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P48199

- CRP_RAT

UniProt

P48199 - CRP_RAT

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Protein

C-reactive protein

Gene

Crp

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).By similarity

Cofactori

Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Calcium 1By similarity
Metal bindingi155 – 1551Calcium 1By similarity
Metal bindingi155 – 1551Calcium 2By similarity
Metal bindingi156 – 1561Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi157 – 1571Calcium 1By similarity
Metal bindingi157 – 1571Calcium 2By similarity
Metal bindingi167 – 1671Calcium 2By similarity

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. cholesterol binding Source: RGD
  3. low-density lipoprotein particle binding Source: Ensembl
  4. protein homodimerization activity Source: RGD

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. aging Source: RGD
  3. cellular response to calcium ion Source: RGD
  4. complement activation, classical pathway Source: RGD
  5. negative regulation of lipid storage Source: Ensembl
  6. negative regulation of macrophage derived foam cell differentiation Source: Ensembl
  7. positive regulation of dendrite development Source: RGD
  8. protein polymerization Source: RGD
  9. regulation of interleukin-8 secretion Source: UniProtKB
  10. response to ethanol Source: RGD
  11. response to hypoxia Source: RGD
  12. response to lead ion Source: RGD
  13. wound healing Source: RGD
Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Gene namesi
Name:Crp
Synonyms:Ptx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi2411. Crp.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
  2. extracellular vesicular exosome Source: Ensembl
  3. filopodium Source: RGD
  4. growth cone Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 230211C-reactive proteinPRO_0000023532Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 114
Glycosylationi147 – 1471N-linked (GlcNAc...)CAR_000154
Disulfide bondi227 ↔ 228In monomeric form
Disulfide bondi227 – 227Interchain; in polymeric form
Disulfide bondi228 – 228Interchain; in polymeric form

Post-translational modificationi

The last two cysteines are involved either in interchain disulfide bonds or in an intrachain bond.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48199.
PRIDEiP48199.

PTM databases

UniCarbKBiP48199.

Expressioni

Tissue specificityi

Found in plasma.

Gene expression databases

ExpressionAtlasiP48199. baseline.
GenevestigatoriP48199.

Interactioni

Subunit structurei

Homopentamer; disulfide-linked. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Two of the five chains form a dimer linked by two interchain disulfide bonds located in the C-terminal heptapeptide and specific to rat CRP. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000058.

Structurei

3D structure databases

ProteinModelPortaliP48199.
SMRiP48199. Positions 22-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 230211PentaxinAdd
BLAST

Sequence similaritiesi

Belongs to the pentaxin family.Curated
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG113288.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP48199.
KOiK16143.
OMAiWRALKYE.
OrthoDBiEOG71RXMB.
PhylomeDBiP48199.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48199-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKLLWCLLI TISFSQAFGH EDMSKQAFVF PGVSATAYVS LEAESKKPLE
60 70 80 90 100
AFTVCLYAHA DVSRSFSIFS YATKTSFNEI LLFWTRGQGF SIAVGGPEIL
110 120 130 140 150
FSASEIPEVP THICATWESA TGIVELWLDG KPRVRKSLQK GYIVGTNASI
160 170 180 190 200
ILGQEQDSYG GGFDANQSLV GDIGDVNMWD FVLSPEQINA VYVGRVFSPN
210 220 230
VLNWRALKYE THGDVFIKPQ LWPLTDCCES
Length:230
Mass (Da):25,468
Last modified:February 1, 1996 - v1
Checksum:iD8CF6BFE72376309
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83176 mRNA. Translation: AAA40964.1.
BC091157 mRNA. Translation: AAH91157.1.
PIRiA42579.
RefSeqiNP_058792.1. NM_017096.3.
UniGeneiRn.16463.

Genome annotation databases

EnsembliENSRNOT00000000058; ENSRNOP00000000058; ENSRNOG00000000053.
GeneIDi25419.
KEGGirno:25419.
UCSCiRGD:2411. rat.

Cross-referencesi

Web resourcesi

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83176 mRNA. Translation: AAA40964.1 .
BC091157 mRNA. Translation: AAH91157.1 .
PIRi A42579.
RefSeqi NP_058792.1. NM_017096.3.
UniGenei Rn.16463.

3D structure databases

ProteinModelPortali P48199.
SMRi P48199. Positions 22-223.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000058.

PTM databases

UniCarbKBi P48199.

Proteomic databases

PaxDbi P48199.
PRIDEi P48199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000000058 ; ENSRNOP00000000058 ; ENSRNOG00000000053 .
GeneIDi 25419.
KEGGi rno:25419.
UCSCi RGD:2411. rat.

Organism-specific databases

CTDi 1401.
RGDi 2411. Crp.

Phylogenomic databases

eggNOGi NOG113288.
GeneTreei ENSGT00760000119128.
HOGENOMi HOG000247043.
HOVERGENi HBG005405.
InParanoidi P48199.
KOi K16143.
OMAi WRALKYE.
OrthoDBi EOG71RXMB.
PhylomeDBi P48199.
TreeFami TF330208.

Miscellaneous databases

NextBioi 606575.
PROi P48199.

Gene expression databases

ExpressionAtlasi P48199. baseline.
Genevestigatori P48199.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00159. PTX. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00289. PENTAXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Derivation of the amino acid sequence of rat C-reactive protein from cDNA cloning with additional studies on the nature of its dimeric component."
    Rassouli M., Sambasivam H., Azadi P., Dell A., Morris H.R., Nagpurkar A., Mookerjea S., Murray R.K.
    J. Biol. Chem. 267:2947-2954(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 65-74 AND 196-205, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCRP_RAT
AccessioniPrimary (citable) accession number: P48199
Secondary accession number(s): Q5BK94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3