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P48145

- NPBW1_HUMAN

UniProt

P48145 - NPBW1_HUMAN

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Protein

Neuropeptides B/W receptor type 1

Gene
NPBWR1, GPR7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

GO - Molecular functioni

  1. neuropeptide receptor activity Source: InterPro
  2. opioid receptor activity Source: ProtInc
  3. protein binding Source: HGNC

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: HGNC
  2. opioid receptor signaling pathway Source: GOC
  3. regulation of metabolic process Source: Ensembl
  4. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptides B/W receptor type 1
Alternative name(s):
G-protein coupled receptor 7
Gene namesi
Name:NPBWR1
Synonyms:GPR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:4522. NPBWR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737Extracellular Reviewed predictionAdd
BLAST
Transmembranei38 – 6124Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini62 – 7211Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei73 – 9725Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini98 – 11215Extracellular Reviewed predictionAdd
BLAST
Transmembranei113 – 13220Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini133 – 15725Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei158 – 17720Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini178 – 20225Extracellular Reviewed predictionAdd
BLAST
Transmembranei203 – 22422Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini225 – 24824Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei249 – 27325Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini274 – 28310Extracellular Reviewed prediction
Transmembranei284 – 29815Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini299 – 32830Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: HGNC
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Neuropeptides B/W receptor type 1PRO_0000069518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13 – 131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi25 – 251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi109 ↔ 188 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP48145.

Expressioni

Tissue specificityi

Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.1 Publication

Gene expression databases

ArrayExpressiP48145.
BgeeiP48145.
CleanExiHS_NPBWR1.
GenevestigatoriP48145.

Interactioni

Protein-protein interaction databases

BioGridi109092. 2 interactions.
STRINGi9606.ENSP00000330284.

Structurei

3D structure databases

ProteinModelPortaliP48145.
SMRiP48145. Positions 25-325.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283184.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP48145.
KOiK05268.
OMAiLGCPNAS.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP48145.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027348. NPBW1.
[Graphical view]
PANTHERiPTHR24229:SF29. PTHR24229:SF29. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48145-1 [UniParc]FASTAAdd to Basket

« Hide

MDNASFSEPW PANASGPDPA LSCSNASTLA PLPAPLAVAV PVVYAVICAV    50
GLAGNSAVLY VLLRAPRMKT VTNLFILNLA IADELFTLVL PINIADFLLR 100
QWPFGELMCK LIVAIDQYNT FSSLYFLTVM SADRYLVVLA TAESRRVAGR 150
TYSAARAVSL AVWGIVTLVV LPFAVFARLD DEQGRRQCVL VFPQPEAFWW 200
RASRLYTLVL GFAIPVSTIC VLYTTLLCRL HAMRLDSHAK ALERAKKRVT 250
FLVVAILAVC LLCWTPYHLS TVVALTTDLP QTPLVIAISY FITSLSYANS 300
CLNPFLYAFL DASFRRNLRQ LITCRAAA 328
Length:328
Mass (Da):36,103
Last modified:November 25, 2008 - v2
Checksum:i7A90F85AD64A3980
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191P → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_035765
Natural varianti135 – 1351Y → F.
Corresponds to variant rs33977775 [ dbSNP | Ensembl ].
VAR_047788
Natural varianti319 – 3191R → C.
Corresponds to variant rs36068168 [ dbSNP | Ensembl ].
VAR_047789

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti296 – 2961S → T in AAC50197. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22491 Genomic DNA. Translation: AAC50197.1.
CH471068 Genomic DNA. Translation: EAW86722.1.
BC069117 mRNA. Translation: AAH69117.1.
BC107101 mRNA. Translation: AAI07102.1.
CCDSiCCDS6151.1.
PIRiI38973.
RefSeqiNP_005276.2. NM_005285.3.
UniGeneiHs.248117.

Genome annotation databases

EnsembliENST00000331251; ENSP00000330284; ENSG00000183729.
GeneIDi2831.
KEGGihsa:2831.
UCSCiuc011ldu.2. human.

Polymorphism databases

DMDMi215274092.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22491 Genomic DNA. Translation: AAC50197.1 .
CH471068 Genomic DNA. Translation: EAW86722.1 .
BC069117 mRNA. Translation: AAH69117.1 .
BC107101 mRNA. Translation: AAI07102.1 .
CCDSi CCDS6151.1.
PIRi I38973.
RefSeqi NP_005276.2. NM_005285.3.
UniGenei Hs.248117.

3D structure databases

ProteinModelPortali P48145.
SMRi P48145. Positions 25-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109092. 2 interactions.
STRINGi 9606.ENSP00000330284.

Chemistry

BindingDBi P48145.
ChEMBLi CHEMBL1293293.
GuidetoPHARMACOLOGYi 303.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 215274092.

Proteomic databases

PRIDEi P48145.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331251 ; ENSP00000330284 ; ENSG00000183729 .
GeneIDi 2831.
KEGGi hsa:2831.
UCSCi uc011ldu.2. human.

Organism-specific databases

CTDi 2831.
GeneCardsi GC08P053850.
H-InvDB HIX0034348.
HGNCi HGNC:4522. NPBWR1.
MIMi 600730. gene.
neXtProti NX_P48145.
PharmGKBi PA28912.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283184.
HOGENOMi HOG000230485.
HOVERGENi HBG106919.
InParanoidi P48145.
KOi K05268.
OMAi LGCPNAS.
OrthoDBi EOG7BKCVQ.
PhylomeDBi P48145.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Neuropeptides_B/W_receptor_1.
GenomeRNAii 2831.
NextBioi 11173.
PROi P48145.
SOURCEi Search...

Gene expression databases

ArrayExpressi P48145.
Bgeei P48145.
CleanExi HS_NPBWR1.
Genevestigatori P48145.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027348. NPBW1.
[Graphical view ]
PANTHERi PTHR24229:SF29. PTHR24229:SF29. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain."
    O'Dowd B.F., Scheideler M.A., Nguyen T., Cheng R., Rasmussen J.S., Marchese A., Zastawny R., Heng H.H.Q., Tsui L.-C., Shi X., Asa S., Puy L., George S.R.
    Genomics 28:84-91(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8."
    Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V., Lucchetti J., Detheux M., Parmentier M.
    J. Biol. Chem. 278:776-783(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH NEUROPEPTIDES B AND W.
  5. Cited for: INTERACTION WITH NEUROPEPTIDES B AND W.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-19.

Entry informationi

Entry nameiNPBW1_HUMAN
AccessioniPrimary (citable) accession number: P48145
Secondary accession number(s): Q6NTC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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