Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P48241 (LCB2_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine palmitoyltransferase 2

Short name=SPT 2
EC=2.3.1.50
Alternative name(s):
Long chain base biosynthesis protein 2
Gene names
Name:LCB2
Ordered Locus Names:KLLA0D02134g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

Cofactor

Pyridoxal phosphate.

Pathway

Lipid metabolism; sphingolipid metabolism.

Subcellular location

Membrane; Single-pass membrane protein.

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
   Biological processLipid metabolism
Sphingolipid metabolism
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandPyridoxal phosphate
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processbiosynthetic process

Inferred from electronic annotation. Source: InterPro

sphingolipid metabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

serine C-palmitoyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Serine palmitoyltransferase 2
PRO_0000163860

Regions

Transmembrane61 – 8121Helical; Potential

Amino acid modifications

Modified residue3651N6-(pyridoxal phosphate)lysine By similarity

Experimental info

Sequence conflict1911G → V in AAC49535. Ref.1
Sequence conflict4921S → L in AAC49535. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P48241 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: A23388A0BB681B1D

FASTA56262,937
        10         20         30         40         50         60 
MISISSTRVP LIPPEDIPLE DKKENEFGQL TSEEYLYQSK SRDGKALQDP ILDAPAYHVS 

        70         80         90        100        110        120 
LITYLNYLIL IILGHIHDFL GLTFQKEKHK DIMEQDGLAP WFSTFESFYV RRLKQRIDDC 

       130        140        150        160        170        180 
FSRPTTGVPG RFIRCLDRVS HNLNDYFTYP GTTSMCLNLS SYNYLGFAQS EGQCTTAALE 

       190        200        210        220        230        240 
ATDKYGVYSG GPRTRIGTTD LHVMTEKYVA QFVGKEDAIL FSMGYGTNAN FFNSFLDSKC 

       250        260        270        280        290        300 
LVISDSLNHT SIRTGVRLSG AAVKTFKHND MRALEKLIRE QIVQGQSKTH RPWKKIIICV 

       310        320        330        340        350        360 
EGLYSMEGTM ANLPKLVELK KKYKCYLFVD EAHSIGAMGP SGRGVCDFFG IPCSDIDIMM 

       370        380        390        400        410        420 
GTLTKSFGAA GGYIAADKWI IDRFRLDLTT PHYGEPTPAP VLAQIASSLK TITGDINPGE 

       430        440        450        460        470        480 
GQERLQRIAF NARYLRLALQ RLGFIVYGIA DSPVIPMLLY APSKMPAFSR MMLQRKIAVV 

       490        500        510        520        530        540 
VVAYPATPLI ESRVRFCVSA ALTKEDIDYL LQHINEVGDK LFLKVSSGKA GGSLDGKPPR 

       550        560 
WNIDEVIKRT PTDCKDDSFF RI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15646 Genomic DNA. Translation: AAC49535.1.
CR382124 Genomic DNA. Translation: CAH00259.1.
PIRJC5182.
RefSeqXP_453163.1. XM_453163.1.

3D structure databases

ProteinModelPortalP48241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.P48241.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2892894.
KEGGkla:KLLA0D02134g.

Phylogenomic databases

eggNOGCOG0156.
HOGENOMHOG000206826.
KOK00654.
OMAPEPGGCC.
OrthoDBEOG7XPZG0.

Enzyme and pathway databases

UniPathwayUPA00222.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCB2_KLULA
AccessionPrimary (citable) accession number: P48241
Secondary accession number(s): Q6CSC6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 27, 2004
Last modified: February 19, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways