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Protein

Extender of the chronological lifespan protein 1

Gene

ECL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in chronological cell aging.1 Publication

Enzyme and pathway databases

BioCyciYEAST:G3O-30850-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Extender of the chronological lifespan protein 1
Gene namesi
Name:ECL1
Ordered Locus Names:YGR146C
ORF Names:G6626
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR146c.
SGDiS000003378. ECL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Extender of the chronological lifespan protein 1PRO_0000202828Add
BLAST

Proteomic databases

PaxDbiP48235.

Expressioni

Inductioni

Expression is induced by the AFT2 iron homeostasis transcription factor, as well as by 8-methoxypsoralen and UVA radiation.2 Publications

Gene expression databases

GenevestigatoriP48235.

Interactioni

Protein-protein interaction databases

BioGridi33394. 6 interactions.
DIPiDIP-2885N.
IntActiP48235. 2 interactions.
MINTiMINT-515041.
STRINGi4932.YGR146C.

Structurei

3D structure databases

ProteinModelPortaliP48235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ecl1 family.Curated

Phylogenomic databases

InParanoidiP48235.
OrthoDBiEOG7008MJ.

Family and domain databases

InterProiIPR024368. Ecl1/3.
[Graphical view]
PfamiPF12855. Ecl1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48235-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTAFNDYCT VCDRLIPTSP QKTNINTRKI QRDNETKSSL QSNKLYCSED
60 70 80 90 100
CKLKDSNPLN EKLLSHLHKK SKTSHSHNLT PPLSYSKNLT ASNLFEPTTS
110 120 130 140 150
LSSSPTSSTI PFDELEKLES LLISPLLLPQ DGIVNPKQES NPSRVDEYDE
160 170 180 190 200
NEHYLNLADS LRLDSSYQLH SKAHLGYENN LPRSNDLIDD HLISDQIIEN
210
NYNLWFRLSS S
Length:211
Mass (Da):23,997
Last modified:February 1, 1996 - v1
Checksum:i1EA1B71CB31908E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85807 Genomic DNA. Translation: CAA59804.1.
Z72931 Genomic DNA. Translation: CAA97160.1.
BK006941 Genomic DNA. Translation: DAA08237.1.
PIRiS60437.
RefSeqiNP_011662.3. NM_001181275.3.

Genome annotation databases

EnsemblFungiiYGR146C; YGR146C; YGR146C.
GeneIDi853049.
KEGGisce:YGR146C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85807 Genomic DNA. Translation: CAA59804.1.
Z72931 Genomic DNA. Translation: CAA97160.1.
BK006941 Genomic DNA. Translation: DAA08237.1.
PIRiS60437.
RefSeqiNP_011662.3. NM_001181275.3.

3D structure databases

ProteinModelPortaliP48235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33394. 6 interactions.
DIPiDIP-2885N.
IntActiP48235. 2 interactions.
MINTiMINT-515041.
STRINGi4932.YGR146C.

Proteomic databases

PaxDbiP48235.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR146C; YGR146C; YGR146C.
GeneIDi853049.
KEGGisce:YGR146C.

Organism-specific databases

CYGDiYGR146c.
SGDiS000003378. ECL1.

Phylogenomic databases

InParanoidiP48235.
OrthoDBiEOG7008MJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-30850-MONOMER.

Miscellaneous databases

NextBioi972966.

Gene expression databases

GenevestigatoriP48235.

Family and domain databases

InterProiIPR024368. Ecl1/3.
[Graphical view]
PfamiPF12855. Ecl1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a 27 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals MOL1, NAT2, RPL30B, RSR1, CYS4, PEM1/CHO2, NSR1 genes and ten new open reading frames."
    Skala J., Nawrocki A., Goffeau A.
    Yeast 11:1421-1427(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements."
    Rutherford J.C., Jaron S., Winge D.R.
    J. Biol. Chem. 278:27636-27643(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast."
    Dardalhon M., Lin W., Nicolas A., Averbeck D.
    FEMS Yeast Res. 7:866-878(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "Identification and characterization of an Ecl1-family gene in Saccharomyces cerevisiae."
    Azuma K., Ohtsuka H., Mita S., Murakami H., Aiba H.
    Biosci. Biotechnol. Biochem. 73:2787-2789(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiECL1_YEAST
AccessioniPrimary (citable) accession number: P48235
Secondary accession number(s): D6VUS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.