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Protein

Tricalbin-2

Gene

TCB2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in membrane trafficking.2 Publications

Miscellaneous

Present with 2630 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • lipid binding Source: SGD

GO - Biological processi

  • endoplasmic reticulum membrane organization Source: SGD
  • endoplasmic reticulum-plasma membrane tethering Source: InterPro
  • lipid transport Source: UniProtKB-KW
  • regulation of phosphatidylinositol dephosphorylation Source: SGD

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33116-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tricalbin-2
Gene namesi
Name:TCB2
Ordered Locus Names:YNL087W
ORF Names:N2250
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL087W
SGDiS000005031 TCB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 98CytoplasmicBy similarityAdd BLAST98
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120ExtracellularBy similarity1
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 1178CytoplasmicBy similarityAdd BLAST1037

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002034441 – 1178Tricalbin-2Add BLAST1178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei991PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP48231
PaxDbiP48231
PRIDEiP48231

PTM databases

iPTMnetiP48231

Interactioni

Subunit structurei

Interacts with TCB1 and TCB3 via its C-terminal domain.1 Publication

Protein-protein interaction databases

BioGridi35736, 91 interactors
DIPiDIP-2709N
IntActiP48231, 6 interactors
MINTiP48231
STRINGi4932.YNL087W

Structurei

3D structure databases

ProteinModelPortaliP48231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 367SMP-LTDPROSITE-ProRule annotationAdd BLAST204
Domaini365 – 463C2 1PROSITE-ProRule annotationAdd BLAST99
Domaini637 – 733C2 2PROSITE-ProRule annotationAdd BLAST97
Domaini970 – 1070C2 3PROSITE-ProRule annotationAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili784 – 821Sequence analysisAdd BLAST38

Domaini

The C2 domains show Ca2+-independent phospholipid binding. None of the C2 domains retains all 5 conserved Asp residues found in calcium-binding C2 domains.

Sequence similaritiesi

Belongs to the tricalbin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000113103
HOGENOMiHOG000248700
InParanoidiP48231
OMAiENFICEV
OrthoDBiEOG092C1LY5

Family and domain databases

CDDicd04044 C2A_Tricalbin-like, 1 hit
cd04052 C2B_Tricalbin-like, 1 hit
cd04045 C2C_Tricalbin-like, 1 hit
cd04040 C2D_Tricalbin-like, 1 hit
Gene3Di2.60.40.150, 4 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037761 C2A_Tricalbin
IPR037765 C2B_Tricalbin
IPR037762 C2C_Tricalbin
IPR037756 C2D_Tricalbin
IPR031468 SMP_LBD
IPR017147 Tricalbin
PfamiView protein in Pfam
PF00168 C2, 4 hits
PIRSFiPIRSF037232 Tricalbin, 1 hit
PRINTSiPR00360 C2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 4 hits
PROSITEiView protein in PROSITE
PS50004 C2, 3 hits
PS51847 SMP, 1 hit

Sequencei

Sequence statusi: Complete.

P48231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPNSSKTRT DQISSMPGIN EATKVESKNV VKDAVPIKSE VETNGTSIVR
60 70 80 90 100
EKQDPSYVGW KQVGGWEEKD ELTSEDLLVD VNKDTFLGNL LPDKFYGDWY
110 120 130 140 150
HEVAILIIAG LCSFVLGYFK FSLASVLIVM LTTGMLYRTS SKKYRESLRD
160 170 180 190 200
LAQKEQTVEK ITSDYESVEW LNTFLDKYWP IIEPSVSQQI VDGTNTALSE
210 220 230 240 250
NVAIPKFIKA IWLDQFTLGV KPPRIDAIKT FQNTKSDVVV MDVCLSFTPH
260 270 280 290 300
DMSDLDAKQC RNYVNSNVVL KAKIFGMDIP VSVADIFFQV FVRFRFQLMT
310 320 330 340 350
TLPLVETINI QLLEVPEVDF ISRLLGNSVF NWEILAIPGL MRLIQKMAFK
360 370 380 390 400
YLSPVLLPPF SLQLNIPQLL SKTGLPIGVL EIKVKNAHGL RKLVGMIKKT
410 420 430 440 450
VDPYLTFELS GKIVGKTKVF KNSANPVWNE SIYILLQSFT DPLTIAVYDK
460 470 480 490 500
RETLSDKKMG TVIFNLNKLH ANHYHKNEKV HFLRNSKPVG ELTFDLRFFP
510 520 530 540 550
TIEPKKLLNG DEEPLPDMNT GITKITIREL KGLDELSDKK FVFAELYVNA
560 570 580 590 600
ELVMTTKKEK RTAHLKWNSD YYSVVTDRRK TICRFVLKDQ SGKVISSSVQ
610 620 630 640 650
PLNHLIDRTE VNKEWIPLRN GKGELKVTTY WRPVDIDLGL KSVGYTTPIG
660 670 680 690 700
MLRVFINKAE NLRNPDSLGK ISPYAKVSVN GVARGRTNER IETLNPIWNQ
710 720 730 740 750
SIYVSVTSPL QKVSIDCFGI DTNGDDHNLG SLNIQTQNIY HKDNDDKYTI
760 770 780 790 800
FIDNAPRTGN LIGKKGVKGT VTYYLSFYPV VPVLSLEEAK EVDEINEKKD
810 820 830 840 850
KLEKQKSTLD DKNISKEEKE RIKKEEFRLT EKYDMYSYKM KLDLDELLQY
860 870 880 890 900
NAGVLGVTVL GGELPQPGLY VQTFFDSCGY AAITSAKNAI RTIKTGWSGD
910 920 930 940 950
FMIKELEWSV TTFRVTKTKD ANKAENFICE VNIPTIELVR NCYYKPSVLN
960 970 980 990 1000
LIGKKSAKLL VQVSWFPVTA TELPQSDLIT NSGDLKITAK SAENLIGVNK
1010 1020 1030 1040 1050
NGYSDPYVEF FLNEKSTSPF FKTAVQKKTL NPTWNESKTI EVSNRVNDYL
1060 1070 1080 1090 1100
TINVKDYEST NSNRSIGKAV VPLSTIDPES DTTFNIPLVG PKGEDGGVLH
1110 1120 1130 1140 1150
LEFEFEPRYT TNVVKREAGL GNFATKGLGT GIKAGSTVFA LGTNVVSTGL
1160 1170
GTIDKVKAGV FGGKKSTTTG DKKSEEKQ
Length:1,178
Mass (Da):132,509
Last modified:February 1, 1996 - v1
Checksum:i6597DE191C739F41
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11 – 13DQI → EQV in strain: SK1. 3
Natural varianti121F → S in strain: SK1. 1 Publication1
Natural varianti528R → G in strain: SK1. 1 Publication1
Natural varianti691 – 692IE → MK in strain: SK1. 2
Natural varianti1159G → R in strain: SK1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115393 Genomic DNA Translation: AAZ22521.1
X89016 Genomic DNA Translation: CAA61423.1
Z71363 Genomic DNA Translation: CAA95963.1
BK006947 Genomic DNA Translation: DAA10458.1
PIRiS57535
RefSeqiNP_014312.1, NM_001182925.1

Genome annotation databases

EnsemblFungiiYNL087W; YNL087W; YNL087W
GeneIDi855637
KEGGisce:YNL087W

Similar proteinsi

Entry informationi

Entry nameiTCB2_YEAST
AccessioniPrimary (citable) accession number: P48231
Secondary accession number(s): D6W192, Q45TY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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