true
1996-02-01
2024-01-24
153
GTO1_YEAST
The sequence of a 27 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals MOL1, NAT2, RPL30B, RSR1, CYS4, PEM1/CHO2, NSR1 genes and ten new open reading frames.
Skala J.
Nawrocki A.
Goffeau A.
doi:10.1002/yea.320111410
1995
Yeast
11
1421-1427
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
ATCC 204508 / S288c
The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.
Tettelin H.
Agostoni-Carbone M.L.
Albermann K.
Albers M.
Arroyo J.
Backes U.
Barreiros T.
Bertani I.
Bjourson A.J.
Brueckner M.
Bruschi C.V.
Carignani G.
Castagnoli L.
Cerdan E.
Clemente M.L.
Coblenz A.
Coglievina M.
Coissac E.
Defoor E.
Del Bino S.
Delius H.
Delneri D.
de Wergifosse P.
Dujon B.
Durand P.
Entian K.-D.
Eraso P.
Escribano V.
Fabiani L.
Fartmann B.
Feroli F.
Feuermann M.
Frontali L.
Garcia-Gonzalez M.
Garcia-Saez M.I.
Goffeau A.
Guerreiro P.
Hani J.
Hansen M.
Hebling U.
Hernandez K.
Heumann K.
Hilger F.
Hofmann B.
Indge K.J.
James C.M.
Klima R.
Koetter P.
Kramer B.
Kramer W.
Lauquin G.
Leuther H.
Louis E.J.
Maillier E.
Marconi A.
Martegani E.
Mazon M.J.
Mazzoni C.
McReynolds A.D.K.
Melchioretto P.
Mewes H.-W.
Minenkova O.
Mueller-Auer S.
Nawrocki A.
Netter P.
Neu R.
Nombela C.
Oliver S.G.
Panzeri L.
Paoluzi S.
Plevani P.
Portetelle D.
Portillo F.
Potier S.
Purnelle B.
Rieger M.
Riles L.
Rinaldi T.
Robben J.
Rodrigues-Pousada C.
Rodriguez-Belmonte E.
Rodriguez-Torres A.M.
Rose M.
Ruzzi M.
Saliola M.
Sanchez-Perez M.
Schaefer B.
Schaefer M.
Scharfe M.
Schmidheini T.
Schreer A.
Skala J.
Souciet J.-L.
Steensma H.Y.
Talla E.
Thierry A.
Vandenbol M.
van der Aart Q.J.M.
Van Dyck L.
Vanoni M.
Verhasselt P.
Voet M.
Volckaert G.
Wambutt R.
Watson M.D.
Weber N.
Wedler E.
Wedler H.
Wipfli P.
Wolf K.
Wright L.F.
Zaccaria P.
Zimmermann M.
Zollner A.
Kleine K.
1997
Nature
387
81-84
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
Engel S.R.
Dietrich F.S.
Fisk D.G.
Binkley G.
Balakrishnan R.
Costanzo M.C.
Dwight S.S.
Hitz B.C.
Karra K.
Nash R.S.
Weng S.
Wong E.D.
Lloyd P.
Skrzypek M.S.
Miyasato S.R.
Simison M.
Cherry J.M.
doi:10.1534/g3.113.008995
2014
G3 (Bethesda)
4
389-398
GENOME REANNOTATION
Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases.
Garcera A.
Barreto L.
Piedrafita L.
Tamarit J.
Herrero E.
doi:10.1042/bj20060034
2006
Biochem. J.
398
187-196
FUNCTION
ENZYME ACTIVITY
BIOPHYSICOCHEMICAL PROPERTIES
A peroxisomal glutathione transferase of Saccharomyces cerevisiae is functionally related to sulfur amino acid metabolism.
Barreto L.
Garcera A.
Jansson K.
Sunnerhagen P.
Herrero E.
doi:10.1128/ec.00216-06
2006
Eukaryot. Cell
5
1748-1759
DISRUPTION PHENOTYPE
SUBCELLULAR LOCATION
INDUCTION
79
2
GTO1
Eukaryota
1 hit in 10 CRISPR screens
Protein
GST_C_Omega_like
Glutaredoxin
Glutathione-S-Trfase_C_sf
Glutathione_S-Trfase_N
GST_Omega-like_C
GST_Omega/GSH
Thioredoxin-like_sf
GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED
GLUTATHIONYL-HYDROQUINONE REDUCTASE
GST_C_2
GST_N_2
GST
GST C-terminal domain-like
Thioredoxin-like
Glutathione S-transferase omega-like 1
2.5.1.18
Glutathione-dependent dehydroascorbate reductase
1.8.5.1
GTO1
YGR154C
G6664
Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB).
1.13 mM for reduced glutathione (GSH)
By diamide and 1-chloro-2,4-dinitrobenzene (CDNB) in a transcriptional factors YAP1 and/or MSN2/4-dependent manner.
Null mutants display increased sensitivity to cadmium in the absence of GTT1 and GTT2. Null mutants also show growth defects on oleic acid-based medium, indicative of abnormal peroxisomal functions and altered expression of genes related to sulfur amino acid metabolism, and have low levels of reduced glutathione.
Belongs to the GST superfamily. Omega family.
Glutathione S-transferase omega-like 1
41301
1
356
214
257
Nucleophile
31
1996-02-01
1
41301
fe5b16181d0570321daa51ce3074a781
MSVSYKGTISKTHSVFKPEKGRYYIYGALGCPFTHRAILARSLKKLEPVLGLVLSHWQLDSKGARFLPAPHRPEKYKERFFTATGGIASAKLDESEELGDVNNDSARLFVDGAFDPVENISRLSELYYLNDPKYPGTKFTVPVLWDSKTRKIVNNESGDIIRILNSGVFDEFIQSEETNVIDLVPHDLIDEIDKNIKWVHPKINLGVYKVGLAENGKIYETEVKTLFENLQKMECVLKENYKRLEEQFSGNKQKILAKYFVLGQRLTEADIRLYPSIIRFDVVYVQHFKCNLKTIRDGFPYLHLWLINLYWNYAEFRFTTDFNHIKLFYIRMEVSRNKINQFGIVPLGPKPDISRL
true
true
true
true
true
true
true
true