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P48281

- VDR_MOUSE

UniProt

P48281 - VDR_MOUSE

Protein

Vitamin D3 receptor

Gene

Vdr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431Vitamin D3By similarity
    Binding sitei300 – 3001Vitamin D3By similarity
    Binding sitei392 – 3921Vitamin D3By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi21 – 9676Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri24 – 4421NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri60 – 8425NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcitriol binding Source: Ensembl
    2. calcitriol receptor activity Source: InterPro
    3. DNA binding Source: MGI
    4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    5. lithocholic acid binding Source: Ensembl
    6. lithocholic acid receptor activity Source: Ensembl
    7. protein binding Source: UniProtKB
    8. sequence-specific DNA binding Source: InterPro
    9. steroid hormone receptor activity Source: InterPro
    10. vitamin D response element binding Source: Ensembl
    11. zinc ion binding Source: InterPro

    GO - Biological processi

    1. calcium ion transport Source: MGI
    2. cell morphogenesis Source: Ensembl
    3. cellular calcium ion homeostasis Source: MGI
    4. decidualization Source: Ensembl
    5. intestinal absorption Source: MGI
    6. lactation Source: MGI
    7. mammary gland branching involved in pregnancy Source: MGI
    8. multicellular organismal development Source: MGI
    9. negative regulation of keratinocyte proliferation Source: Ensembl
    10. negative regulation of transcription, DNA-templated Source: MGI
    11. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. organ morphogenesis Source: MGI
    13. positive regulation of apoptotic process involved in mammary gland involution Source: MGI
    14. positive regulation of keratinocyte differentiation Source: Ensembl
    15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. positive regulation of vitamin D 24-hydroxylase activity Source: Ensembl
    17. regulation of calcidiol 1-monooxygenase activity Source: BHF-UCL
    18. regulation of transcription, DNA-templated Source: MGI
    19. skeletal system development Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vitamin D3 receptor
    Short name:
    VDR
    Alternative name(s):
    1,25-dihydroxyvitamin D3 receptor
    Nuclear receptor subfamily 1 group I member 1
    Gene namesi
    Name:Vdr
    Synonyms:Nr1i1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:103076. Vdr.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Vitamin D3 receptorPRO_0000053543Add
    BLAST

    Proteomic databases

    MaxQBiP48281.
    PRIDEiP48281.

    PTM databases

    PhosphoSiteiP48281.

    Expressioni

    Inductioni

    By 1,25-dihydroxyvitamin D3 in kidney.1 Publication

    Gene expression databases

    ArrayExpressiP48281.
    BgeeiP48281.
    CleanExiMM_VDR.
    GenevestigatoriP48281.

    Interactioni

    Subunit structurei

    Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF. Interacts with SNW1. Interacts with IRX4, the interaction doesn't affect its transactivation activity By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Grip1Q925T62EBI-346797,EBI-537752
    GTF2BQ004032EBI-346797,EBI-389564From a different organism.
    NCOA3Q9Y6Q92EBI-346797,EBI-81196From a different organism.
    SNW1Q135732EBI-346797,EBI-632715From a different organism.

    Protein-protein interaction databases

    BioGridi204511. 4 interactions.
    DIPiDIP-31478N.
    IntActiP48281. 8 interactions.
    STRINGi10090.ENSMUSP00000023119.

    Structurei

    3D structure databases

    ProteinModelPortaliP48281.
    SMRiP48281. Positions 22-106, 124-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni97 – 18690HingeAdd
    BLAST
    Regioni187 – 422236Ligand-bindingAdd
    BLAST
    Regioni222 – 23211Vitamin D3 bindingBy similarityAdd
    BLAST
    Regioni241 – 25919Interaction with coactivator LXXLL motifBy similarityAdd
    BLAST
    Regioni266 – 2738Vitamin D3 bindingBy similarity

