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Protein

Endothelin-3

Gene

Edn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: MGI
  • cellular calcium ion homeostasis Source: MGI
  • cellular magnesium ion homeostasis Source: MGI
  • inositol phosphate-mediated signaling Source: MGI
  • melanocyte differentiation Source: MGI
  • neural crest cell migration Source: MGI
  • neuron differentiation Source: MGI
  • neutrophil chemotaxis Source: MGI
  • peptide hormone secretion Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of heart rate Source: MGI
  • positive regulation of hormone secretion Source: MGI
  • positive regulation of leukocyte chemotaxis Source: MGI
  • positive regulation of MAP kinase activity Source: MGI
  • positive regulation of mitotic nuclear division Source: MGI
  • positive regulation of potassium ion transmembrane transport Source: MGI
  • regulation of cell migration Source: MGI
  • regulation of developmental pigmentation Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of systemic arterial blood pressure by endothelin Source: MGI
  • regulation of vasoconstriction Source: InterPro
  • vasoconstriction Source: MGI
  • vein smooth muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-3
Short name:
ET-3
Alternative name(s):
Preproendothelin-3
Short name:
PPET3
Gene namesi
Name:Edn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95285. Edn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000000811417 – 94Add BLAST78
PeptideiPRO_000000811597 – 117Endothelin-3Add BLAST21
PropeptideiPRO_0000008116118 – 214Add BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 111By similarity
Disulfide bondi99 ↔ 107By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei117 – 118Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP48299.
PRIDEiP48299.

PTM databases

PhosphoSitePlusiP48299.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027524.
CleanExiMM_EDN3.
ExpressionAtlasiP48299. baseline and differential.
GenevisibleiP48299. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029030.

Structurei

3D structure databases

ProteinModelPortaliP48299.
SMRiP48299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni159 – 173Endothelin-likeAdd BLAST15

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXXK. Eukaryota.
ENOG410YW48. LUCA.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiP48299.
KOiK05227.
OMAiRSRRCTC.
OrthoDBiEOG091G0OPZ.
PhylomeDBiP48299.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGLWLLLG LTVTSAAGLV PCPQSGDSGR ASVSQGPPEA GSERGCEETV
60 70 80 90 100
AGPGERIVSP TVALPAQPES AGQERAPGRS GKQEDKGLPA HHRPRRCTCF
110 120 130 140 150
TYKDKECVYY CHLDIIWINT PEQTVPYGLS NYRESLRGKR SLGPVPESSQ
160 170 180 190 200
PSPWTRLRCT CMGADDKACA HFCARTRDVT SYSGRAERPA AEEMRETGGP
210
RQRLMSRTDK AHRP
Length:214
Mass (Da):23,322
Last modified:February 1, 1996 - v1
Checksum:i8911260872D6A713
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32330 mRNA. Translation: AAB60509.1.
AK048006 mRNA. Translation: BAC33211.1.
AK049775 mRNA. Translation: BAC33915.1.
AK079150 mRNA. Translation: BAC37561.1.
CCDSiCCDS17156.1.
PIRiI49351.
RefSeqiNP_031929.1. NM_007903.5.
UniGeneiMm.9478.

Genome annotation databases

EnsembliENSMUST00000029030; ENSMUSP00000029030; ENSMUSG00000027524.
GeneIDi13616.
KEGGimmu:13616.
UCSCiuc008ofi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32330 mRNA. Translation: AAB60509.1.
AK048006 mRNA. Translation: BAC33211.1.
AK049775 mRNA. Translation: BAC33915.1.
AK079150 mRNA. Translation: BAC37561.1.
CCDSiCCDS17156.1.
PIRiI49351.
RefSeqiNP_031929.1. NM_007903.5.
UniGeneiMm.9478.

3D structure databases

ProteinModelPortaliP48299.
SMRiP48299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029030.

PTM databases

PhosphoSitePlusiP48299.

Proteomic databases

PaxDbiP48299.
PRIDEiP48299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029030; ENSMUSP00000029030; ENSMUSG00000027524.
GeneIDi13616.
KEGGimmu:13616.
UCSCiuc008ofi.2. mouse.

Organism-specific databases

CTDi1908.
MGIiMGI:95285. Edn3.

Phylogenomic databases

eggNOGiENOG410IXXK. Eukaryota.
ENOG410YW48. LUCA.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiP48299.
KOiK05227.
OMAiRSRRCTC.
OrthoDBiEOG091G0OPZ.
PhylomeDBiP48299.
TreeFamiTF333184.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP48299.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027524.
CleanExiMM_EDN3.
ExpressionAtlasiP48299. baseline and differential.
GenevisibleiP48299. MM.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDN3_MOUSE
AccessioniPrimary (citable) accession number: P48299
Secondary accession number(s): Q543L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.