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P48235 (ECL1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Extender of the chronological lifespan protein 1
Gene names
Name:ECL1
Ordered Locus Names:YGR146C
ORF Names:G6626
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in chronological cell aging. Ref.7

Induction

Expression is induced by the AFT2 iron homeostasis transcription factor, as well as by 8-methoxypsoralen and UVA radiation. Ref.4 Ref.6

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the ecl1 family.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Extender of the chronological lifespan protein 1
PRO_0000202828

Sequences

Sequence LengthMass (Da)Tools
P48235 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 1EA1B71CB31908E8

FASTA21123,997
        10         20         30         40         50         60 
MSTAFNDYCT VCDRLIPTSP QKTNINTRKI QRDNETKSSL QSNKLYCSED CKLKDSNPLN 

        70         80         90        100        110        120 
EKLLSHLHKK SKTSHSHNLT PPLSYSKNLT ASNLFEPTTS LSSSPTSSTI PFDELEKLES 

       130        140        150        160        170        180 
LLISPLLLPQ DGIVNPKQES NPSRVDEYDE NEHYLNLADS LRLDSSYQLH SKAHLGYENN 

       190        200        210 
LPRSNDLIDD HLISDQIIEN NYNLWFRLSS S 

« Hide

References

« Hide 'large scale' references
[1]"The sequence of a 27 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals MOL1, NAT2, RPL30B, RSR1, CYS4, PEM1/CHO2, NSR1 genes and ten new open reading frames."
Skala J., Nawrocki A., Goffeau A.
Yeast 11:1421-1427(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements."
Rutherford J.C., Jaron S., Winge D.R.
J. Biol. Chem. 278:27636-27643(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast."
Dardalhon M., Lin W., Nicolas A., Averbeck D.
FEMS Yeast Res. 7:866-878(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[7]"Identification and characterization of an Ecl1-family gene in Saccharomyces cerevisiae."
Azuma K., Ohtsuka H., Mita S., Murakami H., Aiba H.
Biosci. Biotechnol. Biochem. 73:2787-2789(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X85807 Genomic DNA. Translation: CAA59804.1.
Z72931 Genomic DNA. Translation: CAA97160.1.
BK006941 Genomic DNA. Translation: DAA08237.1.
PIRS60437.
RefSeqNP_011662.3. NM_001181275.3.

3D structure databases

ProteinModelPortalP48235.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33394. 6 interactions.
DIPDIP-2885N.
IntActP48235. 2 interactions.
MINTMINT-515041.
STRING4932.YGR146C.

Proteomic databases

PaxDbP48235.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGR146C; YGR146C; YGR146C.
GeneID853049.
KEGGsce:YGR146C.

Organism-specific databases

CYGDYGR146c.
SGDS000003378. ECL1.

Phylogenomic databases

OMANIAEERT.
OrthoDBEOG7008MJ.

Enzyme and pathway databases

BioCycYEAST:G3O-30850-MONOMER.

Gene expression databases

GenevestigatorP48235.

Family and domain databases

InterProIPR024368. Ecl1/3.
[Graphical view]
PfamPF12855. Ecl1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio972966.

Entry information

Entry nameECL1_YEAST
AccessionPrimary (citable) accession number: P48235
Secondary accession number(s): D6VUS6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families