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Protein

Mitochondrial group I intron splicing factor CCM1

Gene

CCM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome.3 Publications

Miscellaneous

Present with 876 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • endonuclease activity Source: GO_Central
  • rRNA binding Source: SGD

GO - Biological processi

  • mitochondrial genome maintenance Source: SGD
  • mitochondrial RNA processing Source: SGD
  • mRNA processing Source: UniProtKB-KW
  • RNA modification Source: GO_Central
  • RNA splicing Source: SGD
  • rRNA metabolic process Source: SGD

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-30853-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial group I intron splicing factor CCM1
Alternative name(s):
COB and COX1 mRNA maturation protein 1
Required for respiratory growth protein 2
Gene namesi
Name:CCM1
Synonyms:DMR1, RRG2
Ordered Locus Names:YGR150C
ORF Names:G6642
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR150C.
SGDiS000003382. CCM1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000202830? – 864Mitochondrial group I intron splicing factor CCM1
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP48237.
PRIDEiP48237.

Interactioni

Protein-protein interaction databases

BioGridi33398. 33 interactors.
DIPiDIP-6575N.
IntActiP48237. 3 interactors.
MINTiMINT-651020.
STRINGi4932.YGR150C.

Structurei

3D structure databases

ProteinModelPortaliP48237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati319 – 355PPR 1Add BLAST37
Repeati356 – 390PPR 2Add BLAST35

Sequence similaritiesi

Belongs to the CCM1 family.Curated

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

InParanoidiP48237.
OMAiESSAIWA.
OrthoDBiEOG092C4LVT.

Family and domain databases

InterProiView protein in InterPro
IPR002885. Pentatricopeptide_repeat.
PfamiView protein in Pfam
PF13041. PPR_2. 1 hit.
TIGRFAMsiTIGR00756. PPR. 1 hit.
PROSITEiView protein in PROSITE
PS51375. PPR. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYMARCGPKN NVLCFPFQLS FLFSKRLINK RFKYTLQTED EKNMMGSLSK
60 70 80 90 100
NKIITPEDVE FKLAQLREFS NTLKERIHNT KSVNSDGHQS NSIAPISEDS
110 120 130 140 150
RNVNVTKTSS VPNEEKSKNL SDLIHSSFLE KMDHLVPKVI RERVADDDIL
160 170 180 190 200
AKNLFDRSHS NWAPVIDRLY VSEKRFMDID SREFSVWLNG TVKYLPFHSI
210 220 230 240 250
LHLDEMLLEQ INGDVVKFNT HMYECIFNNL GNLKPTNFNQ DGTNDKVILK
260 270 280 290 300
MKELLERYDK ALKITEERIN KKEGFPSKVP KMTQAILNNC LKYSTKCSSF
310 320 330 340 350
HDMDYFITKF RDDYGITPNK QNLTTVIQFY SRKEMTKQAW NTFDTMKFLS
360 370 380 390 400
TKHFPDICTY NTMLRICEKE RNFPKALDLF QEIQDHNIKP TTNTYIMMAR
410 420 430 440 450
VLASSSSNAV VSEGKSDSLR LLGWKYLHEL EDKNLYRHKK DDLNLFLAMM
460 470 480 490 500
ALAAFDGDIE LSRALYYLFI AKKYKTLCAN WKGNILVDQD TIWKSTLMPE
510 520 530 540 550
MLNYLMLAYA RFDPRNLPVL SGYEKGIELR RKFLREFDSS MRLDDTDKLV
560 570 580 590 600
KFKLPFLPIS DLNSEAQVLA ESNAIWSFNM ENGGTRNTLT SSNEAALEDI
610 620 630 640 650
KKYRQLLDSF AQEAEDFNEF KFKVMYEVTK MQRESINVNV FNKISLHTYL
660 670 680 690 700
SIPINLKQQK EFLRRLTFFT FQQHEFEAVI KRLYEGYRNI PSSHTRDQNS
710 720 730 740 750
ISTEAISVSK PETTEDLNLI MHDIWYITCL RHKIMMDTTL YELVMKAAIE
760 770 780 790 800
FQNEDLAKKV WNDRGKFRTT VPFLKMDQRI RIAKDQKFAH LMVEFFTKQG
810 820 830 840 850
KYSDAIAIIL SSKNRFNWTY SMVRNLHKAL EEIEDRNSVE ILLDVVNKKS
860
HAKALKWEEQ ELNM
Length:864
Mass (Da):101,423
Last modified:February 1, 1996 - v1
Checksum:i5A773DEAA33D84FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85807 Genomic DNA. Translation: CAA59808.1.
Z72935 Genomic DNA. Translation: CAA97164.1.
BK006941 Genomic DNA. Translation: DAA08242.1.
PIRiS60441.
RefSeqiNP_011666.1. NM_001181279.1.

Genome annotation databases

EnsemblFungiiYGR150C; YGR150C; YGR150C.
GeneIDi853053.
KEGGisce:YGR150C.

Similar proteinsi

Entry informationi

Entry nameiCCM1_YEAST
AccessioniPrimary (citable) accession number: P48237
Secondary accession number(s): D6VUT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 27, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names