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Protein

VIP peptides

Gene

VIP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHI also causes vasodilation.

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: AgBase
  • epinephrine secretion Source: AgBase
  • gene expression Source: AgBase
  • mRNA stabilization Source: AgBase
  • positive regulation of epinephrine secretion Source: AgBase
  • positive regulation of gene expression Source: AgBase
  • positive regulation of peptide hormone secretion Source: AgBase
  • prolactin secretion Source: AgBase

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-GGA-418555 G alpha (s) signalling events
R-GGA-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
VIP peptides
Cleaved into the following 2 chains:
Alternative name(s):
Vasoactive intestinal polypeptide
Gene namesi
Name:VIP
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000001147626 – 87Add BLAST62
PeptideiPRO_000001147789 – 115Intestinal peptide PHI-27-likeAdd BLAST27
PropeptideiPRO_0000011478119 – 1268
PeptideiPRO_0000011479129 – 156Vasoactive intestinal peptideAdd BLAST28
PropeptideiPRO_0000011480160 – 200Add BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei156Threonine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP48143

Miscellaneous databases

PMAP-CutDBiP48143

Expressioni

Gene expression databases

BgeeiENSGALG00000013604
ExpressionAtlasiP48143 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022093

Structurei

3D structure databases

SMRiP48143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW68 Eukaryota
ENOG4111JKK LUCA
GeneTreeiENSGT00530000063592
HOGENOMiHOG000253943
HOVERGENiHBG018069
InParanoidiP48143
KOiK05264
PhylomeDBiP48143

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
IPR015523 VIP
PANTHERiPTHR11213:SF5 PTHR11213:SF5, 1 hit
PfamiView protein in Pfam
PF00123 Hormone_2, 2 hits
SMARTiView protein in SMART
SM00070 GLUCA, 2 hits
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P48143-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHRGASPLL LALALLSALC WRARALPPRG AAFPAVPRLG NRLPFDAASE
60 70 80 90 100
SDRAHGSLKS ESDILQNTLP ENEKFYFDLS RIIDRNARHA DGIFTSVYSH
110 120 130 140 150
LLAKLAVKRY LHSLIRKRVS SQDSPVKRHS DAVFTDNYSR FRKQMAVKKY
160 170 180 190 200
LNSVLTGKRS QEELNPAKLR GEAEILEPSF SENYDDVSVD ELLSHLPLDL
Length:200
Mass (Da):22,540
Last modified:February 1, 1996 - v1
Checksum:i902A88F998CAB402
GO
Isoform Short (identifier: P48143-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-119: Missing.

Show »
Length:165
Mass (Da):18,467
Checksum:i0DEC8BB4BFF27393
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00175885 – 119Missing in isoform Short. CuratedAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09350 mRNA Translation: AAA87896.1
X80906 mRNA Translation: CAA56867.1
PIRiS47470 VRCH
RefSeqiNP_001170780.1, NM_001177309.1 [P48143-2]
UniGeneiGga.666

Genome annotation databases

EnsembliENSGALT00000022132; ENSGALP00000022093; ENSGALG00000013604 [P48143-2]
GeneIDi396323
KEGGigga:396323

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVIP_CHICK
AccessioniPrimary (citable) accession number: P48143
Secondary accession number(s): P01285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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