Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60 kDa chaperonin

Gene

groL

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:Erum6420, ERWE_CDS_06730
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000001021 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000633651 – 55160 kDa chaperoninAdd BLAST551

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi254945.ERWE_CDS_06730

Structurei

3D structure databases

ProteinModelPortaliP48213
SMRiP48213
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9 Bacteria
COG0459 LUCA
HOGENOMiHOG000076290
KOiK04077
OMAiTDTDKME
OrthoDBiPOG091H00E7

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

P48213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANMVVTGEQ LDKSIREVVR ILEDAVGCTA GPKGLTVAIS KPYGAPEVTK
60 70 80 90 100
DGYKVMKSIK PEDPLALAIA NIIAQSASQC NDKVGDGTTT CSILTAKVIE
110 120 130 140 150
EVSKVKAAGA DIICVREGVL KAKEAVLEAL KCMKREVLSE EEIAQVATIS
160 170 180 190 200
ANGDKNIGTK IAQCVKEVGK DGVITVEESK GFKELDVEKT DGMQFDRGYL
210 220 230 240 250
SPYFVTNSEK MLVEFENPYI LLTEKKLNII QPLLPILENI ARSGRPLLII
260 270 280 290 300
AEDVEGEALS TLVLNKLRGG LHVAAVKAPG FGDRRKDMLG DIAILTGAKH
310 320 330 340 350
VINDELAIKM EDLTLCDLGT AKNIRITKDT TTIIGSVDNS CAHVQSRICQ
360 370 380 390 400
IRMQIDNSTS DYDKEKLQER LAKLSGGVAV LKVGGSSEVE VKERKDRVED
410 420 430 440 450
ALHATRAAVE EGVVPGGGAA LLYTLSALDN LKSKNDDEQL GINIVKRALQ
460 470 480 490 500
APIKRIIKNA GSENAPCVIA HLLKQNDKEL IFNVDVMNFA NAFTSGVIDP
510 520 530 540 550
LKVVRIAFDF AVSLAAVFMT LNAIVVDIPS KDDNSAAGGA GMGGMGGMGG

F
Length:551
Mass (Da):58,859
Last modified:April 12, 2005 - v2
Checksum:i8446286E28E4E277
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti487M → T in AAA93153 (PubMed:7496520).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13638 Genomic DNA Translation: AAA93153.1
CR767821 Genomic DNA Translation: CAH58374.1
CR925678 Genomic DNA Translation: CAI27167.1
RefSeqiWP_011155322.1, NC_006832.1

Genome annotation databases

EnsemblBacteriaiCAH58374; CAH58374; Erum6420
CAI27167; CAI27167; ERWE_CDS_06730
GeneIDi33057703
KEGGieru:Erum6420
erw:ERWE_CDS_06730

Similar proteinsi

Entry informationi

Entry nameiCH60_EHRRW
AccessioniPrimary (citable) accession number: P48213
Secondary accession number(s): Q5FDA8, Q5HAN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health