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Protein

Neuropeptides B/W receptor type 1

Gene

NPBWR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

GO - Molecular functioni

  • neuropeptide binding Source: GO_Central
  • neuropeptide receptor activity Source: InterPro
  • opioid receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptides B/W receptor type 1
Alternative name(s):
G-protein coupled receptor 7
Gene namesi
Name:NPBWR1
Synonyms:GPR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000183729.3.
HGNCiHGNC:4522. NPBWR1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 61Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini62 – 72CytoplasmicSequence analysisAdd BLAST11
Transmembranei73 – 97Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini98 – 112ExtracellularSequence analysisAdd BLAST15
Transmembranei113 – 132Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini133 – 157CytoplasmicSequence analysisAdd BLAST25
Transmembranei158 – 177Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini178 – 202ExtracellularSequence analysisAdd BLAST25
Transmembranei203 – 224Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini225 – 248CytoplasmicSequence analysisAdd BLAST24
Transmembranei249 – 273Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini274 – 283ExtracellularSequence analysis10
Transmembranei284 – 298Helical; Name=7Sequence analysisAdd BLAST15
Topological domaini299 – 328CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2831.
OpenTargetsiENSG00000183729.
PharmGKBiPA28912.

Chemistry databases

ChEMBLiCHEMBL1293293.
GuidetoPHARMACOLOGYi303.

Polymorphism and mutation databases

BioMutaiNPBWR1.
DMDMi215274092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695181 – 328Neuropeptides B/W receptor type 1Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48145.
PeptideAtlasiP48145.
PRIDEiP48145.

PTM databases

PhosphoSitePlusiP48145.

Expressioni

Tissue specificityi

Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.1 Publication

Gene expression databases

BgeeiENSG00000183729.
CleanExiHS_NPBWR1.
ExpressionAtlasiP48145. baseline and differential.
GenevisibleiP48145. HS.

Interactioni

Protein-protein interaction databases

BioGridi109092. 2 interactors.
IntActiP48145. 1 interactor.
STRINGi9606.ENSP00000330284.

Chemistry databases

BindingDBiP48145.

Structurei

3D structure databases

ProteinModelPortaliP48145.
SMRiP48145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP48145.
KOiK05268.
OMAiSIDQYNT.
OrthoDBiEOG091G0HEN.
PhylomeDBiP48145.
TreeFamiTF315737.

Family and domain databases

CDDicd15087. 7tmA_NPBWR. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027348. NPBW1.
PANTHERiPTHR24229:SF49. PTHR24229:SF49. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P48145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNASFSEPW PANASGPDPA LSCSNASTLA PLPAPLAVAV PVVYAVICAV
60 70 80 90 100
GLAGNSAVLY VLLRAPRMKT VTNLFILNLA IADELFTLVL PINIADFLLR
110 120 130 140 150
QWPFGELMCK LIVAIDQYNT FSSLYFLTVM SADRYLVVLA TAESRRVAGR
160 170 180 190 200
TYSAARAVSL AVWGIVTLVV LPFAVFARLD DEQGRRQCVL VFPQPEAFWW
210 220 230 240 250
RASRLYTLVL GFAIPVSTIC VLYTTLLCRL HAMRLDSHAK ALERAKKRVT
260 270 280 290 300
FLVVAILAVC LLCWTPYHLS TVVALTTDLP QTPLVIAISY FITSLSYANS
310 320
CLNPFLYAFL DASFRRNLRQ LITCRAAA
Length:328
Mass (Da):36,103
Last modified:November 25, 2008 - v2
Checksum:i7A90F85AD64A3980
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296S → T in AAC50197 (PubMed:7590751).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03576519P → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_047788135Y → F. Corresponds to variant dbSNP:rs33977775Ensembl.1
Natural variantiVAR_047789319R → C. Corresponds to variant dbSNP:rs36068168Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22491 Genomic DNA. Translation: AAC50197.1.
CH471068 Genomic DNA. Translation: EAW86722.1.
BC069117 mRNA. Translation: AAH69117.1.
BC107101 mRNA. Translation: AAI07102.1.
CCDSiCCDS6151.1.
PIRiI38973.
RefSeqiNP_005276.2. NM_005285.3.
UniGeneiHs.248117.

Genome annotation databases

EnsembliENST00000331251; ENSP00000330284; ENSG00000183729.
GeneIDi2831.
KEGGihsa:2831.
UCSCiuc011ldu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNPBW1_HUMAN
AccessioniPrimary (citable) accession number: P48145
Secondary accession number(s): Q6NTC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 25, 2008
Last modified: September 27, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families