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Protein

Eotaxin

Gene

Ccl11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene namesi
Name:Ccl11
Synonyms:Scya11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:103576. Ccl11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000519724 – 97EotaxinAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity
Glycosylationi94O-linked (GalNAc...)By similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48298.
PRIDEiP48298.

PTM databases

iPTMnetiP48298.
PhosphoSitePlusiP48298.

Expressioni

Tissue specificityi

Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney.

Inductioni

By interferon gamma and lipopolysaccharides (LPS).

Gene expression databases

BgeeiENSMUSG00000020676.
CleanExiMM_CCL11.
GenevisibleiP48298. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000342.

Structurei

3D structure databases

ProteinModelPortaliP48298.
SMRiP48298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP48298.
KOiK16597.
OMAiRITNNRC.
OrthoDBiEOG091G14KV.
PhylomeDBiP48298.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSSTALLFL LLTVTSFTSQ VLAHPGSIPT SCCFIMTSKK IPNTLLKSYK
60 70 80 90
RITNNRCTLK AIVFKTRLGK EICADPKKKW VQDATKHLDQ KLQTPKP
Length:97
Mass (Da):10,893
Last modified:February 1, 1996 - v1
Checksum:i36C9812107FC6CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26426 mRNA. Translation: AAC52256.1.
U40672 mRNA. Translation: AAA99776.1.
AF128205 mRNA. Translation: AAF22546.1.
AF128206 mRNA. Translation: AAF22547.1.
AF128207 mRNA. Translation: AAF22548.1.
AF128208 mRNA. Translation: AAF22549.1.
AF128209 mRNA. Translation: AAF22550.1.
AK010146 mRNA. Translation: BAB26731.1.
BC027521 mRNA. Translation: AAH27521.1.
U77462 Genomic DNA. Translation: AAC53321.1.
CCDSiCCDS36246.1.
RefSeqiNP_035460.1. NM_011330.3.
UniGeneiMm.4686.

Genome annotation databases

EnsembliENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676.
GeneIDi20292.
KEGGimmu:20292.
UCSCiuc007kmr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26426 mRNA. Translation: AAC52256.1.
U40672 mRNA. Translation: AAA99776.1.
AF128205 mRNA. Translation: AAF22546.1.
AF128206 mRNA. Translation: AAF22547.1.
AF128207 mRNA. Translation: AAF22548.1.
AF128208 mRNA. Translation: AAF22549.1.
AF128209 mRNA. Translation: AAF22550.1.
AK010146 mRNA. Translation: BAB26731.1.
BC027521 mRNA. Translation: AAH27521.1.
U77462 Genomic DNA. Translation: AAC53321.1.
CCDSiCCDS36246.1.
RefSeqiNP_035460.1. NM_011330.3.
UniGeneiMm.4686.

3D structure databases

ProteinModelPortaliP48298.
SMRiP48298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000342.

PTM databases

iPTMnetiP48298.
PhosphoSitePlusiP48298.

Proteomic databases

PaxDbiP48298.
PRIDEiP48298.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676.
GeneIDi20292.
KEGGimmu:20292.
UCSCiuc007kmr.2. mouse.

Organism-specific databases

CTDi6356.
MGIiMGI:103576. Ccl11.

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP48298.
KOiK16597.
OMAiRITNNRC.
OrthoDBiEOG091G14KV.
PhylomeDBiP48298.
TreeFamiTF334888.

Miscellaneous databases

PROiP48298.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020676.
CleanExiMM_CCL11.
GenevisibleiP48298. MM.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL11_MOUSE
AccessioniPrimary (citable) accession number: P48298
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.