SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P48299

- EDN3_MOUSE

UniProt

P48299 - EDN3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Endothelin-3

Gene
Edn3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei117 – 1182Cleavage; by KEL By similarity

GO - Biological processi

  1. cell surface receptor signaling pathway Source: Ensembl
  2. inositol phosphate-mediated signaling Source: Ensembl
  3. melanocyte differentiation Source: MGI
  4. neural crest cell migration Source: MGI
  5. neuron differentiation Source: MGI
  6. neutrophil chemotaxis Source: Ensembl
  7. peptide hormone secretion Source: Ensembl
  8. positive regulation of cell proliferation Source: MGI
  9. positive regulation of heart rate Source: Ensembl
  10. positive regulation of hormone secretion Source: Ensembl
  11. positive regulation of leukocyte chemotaxis Source: Ensembl
  12. positive regulation of MAP kinase activity Source: Ensembl
  13. positive regulation of mitosis Source: Ensembl
  14. regulation of cell migration Source: MGI
  15. regulation of developmental pigmentation Source: MGI
  16. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  17. regulation of vasoconstriction Source: InterPro
  18. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-3
Short name:
ET-3
Alternative name(s):
Preproendothelin-3
Short name:
PPET3
Gene namesi
Name:Edn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:95285. Edn3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed predictionAdd
BLAST
Propeptidei17 – 9478PRO_0000008114Add
BLAST
Peptidei97 – 11721Endothelin-3PRO_0000008115Add
BLAST
Propeptidei118 – 21497PRO_0000008116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi97 ↔ 111 By similarity
Disulfide bondi99 ↔ 107 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP48299.

Expressioni

Gene expression databases

ArrayExpressiP48299.
BgeeiP48299.
CleanExiMM_EDN3.
GenevestigatoriP48299.

Structurei

3D structure databases

ProteinModelPortaliP48299.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni159 – 17315Endothelin-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41573.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiP48299.
KOiK05227.
OMAiHHRSRRC.
OrthoDBiEOG7PCJHP.
PhylomeDBiP48299.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48299-1 [UniParc]FASTAAdd to Basket

« Hide

MEPGLWLLLG LTVTSAAGLV PCPQSGDSGR ASVSQGPPEA GSERGCEETV    50
AGPGERIVSP TVALPAQPES AGQERAPGRS GKQEDKGLPA HHRPRRCTCF 100
TYKDKECVYY CHLDIIWINT PEQTVPYGLS NYRESLRGKR SLGPVPESSQ 150
PSPWTRLRCT CMGADDKACA HFCARTRDVT SYSGRAERPA AEEMRETGGP 200
RQRLMSRTDK AHRP 214
Length:214
Mass (Da):23,322
Last modified:February 1, 1996 - v1
Checksum:i8911260872D6A713
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32330 mRNA. Translation: AAB60509.1.
AK048006 mRNA. Translation: BAC33211.1.
AK049775 mRNA. Translation: BAC33915.1.
AK079150 mRNA. Translation: BAC37561.1.
CCDSiCCDS17156.1.
PIRiI49351.
RefSeqiNP_031929.1. NM_007903.4.
UniGeneiMm.9478.

Genome annotation databases

EnsembliENSMUST00000029030; ENSMUSP00000029030; ENSMUSG00000027524.
GeneIDi13616.
KEGGimmu:13616.
UCSCiuc008ofi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32330 mRNA. Translation: AAB60509.1 .
AK048006 mRNA. Translation: BAC33211.1 .
AK049775 mRNA. Translation: BAC33915.1 .
AK079150 mRNA. Translation: BAC37561.1 .
CCDSi CCDS17156.1.
PIRi I49351.
RefSeqi NP_031929.1. NM_007903.4.
UniGenei Mm.9478.

3D structure databases

ProteinModelPortali P48299.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P48299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029030 ; ENSMUSP00000029030 ; ENSMUSG00000027524 .
GeneIDi 13616.
KEGGi mmu:13616.
UCSCi uc008ofi.1. mouse.

Organism-specific databases

CTDi 1908.
MGIi MGI:95285. Edn3.

Phylogenomic databases

eggNOGi NOG41573.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051442.
InParanoidi P48299.
KOi K05227.
OMAi HHRSRRC.
OrthoDBi EOG7PCJHP.
PhylomeDBi P48299.
TreeFami TF333184.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 284280.
PROi P48299.
SOURCEi Search...

Gene expression databases

ArrayExpressi P48299.
Bgeei P48299.
CleanExi MM_EDN3.
Genevestigatori P48299.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons."
    Baynash A.G., Hosoda K., Giaid A., Richardson J.A., Emoto N., Hammer R.E., Yanagisawa M.
    Cell 79:1277-1285(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Spinal cord.

Entry informationi

Entry nameiEDN3_MOUSE
AccessioniPrimary (citable) accession number: P48299
Secondary accession number(s): Q543L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi