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P48145 (NPBW1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropeptides B/W receptor type 1
Alternative name(s):
G-protein coupled receptor 7
Gene names
Name:NPBWR1
Synonyms:GPR7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma. Ref.4

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328Neuropeptides B/W receptor type 1
PRO_0000069518

Regions

Topological domain1 – 3737Extracellular Potential
Transmembrane38 – 6124Helical; Name=1; Potential
Topological domain62 – 7211Cytoplasmic Potential
Transmembrane73 – 9725Helical; Name=2; Potential
Topological domain98 – 11215Extracellular Potential
Transmembrane113 – 13220Helical; Name=3; Potential
Topological domain133 – 15725Cytoplasmic Potential
Transmembrane158 – 17720Helical; Name=4; Potential
Topological domain178 – 20225Extracellular Potential
Transmembrane203 – 22422Helical; Name=5; Potential
Topological domain225 – 24824Cytoplasmic Potential
Transmembrane249 – 27325Helical; Name=6; Potential
Topological domain274 – 28310Extracellular Potential
Transmembrane284 – 29815Helical; Name=7; Potential
Topological domain299 – 32830Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation131N-linked (GlcNAc...) Potential
Glycosylation251N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 188 By similarity

Natural variations

Natural variant191P → Q in a breast cancer sample; somatic mutation. Ref.6
VAR_035765
Natural variant1351Y → F.
Corresponds to variant rs33977775 [ dbSNP | Ensembl ].
VAR_047788
Natural variant3191R → C.
Corresponds to variant rs36068168 [ dbSNP | Ensembl ].
VAR_047789

Experimental info

Sequence conflict2961S → T in AAC50197. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P48145 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 7A90F85AD64A3980

FASTA32836,103
        10         20         30         40         50         60 
MDNASFSEPW PANASGPDPA LSCSNASTLA PLPAPLAVAV PVVYAVICAV GLAGNSAVLY 

        70         80         90        100        110        120 
VLLRAPRMKT VTNLFILNLA IADELFTLVL PINIADFLLR QWPFGELMCK LIVAIDQYNT 

       130        140        150        160        170        180 
FSSLYFLTVM SADRYLVVLA TAESRRVAGR TYSAARAVSL AVWGIVTLVV LPFAVFARLD 

       190        200        210        220        230        240 
DEQGRRQCVL VFPQPEAFWW RASRLYTLVL GFAIPVSTIC VLYTTLLCRL HAMRLDSHAK 

       250        260        270        280        290        300 
ALERAKKRVT FLVVAILAVC LLCWTPYHLS TVVALTTDLP QTPLVIAISY FITSLSYANS 

       310        320 
CLNPFLYAFL DASFRRNLRQ LITCRAAA 

« Hide

References

« Hide 'large scale' references
[1]"The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain."
O'Dowd B.F., Scheideler M.A., Nguyen T., Cheng R., Rasmussen J.S., Marchese A., Zastawny R., Heng H.H.Q., Tsui L.-C., Shi X., Asa S., Puy L., George S.R.
Genomics 28:84-91(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8."
Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V., Lucchetti J., Detheux M., Parmentier M.
J. Biol. Chem. 278:776-783(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH NEUROPEPTIDES B AND W.
[5]"Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8."
Tanaka H., Yoshida T., Miyamoto N., Motoike T., Kurosu H., Shibata K., Yamanaka A., Williams S.C., Richardson J.A., Tsujino N., Garry M.G., Lerner M.R., King D.S., O'Dowd B.F., Sakurai T., Yanagisawa M.
Proc. Natl. Acad. Sci. U.S.A. 100:6251-6256(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NEUROPEPTIDES B AND W.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-19.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U22491 Genomic DNA. Translation: AAC50197.1.
CH471068 Genomic DNA. Translation: EAW86722.1.
BC069117 mRNA. Translation: AAH69117.1.
BC107101 mRNA. Translation: AAI07102.1.
CCDSCCDS6151.1.
PIRI38973.
RefSeqNP_005276.2. NM_005285.3.
UniGeneHs.248117.

3D structure databases

ProteinModelPortalP48145.
SMRP48145. Positions 25-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109092. 2 interactions.
STRING9606.ENSP00000330284.

Chemistry

BindingDBP48145.
ChEMBLCHEMBL1293293.
GuidetoPHARMACOLOGY303.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM215274092.

Proteomic databases

PRIDEP48145.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331251; ENSP00000330284; ENSG00000183729.
GeneID2831.
KEGGhsa:2831.
UCSCuc011ldu.2. human.

Organism-specific databases

CTD2831.
GeneCardsGC08P053850.
H-InvDBHIX0034348.
HGNCHGNC:4522. NPBWR1.
MIM600730. gene.
neXtProtNX_P48145.
PharmGKBPA28912.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG283184.
HOGENOMHOG000230485.
HOVERGENHBG106919.
InParanoidP48145.
KOK05268.
OMALGCPNAS.
OrthoDBEOG7BKCVQ.
PhylomeDBP48145.
TreeFamTF315737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP48145.
BgeeP48145.
CleanExHS_NPBWR1.
GenevestigatorP48145.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027348. NPBW1.
[Graphical view]
PANTHERPTHR24229:SF29. PTHR24229:SF29. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNeuropeptides_B/W_receptor_1.
GenomeRNAi2831.
NextBio11173.
PROP48145.
SOURCESearch...

Entry information

Entry nameNPBW1_HUMAN
AccessionPrimary (citable) accession number: P48145
Secondary accession number(s): Q6NTC7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries