ID   ECL1_YEAST              Reviewed;         211 AA.
AC   P48235; D6VUS6;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   27-MAR-2024, entry version 123.
DE   RecName: Full=Extender of the chronological lifespan protein 1;
GN   Name=ECL1; OrderedLocusNames=YGR146C; ORFNames=G6626;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8585325; DOI=10.1002/yea.320111410;
RA   Skala J., Nawrocki A., Goffeau A.;
RT   "The sequence of a 27 kb segment on the right arm of chromosome VII from
RT   Saccharomyces cerevisiae reveals MOL1, NAT2, RPL30B, RSR1, CYS4, PEM1/CHO2,
RT   NSR1 genes and ten new open reading frames.";
RL   Yeast 11:1421-1427(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169869;
RA   Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA   Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA   Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA   Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA   Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA   Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA   Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA   Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA   Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA   Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA   Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA   Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA   Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA   Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA   Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA   Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA   Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA   Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA   Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA   Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA   Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA   Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL   Nature 387:81-84(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   INDUCTION.
RX   PubMed=12756250; DOI=10.1074/jbc.m300076200;
RA   Rutherford J.C., Jaron S., Winge D.R.;
RT   "Aft1p and Aft2p mediate iron-responsive gene expression in yeast through
RT   related promoter elements.";
RL   J. Biol. Chem. 278:27636-27643(2003).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   INDUCTION.
RX   PubMed=17608707; DOI=10.1111/j.1567-1364.2007.00270.x;
RA   Dardalhon M., Lin W., Nicolas A., Averbeck D.;
RT   "Specific transcriptional responses induced by 8-methoxypsoralen and UVA in
RT   yeast.";
RL   FEMS Yeast Res. 7:866-878(2007).
RN   [7]
RP   FUNCTION.
RX   PubMed=19966476; DOI=10.1271/bbb.90599;
RA   Azuma K., Ohtsuka H., Mita S., Murakami H., Aiba H.;
RT   "Identification and characterization of an Ecl1-family gene in
RT   Saccharomyces cerevisiae.";
RL   Biosci. Biotechnol. Biochem. 73:2787-2789(2009).
CC   -!- FUNCTION: Involved in chronological cell aging.
CC       {ECO:0000269|PubMed:19966476}.
CC   -!- INDUCTION: Expression is induced by the AFT2 iron homeostasis
CC       transcription factor, as well as by 8-methoxypsoralen and UVA
CC       radiation. {ECO:0000269|PubMed:12756250, ECO:0000269|PubMed:17608707}.
CC   -!- MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the ecl1 family. {ECO:0000305}.
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DR   EMBL; X85807; CAA59804.1; -; Genomic_DNA.
DR   EMBL; Z72931; CAA97160.1; -; Genomic_DNA.
DR   EMBL; BK006941; DAA08237.1; -; Genomic_DNA.
DR   PIR; S60437; S60437.
DR   RefSeq; NP_011662.3; NM_001181275.3.
DR   AlphaFoldDB; P48235; -.
DR   BioGRID; 33394; 58.
DR   DIP; DIP-2885N; -.
DR   IntAct; P48235; 2.
DR   STRING; 4932.YGR146C; -.
DR   PaxDb; 4932-YGR146C; -.
DR   PeptideAtlas; P48235; -.
DR   EnsemblFungi; YGR146C_mRNA; YGR146C; YGR146C.
DR   GeneID; 853049; -.
DR   KEGG; sce:YGR146C; -.
DR   AGR; SGD:S000003378; -.
DR   SGD; S000003378; ECL1.
DR   VEuPathDB; FungiDB:YGR146C; -.
DR   HOGENOM; CLU_125577_0_0_1; -.
DR   InParanoid; P48235; -.
DR   OMA; MCKLRDS; -.
DR   OrthoDB; 2048112at2759; -.
DR   BioCyc; YEAST:G3O-30850-MONOMER; -.
DR   BioGRID-ORCS; 853049; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P48235; -.
DR   Proteomes; UP000002311; Chromosome VII.
DR   RNAct; P48235; Protein.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..211
FT                   /note="Extender of the chronological lifespan protein 1"
FT                   /id="PRO_0000202828"
SQ   SEQUENCE   211 AA;  23997 MW;  1EA1B71CB31908E8 CRC64;
     MSTAFNDYCT VCDRLIPTSP QKTNINTRKI QRDNETKSSL QSNKLYCSED CKLKDSNPLN
     EKLLSHLHKK SKTSHSHNLT PPLSYSKNLT ASNLFEPTTS LSSSPTSSTI PFDELEKLES
     LLISPLLLPQ DGIVNPKQES NPSRVDEYDE NEHYLNLADS LRLDSSYQLH SKAHLGYENN
     LPRSNDLIDD HLISDQIIEN NYNLWFRLSS S
//