Reviewed, UniProtKB/Swiss-Prot P48282 (CAH1_SHEEP)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 1
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase I
      Short name=CA-I
    Carbonate dehydratase I

Gene names

Name:

CA1

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 261	260	Carbonic anhydrase 1		PRO_0000077416
Sites
	Metal binding	95	1	Zinc; catalytic
	Metal binding	97	1	Zinc; catalytic
	Metal binding	120	1	Zinc; catalytic

Sequences

	Sequence		Length	Mass (Da)
	P48282-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: EA1E908F44F171CE	FASTA	261	28,898
	10 20 30 40 50 60 MASPDWGYDG ENGPEHWCKL HPIANGNNQS PIDIKTSETK RDPSLKPLSI SYNPATAKEI 70 80 90 100 110 120 VNVGHSFHVN FEDSDNRSVL KGGPLPESYR LRQFHFHWGS TDDCGSEHLV DGATFSAELH 130 140 150 160 170 180 LVHWNSAKYP SFADAASQAD GLVVVGVLMK VGQANPNLQK VLDALKTVKT KNKKAPFTNF 190 200 210 220 230 240 DPSVLLPSCP DYWAYFGSLT HPPLHESVTW IIFKETISVS AEQLAQFRSL LANAEGDKEV 250 260 CIKQNYRPPQ PLKGRTVKAS F

References

[1]	"Isolation and characterization of a cDNA clone encoding ovine type I carbonic anhydrase." Wang L.Q., Baldwin R.L., Jesse B.W. J. Anim. Sci. 74:345-353(1996) [PubMed: 8690670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Dorset. Tissue: Ruminal epithelium.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42178 mRNA. Translation: AAC41634.1.
RefSeq	NP_001009771.1.
UniGene	Oar.635
3D structure databases
SMR	P48282. Positions 2-261.
ModBase	Search...
Genome annotation databases
GeneID	443309.
Organism-specific databases
CTD	443309.
Phylogenomic databases
HOVERGEN	P48282.
Enzyme and pathway databases
BRENDA	4.2.1.1. 271.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018442. Carbonic_anhydrase_CA1. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF30. Carbonic_anhydrase_CA1. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH1_SHEEP

Accession

Primary (citable) accession number: P48282

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)