P48147Q8N6D4PPCE_HUMANProlyl endopeptidasePE3.4.21.26Post-proline cleaving enzymePREPPEPHomo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoCloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase.NUCLEOTIDE SEQUENCE [MRNA]Molecular cloning and characterization of prolyl endopeptidase from human T cells.NUCLEOTIDE SEQUENCE [MRNA]VARIANT ILE-706cDNA cloning and recombinant expression of human brain prolyl oligopeptidase.NUCLEOTIDE SEQUENCE [MRNA]The DNA sequence and analysis of human chromosome 6.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family.PROTEIN SEQUENCE OF 136-149SUBUNITCHARACTERIZATIONLysine acetylation targets protein complexes and co-regulates major cellular functions.ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-157IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Initial characterization of the human central proteome.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP).X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 2-710 IN COMPLEX WITH INHIBITORCleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.Monomer.P48147P04406false5CytoplasmThe N-terminus is blocked.Belongs to the peptidase S9A family.3D-structureAcetylationCytoplasmDirect protein sequencingHydrolaseProteaseReference proteomeSerine proteaseLVVILFVIRCTARWILGSMLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
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