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P48172

- COX3_ONCMY

UniProt

P48172 - COX3_ONCMY

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Protein
Cytochrome c oxidase subunit 3
Gene
mt-co3, coiii, coxiii, mtco3
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt-co3
Synonyms:coiii, coxiii, mtco3
Encoded oniMitochondrion
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Transmembranei32 – 5221Helical; Reviewed prediction
Add
BLAST
Transmembranei81 – 10121Helical; Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183818Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP48172.
SMRiP48172. Positions 1-261.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016686.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48172-1 [UniParc]FASTAAdd to Basket

« Hide

MAHQAHAYHM VDPSPWPLTG AIAALLLTSG TAVWFHFHSL TLLTLGNILL    50
LLTMYQWWRD IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA 100
FYHASLAPTP ELGGCWPPAG ITTLDPFEVP LLNTAVLLAS GVTVTWAHHS 150
IMEGERKQTI QALTLTILLG FYFTFLQGME YYEAPFTIAD GVYGSTFFVA 200
TGFHGLHVII GSTFLAVCLL RQVQYHFTSE HHFGFEAAAW YWHFVDVVWL 250
FLYVSIYWWG S 261
Length:261
Mass (Da):29,675
Last modified:February 1, 1996 - v1
Checksum:iAD4F7AA21255D96E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29771 Genomic DNA. Translation: AAB03353.1.
PIRiG34012.
RefSeqiNP_008296.1. NC_001717.1.

Genome annotation databases

GeneIDi807973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29771 Genomic DNA. Translation: AAB03353.1 .
PIRi G34012.
RefSeqi NP_008296.1. NC_001717.1.

3D structure databases

ProteinModelPortali P48172.
SMRi P48172. Positions 1-261.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807973.

Organism-specific databases

CTDi 4514.

Phylogenomic databases

HOVERGENi HBG016686.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of the mitochondrial DNA genome of the rainbow trout, Oncorhynchus mykiss."
    Zardoya R., Garrido-Pertierra A., Bautista J.M.
    J. Mol. Evol. 41:942-951(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Variation in salmonid mitochondrial DNA: evolutionary constraints and mechanisms of substitution."
    Thomas W.K., Beckenbach A.T.
    J. Mol. Evol. 29:233-245(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiCOX3_ONCMY
AccessioniPrimary (citable) accession number: P48172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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