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P48298

- CCL11_MOUSE

UniProt

P48298 - CCL11_MOUSE

Protein

Eotaxin

Gene

Ccl11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils.

    GO - Biological processi

    1. actin filament organization Source: Ensembl
    2. branching involved in mammary gland duct morphogenesis Source: MGI
    3. chronic inflammatory response Source: Ensembl
    4. eosinophil chemotaxis Source: Ensembl
    5. ERK1 and ERK2 cascade Source: Ensembl
    6. immune response Source: InterPro
    7. mammary duct terminal end bud growth Source: MGI
    8. mast cell chemotaxis Source: Ensembl
    9. positive regulation of actin filament polymerization Source: Ensembl
    10. positive regulation of angiogenesis Source: BHF-UCL
    11. positive regulation of cell migration Source: Ensembl
    12. positive regulation of endothelial cell proliferation Source: Ensembl
    13. positive regulation of Rac GTPase activity Source: Ensembl
    14. regulation of cell shape Source: Ensembl
    15. response to interleukin-4 Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eotaxin
    Alternative name(s):
    C-C motif chemokine 11
    Eosinophil chemotactic protein
    Small-inducible cytokine A11
    Gene namesi
    Name:Ccl11
    Synonyms:Scya11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:103576. Ccl11.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9774EotaxinPRO_0000005197Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 57By similarity
    Disulfide bondi33 ↔ 73By similarity
    Glycosylationi94 – 941O-linked (GalNAc...)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP48298.

    PTM databases

    PhosphoSiteiP48298.

    Expressioni

    Tissue specificityi

    Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney.

    Inductioni

    By interferon gamma and lipopolysaccharides (LPS).

    Gene expression databases

    BgeeiP48298.
    CleanExiMM_CCL11.
    GenevestigatoriP48298.

    Structurei

    3D structure databases

    ProteinModelPortaliP48298.
    SMRiP48298. Positions 25-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46290.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiP48298.
    KOiK16597.
    OMAiQSYRRIT.
    OrthoDBiEOG7673DP.
    PhylomeDBiP48298.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48298-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSSTALLFL LLTVTSFTSQ VLAHPGSIPT SCCFIMTSKK IPNTLLKSYK   50
    RITNNRCTLK AIVFKTRLGK EICADPKKKW VQDATKHLDQ KLQTPKP 97
    Length:97
    Mass (Da):10,893
    Last modified:February 1, 1996 - v1
    Checksum:i36C9812107FC6CA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U26426 mRNA. Translation: AAC52256.1.
    U40672 mRNA. Translation: AAA99776.1.
    AF128205 mRNA. Translation: AAF22546.1.
    AF128206 mRNA. Translation: AAF22547.1.
    AF128207 mRNA. Translation: AAF22548.1.
    AF128208 mRNA. Translation: AAF22549.1.
    AF128209 mRNA. Translation: AAF22550.1.
    AK010146 mRNA. Translation: BAB26731.1.
    BC027521 mRNA. Translation: AAH27521.1.
    U77462 Genomic DNA. Translation: AAC53321.1.
    CCDSiCCDS36246.1.
    RefSeqiNP_035460.1. NM_011330.3.
    UniGeneiMm.4686.

    Genome annotation databases

    EnsembliENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676.
    GeneIDi20292.
    KEGGimmu:20292.
    UCSCiuc007kmr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U26426 mRNA. Translation: AAC52256.1 .
    U40672 mRNA. Translation: AAA99776.1 .
    AF128205 mRNA. Translation: AAF22546.1 .
    AF128206 mRNA. Translation: AAF22547.1 .
    AF128207 mRNA. Translation: AAF22548.1 .
    AF128208 mRNA. Translation: AAF22549.1 .
    AF128209 mRNA. Translation: AAF22550.1 .
    AK010146 mRNA. Translation: BAB26731.1 .
    BC027521 mRNA. Translation: AAH27521.1 .
    U77462 Genomic DNA. Translation: AAC53321.1 .
    CCDSi CCDS36246.1.
    RefSeqi NP_035460.1. NM_011330.3.
    UniGenei Mm.4686.

    3D structure databases

    ProteinModelPortali P48298.
    SMRi P48298. Positions 25-97.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P48298.

    Proteomic databases

    PRIDEi P48298.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000342 ; ENSMUSP00000000342 ; ENSMUSG00000020676 .
    GeneIDi 20292.
    KEGGi mmu:20292.
    UCSCi uc007kmr.2. mouse.

    Organism-specific databases

    CTDi 6356.
    MGIi MGI:103576. Ccl11.

    Phylogenomic databases

    eggNOGi NOG46290.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi P48298.
    KOi K16597.
    OMAi QSYRRIT.
    OrthoDBi EOG7673DP.
    PhylomeDBi P48298.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 298007.
    PROi P48298.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48298.
    CleanExi MM_CCL11.
    Genevestigatori P48298.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression."
      Rothenberg M.E., Luster A.D., Leder P.
      Proc. Natl. Acad. Sci. U.S.A. 92:8960-8964(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response."
      Gonzalo J.-A., Jia G.-Q., Aguirre V., Friend D., Coyle A.J., Jenkins N.A., Lin G.-S., Katz H., Lichtman A., Copeland N.G., Kopf M., Gutierrez-Ramos J.-C.
      Immunity 4:1-14(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.
    3. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
      Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
      J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
      Tissue: Spleen.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Tongue.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    6. "Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine."
      Garcia-Zepeda E.A., Rothenberg M.E., Weremowicz S., Sarafi M.N., Morton C.C., Luster A.D.
      Genomics 41:471-476(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.

    Entry informationi

    Entry nameiCCL11_MOUSE
    AccessioniPrimary (citable) accession number: P48298
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3