Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P48199 (CRP_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-reactive protein
Gene names
Name:Crp
Synonyms:Ptx1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells By similarity.

Cofactor

Binds 2 calcium ions per subunit By similarity.

Subunit structure

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Two of the five chains form a dimer linked by two interchain disulfide bonds located in the C-terminal heptapeptide and specific to rat CRP.

Subcellular location

Secreted.

Tissue specificity

Found in plasma.

Post-translational modification

The last two cysteines are involved either in interchain disulfide bonds or in an intrachain bond.

Sequence similarities

Belongs to the pentaxin family.

Contains 1 pentaxin domain.

Ontologies

Keywords
   Biological processAcute phase
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Metal-binding
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processacute-phase response

Inferred from electronic annotation. Source: UniProtKB-KW

aging

Inferred from expression pattern PubMed 21835237. Source: RGD

cellular response to calcium ion

Inferred from direct assay PubMed 22090504. Source: RGD

complement activation, classical pathway

Inferred from mutant phenotype PubMed 16367929. Source: RGD

negative regulation of lipid storage

Inferred from electronic annotation. Source: Ensembl

negative regulation of macrophage derived foam cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of dendrite development

Inferred from mutant phenotype PubMed 22090504. Source: RGD

protein polymerization

Inferred from direct assay Ref.1. Source: RGD

response to ethanol

Inferred from expression pattern PubMed 22521742. Source: RGD

response to hypoxia

Inferred from expression pattern PubMed 21158023. Source: RGD

response to lead ion

Inferred from expression pattern PubMed 21378372. Source: RGD

wound healing

Inferred from mutant phenotype PubMed 22447201. Source: RGD

   Cellular_componentextracellular space

Inferred from direct assay Ref.1. Source: RGD

filopodium

Inferred from direct assay PubMed 22090504. Source: RGD

growth cone

Inferred from direct assay PubMed 22090504. Source: RGD

   Molecular_functioncholesterol binding

Inferred from direct assay PubMed 15766555. Source: RGD

low-density lipoprotein particle binding

Inferred from electronic annotation. Source: Ensembl

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein homodimerization activity

Inferred from direct assay Ref.1. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 230211C-reactive protein
PRO_0000023532

Regions

Domain20 – 230211Pentaxin

Sites

Metal binding781Calcium 1 By similarity
Metal binding1551Calcium 1 By similarity
Metal binding1551Calcium 2 By similarity
Metal binding1561Calcium 1; via carbonyl oxygen By similarity
Metal binding1571Calcium 1 By similarity
Metal binding1571Calcium 2 By similarity
Metal binding1671Calcium 2 By similarity

Amino acid modifications

Glycosylation1471N-linked (GlcNAc...)
CAR_000154
Disulfide bond55 ↔ 114
Disulfide bond227 ↔ 228In monomeric form
Disulfide bond227Interchain; in polymeric form
Disulfide bond228Interchain; in polymeric form

Sequences

Sequence LengthMass (Da)Tools
P48199 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: D8CF6BFE72376309

FASTA23025,468
        10         20         30         40         50         60 
MEKLLWCLLI TISFSQAFGH EDMSKQAFVF PGVSATAYVS LEAESKKPLE AFTVCLYAHA 

        70         80         90        100        110        120 
DVSRSFSIFS YATKTSFNEI LLFWTRGQGF SIAVGGPEIL FSASEIPEVP THICATWESA 

       130        140        150        160        170        180 
TGIVELWLDG KPRVRKSLQK GYIVGTNASI ILGQEQDSYG GGFDANQSLV GDIGDVNMWD 

       190        200        210        220        230 
FVLSPEQINA VYVGRVFSPN VLNWRALKYE THGDVFIKPQ LWPLTDCCES 

« Hide

References

« Hide 'large scale' references
[1]"Derivation of the amino acid sequence of rat C-reactive protein from cDNA cloning with additional studies on the nature of its dimeric component."
Rassouli M., Sambasivam H., Azadi P., Dell A., Morris H.R., Nagpurkar A., Mookerjea S., Murray R.K.
J. Biol. Chem. 267:2947-2954(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Strain: Sprague-Dawley.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
[3]Lubec G., Kang S.U., Lubec S.
Submitted (SEP-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 65-74 AND 196-205, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Web resources

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M83176 mRNA. Translation: AAA40964.1.
BC091157 mRNA. Translation: AAH91157.1.
PIRA42579.
RefSeqNP_058792.1. NM_017096.3.
UniGeneRn.16463.

3D structure databases

ProteinModelPortalP48199.
SMRP48199. Positions 22-223.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000000058.

PTM databases

UniCarbKBP48199.

Proteomic databases

PaxDbP48199.
PRIDEP48199.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000000058; ENSRNOP00000000058; ENSRNOG00000000053.
GeneID25419.
KEGGrno:25419.
UCSCRGD:2411. rat.

Organism-specific databases

CTD1401.
RGD2411. Crp.

Phylogenomic databases

eggNOGNOG113288.
GeneTreeENSGT00650000093195.
HOGENOMHOG000247043.
HOVERGENHBG005405.
KOK16143.
OMAWRALKYE.
OrthoDBEOG71RXMB.
PhylomeDBP48199.
TreeFamTF330208.

Gene expression databases

GenevestigatorP48199.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio606575.
PROP48199.

Entry information

Entry nameCRP_RAT
AccessionPrimary (citable) accession number: P48199
Secondary accession number(s): Q5BK94
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries