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P48298

- CCL11_MOUSE

UniProt

P48298 - CCL11_MOUSE

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Protein

Eotaxin

Gene

Ccl11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils.

GO - Biological processi

  1. actin filament organization Source: Ensembl
  2. branching involved in mammary gland duct morphogenesis Source: MGI
  3. chronic inflammatory response Source: Ensembl
  4. eosinophil chemotaxis Source: Ensembl
  5. ERK1 and ERK2 cascade Source: Ensembl
  6. immune response Source: InterPro
  7. mammary duct terminal end bud growth Source: MGI
  8. mast cell chemotaxis Source: Ensembl
  9. positive regulation of actin filament polymerization Source: Ensembl
  10. positive regulation of angiogenesis Source: BHF-UCL
  11. positive regulation of cell migration Source: Ensembl
  12. positive regulation of endothelial cell proliferation Source: Ensembl
  13. positive regulation of Rac GTPase activity Source: Ensembl
  14. regulation of cell shape Source: Ensembl
  15. response to interleukin-4 Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene namesi
Name:Ccl11
Synonyms:Scya11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:103576. Ccl11.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9774EotaxinPRO_0000005197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity
Glycosylationi94 – 941O-linked (GalNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP48298.

PTM databases

PhosphoSiteiP48298.

Expressioni

Tissue specificityi

Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney.

Inductioni

By interferon gamma and lipopolysaccharides (LPS).

Gene expression databases

BgeeiP48298.
CleanExiMM_CCL11.
GenevestigatoriP48298.

Structurei

3D structure databases

ProteinModelPortaliP48298.
SMRiP48298. Positions 25-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46290.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP48298.
KOiK16597.
OMAiQSYRRIT.
OrthoDBiEOG7673DP.
PhylomeDBiP48298.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48298-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSSTALLFL LLTVTSFTSQ VLAHPGSIPT SCCFIMTSKK IPNTLLKSYK
60 70 80 90
RITNNRCTLK AIVFKTRLGK EICADPKKKW VQDATKHLDQ KLQTPKP
Length:97
Mass (Da):10,893
Last modified:February 1, 1996 - v1
Checksum:i36C9812107FC6CA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U26426 mRNA. Translation: AAC52256.1.
U40672 mRNA. Translation: AAA99776.1.
AF128205 mRNA. Translation: AAF22546.1.
AF128206 mRNA. Translation: AAF22547.1.
AF128207 mRNA. Translation: AAF22548.1.
AF128208 mRNA. Translation: AAF22549.1.
AF128209 mRNA. Translation: AAF22550.1.
AK010146 mRNA. Translation: BAB26731.1.
BC027521 mRNA. Translation: AAH27521.1.
U77462 Genomic DNA. Translation: AAC53321.1.
CCDSiCCDS36246.1.
RefSeqiNP_035460.1. NM_011330.3.
UniGeneiMm.4686.

Genome annotation databases

EnsembliENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676.
GeneIDi20292.
KEGGimmu:20292.
UCSCiuc007kmr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U26426 mRNA. Translation: AAC52256.1 .
U40672 mRNA. Translation: AAA99776.1 .
AF128205 mRNA. Translation: AAF22546.1 .
AF128206 mRNA. Translation: AAF22547.1 .
AF128207 mRNA. Translation: AAF22548.1 .
AF128208 mRNA. Translation: AAF22549.1 .
AF128209 mRNA. Translation: AAF22550.1 .
AK010146 mRNA. Translation: BAB26731.1 .
BC027521 mRNA. Translation: AAH27521.1 .
U77462 Genomic DNA. Translation: AAC53321.1 .
CCDSi CCDS36246.1.
RefSeqi NP_035460.1. NM_011330.3.
UniGenei Mm.4686.

3D structure databases

ProteinModelPortali P48298.
SMRi P48298. Positions 25-97.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P48298.

Proteomic databases

PRIDEi P48298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000342 ; ENSMUSP00000000342 ; ENSMUSG00000020676 .
GeneIDi 20292.
KEGGi mmu:20292.
UCSCi uc007kmr.2. mouse.

Organism-specific databases

CTDi 6356.
MGIi MGI:103576. Ccl11.

Phylogenomic databases

eggNOGi NOG46290.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi P48298.
KOi K16597.
OMAi QSYRRIT.
OrthoDBi EOG7673DP.
PhylomeDBi P48298.
TreeFami TF334888.

Miscellaneous databases

NextBioi 298007.
PROi P48298.
SOURCEi Search...

Gene expression databases

Bgeei P48298.
CleanExi MM_CCL11.
Genevestigatori P48298.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression."
    Rothenberg M.E., Luster A.D., Leder P.
    Proc. Natl. Acad. Sci. U.S.A. 92:8960-8964(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response."
    Gonzalo J.-A., Jia G.-Q., Aguirre V., Friend D., Coyle A.J., Jenkins N.A., Lin G.-S., Katz H., Lichtman A., Copeland N.G., Kopf M., Gutierrez-Ramos J.-C.
    Immunity 4:1-14(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  3. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
    Tissue: Spleen.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  6. "Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine."
    Garcia-Zepeda E.A., Rothenberg M.E., Weremowicz S., Sarafi M.N., Morton C.C., Luster A.D.
    Genomics 41:471-476(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.

Entry informationi

Entry nameiCCL11_MOUSE
AccessioniPrimary (citable) accession number: P48298
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3