P48180 (ACH1_CAEEL) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 90.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Acetylcholine receptor subunit alpha-type acr-16 | ||||||
| Gene names |
| ||||||
| Organism | Caenorhabditis elegans | ||||||
| Taxonomic identifier | 6239 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 498 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane By similarity. A subunit of the levamisole-insensitive nicotinic receptor. Ref.1 Ref.4 |
| Subcellular location | Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note: The cam-1 protein is required for correct localization. Ref.5 |
| Tissue specificity | Expressed in the body wall muscle. Ref.4 |
| Disruption phenotype | Uncoordinated movement and reduced body wall muscle currents. These phenotypes are probably related. Ref.5 Ref.6 |
| Sequence similarities | Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. [View classification] |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform a (identifier: P48180-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform b (identifier: P48180-2) The sequence of this isoform differs from the canonical sequence as follows: 470-480: VDRLCLYVFTI → RTYISRKIENF | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | ||||||||
| Chain | 20 – 498 | 479 | Acetylcholine receptor subunit alpha-type acr-16 | PRO_0000000395 | |||||||
Regions | |||||||||||
| Topological domain | 20 – 230 | 211 | Extracellular Potential | ||||||||
| Transmembrane | 231 – 252 | 22 | Helical; Potential | ||||||||
| Transmembrane | 261 – 279 | 19 | Helical; Potential | ||||||||
| Transmembrane | 295 – 314 | 20 | Helical; Potential | ||||||||
| Topological domain | 315 – 472 | 158 | Cytoplasmic Potential | ||||||||
| Transmembrane | 473 – 493 | 21 | Helical; Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 43 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 93 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 147 ↔ 161 | By similarity | |||||||||
| Disulfide bond | 211 ↔ 212 | Associated with receptor activation By similarity | |||||||||
Natural variations | |||||||||||
| Alternative sequence | 470 – 480 | 11 | VDRLCLYVFTI → RTYISRKIENF in isoform b. | VSP_036472 | |||||||
Sequences
| ||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans." Ballivet M., Alliod C., Bertrand S., Bertrand D. J. Mol. Biol. 258:261-269(1996) [PubMed: 8627624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION. Strain: Bristol N2. |
| [2] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2. |
| [3] | "The Caenorhabditis elegans transcriptome project, a complementary view of the genome." Kohara Y., Shin-i T., Suzuki Y., Sugano S., Thierry-Mieg D., Thierry-Mieg J. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Strain: Bristol N2. |
| [4] | "acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction." Touroutine D., Fox R.M., Von Stetina S.E., Burdina A., Miller D.M. III, Richmond J.E. J. Biol. Chem. 280:27013-27021(2005) [PubMed: 15917232] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY. |
| [5] | "The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction." Francis M.M., Evans S.P., Jensen M., Madsen D.M., Mancuso J., Norman K.R., Maricq A.V. Neuron 46:581-594(2005) [PubMed: 15944127] [Abstract] Cited for: SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE. |
| [6] | "PKC-1 regulates secretion of neuropeptides." Sieburth D., Madison J.M., Kaplan J.M. Nat. Neurosci. 10:49-57(2007) [PubMed: 17128266] [Abstract] Cited for: DISRUPTION PHENOTYPE. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X83887 mRNA. Translation: CAA58764.1. FO080489 Genomic DNA. Translation: CCD64102.1. FO080489 Genomic DNA. Translation: CCD64103.1. AY523511 mRNA. Translation: AAR98633.1. |
| PIR | S68588. |
| RefSeq | NP_001023847.1. NM_001028676.2. NP_505207.1. NM_072806.3. |
| UniGene | Cel.18045. |
3D structure databases | |
| ProteinModelPortal | P48180. |
| SMR | P48180. Positions 20-493. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P48180. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | F25G6.3a; F25G6.3a; F25G6.3. |
| GeneID | 179235. |
| KEGG | cel:F25G6.3. |
| UCSC | F25G6.3a.1. c. elegans. |
Organism-specific databases | |
| CTD | 179235. |
| WormBase | F25G6.3a; CE09639; WBGene00000055; acr-16. F25G6.3b; CE32878; WBGene00000055; acr-16. |
Phylogenomic databases | |
| eggNOG | meNOG06474. |
| GeneTree | EMGT00050000005191. |
| HOGENOM | HBG387619. |
| InParanoid | P48180. |
| OMA | MISSANG. |
| PhylomeDB | P48180. |
Gene expression databases | |
| ArrayExpress | P48180. |
Family and domain databases | |
| InterPro | IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. IPR002394. Nicotinic_acetylcholine_rcpt. [Graphical view] |
| Gene3D | G3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit. |
| KO | K05312. |
| PANTHER | PTHR18945. Neur_channel. 1 hit. |
| Pfam | PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view] |
| PRINTS | PR00254. NICOTINICR. PR00252. NRIONCHANNEL. |
| SUPFAM | SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit. |
| TIGRFAMs | TIGR00860. LIC. 1 hit. |
| PROSITE | PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 904496. |
Entry information
| Entry name | ACH1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: P48180 Secondary accession number(s): Q8I932 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

Clusters with