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P48067

- SC6A9_HUMAN

UniProt

P48067 - SC6A9_HUMAN

Protein

Sodium- and chloride-dependent glycine transporter 1

Gene

SLC6A9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.

    GO - Molecular functioni

    1. glycine:sodium symporter activity Source: ProtInc
    2. neurotransmitter:sodium symporter activity Source: InterPro

    GO - Biological processi

    1. transmembrane transport Source: Reactome
    2. transport Source: ProtInc

    Keywords - Biological processi

    Amino-acid transport, Neurotransmitter transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_20506. Na+/Cl- dependent neurotransmitter transporters.

    Protein family/group databases

    TCDBi2.A.22.2.12. the neurotransmitter:sodium symporter (nss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent glycine transporter 1
    Short name:
    GlyT-1
    Short name:
    GlyT1
    Alternative name(s):
    Solute carrier family 6 member 9
    Gene namesi
    Name:SLC6A9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11056. SLC6A9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35916.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 706706Sodium- and chloride-dependent glycine transporter 1PRO_0000214780Add
    BLAST

    Proteomic databases

    MaxQBiP48067.
    PRIDEiP48067.

    PTM databases

    PhosphoSiteiP48067.

    Expressioni

    Tissue specificityi

    Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain.

    Gene expression databases

    ArrayExpressiP48067.
    BgeeiP48067.
    CleanExiHS_SLC6A9.
    GenevestigatoriP48067.

    Organism-specific databases

    HPAiHPA013977.

    Interactioni

    Protein-protein interaction databases

    BioGridi112427. 2 interactions.
    IntActiP48067. 1 interaction.
    STRINGi9606.ENSP00000361381.

    Structurei

    3D structure databases

    ProteinModelPortaliP48067.
    SMRiP48067. Positions 99-653.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 108108CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini209 – 28577ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini631 – 70676CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei109 – 12921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei360 – 38021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei450 – 47021Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei506 – 52621Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei530 – 55021Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei570 – 59021Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei610 – 63021Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    HOVERGENiHBG071421.
    InParanoidiP48067.
    KOiK05038.
    OrthoDBiEOG793B71.
    PhylomeDBiP48067.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR003028. Na/ntran_symport_glycine_GLY1.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR01204. GLY1TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform GlyT-1C (identifier: P48067-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGGDTRAAI ARPRMAAAHG PVAPSSPEQV TLLPVQRSFF LPPFSGATPS    50
    TSLAESVLKV WHGAYNSGLL PQLMAQHSLA MAQNGAVPSE ATKRDQNLKR 100
    GNWGNQIEFV LTSVGYAVGL GNVWRFPYLC YRNGGGAFMF PYFIMLIFCG 150
    IPLFFMELSF GQFASQGCLG VWRISPMFKG VGYGMMVVST YIGIYYNVVI 200
    CIAFYYFFSS MTHVLPWAYC NNPWNTHDCA GVLDASNLTN GSRPAALPSN 250
    LSHLLNHSLQ RTSPSEEYWR LYVLKLSDDI GNFGEVRLPL LGCLGVSWLV 300
    VFLCLIRGVK SSGKVVYFTA TFPYVVLTIL FVRGVTLEGA FDGIMYYLTP 350
    QWDKILEAKV WGDAASQIFY SLGCAWGGLI TMASYNKFHN NCYRDSVIIS 400
    ITNCATSVYA GFVIFSILGF MANHLGVDVS RVADHGPGLA FVAYPEALTL 450
    LPISPLWSLL FFFMLILLGL GTQFCLLETL VTAIVDEVGN EWILQKKTYV 500
    TLGVAVAGFL LGIPLTSQAG IYWLLLMDNY AASFSLVVIS CIMCVAIMYI 550
    YGHRNYFQDI QMMLGFPPPL FFQICWRFVS PAIIFFILVF TVIQYQPITY 600
    NHYQYPGWAV AIGFLMALSS VLCIPLYAMF RLCRTDGDTL LQRLKNATKP 650
    SRDWGPALLE HRTGRYAPTI APSPEDGFEV QPLHPDKAQI PIVGSNGSSR 700
    LQDSRI 706
    Length:706
    Mass (Da):78,260
    Last modified:August 10, 2010 - v3
    Checksum:i654B208568F843F4
    GO
    Isoform GlyT-1A (identifier: P48067-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-83: MSGGDTRAAI...MAQHSLAMAQ → MVGKGAKGML

    Show »
    Length:633
    Mass (Da):70,583
    Checksum:i7D72C44BC76E80EA
    GO
    Isoform GlyT-1B (identifier: P48067-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         29-82: Missing.