    Domaini

    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri24 – 4421NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri60 – 8425NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG283526.
    GeneTreeiENSGT00720000108423.
    HOGENOMiHOG000220844.
    HOVERGENiHBG108655.
    InParanoidiQ922X0.
    KOiK08539.
    OMAiFCQFRPP.
    OrthoDBiEOG79KPF8.
    TreeFamiTF316304.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR000324. VitD_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    PR00350. VITAMINDR.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48281-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR    50
    SMKRKALFTC PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV 100
    QRKREMIMKR KEEEALKDSL RPKLSEEQQH IIAILLDAHH KTYDPTYADF 150
    RDFRPPIRAD VSTGSYSPRP TLSFSGDSSS NSDLYTPSLD MMEPASFSTM 200
    DLNEEGSDDP SVTLDLSPLS MLPHLADLVS YSIQKVIGFA KMIPGFRDLT 250
    SDDQIVLLKS SAIEVIMLRS NQSFTLDDMS WDCGSQDYKY DITDVSRAGH 300
    TLELIEPLIK FQVGLKKLNL HEEEHVLLMA ICIVSPDRPG VQDAKLVEAI 350
    QDRLSNTLQT YIRCRHPPPG SHQLYAKMIQ KLADLRSLNE EHSKQYRSLS 400
    FQPENSMKLT PLVLEVFGNE IS 422
    Length:422
    Mass (Da):47,834
    Last modified:July 27, 2011 - v2
    Checksum:i4614DD4A129F2732
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti276 – 2761L → M in BAA06737. (PubMed:7835717)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31969 mRNA. Translation: BAA06737.1.
    AK030339 mRNA. Translation: BAC26911.1.
    AK154647 mRNA. Translation: BAE32738.1.
    CH466550 Genomic DNA. Translation: EDL04218.1.
    BC006716 mRNA. Translation: AAH06716.1.
    CCDSiCCDS27784.1.
    PIRiPC4019.
    RefSeqiNP_033530.2. NM_009504.4.
    UniGeneiMm.245084.

    Genome annotation databases

    EnsembliENSMUST00000023119; ENSMUSP00000023119; ENSMUSG00000022479.
    GeneIDi22337.
    KEGGimmu:22337.
    UCSCiuc007xlk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31969 mRNA. Translation: BAA06737.1 .
    AK030339 mRNA. Translation: BAC26911.1 .
    AK154647 mRNA. Translation: BAE32738.1 .
    CH466550 Genomic DNA. Translation: EDL04218.1 .
    BC006716 mRNA. Translation: AAH06716.1 .
    CCDSi CCDS27784.1.
    PIRi PC4019.
    RefSeqi NP_033530.2. NM_009504.4.
    UniGenei Mm.245084.

    3D structure databases

    ProteinModelPortali P48281.
    SMRi P48281. Positions 22-106, 124-421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204511. 4 interactions.
    DIPi DIP-31478N.
    IntActi P48281. 8 interactions.
    STRINGi 10090.ENSMUSP00000023119.

    Chemistry

    BindingDBi P48281.
    ChEMBLi CHEMBL5601.
    GuidetoPHARMACOLOGYi 605.

    PTM databases

    PhosphoSitei P48281.

    Proteomic databases

    MaxQBi P48281.
    PRIDEi P48281.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023119 ; ENSMUSP00000023119 ; ENSMUSG00000022479 .
    GeneIDi 22337.
    KEGGi mmu:22337.
    UCSCi uc007xlk.1. mouse.

    Organism-specific databases

    CTDi 7421.
    MGIi MGI:103076. Vdr.

    Phylogenomic databases

    eggNOGi NOG283526.
    GeneTreei ENSGT00720000108423.
    HOGENOMi HOG000220844.
    HOVERGENi HBG108655.
    InParanoidi Q922X0.
    KOi K08539.
    OMAi FCQFRPP.
    OrthoDBi EOG79KPF8.
    TreeFami TF316304.

    Miscellaneous databases

    ChiTaRSi VDR. mouse.
    NextBioi 302589.
    PROi P48281.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48281.
    Bgeei P48281.
    CleanExi MM_VDR.
    Genevestigatori P48281.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR000324. VitD_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    PR00350. VITAMINDR.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the gene encoding the mouse vitamin D receptor."
      Kamei Y., Kawada T., Fukuwatari T., Ono T., Kato S., Sugimoto E.
      Gene 152:281-282(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Intestine.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    5. "Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system."
      Tsujikawa H., Kurotaki Y., Fujimori T., Fukuda K., Nabeshima Y.
      Mol. Endocrinol. 17:2393-2403(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiVDR_MOUSE
    AccessioniPrimary (citable) accession number: P48281
    Secondary accession number(s): Q922X0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3