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P48206

- RNPA_STRCO

UniProt

P48206 - RNPA_STRCO

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Protein

Ribonuclease P protein component

Gene
rnpA, SCO3881, STH24.03
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-EC
  2. tRNA binding Source: InterPro

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein component (EC:3.1.26.5)
Short name:
RNase P protein
Short name:
RNaseP protein
Alternative name(s):
Protein C5
Gene namesi
Name:rnpA
Ordered Locus Names:SCO3881
ORF Names:STH24.03
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 123123Ribonuclease P protein componentUniRule annotationPRO_0000198538Add
BLAST

Interactioni

Subunit structurei

Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit By similarity.

Protein-protein interaction databases

STRINGi100226.SCO3881.

Structurei

3D structure databases

ProteinModelPortaliP48206.

Family & Domainsi

Sequence similaritiesi

Belongs to the RnpA family.

Phylogenomic databases

HOGENOMiHOG000266301.
KOiK03536.
OMAiMLPTENR.
OrthoDBiEOG6XWV8K.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_00227. RNase_P.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
[Graphical view]
PfamiPF00825. Ribonuclease_P. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00188. rnpA. 1 hit.
PROSITEiPS00648. RIBONUCLEASE_P. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48206-1 [UniParc]FASTAAdd to Basket

« Hide

MLPTENRLRR REDFATAVRR GRRVGRSTLV VHLRSGATDP HAPGESAPRT    50
RAGFVVSKAV GVAVVRNKVK RRLRHLMRDR IDLLPPGSLV VVRALPGAGD 100
ADHAQLARDL DAALARLLGG GAR 123
Length:123
Mass (Da):13,320
Last modified:February 1, 1996 - v1
Checksum:i0D4D4E26A20B6C39
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF187159 Genomic DNA. Translation: AAA26732.1.
AL939118 Genomic DNA. Translation: CAB42696.1.
PIRiD41870.
RefSeqiNP_628067.1. NC_003888.3.
WP_011029288.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB42696; CAB42696; CAB42696.
GeneIDi1099317.
KEGGisco:SCO3881.
PATRICi23737546. VBIStrCoe124346_3954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF187159 Genomic DNA. Translation: AAA26732.1 .
AL939118 Genomic DNA. Translation: CAB42696.1 .
PIRi D41870.
RefSeqi NP_628067.1. NC_003888.3.
WP_011029288.1. NC_003888.3.

3D structure databases

ProteinModelPortali P48206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO3881.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB42696 ; CAB42696 ; CAB42696 .
GeneIDi 1099317.
KEGGi sco:SCO3881.
PATRICi 23737546. VBIStrCoe124346_3954.

Phylogenomic databases

HOGENOMi HOG000266301.
KOi K03536.
OMAi MLPTENR.
OrthoDBi EOG6XWV8K.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
HAMAPi MF_00227. RNase_P.
InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
[Graphical view ]
Pfami PF00825. Ribonuclease_P. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 1 hit.
TIGRFAMsi TIGR00188. rnpA. 1 hit.
PROSITEi PS00648. RIBONUCLEASE_P. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Conserved gene arrangement in the origin region of the Streptomyces coelicolor chromosome."
    Calcutt M.J., Schmidt F.J.
    J. Bacteriol. 174:3220-3226(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiRNPA_STRCO
AccessioniPrimary (citable) accession number: P48206
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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