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P48199

- CRP_RAT

UniProt

P48199 - CRP_RAT

Protein

C-reactive protein

Gene

Crp

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells By similarity.By similarity

    Cofactori

    Binds 2 calcium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Calcium 1By similarity
    Metal bindingi155 – 1551Calcium 1By similarity
    Metal bindingi155 – 1551Calcium 2By similarity
    Metal bindingi156 – 1561Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi157 – 1571Calcium 1By similarity
    Metal bindingi157 – 1571Calcium 2By similarity
    Metal bindingi167 – 1671Calcium 2By similarity

    GO - Molecular functioni

    1. cholesterol binding Source: RGD
    2. low-density lipoprotein particle binding Source: Ensembl
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: RGD
    5. protein homodimerization activity Source: RGD

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW
    2. aging Source: RGD
    3. cellular response to calcium ion Source: RGD
    4. complement activation, classical pathway Source: RGD
    5. negative regulation of lipid storage Source: Ensembl
    6. negative regulation of macrophage derived foam cell differentiation Source: Ensembl
    7. positive regulation of dendrite development Source: RGD
    8. protein polymerization Source: RGD
    9. regulation of interleukin-8 secretion Source: UniProtKB
    10. response to ethanol Source: RGD
    11. response to hypoxia Source: RGD
    12. response to lead ion Source: RGD
    13. wound healing Source: RGD

    Keywords - Biological processi

    Acute phase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-reactive protein
    Gene namesi
    Name:Crp
    Synonyms:Ptx1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi2411. Crp.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD
    2. filopodium Source: RGD
    3. growth cone Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 230211C-reactive proteinPRO_0000023532Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi55 ↔ 114
    Glycosylationi147 – 1471N-linked (GlcNAc...)CAR_000154
    Disulfide bondi227 ↔ 228In monomeric form
    Disulfide bondi227 – 227Interchain; in polymeric form
    Disulfide bondi228 – 228Interchain; in polymeric form

    Post-translational modificationi

    The last two cysteines are involved either in interchain disulfide bonds or in an intrachain bond.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP48199.
    PRIDEiP48199.

    PTM databases

    UniCarbKBiP48199.

    Expressioni

    Tissue specificityi

    Found in plasma.

    Gene expression databases

    GenevestigatoriP48199.

    Interactioni

    Subunit structurei

    Homopentamer; disulfide-linked. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Two of the five chains form a dimer linked by two interchain disulfide bonds located in the C-terminal heptapeptide and specific to rat CRP. Interacts with FCN1; may regulate monocyte activation by FCN1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000000058.

    Structurei

    3D structure databases

    ProteinModelPortaliP48199.
    SMRiP48199. Positions 22-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 230211PentaxinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pentaxin family.Curated
    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG113288.
    GeneTreeiENSGT00650000093195.
    HOGENOMiHOG000247043.
    HOVERGENiHBG005405.
    KOiK16143.
    OMAiWRALKYE.
    OrthoDBiEOG71RXMB.
    PhylomeDBiP48199.
    TreeFamiTF330208.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00159. PTX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00289. PENTAXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48199-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKLLWCLLI TISFSQAFGH EDMSKQAFVF PGVSATAYVS LEAESKKPLE    50
    AFTVCLYAHA DVSRSFSIFS YATKTSFNEI LLFWTRGQGF SIAVGGPEIL 100
    FSASEIPEVP THICATWESA TGIVELWLDG KPRVRKSLQK GYIVGTNASI 150
    ILGQEQDSYG GGFDANQSLV GDIGDVNMWD FVLSPEQINA VYVGRVFSPN 200
    VLNWRALKYE THGDVFIKPQ LWPLTDCCES 230
    Length:230
    Mass (Da):25,468
    Last modified:February 1, 1996 - v1
    Checksum:iD8CF6BFE72376309
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83176 mRNA. Translation: AAA40964.1.
    BC091157 mRNA. Translation: AAH91157.1.
    PIRiA42579.
    RefSeqiNP_058792.1. NM_017096.3.
    UniGeneiRn.16463.

    Genome annotation databases

    EnsembliENSRNOT00000000058; ENSRNOP00000000058; ENSRNOG00000000053.
    GeneIDi25419.
    KEGGirno:25419.
    UCSCiRGD:2411. rat.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    No more Christmas pudding? - Issue 30 of January 2003

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83176 mRNA. Translation: AAA40964.1 .
    BC091157 mRNA. Translation: AAH91157.1 .
    PIRi A42579.
    RefSeqi NP_058792.1. NM_017096.3.
    UniGenei Rn.16463.

    3D structure databases

    ProteinModelPortali P48199.
    SMRi P48199. Positions 22-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000000058.

    PTM databases

    UniCarbKBi P48199.

    Proteomic databases

    PaxDbi P48199.
    PRIDEi P48199.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000000058 ; ENSRNOP00000000058 ; ENSRNOG00000000053 .
    GeneIDi 25419.
    KEGGi rno:25419.
    UCSCi RGD:2411. rat.

    Organism-specific databases

    CTDi 1401.
    RGDi 2411. Crp.

    Phylogenomic databases

    eggNOGi NOG113288.
    GeneTreei ENSGT00650000093195.
    HOGENOMi HOG000247043.
    HOVERGENi HBG005405.
    KOi K16143.
    OMAi WRALKYE.
    OrthoDBi EOG71RXMB.
    PhylomeDBi P48199.
    TreeFami TF330208.

    Miscellaneous databases

    NextBioi 606575.
    PROi P48199.

    Gene expression databases

    Genevestigatori P48199.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00159. PTX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00289. PENTAXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Derivation of the amino acid sequence of rat C-reactive protein from cDNA cloning with additional studies on the nature of its dimeric component."
      Rassouli M., Sambasivam H., Azadi P., Dell A., Morris H.R., Nagpurkar A., Mookerjea S., Murray R.K.
      J. Biol. Chem. 267:2947-2954(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    3. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 65-74 AND 196-205, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiCRP_RAT
    AccessioniPrimary (citable) accession number: P48199
    Secondary accession number(s): Q5BK94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3