P48182 (ACR2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylcholine receptor subunit beta-type acr-2

Gene names

Name:	acr-2
ORF Names:	K11G12.2

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	575 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acetylcholine receptor.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ionic channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	synaptic transmission Inferred from mutant phenotype Ref.1. Source: WormBase
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetylcholine-activated cation-selective channel activity Inferred from electronic annotation. Source: InterPro receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 575	555	Acetylcholine receptor subunit beta-type acr-2		PRO_0000000398
Regions
	Topological domain	21 – 270	250	Extracellular Potential
	Transmembrane	271 – 291	21	Helical; Potential
	Transmembrane	299 – 319	21	Helical; Potential
	Transmembrane	331 – 351	21	Helical; Potential
	Topological domain	352 – 527	176	Cytoplasmic Potential
	Transmembrane	528 – 548	21	Helical; Potential
Amino acid modifications
	Glycosylation	41	1	N-linked (GlcNAc...) Potential
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Glycosylation	80	1	N-linked (GlcNAc...) Potential
	Glycosylation	131	1	N-linked (GlcNAc...) Potential
	Disulfide bond	185 ↔ 199		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48182 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 7EB24296100EEB05	FASTA	575	65,595
	10 20 30 40 50 60 MKKTVKILLI LITVFLKVHC NGGHDDEAAD FLSHTNIDDP NNSSDPNKNS DQGDTMGEDE 70 80 90 100 110 120 DRLVIDLFRE YNFLIRPVKN VSSPPVVVDF GVAMILLINV DEKNQILQTN VWLTMKWNDF 130 140 150 160 170 180 QLAWNPAEYG NISNLHVPSD RVWLPDIVLF NNADGNYEVS FKSNVFVDHH GDVTWVPPAM 190 200 210 220 230 240 FKSSCRIDVE WFPFDEQCCT LVFGSWTYNS EEVRLHWYNN IQAVQLHDYS YSGIWDVIDV 250 260 270 280 290 300 PGQLVHKPDL KENKMVFNVV IRRKTLFYTV ILIIPTVLMA FLSVMAFYLP VDSGEKVSLT 310 320 330 340 350 360 ISLLLALVVF LLLVSKILPP TSNIPLMGKY LLLAFVLNIT AVVGTVVIVN IYFRSALSHK 370 380 390 400 410 420 MPTWVRKVFL EFLPHLLVMK RPERIPIFNG YFVEEYCASE IFDASLVMPS MTATMLPFLQ 430 440 450 460 470 480 VTTNLKAASS TSSGQSSEHH ENCSKWKKRL SIRMSKRRAP RARLDDDSED IIDDTNGNHV 490 500 510 520 530 540 DSLQEKISKE MKTTVEAIAY IAEHMKREMS LKKMRDDWKY VAMVLDRLIL LIFFGVTLGG 550 560 570 TLGIICSAPH VFDFVDQEAI ISKLNAKYLP SDMYS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2)." Squire M.D., Tornoe C.A., Baylis H.A., Fleming J.T., Barnard E.A., Sattelle D.B. Recept. Channels 3:107-115(1995) [PubMed: 8581398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X86403 mRNA. Translation: CAA60157.1. FO081325 Genomic DNA. Translation: CCD70794.1.
PIR	S57648.
RefSeq	NP_509128.1. NM_076727.4.
UniGene	Cel.18149.
3D structure databases
ProteinModelPortal	P48182.
SMR	P48182. Positions 57-554.
ModBase	Search...
Protein family/group databases
TCDB	1.A.9.1.2. neurotransmitter receptor, cys loop, ligand-gated ion channel (LIC) family.
Proteomic databases
PRIDE	P48182.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	K11G12.2; K11G12.2; K11G12.2.
GeneID	180936.
KEGG	cel:K11G12.2.
UCSC	K11G12.2. c. elegans.
Organism-specific databases
CTD	180936.
WormBase	K11G12.2; CE07380; WBGene00000042; acr-2.
Phylogenomic databases
eggNOG	meNOG06680.
GeneTree	EMGT00050000005191.
HOGENOM	HBG387619.
InParanoid	P48182.
OMA	ENCSKWK.
PhylomeDB	P48182.
Gene expression databases
ArrayExpress	P48182.
Family and domain databases
InterPro	IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. IPR002394. Nicotinic_acetylcholine_rcpt. [Graphical view]
Gene3D	G3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit.
KO	K05312.
PANTHER	PTHR18945. Neur_channel. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR00254. NICOTINICR. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	911638.

Entry information

Entry name

ACR2_CAEEL

Accession

Primary (citable) accession number: P48182

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project