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P48145

- NPBW1_HUMAN

UniProt

P48145 - NPBW1_HUMAN

Protein

Neuropeptides B/W receptor type 1

Gene

NPBWR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

    GO - Molecular functioni

    1. neuropeptide receptor activity Source: InterPro
    2. opioid receptor activity Source: ProtInc
    3. protein binding Source: HGNC

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: HGNC
    2. opioid receptor signaling pathway Source: GOC
    3. regulation of metabolic process Source: Ensembl
    4. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropeptides B/W receptor type 1
    Alternative name(s):
    G-protein coupled receptor 7
    Gene namesi
    Name:NPBWR1
    Synonyms:GPR7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:4522. NPBWR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: HGNC
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28912.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Neuropeptides B/W receptor type 1PRO_0000069518Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi109 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP48145.

    Expressioni

    Tissue specificityi

    Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.1 Publication

    Gene expression databases

    ArrayExpressiP48145.
    BgeeiP48145.
    CleanExiHS_NPBWR1.
    GenevestigatoriP48145.

    Interactioni

    Protein-protein interaction databases

    BioGridi109092. 2 interactions.
    STRINGi9606.ENSP00000330284.

    Structurei

    3D structure databases

    ProteinModelPortaliP48145.
    SMRiP48145. Positions 25-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini62 – 7211CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 11215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini133 – 15725CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 20225ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 24824CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28310ExtracellularSequence Analysis
    Topological domaini299 – 32830CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 6124Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei73 – 9725Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13220Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17720Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22422Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei249 – 27325Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 29815Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283184.
    HOGENOMiHOG000230485.
    HOVERGENiHBG106919.
    InParanoidiP48145.
    KOiK05268.
    OMAiLGCPNAS.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiP48145.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR009150. Neuropept_B/W_rcpt.
    IPR027348. NPBW1.
    [Graphical view]
    PANTHERiPTHR24229:SF29. PTHR24229:SF29. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01855. NRPEPTIDEWR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48145-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNASFSEPW PANASGPDPA LSCSNASTLA PLPAPLAVAV PVVYAVICAV    50
    GLAGNSAVLY VLLRAPRMKT VTNLFILNLA IADELFTLVL PINIADFLLR 100
    QWPFGELMCK LIVAIDQYNT FSSLYFLTVM SADRYLVVLA TAESRRVAGR 150
    TYSAARAVSL AVWGIVTLVV LPFAVFARLD DEQGRRQCVL VFPQPEAFWW 200
    RASRLYTLVL GFAIPVSTIC VLYTTLLCRL HAMRLDSHAK ALERAKKRVT 250
    FLVVAILAVC LLCWTPYHLS TVVALTTDLP QTPLVIAISY FITSLSYANS 300
    CLNPFLYAFL DASFRRNLRQ LITCRAAA 328
    Length:328
    Mass (Da):36,103
    Last modified:November 25, 2008 - v2
    Checksum:i7A90F85AD64A3980
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti296 – 2961S → T in AAC50197. (PubMed:7590751)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191P → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035765
    Natural varianti135 – 1351Y → F.
    Corresponds to variant rs33977775 [ dbSNP | Ensembl ].
    VAR_047788
    Natural varianti319 – 3191R → C.
    Corresponds to variant rs36068168 [ dbSNP | Ensembl ].
    VAR_047789

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22491 Genomic DNA. Translation: AAC50197.1.
    CH471068 Genomic DNA. Translation: EAW86722.1.
    BC069117 mRNA. Translation: AAH69117.1.
    BC107101 mRNA. Translation: AAI07102.1.
    CCDSiCCDS6151.1.
    PIRiI38973.
    RefSeqiNP_005276.2. NM_005285.3.
    UniGeneiHs.248117.

    Genome annotation databases

    EnsembliENST00000331251; ENSP00000330284; ENSG00000183729.
    GeneIDi2831.
    KEGGihsa:2831.
    UCSCiuc011ldu.2. human.

    Polymorphism databases

    DMDMi215274092.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22491 Genomic DNA. Translation: AAC50197.1 .
    CH471068 Genomic DNA. Translation: EAW86722.1 .
    BC069117 mRNA. Translation: AAH69117.1 .
    BC107101 mRNA. Translation: AAI07102.1 .
    CCDSi CCDS6151.1.
    PIRi I38973.
    RefSeqi NP_005276.2. NM_005285.3.
    UniGenei Hs.248117.

    3D structure databases

    ProteinModelPortali P48145.
    SMRi P48145. Positions 25-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109092. 2 interactions.
    STRINGi 9606.ENSP00000330284.

    Chemistry

    BindingDBi P48145.
    ChEMBLi CHEMBL1293293.
    GuidetoPHARMACOLOGYi 303.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 215274092.

    Proteomic databases

    PRIDEi P48145.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331251 ; ENSP00000330284 ; ENSG00000183729 .
    GeneIDi 2831.
    KEGGi hsa:2831.
    UCSCi uc011ldu.2. human.

    Organism-specific databases

    CTDi 2831.
    GeneCardsi GC08P053850.
    H-InvDB HIX0034348.
    HGNCi HGNC:4522. NPBWR1.
    MIMi 600730. gene.
    neXtProti NX_P48145.
    PharmGKBi PA28912.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283184.
    HOGENOMi HOG000230485.
    HOVERGENi HBG106919.
    InParanoidi P48145.
    KOi K05268.
    OMAi LGCPNAS.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi P48145.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Neuropeptides_B/W_receptor_1.
    GenomeRNAii 2831.
    NextBioi 11173.
    PROi P48145.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48145.
    Bgeei P48145.
    CleanExi HS_NPBWR1.
    Genevestigatori P48145.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR009150. Neuropept_B/W_rcpt.
    IPR027348. NPBW1.
    [Graphical view ]
    PANTHERi PTHR24229:SF29. PTHR24229:SF29. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01855. NRPEPTIDEWR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain."
      O'Dowd B.F., Scheideler M.A., Nguyen T., Cheng R., Rasmussen J.S., Marchese A., Zastawny R., Heng H.H.Q., Tsui L.-C., Shi X., Asa S., Puy L., George S.R.
      Genomics 28:84-91(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8."
      Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V., Lucchetti J., Detheux M., Parmentier M.
      J. Biol. Chem. 278:776-783(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INTERACTION WITH NEUROPEPTIDES B AND W.
    5. Cited for: INTERACTION WITH NEUROPEPTIDES B AND W.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-19.

    Entry informationi

    Entry nameiNPBW1_HUMAN
    AccessioniPrimary (citable) accession number: P48145
    Secondary accession number(s): Q6NTC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3