P48235 (ECL1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Extender of the chronological lifespan protein 1

Gene names

Name:	ECL1
Ordered Locus Names:	YGR146C
ORF Names:	G6626

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in chronological cell aging. Ref.7
Induction	Expression is induced by the AFT2 iron homeostasis transcription factor, as well as by 8-methoxypsoralen and UVA radiation. Ref.4 Ref.6
Miscellaneous	Present with 589 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the ecl1 family.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Extender of the chronological lifespan protein 1		PRO_0000202828

Sequences

	Sequence		Length	Mass (Da)
	P48235 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 1EA1B71CB31908E8	FASTA	211	23,997
	10 20 30 40 50 60 MSTAFNDYCT VCDRLIPTSP QKTNINTRKI QRDNETKSSL QSNKLYCSED CKLKDSNPLN 70 80 90 100 110 120 EKLLSHLHKK SKTSHSHNLT PPLSYSKNLT ASNLFEPTTS LSSSPTSSTI PFDELEKLES 130 140 150 160 170 180 LLISPLLLPQ DGIVNPKQES NPSRVDEYDE NEHYLNLADS LRLDSSYQLH SKAHLGYENN 190 200 210 LPRSNDLIDD HLISDQIIEN NYNLWFRLSS S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of a 27 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals MOL1, NAT2, RPL30B, RSR1, CYS4, PEM1/CHO2, NSR1 genes and ten new open reading frames." Skala J., Nawrocki A., Goffeau A. Yeast 11:1421-1427(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements." Rutherford J.C., Jaron S., Winge D.R. J. Biol. Chem. 278:27636-27643(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast." Dardalhon M., Lin W., Nicolas A., Averbeck D. FEMS Yeast Res. 7:866-878(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[7]	"Identification and characterization of an Ecl1-family gene in Saccharomyces cerevisiae." Azuma K., Ohtsuka H., Mita S., Murakami H., Aiba H. Biosci. Biotechnol. Biochem. 73:2787-2789(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85807 Genomic DNA. Translation: CAA59804.1. Z72931 Genomic DNA. Translation: CAA97160.1. BK006941 Genomic DNA. Translation: DAA08237.1.
PIR	S60437.
RefSeq	NP_011662.3. NM_001181275.3.
3D structure databases
ProteinModelPortal	P48235.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2885N.
IntAct	P48235. 2 interactions.
MINT	MINT-515041.
STRING	4932.YGR146C.
Proteomic databases
PaxDb	P48235.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGR146C; YGR146C; YGR146C.
GeneID	853049.
KEGG	sce:YGR146C. sce:YGR152C.
Organism-specific databases
CYGD	YGR146c.
SGD	S000003378. ECL1.
Phylogenomic databases
KO	K07974.
Gene expression databases
Genevestigator	P48235.
GermOnline	YGR146C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR024368. Ecl1/3. [Graphical view]
Pfam	PF12855. Ecl1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	972966.

Entry information

Entry name

ECL1_YEAST

Accession

Primary (citable) accession number: P48235
Secondary accession number(s): D6VUS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program