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P48235

- ECL1_YEAST

UniProt

P48235 - ECL1_YEAST

Protein

Extender of the chronological lifespan protein 1

Gene

ECL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Involved in chronological cell aging.1 Publication

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30850-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Extender of the chronological lifespan protein 1
    Gene namesi
    Name:ECL1
    Ordered Locus Names:YGR146C
    ORF Names:G6626
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR146c.
    SGDiS000003378. ECL1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Extender of the chronological lifespan protein 1PRO_0000202828Add
    BLAST

    Proteomic databases

    PaxDbiP48235.

    Expressioni

    Inductioni

    Expression is induced by the AFT2 iron homeostasis transcription factor, as well as by 8-methoxypsoralen and UVA radiation.2 Publications

    Gene expression databases

    GenevestigatoriP48235.

    Interactioni

    Protein-protein interaction databases

    BioGridi33394. 6 interactions.
    DIPiDIP-2885N.
    IntActiP48235. 2 interactions.
    MINTiMINT-515041.
    STRINGi4932.YGR146C.

    Structurei

    3D structure databases

    ProteinModelPortaliP48235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ecl1 family.Curated

    Phylogenomic databases

    OMAiNIAEERT.
    OrthoDBiEOG7008MJ.

    Family and domain databases

    InterProiIPR024368. Ecl1/3.
    [Graphical view]
    PfamiPF12855. Ecl1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48235-1 [UniParc]FASTAAdd to Basket

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    MSTAFNDYCT VCDRLIPTSP QKTNINTRKI QRDNETKSSL QSNKLYCSED    50
    CKLKDSNPLN EKLLSHLHKK SKTSHSHNLT PPLSYSKNLT ASNLFEPTTS 100
    LSSSPTSSTI PFDELEKLES LLISPLLLPQ DGIVNPKQES NPSRVDEYDE 150
    NEHYLNLADS LRLDSSYQLH SKAHLGYENN LPRSNDLIDD HLISDQIIEN 200
    NYNLWFRLSS S 211
    Length:211
    Mass (Da):23,997
    Last modified:February 1, 1996 - v1
    Checksum:i1EA1B71CB31908E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85807 Genomic DNA. Translation: CAA59804.1.
    Z72931 Genomic DNA. Translation: CAA97160.1.
    BK006941 Genomic DNA. Translation: DAA08237.1.
    PIRiS60437.
    RefSeqiNP_011662.3. NM_001181275.3.

    Genome annotation databases

    EnsemblFungiiYGR146C; YGR146C; YGR146C.
    GeneIDi853049.
    KEGGisce:YGR146C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85807 Genomic DNA. Translation: CAA59804.1 .
    Z72931 Genomic DNA. Translation: CAA97160.1 .
    BK006941 Genomic DNA. Translation: DAA08237.1 .
    PIRi S60437.
    RefSeqi NP_011662.3. NM_001181275.3.

    3D structure databases

    ProteinModelPortali P48235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33394. 6 interactions.
    DIPi DIP-2885N.
    IntActi P48235. 2 interactions.
    MINTi MINT-515041.
    STRINGi 4932.YGR146C.

    Proteomic databases

    PaxDbi P48235.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR146C ; YGR146C ; YGR146C .
    GeneIDi 853049.
    KEGGi sce:YGR146C.

    Organism-specific databases

    CYGDi YGR146c.
    SGDi S000003378. ECL1.

    Phylogenomic databases

    OMAi NIAEERT.
    OrthoDBi EOG7008MJ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30850-MONOMER.

    Miscellaneous databases

    NextBioi 972966.

    Gene expression databases

    Genevestigatori P48235.

    Family and domain databases

    InterProi IPR024368. Ecl1/3.
    [Graphical view ]
    Pfami PF12855. Ecl1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of a 27 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals MOL1, NAT2, RPL30B, RSR1, CYS4, PEM1/CHO2, NSR1 genes and ten new open reading frames."
      Skala J., Nawrocki A., Goffeau A.
      Yeast 11:1421-1427(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements."
      Rutherford J.C., Jaron S., Winge D.R.
      J. Biol. Chem. 278:27636-27643(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast."
      Dardalhon M., Lin W., Nicolas A., Averbeck D.
      FEMS Yeast Res. 7:866-878(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    7. "Identification and characterization of an Ecl1-family gene in Saccharomyces cerevisiae."
      Azuma K., Ohtsuka H., Mita S., Murakami H., Aiba H.
      Biosci. Biotechnol. Biochem. 73:2787-2789(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiECL1_YEAST
    AccessioniPrimary (citable) accession number: P48235
    Secondary accession number(s): D6VUS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 589 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3