Reviewed,
UniProtKB/Swiss-Prot P48281 (VDR_MOUSE)
Last modified
June 16, 2009.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Vitamin D3 receptor Short name=VDR Alternative name(s): 1,25-dihydroxyvitamin D3 receptor Nuclear receptor subfamily 1 group I member 1 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 422 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis By similarity. |
| Subunit structure | Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF By similarity. |
| Subcellular location | Nucleus By similarity. |
| Induction | By 1,25-dihydroxyvitamin D3 in kidney. Ref.2 |
| Domain | Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain By similarity. |
| Sequence similarities | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 422 | 422 | Vitamin D3 receptor | PRO_0000053543 | |||||
Regions | |||||||||
| DNA binding | 21 – 96 | 76 | Nuclear receptor | ||||||
| Zinc finger | 24 – 44 | 21 | NR C4-type | ||||||
| Zinc finger | 60 – 84 | 25 | NR C4-type | ||||||
| Region | 97 – 186 | 90 | Hinge | ||||||
| Region | 187 – 422 | 236 | Ligand-binding | ||||||
| Region | 222 – 232 | 11 | Vitamin D3 binding By similarity | ||||||
| Region | 241 – 259 | 19 | with Interaction with coactivator LXXLL motif By similarity | ||||||
| Region | 266 – 273 | 8 | Vitamin D3 binding By similarity | ||||||
Sites | |||||||||
| Binding site | 143 | 1 | Vitamin D3 By similarity | ||||||
| Binding site | 300 | 1 | Vitamin D3 By similarity | ||||||
| Binding site | 392 | 1 | Vitamin D3 By similarity | ||||||
Sequences
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References
| [1] | "Cloning and sequencing of the gene encoding the mouse vitamin D receptor." Kamei Y., Kawada T., Fukuwatari T., Ono T., Kato S., Sugimoto E. Gene 152:281-282(1995) [PubMed: 7835717] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system." Tsujikawa H., Kurotaki Y., Fujimori T., Fukuda K., Nabeshima Y. Mol. Endocrinol. 17:2393-2403(2003) [PubMed: 14528024] [Abstract] Cited for: INDUCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D31969 mRNA. Translation: BAA06737.1. | |
| IPI | IPI00311693. |
| PIR | PC4019. |
| UniGene | Mm.245084 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KB2 based on UniProtKB P11473. |
| SMR | P48281. Positions 21-121, 165-418. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P48281. 1 interaction. |
PTM databases | |
| PhosphoSite | P48281. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000022479. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:103076. Vdr. |
Phylogenomic databases | |
| HOGENOM | P48281. |
| HOVERGEN | P48281. |
Gene expression databases | |
| ArrayExpress | P48281. |
| Bgee | P48281. |
| CleanEx | MM_VDR. |
| GermOnline | ENSMUSG00000022479. Mus musculus. |
Family and domain databases | |
| InterPro | IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR000324. VitD_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view] |
| Gene3D | G3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 1 hit. G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit. |
| Pfam | PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view] |
| PRINTS | PR00398. STRDHORMONER. PR00047. STROIDFINGER. PR00350. VITAMINDR. |
| ProDom | PD000035. Znf_C4steroid. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view] |
| PROSITE | PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | VDR_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P48281 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


