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Protein

60 kDa chaperonin

Gene

groL

Organism
Ehrlichia ruminantium (strain Welgevonden)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:Erum6420, ERWE_CDS_06730
OrganismiEhrlichia ruminantium (strain Welgevonden)
Taxonomic identifieri254945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000001021 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000633651 – 55160 kDa chaperoninAdd BLAST551

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi254945.ERWE_CDS_06730.

Structurei

3D structure databases

ProteinModelPortaliP48213.
SMRiP48213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiTDTDKME.
OrthoDBiPOG091H00E7.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

P48213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANMVVTGEQ LDKSIREVVR ILEDAVGCTA GPKGLTVAIS KPYGAPEVTK
60 70 80 90 100
DGYKVMKSIK PEDPLALAIA NIIAQSASQC NDKVGDGTTT CSILTAKVIE
110 120 130 140 150
EVSKVKAAGA DIICVREGVL KAKEAVLEAL KCMKREVLSE EEIAQVATIS
160 170 180 190 200
ANGDKNIGTK IAQCVKEVGK DGVITVEESK GFKELDVEKT DGMQFDRGYL
210 220 230 240 250
SPYFVTNSEK MLVEFENPYI LLTEKKLNII QPLLPILENI ARSGRPLLII
260 270 280 290 300
AEDVEGEALS TLVLNKLRGG LHVAAVKAPG FGDRRKDMLG DIAILTGAKH
310 320 330 340 350
VINDELAIKM EDLTLCDLGT AKNIRITKDT TTIIGSVDNS CAHVQSRICQ
360 370 380 390 400
IRMQIDNSTS DYDKEKLQER LAKLSGGVAV LKVGGSSEVE VKERKDRVED
410 420 430 440 450
ALHATRAAVE EGVVPGGGAA LLYTLSALDN LKSKNDDEQL GINIVKRALQ
460 470 480 490 500
APIKRIIKNA GSENAPCVIA HLLKQNDKEL IFNVDVMNFA NAFTSGVIDP
510 520 530 540 550
LKVVRIAFDF AVSLAAVFMT LNAIVVDIPS KDDNSAAGGA GMGGMGGMGG

F
Length:551
Mass (Da):58,859
Last modified:April 12, 2005 - v2
Checksum:i8446286E28E4E277
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti487M → T in AAA93153 (PubMed:7496520).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13638 Genomic DNA. Translation: AAA93153.1.
CR767821 Genomic DNA. Translation: CAH58374.1.
CR925678 Genomic DNA. Translation: CAI27167.1.
RefSeqiWP_011155322.1. NC_006832.1.

Genome annotation databases

EnsemblBacteriaiCAH58374; CAH58374; Erum6420.
CAI27167; CAI27167; ERWE_CDS_06730.
GeneIDi33057703.
KEGGieru:Erum6420.
erw:ERWE_CDS_06730.

Similar proteinsi

Entry informationi

Entry nameiCH60_EHRRW
AccessioniPrimary (citable) accession number: P48213
Secondary accession number(s): Q5FDA8, Q5HAN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 12, 2005
Last modified: November 22, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families