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Protein

Mitochondrial group I intron splicing factor CCM1

Gene

CCM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome.3 Publications

GO - Molecular functioni

  • rRNA binding Source: SGD

GO - Biological processi

  • mitochondrial genome maintenance Source: SGD
  • mitochondrial RNA processing Source: SGD
  • mRNA processing Source: UniProtKB-KW
  • RNA splicing Source: SGD
  • rRNA metabolic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-30853-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial group I intron splicing factor CCM1
Alternative name(s):
COB and COX1 mRNA maturation protein 1
Required for respiratory growth protein 2
Gene namesi
Name:CCM1
Synonyms:DMR1, RRG2
Ordered Locus Names:YGR150C
ORF Names:G6642
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR150C.
SGDiS000003382. CCM1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 864Mitochondrial group I intron splicing factor CCM1PRO_0000202830
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP48237.

Interactioni

Protein-protein interaction databases

BioGridi33398. 32 interactions.
DIPiDIP-6575N.
IntActiP48237. 1 interaction.
MINTiMINT-651020.

Structurei

3D structure databases

ProteinModelPortaliP48237.
SMRiP48237. Positions 286-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati319 – 35537PPR 1Add
BLAST
Repeati356 – 39035PPR 2Add
BLAST

Sequence similaritiesi

Belongs to the CCM1 family.Curated
Contains 2 PPR (pentatricopeptide) repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

InParanoidiP48237.
OMAiFARALYY.
OrthoDBiEOG092C4LVT.

Family and domain databases

InterProiIPR002885. Pentatricopeptide_repeat.
[Graphical view]
PfamiPF13041. PPR_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00756. PPR. 1 hit.
PROSITEiPS51375. PPR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYMARCGPKN NVLCFPFQLS FLFSKRLINK RFKYTLQTED EKNMMGSLSK
60 70 80 90 100
NKIITPEDVE FKLAQLREFS NTLKERIHNT KSVNSDGHQS NSIAPISEDS
110 120 130 140 150
RNVNVTKTSS VPNEEKSKNL SDLIHSSFLE KMDHLVPKVI RERVADDDIL
160 170 180 190 200
AKNLFDRSHS NWAPVIDRLY VSEKRFMDID SREFSVWLNG TVKYLPFHSI
210 220 230 240 250
LHLDEMLLEQ INGDVVKFNT HMYECIFNNL GNLKPTNFNQ DGTNDKVILK
260 270 280 290 300
MKELLERYDK ALKITEERIN KKEGFPSKVP KMTQAILNNC LKYSTKCSSF
310 320 330 340 350
HDMDYFITKF RDDYGITPNK QNLTTVIQFY SRKEMTKQAW NTFDTMKFLS
360 370 380 390 400
TKHFPDICTY NTMLRICEKE RNFPKALDLF QEIQDHNIKP TTNTYIMMAR
410 420 430 440 450
VLASSSSNAV VSEGKSDSLR LLGWKYLHEL EDKNLYRHKK DDLNLFLAMM
460 470 480 490 500
ALAAFDGDIE LSRALYYLFI AKKYKTLCAN WKGNILVDQD TIWKSTLMPE
510 520 530 540 550
MLNYLMLAYA RFDPRNLPVL SGYEKGIELR RKFLREFDSS MRLDDTDKLV
560 570 580 590 600
KFKLPFLPIS DLNSEAQVLA ESNAIWSFNM ENGGTRNTLT SSNEAALEDI
610 620 630 640 650
KKYRQLLDSF AQEAEDFNEF KFKVMYEVTK MQRESINVNV FNKISLHTYL
660 670 680 690 700
SIPINLKQQK EFLRRLTFFT FQQHEFEAVI KRLYEGYRNI PSSHTRDQNS
710 720 730 740 750
ISTEAISVSK PETTEDLNLI MHDIWYITCL RHKIMMDTTL YELVMKAAIE
760 770 780 790 800
FQNEDLAKKV WNDRGKFRTT VPFLKMDQRI RIAKDQKFAH LMVEFFTKQG
810 820 830 840 850
KYSDAIAIIL SSKNRFNWTY SMVRNLHKAL EEIEDRNSVE ILLDVVNKKS
860
HAKALKWEEQ ELNM
Length:864
Mass (Da):101,423
Last modified:February 1, 1996 - v1
Checksum:i5A773DEAA33D84FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85807 Genomic DNA. Translation: CAA59808.1.
Z72935 Genomic DNA. Translation: CAA97164.1.
BK006941 Genomic DNA. Translation: DAA08242.1.
PIRiS60441.
RefSeqiNP_011666.1. NM_001181279.1.

Genome annotation databases

EnsemblFungiiYGR150C; YGR150C; YGR150C.
GeneIDi853053.
KEGGisce:YGR150C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85807 Genomic DNA. Translation: CAA59808.1.
Z72935 Genomic DNA. Translation: CAA97164.1.
BK006941 Genomic DNA. Translation: DAA08242.1.
PIRiS60441.
RefSeqiNP_011666.1. NM_001181279.1.

3D structure databases

ProteinModelPortaliP48237.
SMRiP48237. Positions 286-401.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33398. 32 interactions.
DIPiDIP-6575N.
IntActiP48237. 1 interaction.
MINTiMINT-651020.

Proteomic databases

MaxQBiP48237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR150C; YGR150C; YGR150C.
GeneIDi853053.
KEGGisce:YGR150C.

Organism-specific databases

EuPathDBiFungiDB:YGR150C.
SGDiS000003382. CCM1.

Phylogenomic databases

InParanoidiP48237.
OMAiFARALYY.
OrthoDBiEOG092C4LVT.

Enzyme and pathway databases

BioCyciYEAST:G3O-30853-MONOMER.

Miscellaneous databases

PROiP48237.

Family and domain databases

InterProiIPR002885. Pentatricopeptide_repeat.
[Graphical view]
PfamiPF13041. PPR_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00756. PPR. 1 hit.
PROSITEiPS51375. PPR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCM1_YEAST
AccessioniPrimary (citable) accession number: P48237
Secondary accession number(s): D6VUT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 876 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.