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Protein

Serine palmitoyltransferase 2

Gene

LCB2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

Cofactori

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid metabolism, Sphingolipid metabolism
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00222.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine palmitoyltransferase 2 (EC:2.3.1.50)
Short name:
SPT 2
Alternative name(s):
Long chain base biosynthesis protein 2
Gene namesi
Name:LCB2
Ordered Locus Names:KLLA0D02134g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome D

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001638601 – 562Serine palmitoyltransferase 2Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei365N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_453163.1.

Structurei

3D structure databases

ProteinModelPortaliP48241.
SMRiP48241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1357. Eukaryota.
COG0156. LUCA.
HOGENOMiHOG000206826.
InParanoidiP48241.
KOiK00654.
OMAiTLNMSSY.
OrthoDBiEOG092C2DQ1.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiView protein in InterPro
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00155. Aminotran_1_2. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiView protein in PROSITE
PS00599. AA_TRANSFER_CLASS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P48241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISISSTRVP LIPPEDIPLE DKKENEFGQL TSEEYLYQSK SRDGKALQDP
60 70 80 90 100
ILDAPAYHVS LITYLNYLIL IILGHIHDFL GLTFQKEKHK DIMEQDGLAP
110 120 130 140 150
WFSTFESFYV RRLKQRIDDC FSRPTTGVPG RFIRCLDRVS HNLNDYFTYP
160 170 180 190 200
GTTSMCLNLS SYNYLGFAQS EGQCTTAALE ATDKYGVYSG GPRTRIGTTD
210 220 230 240 250
LHVMTEKYVA QFVGKEDAIL FSMGYGTNAN FFNSFLDSKC LVISDSLNHT
260 270 280 290 300
SIRTGVRLSG AAVKTFKHND MRALEKLIRE QIVQGQSKTH RPWKKIIICV
310 320 330 340 350
EGLYSMEGTM ANLPKLVELK KKYKCYLFVD EAHSIGAMGP SGRGVCDFFG
360 370 380 390 400
IPCSDIDIMM GTLTKSFGAA GGYIAADKWI IDRFRLDLTT PHYGEPTPAP
410 420 430 440 450
VLAQIASSLK TITGDINPGE GQERLQRIAF NARYLRLALQ RLGFIVYGIA
460 470 480 490 500
DSPVIPMLLY APSKMPAFSR MMLQRKIAVV VVAYPATPLI ESRVRFCVSA
510 520 530 540 550
ALTKEDIDYL LQHINEVGDK LFLKVSSGKA GGSLDGKPPR WNIDEVIKRT
560
PTDCKDDSFF RI
Length:562
Mass (Da):62,937
Last modified:September 27, 2004 - v2
Checksum:iA23388A0BB681B1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191G → V in AAC49535 (PubMed:8921873).Curated1
Sequence conflicti492S → L in AAC49535 (PubMed:8921873).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15646 Genomic DNA. Translation: AAC49535.1.
CR382124 Genomic DNA. Translation: CAH00259.1.
PIRiJC5182.
RefSeqiXP_453163.1. XM_453163.1.

Genome annotation databases

EnsemblFungiiCAH00259; CAH00259; KLLA0_D02134g.
KEGGikla:KLLA0D02134g.

Similar proteinsi

Entry informationi

Entry nameiLCB2_KLULA
AccessioniPrimary (citable) accession number: P48241
Secondary accession number(s): Q6CSC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 27, 2004
Last modified: August 30, 2017
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families