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Protein

Eotaxin

Gene

Ccl11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene namesi
Name:Ccl11
Synonyms:Scya11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:103576. Ccl11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9774EotaxinPRO_0000005197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity
Glycosylationi94 – 941O-linked (GalNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP48298.

PTM databases

PhosphoSiteiP48298.

Expressioni

Tissue specificityi

Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney.

Inductioni

By interferon gamma and lipopolysaccharides (LPS).

Gene expression databases

BgeeiP48298.
CleanExiMM_CCL11.
GenevisibleiP48298. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000342.

Structurei

3D structure databases

ProteinModelPortaliP48298.
SMRiP48298. Positions 25-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46290.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP48298.
KOiK16597.
OMAiRITNNRC.
OrthoDBiEOG7673DP.
PhylomeDBiP48298.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSSTALLFL LLTVTSFTSQ VLAHPGSIPT SCCFIMTSKK IPNTLLKSYK
60 70 80 90
RITNNRCTLK AIVFKTRLGK EICADPKKKW VQDATKHLDQ KLQTPKP
Length:97
Mass (Da):10,893
Last modified:February 1, 1996 - v1
Checksum:i36C9812107FC6CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26426 mRNA. Translation: AAC52256.1.
U40672 mRNA. Translation: AAA99776.1.
AF128205 mRNA. Translation: AAF22546.1.
AF128206 mRNA. Translation: AAF22547.1.
AF128207 mRNA. Translation: AAF22548.1.
AF128208 mRNA. Translation: AAF22549.1.
AF128209 mRNA. Translation: AAF22550.1.
AK010146 mRNA. Translation: BAB26731.1.
BC027521 mRNA. Translation: AAH27521.1.
U77462 Genomic DNA. Translation: AAC53321.1.
CCDSiCCDS36246.1.
RefSeqiNP_035460.1. NM_011330.3.
UniGeneiMm.4686.

Genome annotation databases

EnsembliENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676.
GeneIDi20292.
KEGGimmu:20292.
UCSCiuc007kmr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26426 mRNA. Translation: AAC52256.1.
U40672 mRNA. Translation: AAA99776.1.
AF128205 mRNA. Translation: AAF22546.1.
AF128206 mRNA. Translation: AAF22547.1.
AF128207 mRNA. Translation: AAF22548.1.
AF128208 mRNA. Translation: AAF22549.1.
AF128209 mRNA. Translation: AAF22550.1.
AK010146 mRNA. Translation: BAB26731.1.
BC027521 mRNA. Translation: AAH27521.1.
U77462 Genomic DNA. Translation: AAC53321.1.
CCDSiCCDS36246.1.
RefSeqiNP_035460.1. NM_011330.3.
UniGeneiMm.4686.

3D structure databases

ProteinModelPortaliP48298.
SMRiP48298. Positions 25-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000342.

PTM databases

PhosphoSiteiP48298.

Proteomic databases

PRIDEiP48298.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676.
GeneIDi20292.
KEGGimmu:20292.
UCSCiuc007kmr.2. mouse.

Organism-specific databases

CTDi6356.
MGIiMGI:103576. Ccl11.

Phylogenomic databases

eggNOGiNOG46290.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP48298.
KOiK16597.
OMAiRITNNRC.
OrthoDBiEOG7673DP.
PhylomeDBiP48298.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi298007.
PROiP48298.
SOURCEiSearch...

Gene expression databases

BgeeiP48298.
CleanExiMM_CCL11.
GenevisibleiP48298. MM.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression."
    Rothenberg M.E., Luster A.D., Leder P.
    Proc. Natl. Acad. Sci. U.S.A. 92:8960-8964(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response."
    Gonzalo J.-A., Jia G.-Q., Aguirre V., Friend D., Coyle A.J., Jenkins N.A., Lin G.-S., Katz H., Lichtman A., Copeland N.G., Kopf M., Gutierrez-Ramos J.-C.
    Immunity 4:1-14(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  3. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
    Tissue: Spleen.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  6. "Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine."
    Garcia-Zepeda E.A., Rothenberg M.E., Weremowicz S., Sarafi M.N., Morton C.C., Luster A.D.
    Genomics 41:471-476(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.

Entry informationi

Entry nameiCCL11_MOUSE
AccessioniPrimary (citable) accession number: P48298
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 24, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.