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Protein

Extender of the chronological lifespan protein 1

Gene

ECL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in chronological cell aging.1 Publication

Enzyme and pathway databases

BioCyciYEAST:G3O-30850-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Extender of the chronological lifespan protein 1
Gene namesi
Name:ECL1
Ordered Locus Names:YGR146C
ORF Names:G6626
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR146C.
SGDiS000003378. ECL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028281 – 211Extender of the chronological lifespan protein 1Add BLAST211

Proteomic databases

PRIDEiP48235.

Expressioni

Inductioni

Expression is induced by the AFT2 iron homeostasis transcription factor, as well as by 8-methoxypsoralen and UVA radiation.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi33394. 5 interactors.
DIPiDIP-2885N.
IntActiP48235. 2 interactors.
MINTiMINT-515041.

Structurei

3D structure databases

ProteinModelPortaliP48235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ecl1 family.Curated

Phylogenomic databases

InParanoidiP48235.
OrthoDBiEOG092C5ZBC.

Family and domain databases

InterProiIPR024368. Ecl1/3.
[Graphical view]
PfamiPF12855. Ecl1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAFNDYCT VCDRLIPTSP QKTNINTRKI QRDNETKSSL QSNKLYCSED
60 70 80 90 100
CKLKDSNPLN EKLLSHLHKK SKTSHSHNLT PPLSYSKNLT ASNLFEPTTS
110 120 130 140 150
LSSSPTSSTI PFDELEKLES LLISPLLLPQ DGIVNPKQES NPSRVDEYDE
160 170 180 190 200
NEHYLNLADS LRLDSSYQLH SKAHLGYENN LPRSNDLIDD HLISDQIIEN
210
NYNLWFRLSS S
Length:211
Mass (Da):23,997
Last modified:February 1, 1996 - v1
Checksum:i1EA1B71CB31908E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85807 Genomic DNA. Translation: CAA59804.1.
Z72931 Genomic DNA. Translation: CAA97160.1.
BK006941 Genomic DNA. Translation: DAA08237.1.
PIRiS60437.
RefSeqiNP_011662.3. NM_001181275.3.

Genome annotation databases

EnsemblFungiiYGR146C; YGR146C; YGR146C.
GeneIDi853049.
KEGGisce:YGR146C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85807 Genomic DNA. Translation: CAA59804.1.
Z72931 Genomic DNA. Translation: CAA97160.1.
BK006941 Genomic DNA. Translation: DAA08237.1.
PIRiS60437.
RefSeqiNP_011662.3. NM_001181275.3.

3D structure databases

ProteinModelPortaliP48235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33394. 5 interactors.
DIPiDIP-2885N.
IntActiP48235. 2 interactors.
MINTiMINT-515041.

Proteomic databases

PRIDEiP48235.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR146C; YGR146C; YGR146C.
GeneIDi853049.
KEGGisce:YGR146C.

Organism-specific databases

EuPathDBiFungiDB:YGR146C.
SGDiS000003378. ECL1.

Phylogenomic databases

InParanoidiP48235.
OrthoDBiEOG092C5ZBC.

Enzyme and pathway databases

BioCyciYEAST:G3O-30850-MONOMER.

Miscellaneous databases

PROiP48235.

Family and domain databases

InterProiIPR024368. Ecl1/3.
[Graphical view]
PfamiPF12855. Ecl1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECL1_YEAST
AccessioniPrimary (citable) accession number: P48235
Secondary accession number(s): D6VUS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.