Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vitamin D3 receptor

Gene

Vdr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143Vitamin D3By similarity1
Binding sitei300Vitamin D3By similarity1
Binding sitei392Vitamin D3By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi21 – 96Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri24 – 44NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri60 – 84NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • bile acid signaling pathway Source: MGI
  • calcium ion transport Source: MGI
  • cell morphogenesis Source: MGI
  • cellular calcium ion homeostasis Source: MGI
  • decidualization Source: Ensembl
  • intestinal absorption Source: MGI
  • lactation Source: MGI
  • mammary gland branching involved in pregnancy Source: MGI
  • multicellular organism development Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of keratinocyte proliferation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of apoptotic process involved in mammary gland involution Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of keratinocyte differentiation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of vitamin D 24-hydroxylase activity Source: MGI
  • regulation of calcidiol 1-monooxygenase activity Source: BHF-UCL
  • regulation of transcription, DNA-templated Source: MGI
  • skeletal system development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • vitamin D receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin D3 receptor
Short name:
VDR
Alternative name(s):
1,25-dihydroxyvitamin D3 receptor
Nuclear receptor subfamily 1 group I member 1
Gene namesi
Name:Vdr
Synonyms:Nr1i1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:103076. Vdr.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535431 – 422Vitamin D3 receptorAdd BLAST422

Proteomic databases

MaxQBiP48281.
PaxDbiP48281.
PeptideAtlasiP48281.
PRIDEiP48281.

PTM databases

iPTMnetiP48281.
PhosphoSitePlusiP48281.

Expressioni

Inductioni

By 1,25-dihydroxyvitamin D3 in kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000022479.
CleanExiMM_VDR.
ExpressionAtlasiP48281. baseline and differential.
GenevisibleiP48281. MM.

Interactioni

Subunit structurei

Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF. Interacts with SNW1. Interacts with IRX4, the interaction doesn't affect its transactivation activity (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Grip1Q925T62EBI-346797,EBI-537752
GTF2BQ004032EBI-346797,EBI-389564From a different organism.
NCOA3Q9Y6Q92EBI-346797,EBI-81196From a different organism.
SNW1Q135732EBI-346797,EBI-632715From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204511. 4 interactors.
DIPiDIP-31478N.
IntActiP48281. 8 interactors.
STRINGi10090.ENSMUSP00000023119.

Chemistry databases

BindingDBiP48281.

Structurei

3D structure databases

ProteinModelPortaliP48281.
SMRiP48281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 186HingeAdd BLAST90
Regioni187 – 422Ligand-bindingAdd BLAST236
Regioni222 – 232Vitamin D3 bindingBy similarityAdd BLAST11
Regioni241 – 259Interaction with coactivator LXXLL motifBy similarityAdd BLAST19
Regioni266 – 273Vitamin D3 bindingBy similarity8

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri24 – 44NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri60 – 84NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiP48281.
KOiK08539.
OMAiFCQFRPP.
OrthoDBiEOG091G05X3.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000324. VitD_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00350. VITAMINDR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48281-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR
60 70 80 90 100
SMKRKALFTC PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV
110 120 130 140 150
QRKREMIMKR KEEEALKDSL RPKLSEEQQH IIAILLDAHH KTYDPTYADF
160 170 180 190 200
RDFRPPIRAD VSTGSYSPRP TLSFSGDSSS NSDLYTPSLD MMEPASFSTM
210 220 230 240 250
DLNEEGSDDP SVTLDLSPLS MLPHLADLVS YSIQKVIGFA KMIPGFRDLT
260 270 280 290 300
SDDQIVLLKS SAIEVIMLRS NQSFTLDDMS WDCGSQDYKY DITDVSRAGH
310 320 330 340 350
TLELIEPLIK FQVGLKKLNL HEEEHVLLMA ICIVSPDRPG VQDAKLVEAI
360 370 380 390 400
QDRLSNTLQT YIRCRHPPPG SHQLYAKMIQ KLADLRSLNE EHSKQYRSLS
410 420
FQPENSMKLT PLVLEVFGNE IS
Length:422
Mass (Da):47,834
Last modified:July 27, 2011 - v2
Checksum:i4614DD4A129F2732
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti276L → M in BAA06737 (PubMed:7835717).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31969 mRNA. Translation: BAA06737.1.
AK030339 mRNA. Translation: BAC26911.1.
AK154647 mRNA. Translation: BAE32738.1.
CH466550 Genomic DNA. Translation: EDL04218.1.
BC006716 mRNA. Translation: AAH06716.1.
CCDSiCCDS27784.1.
PIRiPC4019.
RefSeqiNP_033530.2. NM_009504.4.
UniGeneiMm.245084.

Genome annotation databases

EnsembliENSMUST00000023119; ENSMUSP00000023119; ENSMUSG00000022479.
GeneIDi22337.
KEGGimmu:22337.
UCSCiuc007xlk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31969 mRNA. Translation: BAA06737.1.
AK030339 mRNA. Translation: BAC26911.1.
AK154647 mRNA. Translation: BAE32738.1.
CH466550 Genomic DNA. Translation: EDL04218.1.
BC006716 mRNA. Translation: AAH06716.1.
CCDSiCCDS27784.1.
PIRiPC4019.
RefSeqiNP_033530.2. NM_009504.4.
UniGeneiMm.245084.

3D structure databases

ProteinModelPortaliP48281.
SMRiP48281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204511. 4 interactors.
DIPiDIP-31478N.
IntActiP48281. 8 interactors.
STRINGi10090.ENSMUSP00000023119.

Chemistry databases

BindingDBiP48281.
ChEMBLiCHEMBL5601.

PTM databases

iPTMnetiP48281.
PhosphoSitePlusiP48281.

Proteomic databases

MaxQBiP48281.
PaxDbiP48281.
PeptideAtlasiP48281.
PRIDEiP48281.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023119; ENSMUSP00000023119; ENSMUSG00000022479.
GeneIDi22337.
KEGGimmu:22337.
UCSCiuc007xlk.1. mouse.

Organism-specific databases

CTDi7421.
MGIiMGI:103076. Vdr.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiP48281.
KOiK08539.
OMAiFCQFRPP.
OrthoDBiEOG091G05X3.
TreeFamiTF316304.

Enzyme and pathway databases

ReactomeiR-MMU-383280. Nuclear Receptor transcription pathway.

Miscellaneous databases

ChiTaRSiVdr. mouse.
PROiP48281.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022479.
CleanExiMM_VDR.
ExpressionAtlasiP48281. baseline and differential.
GenevisibleiP48281. MM.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000324. VitD_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00350. VITAMINDR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVDR_MOUSE
AccessioniPrimary (citable) accession number: P48281
Secondary accession number(s): Q922X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.