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P48241

- LCB2_KLULA

UniProt

P48241 - LCB2_KLULA

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Protein

Serine palmitoyltransferase 2

Gene

LCB2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

Cofactori

Pyridoxal phosphate.

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. serine C-palmitoyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. sphingolipid metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00222.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine palmitoyltransferase 2 (EC:2.3.1.50)
Short name:
SPT 2
Alternative name(s):
Long chain base biosynthesis protein 2
Gene namesi
Name:LCB2
Ordered Locus Names:KLLA0D02134g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome D

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Serine palmitoyltransferase 2PRO_0000163860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei365 – 3651N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi28985.P48241.

Structurei

3D structure databases

ProteinModelPortaliP48241.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000206826.
InParanoidiP48241.
KOiK00654.
OMAiPEPGGCC.
OrthoDBiEOG7XPZG0.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48241-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISISSTRVP LIPPEDIPLE DKKENEFGQL TSEEYLYQSK SRDGKALQDP
60 70 80 90 100
ILDAPAYHVS LITYLNYLIL IILGHIHDFL GLTFQKEKHK DIMEQDGLAP
110 120 130 140 150
WFSTFESFYV RRLKQRIDDC FSRPTTGVPG RFIRCLDRVS HNLNDYFTYP
160 170 180 190 200
GTTSMCLNLS SYNYLGFAQS EGQCTTAALE ATDKYGVYSG GPRTRIGTTD
210 220 230 240 250
LHVMTEKYVA QFVGKEDAIL FSMGYGTNAN FFNSFLDSKC LVISDSLNHT
260 270 280 290 300
SIRTGVRLSG AAVKTFKHND MRALEKLIRE QIVQGQSKTH RPWKKIIICV
310 320 330 340 350
EGLYSMEGTM ANLPKLVELK KKYKCYLFVD EAHSIGAMGP SGRGVCDFFG
360 370 380 390 400
IPCSDIDIMM GTLTKSFGAA GGYIAADKWI IDRFRLDLTT PHYGEPTPAP
410 420 430 440 450
VLAQIASSLK TITGDINPGE GQERLQRIAF NARYLRLALQ RLGFIVYGIA
460 470 480 490 500
DSPVIPMLLY APSKMPAFSR MMLQRKIAVV VVAYPATPLI ESRVRFCVSA
510 520 530 540 550
ALTKEDIDYL LQHINEVGDK LFLKVSSGKA GGSLDGKPPR WNIDEVIKRT
560
PTDCKDDSFF RI
Length:562
Mass (Da):62,937
Last modified:September 27, 2004 - v2
Checksum:iA23388A0BB681B1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911G → V in AAC49535. (PubMed:8921873)Curated
Sequence conflicti492 – 4921S → L in AAC49535. (PubMed:8921873)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15646 Genomic DNA. Translation: AAC49535.1.
CR382124 Genomic DNA. Translation: CAH00259.1.
PIRiJC5182.
RefSeqiXP_453163.1. XM_453163.1.

Genome annotation databases

GeneIDi2892894.
KEGGikla:KLLA0D02134g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15646 Genomic DNA. Translation: AAC49535.1 .
CR382124 Genomic DNA. Translation: CAH00259.1 .
PIRi JC5182.
RefSeqi XP_453163.1. XM_453163.1.

3D structure databases

ProteinModelPortali P48241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.P48241.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2892894.
KEGGi kla:KLLA0D02134g.

Phylogenomic databases

eggNOGi COG0156.
HOGENOMi HOG000206826.
InParanoidi P48241.
KOi K00654.
OMAi PEPGGCC.
OrthoDBi EOG7XPZG0.

Enzyme and pathway databases

UniPathwayi UPA00222 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase."
    Nagiec M.M., Lester R.L., Dickson R.C.
    Gene 177:237-241(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96263 / JA6.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Entry informationi

Entry nameiLCB2_KLULA
AccessioniPrimary (citable) accession number: P48241
Secondary accession number(s): Q6CSC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 27, 2004
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3