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P48067

- SC6A9_HUMAN

UniProt

P48067 - SC6A9_HUMAN

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Protein

Sodium- and chloride-dependent glycine transporter 1

Gene

SLC6A9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.

GO - Molecular functioni

  1. glycine:sodium symporter activity Source: ProtInc
  2. neurotransmitter:sodium symporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: Reactome
  2. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_20506. Na+/Cl- dependent neurotransmitter transporters.

Protein family/group databases

TCDBi2.A.22.2.12. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent glycine transporter 1
Short name:
GlyT-1
Short name:
GlyT1
Alternative name(s):
Solute carrier family 6 member 9
Gene namesi
Name:SLC6A9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11056. SLC6A9.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35916.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Sodium- and chloride-dependent glycine transporter 1PRO_0000214780Add
BLAST

Proteomic databases

MaxQBiP48067.
PRIDEiP48067.

PTM databases

PhosphoSiteiP48067.

Expressioni

Tissue specificityi

Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain.

Gene expression databases

BgeeiP48067.
CleanExiHS_SLC6A9.
ExpressionAtlasiP48067. baseline and differential.
GenevestigatoriP48067.

Organism-specific databases

HPAiHPA013977.

Interactioni

Protein-protein interaction databases

BioGridi112427. 2 interactions.
IntActiP48067. 1 interaction.
STRINGi9606.ENSP00000361381.

Structurei

3D structure databases

ProteinModelPortaliP48067.
SMRiP48067. Positions 99-653.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 108108CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini209 – 28577ExtracellularSequence AnalysisAdd
BLAST
Topological domaini631 – 70676CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei109 – 12921Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei315 – 33521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei360 – 38021Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei407 – 42721Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei450 – 47021Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei506 – 52621Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei530 – 55021Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei570 – 59021Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei610 – 63021Helical; Name=12Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOVERGENiHBG071421.
InParanoidiP48067.
KOiK05038.
OrthoDBiEOG793B71.
PhylomeDBiP48067.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR003028. Na/ntran_symport_glycine_GLY1.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01204. GLY1TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform GlyT-1C (identifier: P48067-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGDTRAAI ARPRMAAAHG PVAPSSPEQV TLLPVQRSFF LPPFSGATPS
60 70 80 90 100
TSLAESVLKV WHGAYNSGLL PQLMAQHSLA MAQNGAVPSE ATKRDQNLKR
110 120 130 140 150
GNWGNQIEFV LTSVGYAVGL GNVWRFPYLC YRNGGGAFMF PYFIMLIFCG
160 170 180 190 200
IPLFFMELSF GQFASQGCLG VWRISPMFKG VGYGMMVVST YIGIYYNVVI
210 220 230 240 250
CIAFYYFFSS MTHVLPWAYC NNPWNTHDCA GVLDASNLTN GSRPAALPSN
260 270 280 290 300
LSHLLNHSLQ RTSPSEEYWR LYVLKLSDDI GNFGEVRLPL LGCLGVSWLV
310 320 330 340 350
VFLCLIRGVK SSGKVVYFTA TFPYVVLTIL FVRGVTLEGA FDGIMYYLTP
360 370 380 390 400
QWDKILEAKV WGDAASQIFY SLGCAWGGLI TMASYNKFHN NCYRDSVIIS
410 420 430 440 450
ITNCATSVYA GFVIFSILGF MANHLGVDVS RVADHGPGLA FVAYPEALTL
460 470 480 490 500
LPISPLWSLL FFFMLILLGL GTQFCLLETL VTAIVDEVGN EWILQKKTYV
510 520 530 540 550
TLGVAVAGFL LGIPLTSQAG IYWLLLMDNY AASFSLVVIS CIMCVAIMYI
560 570 580 590 600
YGHRNYFQDI QMMLGFPPPL FFQICWRFVS PAIIFFILVF TVIQYQPITY
610 620 630 640 650
NHYQYPGWAV AIGFLMALSS VLCIPLYAMF RLCRTDGDTL LQRLKNATKP
660 670 680 690 700
SRDWGPALLE HRTGRYAPTI APSPEDGFEV QPLHPDKAQI PIVGSNGSSR

LQDSRI
Length:706
Mass (Da):78,260
Last modified:August 10, 2010 - v3
Checksum:i654B208568F843F4
GO
Isoform GlyT-1A (identifier: P48067-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MSGGDTRAAI...MAQHSLAMAQ → MVGKGAKGML

Show »
Length:633
Mass (Da):70,583
Checksum:i7D72C44BC76E80EA
GO
Isoform GlyT-1B (identifier: P48067-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-82: Missing.

