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P48235

- ECL1_YEAST

UniProt

P48235 - ECL1_YEAST

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Protein

Extender of the chronological lifespan protein 1

Gene

ECL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Involved in chronological cell aging.1 Publication

Enzyme and pathway databases

BioCyciYEAST:G3O-30850-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Extender of the chronological lifespan protein 1
Gene namesi
Name:ECL1
Ordered Locus Names:YGR146C
ORF Names:G6626
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR146c.
SGDiS000003378. ECL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Extender of the chronological lifespan protein 1PRO_0000202828Add
BLAST

Proteomic databases

PaxDbiP48235.

Expressioni

Inductioni

Expression is induced by the AFT2 iron homeostasis transcription factor, as well as by 8-methoxypsoralen and UVA radiation.2 Publications

Gene expression databases

GenevestigatoriP48235.

Interactioni

Protein-protein interaction databases

BioGridi33394. 6 interactions.
DIPiDIP-2885N.
IntActiP48235. 2 interactions.
MINTiMINT-515041.
STRINGi4932.YGR146C.

Structurei

3D structure databases

ProteinModelPortaliP48235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ecl1 family.Curated

Phylogenomic databases

InParanoidiP48235.
OMAiNIAEERT.
OrthoDBiEOG7008MJ.

Family and domain databases

InterProiIPR024368. Ecl1/3.
[Graphical view]
PfamiPF12855. Ecl1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48235-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTAFNDYCT VCDRLIPTSP QKTNINTRKI QRDNETKSSL QSNKLYCSED
60 70 80 90 100
CKLKDSNPLN EKLLSHLHKK SKTSHSHNLT PPLSYSKNLT ASNLFEPTTS
110 120 130 140 150
LSSSPTSSTI PFDELEKLES LLISPLLLPQ DGIVNPKQES NPSRVDEYDE
160 170 180 190 200
NEHYLNLADS LRLDSSYQLH SKAHLGYENN LPRSNDLIDD HLISDQIIEN
210
NYNLWFRLSS S
Length:211
Mass (Da):23,997
Last modified:February 1, 1996 - v1
Checksum:i1EA1B71CB31908E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85807 Genomic DNA. Translation: CAA59804.1.
Z72931 Genomic DNA. Translation: CAA97160.1.
BK006941 Genomic DNA. Translation: DAA08237.1.
PIRiS60437.
RefSeqiNP_011662.3. NM_001181275.3.

Genome annotation databases

EnsemblFungiiYGR146C; YGR146C; YGR146C.
GeneIDi853049.
KEGGisce:YGR146C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85807 Genomic DNA. Translation: CAA59804.1 .
Z72931 Genomic DNA. Translation: CAA97160.1 .
BK006941 Genomic DNA. Translation: DAA08237.1 .
PIRi S60437.
RefSeqi NP_011662.3. NM_001181275.3.

3D structure databases

ProteinModelPortali P48235.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33394. 6 interactions.
DIPi DIP-2885N.
IntActi P48235. 2 interactions.
MINTi MINT-515041.
STRINGi 4932.YGR146C.

Proteomic databases

PaxDbi P48235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR146C ; YGR146C ; YGR146C .
GeneIDi 853049.
KEGGi sce:YGR146C.

Organism-specific databases

CYGDi YGR146c.
SGDi S000003378. ECL1.

Phylogenomic databases

InParanoidi P48235.
OMAi NIAEERT.
OrthoDBi EOG7008MJ.

Enzyme and pathway databases

BioCyci YEAST:G3O-30850-MONOMER.

Miscellaneous databases

NextBioi 972966.

Gene expression databases

Genevestigatori P48235.

Family and domain databases

InterProi IPR024368. Ecl1/3.
[Graphical view ]
Pfami PF12855. Ecl1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a 27 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals MOL1, NAT2, RPL30B, RSR1, CYS4, PEM1/CHO2, NSR1 genes and ten new open reading frames."
    Skala J., Nawrocki A., Goffeau A.
    Yeast 11:1421-1427(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements."
    Rutherford J.C., Jaron S., Winge D.R.
    J. Biol. Chem. 278:27636-27643(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast."
    Dardalhon M., Lin W., Nicolas A., Averbeck D.
    FEMS Yeast Res. 7:866-878(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "Identification and characterization of an Ecl1-family gene in Saccharomyces cerevisiae."
    Azuma K., Ohtsuka H., Mita S., Murakami H., Aiba H.
    Biosci. Biotechnol. Biochem. 73:2787-2789(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiECL1_YEAST
AccessioniPrimary (citable) accession number: P48235
Secondary accession number(s): D6VUS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3