P48282 (CAH1_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carbonic anhydrase 1
EC=4.2.1.1

Alternative name(s):
Carbonate dehydratase I
Carbonic anhydrase I
Short name=CA-I

Gene names

Name:

CA1

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc.
Enzyme regulation	Inhibited by acetazolamide By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 261	260	Carbonic anhydrase 1		PRO_0000077416
Regions
	Region	200 – 201	2	Substrate binding By similarity
Sites
	Active site	65	1	Proton acceptor By similarity
	Active site	129	1	By similarity
	Metal binding	95	1	Zinc; catalytic
	Metal binding	97	1	Zinc; catalytic
	Metal binding	120	1	Zinc; catalytic
	Binding site	200	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48282 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: EA1E908F44F171CE	FASTA	261	28,898
	10 20 30 40 50 60 MASPDWGYDG ENGPEHWCKL HPIANGNNQS PIDIKTSETK RDPSLKPLSI SYNPATAKEI 70 80 90 100 110 120 VNVGHSFHVN FEDSDNRSVL KGGPLPESYR LRQFHFHWGS TDDCGSEHLV DGATFSAELH 130 140 150 160 170 180 LVHWNSAKYP SFADAASQAD GLVVVGVLMK VGQANPNLQK VLDALKTVKT KNKKAPFTNF 190 200 210 220 230 240 DPSVLLPSCP DYWAYFGSLT HPPLHESVTW IIFKETISVS AEQLAQFRSL LANAEGDKEV 250 260 CIKQNYRPPQ PLKGRTVKAS F

References

[1]	"Isolation and characterization of a cDNA clone encoding ovine type I carbonic anhydrase." Wang L.Q., Baldwin R.L., Jesse B.W. J. Anim. Sci. 74:345-353(1996) [PubMed: 8690670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Dorset. Tissue: Ruminal epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42178 mRNA. Translation: AAC41634.1.
RefSeq	NP_001009771.1. NM_001009771.1.
UniGene	Oar.635.
3D structure databases
ProteinModelPortal	P48282.
SMR	P48282. Positions 2-261.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	443309.
Organism-specific databases
CTD	759.
Phylogenomic databases
HOVERGEN	HBG002837.
Family and domain databases
InterPro	IPR001148. a_carbonic_anhydrase. IPR023561. Carbonic_anhydrase_a-class. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018442. Carbonic_anhydrase_CA1. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF30. Carbonic_anhydrase_CA1. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
SMART	SM01057. Carb_anhydrase. 1 hit. [Graphical view]
SUPFAM	SSF51069. Euk_COanhd. 1 hit.
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH1_SHEEP

Accession

Primary (citable) accession number: P48282

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program