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Protein

60 kDa chaperonin

Gene

groL

Organism
Yersinia enterocolitica
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
Cross-reacting protein antigen
GroEL proteinUniRule annotation
Heat shock protein 60
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:crpA, groELUniRule annotation, hsp60, mopA
OrganismiYersinia enterocolitica
Taxonomic identifieri630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636141 – 55060 kDa chaperoninAdd BLAST550

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP48219.
SMRiP48219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

P48219-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKDVKFGN DARIKMLRGV NILADAVKVT LGPKGRNVVL DKSFGSPTIT
60 70 80 90 100
KDGVSVAREI ELEDKFENMG AQMVKEVASK ANDAAGDGTT TATVLAQSII
110 120 130 140 150
TEGLKAVAAG MNPMDLKRGI DKAVIAAVEE LKKLSVPCSD SKAIAQVGTI
160 170 180 190 200
SANSDSTVGE LIAQAMEKVG KEGVITVEEG SGLQDELDVV EGMQFDRGYL
210 220 230 240 250
SPYFINKPET GSIELESPFI LLADKKISNI REMLPVLEAV AKAGKPLLII
260 270 280 290 300
AEDVEGEALA TLVVNTMRGI VKVAAVKAPG FGDRRKAMLQ DIATLTAGTV
310 320 330 340 350
ISEEIGLELE KTTLEDLGQA KRVVINKDTT IIIDGVGDEA AIQGRVAQIR
360 370 380 390 400
QQIEEATSDY DKEKLQERVA KLAGGVAVIK VGAATEVEMK EKKARVEDAL
410 420 430 440 450
HATRAAVEEG VVAGGGVALI RAASAITAAG LKGDNEDQNV GIKVALRAME
460 470 480 490 500
SPLRQIVVNA GEEASVIANN VKAGSGSYGY NAYSEEYGDM IAMGILDPTK
510 520 530 540 550
VTRSALQYAA SIAGLMITTE CMITDLPRDD KGADMGAGGM GGMGGMGGMM
Length:550
Mass (Da):57,527
Last modified:February 1, 1996 - v1
Checksum:i2269A4B18E39DA4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16 – 17ML → IV in BAA03164 (PubMed:8190995).Curated2
Sequence conflicti135S → Y in CAA48539 (Ref. 1) Curated1
Sequence conflicti181S → P in CAA48539 (Ref. 1) Curated1
Sequence conflicti297A → V in CAA48539 (Ref. 1) Curated1
Sequence conflicti346V → L in BAA03164 (PubMed:8190995).Curated1
Sequence conflicti347A → T in CAA48539 (Ref. 1) Curated1
Sequence conflicti401H → D in BAA03164 (PubMed:8190995).Curated1
Sequence conflicti423A → R in BAA03164 (PubMed:8190995).Curated1
Sequence conflicti473 – 482AGSGSYGYNA → RVQVATVTS in BAA03164 (PubMed:8190995).Curated10

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti2A → P in strain: WA / Serotype O:8. 1
Natural varianti355E → D in strain: WA / Serotype O:8. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68526 Genomic DNA. Translation: CAA48539.1.
X82212 Genomic DNA. Translation: CAA57694.1.
D14078 Genomic DNA. Translation: BAA03164.1.
PIRiS26423.
S52901.

Similar proteinsi

Entry informationi

Entry nameiCH60_YEREN
AccessioniPrimary (citable) accession number: P48219
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 22, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families