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Protein

Transmembrane 4 L6 family member 4

Gene

TM4SF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi2.A.48.2.3. the reduced folate carrier (rfc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 4
Alternative name(s):
Intestine and liver tetraspan membrane protein
Short name:
IL-TMP
Gene namesi
Name:TM4SF4
Synonyms:ILTMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11856. TM4SF4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence analysis
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Topological domaini31 – 4515ExtracellularSequence analysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence analysisAdd
BLAST
Topological domaini67 – 9327CytoplasmicSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Topological domaini115 – 15844ExtracellularSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Topological domaini180 – 20223CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36557.

Polymorphism and mutation databases

BioMutaiTM4SF4.
DMDMi1352457.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Transmembrane 4 L6 family member 4PRO_0000219299Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)1 Publication
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated. Glycosylation is required for the growth inhibitory effect.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP48230.
PeptideAtlasiP48230.
PRIDEiP48230.

Expressioni

Tissue specificityi

Jejunum and liver.

Gene expression databases

BgeeiP48230.
CleanExiHS_TM4SF4.
ExpressionAtlasiP48230. baseline and differential.
GenevisibleiP48230. HS.

Organism-specific databases

HPAiHPA046430.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-8650934,EBI-743099

Protein-protein interaction databases

BioGridi112959. 2 interactions.
IntActiP48230. 2 interactions.
STRINGi9606.ENSP00000305852.

Structurei

3D structure databases

ProteinModelPortaliP48230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKWR. Eukaryota.
ENOG4111RYW. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiP48230.
OMAiTWGYPFH.
OrthoDBiEOG7SFHZ4.
PhylomeDBiP48230.
TreeFamiTF331371.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTGGCARCL GGTLIPLAFF GFLANILLFF PGGKVIDDND HLSQEIWFFG
60 70 80 90 100
GILGSGVLMI FPALVFLGLK NNDCCGCCGN EGCGKRFAMF TSTIFAVVGF
110 120 130 140 150
LGAGYSFIIS AISINKGPKC LMANSTWGYP FHDGDYLNDE ALWNKCREPL
160 170 180 190 200
NVVPWNLTLF SILLVVGGIQ MVLCAIQVVN GLLGTLCGDC QCCGCCGGDG

PV
Length:202
Mass (Da):21,396
Last modified:February 1, 1996 - v1
Checksum:i402742A2F5F8598F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31449 mRNA. Translation: AAA74745.1.
BT007430 mRNA. Translation: AAP36098.1.
AK315464 mRNA. Translation: BAG37851.1.
CH471052 Genomic DNA. Translation: EAW78871.1.
BC001386 mRNA. Translation: AAH01386.1.
CCDSiCCDS46932.1.
RefSeqiNP_004608.1. NM_004617.3.
UniGeneiHs.133527.

Genome annotation databases

EnsembliENST00000305354; ENSP00000305852; ENSG00000169903.
GeneIDi7104.
KEGGihsa:7104.
UCSCiuc003exd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31449 mRNA. Translation: AAA74745.1.
BT007430 mRNA. Translation: AAP36098.1.
AK315464 mRNA. Translation: BAG37851.1.
CH471052 Genomic DNA. Translation: EAW78871.1.
BC001386 mRNA. Translation: AAH01386.1.
CCDSiCCDS46932.1.
RefSeqiNP_004608.1. NM_004617.3.
UniGeneiHs.133527.

3D structure databases

ProteinModelPortaliP48230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112959. 2 interactions.
IntActiP48230. 2 interactions.
STRINGi9606.ENSP00000305852.

Protein family/group databases

TCDBi2.A.48.2.3. the reduced folate carrier (rfc) family.

Polymorphism and mutation databases

BioMutaiTM4SF4.
DMDMi1352457.

Proteomic databases

PaxDbiP48230.
PeptideAtlasiP48230.
PRIDEiP48230.

Protocols and materials databases

DNASUi7104.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305354; ENSP00000305852; ENSG00000169903.
GeneIDi7104.
KEGGihsa:7104.
UCSCiuc003exd.3. human.

Organism-specific databases

CTDi7104.
GeneCardsiTM4SF4.
HGNCiHGNC:11856. TM4SF4.
HPAiHPA046430.
MIMi606567. gene.
neXtProtiNX_P48230.
PharmGKBiPA36557.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKWR. Eukaryota.
ENOG4111RYW. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiP48230.
OMAiTWGYPFH.
OrthoDBiEOG7SFHZ4.
PhylomeDBiP48230.
TreeFamiTF331371.

Miscellaneous databases

GenomeRNAii7104.
PROiP48230.
SOURCEiSearch...

Gene expression databases

BgeeiP48230.
CleanExiHS_TM4SF4.
ExpressionAtlasiP48230. baseline and differential.
GenevisibleiP48230. HS.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation."
    Wice B.M., Gordon J.I.
    J. Biol. Chem. 270:21907-21918(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine and Liver.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124.
    Tissue: Liver.

Entry informationi

Entry nameiT4S4_HUMAN
AccessioniPrimary (citable) accession number: P48230
Secondary accession number(s): B2RDA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.