Show »
Length:652
Mass (Da):72,482
Checksum:iAA1FDD1DF09E7BCA
GO

Sequence cautioni

The sequence AAB30784.1 differs from that shown. Reason: Frameshift at position 8.
The sequence AAB30785.1 differs from that shown. Reason: Frameshift at position 8.
The sequence CAI19428.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAI19429.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti373 – 3731G → A in AAB30784. (PubMed:8183239)Curated
Sequence conflicti373 – 3731G → A in AAB30785. (PubMed:8183239)Curated
Sequence conflicti682 – 6821P → S in AAB30784. (PubMed:8183239)Curated
Sequence conflicti682 – 6821P → S in AAB30785. (PubMed:8183239)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8383MSGGD…LAMAQ → MVGKGAKGML in isoform GlyT-1A. 1 PublicationVSP_006270Add
BLAST
Alternative sequencei29 – 8254Missing in isoform GlyT-1B. 1 PublicationVSP_006271Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S70609 mRNA. Translation: AAB30784.1. Frameshift.
S70612 mRNA. Translation: AAB30785.1. Frameshift.
AL139220 Genomic DNA. Translation: CAI19428.1. Different initiation.
AL139220 Genomic DNA. Translation: CAI19429.1. Different initiation.
AL139220 Genomic DNA. Translation: CAI19430.1.
CH471059 Genomic DNA. Translation: EAX07056.1.
CH471059 Genomic DNA. Translation: EAX07057.1.
CCDSiCCDS30695.1. [P48067-2]
CCDS41316.1. [P48067-3]
CCDS41317.1. [P48067-1]
PIRiI57956.
I77912.
RefSeqiNP_001020016.1. NM_001024845.2. [P48067-2]
NP_008865.2. NM_006934.3. [P48067-3]
NP_964012.2. NM_201649.3. [P48067-1]
UniGeneiHs.442590.

Genome annotation databases

EnsembliENST00000357730; ENSP00000350362; ENSG00000196517. [P48067-3]
ENST00000360584; ENSP00000353791; ENSG00000196517. [P48067-1]
ENST00000372310; ENSP00000361384; ENSG00000196517. [P48067-2]
GeneIDi6536.
KEGGihsa:6536.
UCSCiuc001cll.4. human. [P48067-1]
uc001clm.4. human. [P48067-3]
uc001cln.4. human. [P48067-2]

Polymorphism databases

DMDMi302393807.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S70609 mRNA. Translation: AAB30784.1 . Frameshift.
S70612 mRNA. Translation: AAB30785.1 . Frameshift.
AL139220 Genomic DNA. Translation: CAI19428.1 . Different initiation.
AL139220 Genomic DNA. Translation: CAI19429.1 . Different initiation.
AL139220 Genomic DNA. Translation: CAI19430.1 .
CH471059 Genomic DNA. Translation: EAX07056.1 .
CH471059 Genomic DNA. Translation: EAX07057.1 .
CCDSi CCDS30695.1. [P48067-2 ]
CCDS41316.1. [P48067-3 ]
CCDS41317.1. [P48067-1 ]
PIRi I57956.
I77912.
RefSeqi NP_001020016.1. NM_001024845.2. [P48067-2 ]
NP_008865.2. NM_006934.3. [P48067-3 ]
NP_964012.2. NM_201649.3. [P48067-1 ]
UniGenei Hs.442590.

3D structure databases

ProteinModelPortali P48067.
SMRi P48067. Positions 99-653.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112427. 2 interactions.
IntActi P48067. 1 interaction.
STRINGi 9606.ENSP00000361381.

Chemistry

BindingDBi P48067.
ChEMBLi CHEMBL2337.
DrugBanki DB00145. Glycine.
GuidetoPHARMACOLOGYi 935.

Protein family/group databases

TCDBi 2.A.22.2.12. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSitei P48067.

Polymorphism databases

DMDMi 302393807.

Proteomic databases

MaxQBi P48067.
PRIDEi P48067.

Protocols and materials databases

DNASUi 6536.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357730 ; ENSP00000350362 ; ENSG00000196517 . [P48067-3 ]
ENST00000360584 ; ENSP00000353791 ; ENSG00000196517 . [P48067-1 ]
ENST00000372310 ; ENSP00000361384 ; ENSG00000196517 . [P48067-2 ]
GeneIDi 6536.
KEGGi hsa:6536.
UCSCi uc001cll.4. human. [P48067-1 ]
uc001clm.4. human. [P48067-3 ]
uc001cln.4. human. [P48067-2 ]

Organism-specific databases

CTDi 6536.
GeneCardsi GC01M044462.
HGNCi HGNC:11056. SLC6A9.
HPAi HPA013977.
MIMi 601019. gene.
neXtProti NX_P48067.
PharmGKBi PA35916.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0733.
GeneTreei ENSGT00760000118857.
HOVERGENi HBG071421.
InParanoidi P48067.
KOi K05038.
OrthoDBi EOG793B71.
PhylomeDBi P48067.
TreeFami TF343812.

Enzyme and pathway databases

Reactomei REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

ChiTaRSi SLC6A9. human.
GeneWikii Glycine_transporter_1.
GenomeRNAii 6536.
NextBioi 25431.
PROi P48067.
SOURCEi Search...

Gene expression databases

Bgeei P48067.
CleanExi HS_SLC6A9.
ExpressionAtlasi P48067. baseline and differential.
Genevestigatori P48067.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR003028. Na/ntran_symport_glycine_GLY1.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR01204. GLY1TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes."
    Kim K.-M., Kingsmore S.F., Han H., Yang-Feng T.L., Godinot N., Seldin M.F., Caron M.G., Giros B.
    Mol. Pharmacol. 45:608-617(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS GLYT-1A; GLYT-1B AND GLYT-1C).
    Tissue: Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSC6A9_HUMAN
AccessioniPrimary (citable) accession number: P48067
Secondary accession number(s): A6NDH1
, A6NII2, A6NNZ8, Q5TAB8, Q5TAB9, Q5TAC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3