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P48246

- HEM4_PSEAE

UniProt

P48246 - HEM4_PSEAE

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Protein
Uroporphyrinogen-III synthase
Gene
hemD, PA5259
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: PseudoCAP
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:PA5259
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA5259.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Uroporphyrinogen-III synthase
PRO_0000135245Add
BLAST

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi208964.PA5259.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84
Helixi12 – 2413
Beta strandi28 – 314
Beta strandi36 – 394
Helixi44 – 518
Helixi53 – 553
Beta strandi57 – 615
Helixi64 – 7714
Beta strandi85 – 906
Helixi91 – 10010
Helixi113 – 1175
Helixi120 – 1256
Beta strandi128 – 1303
Beta strandi132 – 1376
Helixi144 – 1518
Beta strandi155 – 1606
Beta strandi162 – 1654
Helixi173 – 1808
Beta strandi185 – 1873
Helixi191 – 20111
Helixi202 – 2043
Helixi205 – 2084
Beta strandi213 – 2175
Helixi218 – 2269
Beta strandi230 – 2345
Beta strandi236 – 2394
Helixi240 – 24910

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ES6X-ray2.22A1-251[»]
ProteinModelPortaliP48246.
SMRiP48246. Positions 3-237.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000247992.
KOiK01719.
OMAiYCECYQR.
OrthoDBiEOG6RZB2F.
PhylomeDBiP48246.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

P48246-1 [UniParc]FASTAAdd to Basket

« Hide

MSGWRLLLTR PDEECAALAA SLGEAGVHSS SLPLLAIDPL EETPEQRTLM    50
LDLDRYCAVV VVSKPAARLG LERLDRYWPQ PPQQTWCSVG AATAAILEAY 100
GLDVTYPEQG DDSEALLALP AFQDSLRVHD PKVLIMRGEG GREFLAERLR 150
GQGVQVDYLP LYRRRAPDYP AGELLARVRA ERLNGLVVSS GQGLQNLYQL 200
AAADWPEIGR LPLFVPSPRV AEMARELGAQ RVIDCRGASA PALLAALTSA 250
A 251
Length:251
Mass (Da):27,279
Last modified:December 8, 2000 - v2
Checksum:iEEF61A160175264A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 2039QNLYQLAAA → PKSVSVGGS in AAA18908. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74844 Genomic DNA. Translation: AAA18908.1.
AE004091 Genomic DNA. Translation: AAG08644.1.
PIRiA82989.
S41587.
RefSeqiNP_253946.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08644; AAG08644; PA5259.
GeneIDi879724.
KEGGipae:PA5259.
PATRICi19845371. VBIPseAer58763_5512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74844 Genomic DNA. Translation: AAA18908.1 .
AE004091 Genomic DNA. Translation: AAG08644.1 .
PIRi A82989.
S41587.
RefSeqi NP_253946.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4ES6 X-ray 2.22 A 1-251 [» ]
ProteinModelPortali P48246.
SMRi P48246. Positions 3-237.
ModBasei Search...

Protein-protein interaction databases

STRINGi 208964.PA5259.

Protocols and materials databases

DNASUi 879724.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08644 ; AAG08644 ; PA5259 .
GeneIDi 879724.
KEGGi pae:PA5259.
PATRICi 19845371. VBIPseAer58763_5512.

Organism-specific databases

PseudoCAPi PA5259.

Phylogenomic databases

eggNOGi COG1587.
HOGENOMi HOG000247992.
KOi K01719.
OMAi YCECYQR.
OrthoDBi EOG6RZB2F.
PhylomeDBi P48246.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Pseudomonas aeruginosa homologs of hemC and hemD are linked to the gene encoding the regulator of mucoidy AlgR."
    Mohr C.D., Sonsteby S.K., Deretic V.
    Mol. Gen. Genet. 242:177-184(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  3. "The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery."
    Moynie L., Schnell R., McMahon S.A., Sandalova T., Boulkerou W.A., Schmidberger J.W., Alphey M., Cukier C., Duthie F., Kopec J., Liu H., Jacewicz A., Hunter W.N., Naismith J.H., Schneider G.
    Acta Crystallogr. F 69:25-34(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF APOPROTEIN, SUBUNIT.

Entry informationi

Entry nameiHEM4_PSEAE
AccessioniPrimary (citable) accession number: P48246
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 8, 2000
Last modified: July 9, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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