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Protein

VIP peptides

Gene

VIP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHI also causes vasodilation.

GO - Biological processi

  • epinephrine secretion Source: AgBase
  • gene expression Source: AgBase
  • mRNA stabilization Source: AgBase
  • positive regulation of cAMP biosynthetic process Source: AgBase
  • positive regulation of epinephrine secretion Source: AgBase
  • positive regulation of gene expression Source: AgBase
  • positive regulation of peptide hormone secretion Source: AgBase
  • prolactin secretion Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-GGA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
VIP peptides
Cleaved into the following 2 chains:
Alternative name(s):
Vasoactive intestinal polypeptide
Gene namesi
Name:VIP
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • extracellular space Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000001147626 – 87Add BLAST62
PeptideiPRO_000001147789 – 115Intestinal peptide PHI-27-likeAdd BLAST27
PropeptideiPRO_0000011478119 – 1268
PeptideiPRO_0000011479129 – 156Vasoactive intestinal peptideAdd BLAST28
PropeptideiPRO_0000011480160 – 200Add BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei156Threonine amide1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP48143.

Miscellaneous databases

PMAP-CutDBP48143.

Expressioni

Gene expression databases

BgeeiENSGALG00000013604.
ExpressionAtlasiP48143. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022093.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW68. Eukaryota.
ENOG4111JKK. LUCA.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP48143.
KOiK05264.
PhylomeDBiP48143.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P48143-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHRGASPLL LALALLSALC WRARALPPRG AAFPAVPRLG NRLPFDAASE
60 70 80 90 100
SDRAHGSLKS ESDILQNTLP ENEKFYFDLS RIIDRNARHA DGIFTSVYSH
110 120 130 140 150
LLAKLAVKRY LHSLIRKRVS SQDSPVKRHS DAVFTDNYSR FRKQMAVKKY
160 170 180 190 200
LNSVLTGKRS QEELNPAKLR GEAEILEPSF SENYDDVSVD ELLSHLPLDL
Length:200
Mass (Da):22,540
Last modified:February 1, 1996 - v1
Checksum:i902A88F998CAB402
GO
Isoform Short (identifier: P48143-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-119: Missing.

Show »
Length:165
Mass (Da):18,467
Checksum:i0DEC8BB4BFF27393
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00175885 – 119Missing in isoform Short. CuratedAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09350 mRNA. Translation: AAA87896.1.
X80906 mRNA. Translation: CAA56867.1.
PIRiS47470. VRCH.
RefSeqiNP_001170780.1. NM_001177309.1. [P48143-2]
UniGeneiGga.666.

Genome annotation databases

EnsembliENSGALT00000022132; ENSGALP00000022093; ENSGALG00000013604. [P48143-2]
GeneIDi396323.
KEGGigga:396323.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09350 mRNA. Translation: AAA87896.1.
X80906 mRNA. Translation: CAA56867.1.
PIRiS47470. VRCH.
RefSeqiNP_001170780.1. NM_001177309.1. [P48143-2]
UniGeneiGga.666.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022093.

Proteomic databases

PaxDbiP48143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000022132; ENSGALP00000022093; ENSGALG00000013604. [P48143-2]
GeneIDi396323.
KEGGigga:396323.

Organism-specific databases

CTDi7432.

Phylogenomic databases

eggNOGiENOG410IW68. Eukaryota.
ENOG4111JKK. LUCA.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP48143.
KOiK05264.
PhylomeDBiP48143.

Enzyme and pathway databases

ReactomeiR-GGA-418555. G alpha (s) signalling events.

Miscellaneous databases

PMAP-CutDBP48143.
PROiP48143.

Gene expression databases

BgeeiENSGALG00000013604.
ExpressionAtlasiP48143. baseline and differential.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIP_CHICK
AccessioniPrimary (citable) accession number: P48143
Secondary accession number(s): P01285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.