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P48241

- LCB2_KLULA

UniProt

P48241 - LCB2_KLULA

Protein

Serine palmitoyltransferase 2

Gene

LCB2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (27 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. serine C-palmitoyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. sphingolipid metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00222.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine palmitoyltransferase 2 (EC:2.3.1.50)
    Short name:
    SPT 2
    Alternative name(s):
    Long chain base biosynthesis protein 2
    Gene namesi
    Name:LCB2
    Ordered Locus Names:KLLA0D02134g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome D

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Serine palmitoyltransferase 2PRO_0000163860Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei365 – 3651N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.P48241.

    Structurei

    3D structure databases

    ProteinModelPortaliP48241.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000206826.
    KOiK00654.
    OMAiPEPGGCC.
    OrthoDBiEOG7XPZG0.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48241-1 [UniParc]FASTAAdd to Basket

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    MISISSTRVP LIPPEDIPLE DKKENEFGQL TSEEYLYQSK SRDGKALQDP    50
    ILDAPAYHVS LITYLNYLIL IILGHIHDFL GLTFQKEKHK DIMEQDGLAP 100
    WFSTFESFYV RRLKQRIDDC FSRPTTGVPG RFIRCLDRVS HNLNDYFTYP 150
    GTTSMCLNLS SYNYLGFAQS EGQCTTAALE ATDKYGVYSG GPRTRIGTTD 200
    LHVMTEKYVA QFVGKEDAIL FSMGYGTNAN FFNSFLDSKC LVISDSLNHT 250
    SIRTGVRLSG AAVKTFKHND MRALEKLIRE QIVQGQSKTH RPWKKIIICV 300
    EGLYSMEGTM ANLPKLVELK KKYKCYLFVD EAHSIGAMGP SGRGVCDFFG 350
    IPCSDIDIMM GTLTKSFGAA GGYIAADKWI IDRFRLDLTT PHYGEPTPAP 400
    VLAQIASSLK TITGDINPGE GQERLQRIAF NARYLRLALQ RLGFIVYGIA 450
    DSPVIPMLLY APSKMPAFSR MMLQRKIAVV VVAYPATPLI ESRVRFCVSA 500
    ALTKEDIDYL LQHINEVGDK LFLKVSSGKA GGSLDGKPPR WNIDEVIKRT 550
    PTDCKDDSFF RI 562
    Length:562
    Mass (Da):62,937
    Last modified:September 27, 2004 - v2
    Checksum:iA23388A0BB681B1D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1911G → V in AAC49535. (PubMed:8921873)Curated
    Sequence conflicti492 – 4921S → L in AAC49535. (PubMed:8921873)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15646 Genomic DNA. Translation: AAC49535.1.
    CR382124 Genomic DNA. Translation: CAH00259.1.
    PIRiJC5182.
    RefSeqiXP_453163.1. XM_453163.1.

    Genome annotation databases

    GeneIDi2892894.
    KEGGikla:KLLA0D02134g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15646 Genomic DNA. Translation: AAC49535.1 .
    CR382124 Genomic DNA. Translation: CAH00259.1 .
    PIRi JC5182.
    RefSeqi XP_453163.1. XM_453163.1.

    3D structure databases

    ProteinModelPortali P48241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.P48241.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2892894.
    KEGGi kla:KLLA0D02134g.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000206826.
    KOi K00654.
    OMAi PEPGGCC.
    OrthoDBi EOG7XPZG0.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase."
      Nagiec M.M., Lester R.L., Dickson R.C.
      Gene 177:237-241(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96263 / JA6.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

    Entry informationi

    Entry nameiLCB2_KLULA
    AccessioniPrimary (citable) accession number: P48241
    Secondary accession number(s): Q6CSC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3