    Show »
    Length:652
    Mass (Da):72,482
    Checksum:iAA1FDD1DF09E7BCA
    GO

    Sequence cautioni

    The sequence AAB30784.1 differs from that shown. Reason: Frameshift at position 8.
    The sequence AAB30785.1 differs from that shown. Reason: Frameshift at position 8.
    The sequence CAI19428.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAI19429.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti373 – 3731G → A in AAB30784. (PubMed:8183239)Curated
    Sequence conflicti373 – 3731G → A in AAB30785. (PubMed:8183239)Curated
    Sequence conflicti682 – 6821P → S in AAB30784. (PubMed:8183239)Curated
    Sequence conflicti682 – 6821P → S in AAB30785. (PubMed:8183239)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8383MSGGD…LAMAQ → MVGKGAKGML in isoform GlyT-1A. 1 PublicationVSP_006270Add
    BLAST
    Alternative sequencei29 – 8254Missing in isoform GlyT-1B. 1 PublicationVSP_006271Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S70609 mRNA. Translation: AAB30784.1. Frameshift.
    S70612 mRNA. Translation: AAB30785.1. Frameshift.
    AL139220 Genomic DNA. Translation: CAI19428.1. Different initiation.
    AL139220 Genomic DNA. Translation: CAI19429.1. Different initiation.
    AL139220 Genomic DNA. Translation: CAI19430.1.
    CH471059 Genomic DNA. Translation: EAX07056.1.
    CH471059 Genomic DNA. Translation: EAX07057.1.
    CCDSiCCDS30695.1. [P48067-2]
    CCDS41316.1. [P48067-3]
    CCDS41317.1. [P48067-1]
    PIRiI57956.
    I77912.
    RefSeqiNP_001020016.1. NM_001024845.2. [P48067-2]
    NP_008865.2. NM_006934.3. [P48067-3]
    NP_964012.2. NM_201649.3. [P48067-1]
    UniGeneiHs.442590.

    Genome annotation databases

    EnsembliENST00000357730; ENSP00000350362; ENSG00000196517. [P48067-3]
    ENST00000360584; ENSP00000353791; ENSG00000196517. [P48067-1]
    ENST00000372310; ENSP00000361384; ENSG00000196517. [P48067-2]
    GeneIDi6536.
    KEGGihsa:6536.
    UCSCiuc001cll.4. human. [P48067-1]
    uc001clm.4. human. [P48067-3]
    uc001cln.4. human. [P48067-2]

    Polymorphism databases

    DMDMi302393807.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S70609 mRNA. Translation: AAB30784.1 . Frameshift.
    S70612 mRNA. Translation: AAB30785.1 . Frameshift.
    AL139220 Genomic DNA. Translation: CAI19428.1 . Different initiation.
    AL139220 Genomic DNA. Translation: CAI19429.1 . Different initiation.
    AL139220 Genomic DNA. Translation: CAI19430.1 .
    CH471059 Genomic DNA. Translation: EAX07056.1 .
    CH471059 Genomic DNA. Translation: EAX07057.1 .
    CCDSi CCDS30695.1. [P48067-2 ]
    CCDS41316.1. [P48067-3 ]
    CCDS41317.1. [P48067-1 ]
    PIRi I57956.
    I77912.
    RefSeqi NP_001020016.1. NM_001024845.2. [P48067-2 ]
    NP_008865.2. NM_006934.3. [P48067-3 ]
    NP_964012.2. NM_201649.3. [P48067-1 ]
    UniGenei Hs.442590.

    3D structure databases

    ProteinModelPortali P48067.
    SMRi P48067. Positions 99-653.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112427. 2 interactions.
    IntActi P48067. 1 interaction.
    STRINGi 9606.ENSP00000361381.

    Chemistry

    BindingDBi P48067.
    ChEMBLi CHEMBL2337.
    DrugBanki DB00145. Glycine.
    GuidetoPHARMACOLOGYi 935.

    Protein family/group databases

    TCDBi 2.A.22.2.12. the neurotransmitter:sodium symporter (nss) family.

    PTM databases

    PhosphoSitei P48067.

    Polymorphism databases

    DMDMi 302393807.

    Proteomic databases

    MaxQBi P48067.
    PRIDEi P48067.

    Protocols and materials databases

    DNASUi 6536.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357730 ; ENSP00000350362 ; ENSG00000196517 . [P48067-3 ]
    ENST00000360584 ; ENSP00000353791 ; ENSG00000196517 . [P48067-1 ]
    ENST00000372310 ; ENSP00000361384 ; ENSG00000196517 . [P48067-2 ]
    GeneIDi 6536.
    KEGGi hsa:6536.
    UCSCi uc001cll.4. human. [P48067-1 ]
    uc001clm.4. human. [P48067-3 ]
    uc001cln.4. human. [P48067-2 ]

    Organism-specific databases

    CTDi 6536.
    GeneCardsi GC01M044462.
    HGNCi HGNC:11056. SLC6A9.
    HPAi HPA013977.
    MIMi 601019. gene.
    neXtProti NX_P48067.
    PharmGKBi PA35916.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0733.
    HOVERGENi HBG071421.
    InParanoidi P48067.
    KOi K05038.
    OrthoDBi EOG793B71.
    PhylomeDBi P48067.
    TreeFami TF343812.

    Enzyme and pathway databases

    Reactomei REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

    Miscellaneous databases

    ChiTaRSi SLC6A9. human.
    GeneWikii Glycine_transporter_1.
    GenomeRNAii 6536.
    NextBioi 25431.
    PROi P48067.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48067.
    Bgeei P48067.
    CleanExi HS_SLC6A9.
    Genevestigatori P48067.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR003028. Na/ntran_symport_glycine_GLY1.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01204. GLY1TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes."
      Kim K.-M., Kingsmore S.F., Han H., Yang-Feng T.L., Godinot N., Seldin M.F., Caron M.G., Giros B.
      Mol. Pharmacol. 45:608-617(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS GLYT-1A; GLYT-1B AND GLYT-1C).
      Tissue: Brain.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSC6A9_HUMAN
    AccessioniPrimary (citable) accession number: P48067
    Secondary accession number(s): A6NDH1
    , A6NII2, A6NNZ8, Q5TAB8, Q5TAB9, Q5TAC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3