17315Endothelin-like

Sites

Site117 – 1182Cleavage; by KEL By similarity

Amino acid modifications

Disulfide bond97 ↔ 111 By similarity
Disulfide bond99 ↔ 107 By similarity

Sequences

Sequence LengthMass (Da)Tools
P48299 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 8911260872D6A713

FASTA21423,322
        10         20         30         40         50         60 
MEPGLWLLLG LTVTSAAGLV PCPQSGDSGR ASVSQGPPEA GSERGCEETV AGPGERIVSP 

        70         80         90        100        110        120 
TVALPAQPES AGQERAPGRS GKQEDKGLPA HHRPRRCTCF TYKDKECVYY CHLDIIWINT 

       130        140        150        160        170        180 
PEQTVPYGLS NYRESLRGKR SLGPVPESSQ PSPWTRLRCT CMGADDKACA HFCARTRDVT 

       190        200        210 
SYSGRAERPA AEEMRETGGP RQRLMSRTDK AHRP 

« Hide

References

« Hide 'large scale' references
[1]"Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons."
Baynash A.G., Hosoda K., Giaid A., Richardson J.A., Emoto N., Hammer R.E., Yanagisawa M.
Cell 79:1277-1285(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head and Spinal cord.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U32330 mRNA. Translation: AAB60509.1.
AK048006 mRNA. Translation: BAC33211.1.
AK049775 mRNA. Translation: BAC33915.1.
AK079150 mRNA. Translation: BAC37561.1.
PIRI49351.
RefSeqNP_031929.1. NM_007903.4.
UniGeneMm.9478.

3D structure databases

ProteinModelPortalP48299.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP48299.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029030; ENSMUSP00000029030; ENSMUSG00000027524.
GeneID13616.
KEGGmmu:13616.
UCSCuc008ofi.1. mouse.

Organism-specific databases

CTD1908.
MGIMGI:95285. Edn3.

Phylogenomic databases

eggNOGNOG41573.
GeneTreeENSGT00530000063310.
HOGENOMHOG000231110.
HOVERGENHBG051442.
InParanoidP48299.
KOK05227.
OMAHHRSRRC.
OrthoDBEOG7PCJHP.
PhylomeDBP48299.
TreeFamTF333184.

Gene expression databases

ArrayExpressP48299.
BgeeP48299.
CleanExMM_EDN3.
GenevestigatorP48299.

Family and domain databases

InterProIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSPR00365. ENDOTHELIN.
SMARTSM00272. END. 2 hits.
[Graphical view]
PROSITEPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio284280.
PROP48299.
SOURCESearch...

Entry information

Entry nameEDN3_MOUSE
AccessionPrimary (citable) accession number: P48299
Secondary accession number(s): Q543L0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot