Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P48067 (SC6A9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium- and chloride-dependent glycine transporter 1

Short name=GlyT-1
Short name=GlyT1
Alternative name(s):
Solute carrier family 6 member 9
Gene names
Name:SLC6A9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length706 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily. [View classification]

Sequence caution

The sequence AAB30784.1 differs from that shown. Reason: Frameshift at position 8.

The sequence AAB30785.1 differs from that shown. Reason: Frameshift at position 8.

The sequence CAI19428.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAI19429.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform GlyT-1C (identifier: P48067-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform GlyT-1A (identifier: P48067-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MSGGDTRAAI...MAQHSLAMAQ → MVGKGAKGML
Isoform GlyT-1B (identifier: P48067-3)

The sequence of this isoform differs from the canonical sequence as follows:
     29-82: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 706706Sodium- and chloride-dependent glycine transporter 1
PRO_0000214780

Regions

Topological domain1 – 108108Cytoplasmic Potential
Transmembrane109 – 12921Helical; Name=1; Potential
Transmembrane136 – 15621Helical; Name=2; Potential
Transmembrane188 – 20821Helical; Name=3; Potential
Topological domain209 – 28577Extracellular Potential
Transmembrane286 – 30621Helical; Name=4; Potential
Transmembrane315 – 33521Helical; Name=5; Potential
Transmembrane360 – 38021Helical; Name=6; Potential
Transmembrane407 – 42721Helical; Name=7; Potential
Transmembrane450 – 47021Helical; Name=8; Potential
Transmembrane506 – 52621Helical; Name=9; Potential
Transmembrane530 – 55021Helical; Name=10; Potential
Transmembrane570 – 59021Helical; Name=11; Potential
Transmembrane610 – 63021Helical; Name=12; Potential
Topological domain631 – 70676Cytoplasmic Potential

Natural variations

Alternative sequence1 – 8383MSGGD…LAMAQ → MVGKGAKGML in isoform GlyT-1A.
VSP_006270
Alternative sequence29 – 8254Missing in isoform GlyT-1B.
VSP_006271

Experimental info

Sequence conflict3731G → A in AAB30784. Ref.1
Sequence conflict3731G → A in AAB30785. Ref.1
Sequence conflict6821P → S in AAB30784. Ref.1
Sequence conflict6821P → S in AAB30785. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform GlyT-1C [UniParc].

Last modified August 10, 2010. Version 3.
Checksum: 654B208568F843F4

FASTA70678,260
        10         20         30         40         50         60 
MSGGDTRAAI ARPRMAAAHG PVAPSSPEQV TLLPVQRSFF LPPFSGATPS TSLAESVLKV 

        70         80         90        100        110        120 
WHGAYNSGLL PQLMAQHSLA MAQNGAVPSE ATKRDQNLKR GNWGNQIEFV LTSVGYAVGL 

       130        140        150        160        170        180 
GNVWRFPYLC YRNGGGAFMF PYFIMLIFCG IPLFFMELSF GQFASQGCLG VWRISPMFKG 

       190        200        210        220        230        240 
VGYGMMVVST YIGIYYNVVI CIAFYYFFSS MTHVLPWAYC NNPWNTHDCA GVLDASNLTN 

       250        260        270        280        290        300 
GSRPAALPSN LSHLLNHSLQ RTSPSEEYWR LYVLKLSDDI GNFGEVRLPL LGCLGVSWLV 

       310        320        330        340        350        360 
VFLCLIRGVK SSGKVVYFTA TFPYVVLTIL FVRGVTLEGA FDGIMYYLTP QWDKILEAKV 

       370        380        390        400        410        420 
WGDAASQIFY SLGCAWGGLI TMASYNKFHN NCYRDSVIIS ITNCATSVYA GFVIFSILGF 

       430        440        450        460        470        480 
MANHLGVDVS RVADHGPGLA FVAYPEALTL LPISPLWSLL FFFMLILLGL GTQFCLLETL 

       490        500        510        520        530        540 
VTAIVDEVGN EWILQKKTYV TLGVAVAGFL LGIPLTSQAG IYWLLLMDNY AASFSLVVIS 

       550        560        570        580        590        600 
CIMCVAIMYI YGHRNYFQDI QMMLGFPPPL FFQICWRFVS PAIIFFILVF TVIQYQPITY 

       610        620        630        640        650        660 
NHYQYPGWAV AIGFLMALSS VLCIPLYAMF RLCRTDGDTL LQRLKNATKP SRDWGPALLE 

       670        680        690        700 
HRTGRYAPTI APSPEDGFEV QPLHPDKAQI PIVGSNGSSR LQDSRI 

« Hide

Isoform GlyT-1A [UniParc].

Checksum: 7D72C44BC76E80EA
Show »

FASTA63370,583
Isoform GlyT-1B [UniParc].

Checksum: AA1FDD1DF09E7BCA
Show »

FASTA65272,482

References

« Hide 'large scale' references
[1]"Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes."
Kim K.-M., Kingsmore S.F., Han H., Yang-Feng T.L., Godinot N., Seldin M.F., Caron M.G., Giros B.
Mol. Pharmacol. 45:608-617(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS GLYT-1A; GLYT-1B AND GLYT-1C).
Tissue: Brain.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S70609 mRNA. Translation: AAB30784.1. Frameshift.
S70612 mRNA. Translation: AAB30785.1. Frameshift.
AL139220 Genomic DNA. Translation: CAI19428.1. Different initiation.
AL139220 Genomic DNA. Translation: CAI19429.1. Different initiation.
AL139220 Genomic DNA. Translation: CAI19430.1.
CH471059 Genomic DNA. Translation: EAX07056.1.
CH471059 Genomic DNA. Translation: EAX07057.1.
CCDSCCDS30695.1. [P48067-2]
CCDS41316.1. [P48067-3]
CCDS41317.1. [P48067-1]
PIRI57956.
I77912.
RefSeqNP_001020016.1. NM_001024845.2. [P48067-2]
NP_008865.2. NM_006934.3. [P48067-3]
NP_964012.2. NM_201649.3. [P48067-1]
UniGeneHs.442590.

3D structure databases

ProteinModelPortalP48067.
SMRP48067. Positions 99-653.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112427. 2 interactions.
IntActP48067. 1 interaction.
STRING9606.ENSP00000361381.

Chemistry

BindingDBP48067.
ChEMBLCHEMBL2337.
DrugBankDB00145. Glycine.
GuidetoPHARMACOLOGY935.

Protein family/group databases

TCDB2.A.22.2.12. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteP48067.

Polymorphism databases

DMDM302393807.

Proteomic databases

MaxQBP48067.
PRIDEP48067.

Protocols and materials databases

DNASU6536.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357730; ENSP00000350362; ENSG00000196517. [P48067-3]
ENST00000360584; ENSP00000353791; ENSG00000196517. [P48067-1]
ENST00000372310; ENSP00000361384; ENSG00000196517. [P48067-2]
GeneID6536.
KEGGhsa:6536.
UCSCuc001cll.4. human. [P48067-1]
uc001clm.4. human. [P48067-3]
uc001cln.4. human. [P48067-2]

Organism-specific databases

CTD6536.
GeneCardsGC01M044462.
HGNCHGNC:11056. SLC6A9.
HPAHPA013977.
MIM601019. gene.
neXtProtNX_P48067.
PharmGKBPA35916.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0733.
HOVERGENHBG071421.
InParanoidP48067.
KOK05038.
OrthoDBEOG793B71.
PhylomeDBP48067.
TreeFamTF343812.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_20679. Amine compound SLC transporters.

Gene expression databases

ArrayExpressP48067.
BgeeP48067.
CleanExHS_SLC6A9.
GenevestigatorP48067.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR003028. Na/ntran_symport_glycine_GLY1.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR01204. GLY1TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC6A9. human.
GeneWikiGlycine_transporter_1.
GenomeRNAi6536.
NextBio25431.
PROP48067.
SOURCESearch...

Entry information

Entry nameSC6A9_HUMAN
AccessionPrimary (citable) accession number: P48067
Secondary accession number(s): A6NDH1 expand/collapse secondary AC list , A6NII2, A6NNZ8, Q5TAB8, Q5TAB9, Q5TAC0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 10, 2010
Last modified: July 9, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM