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P48066 (S6A11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium- and chloride-dependent GABA transporter 3

Short name=GAT-3
Alternative name(s):
Solute carrier family 6 member 11
Gene names
Name:SLC6A11
Synonyms:GABT3, GAT3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length632 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Widespread distribution in the brain.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 632632Sodium- and chloride-dependent GABA transporter 3
PRO_0000214784

Regions

Topological domain1 – 5858Cytoplasmic Potential
Transmembrane59 – 7921Helical; Name=1; Potential
Transmembrane87 – 10620Helical; Name=2; Potential
Transmembrane131 – 15121Helical; Name=3; Potential
Topological domain152 – 22574Extracellular Potential
Transmembrane226 – 24419Helical; Name=4; Potential
Transmembrane253 – 27018Helical; Name=5; Potential
Transmembrane306 – 32318Helical; Name=6; Potential
Transmembrane335 – 35622Helical; Name=7; Potential
Transmembrane389 – 40820Helical; Name=8; Potential
Transmembrane438 – 45619Helical; Name=9; Potential
Transmembrane473 – 49321Helical; Name=10; Potential
Transmembrane514 – 53320Helical; Name=11; Potential
Transmembrane553 – 57119Helical; Name=12; Potential
Topological domain572 – 63261Cytoplasmic Potential

Amino acid modifications

Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2841F → L in BAG35593. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P48066 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: D75C5B988E983278

FASTA63270,606
        10         20         30         40         50         60 
MTAEKALPLG NGKAAEEARE SEAPGGGCSS GGAAPARHPR VKRDKAVHER GHWNNKVEFV 

        70         80         90        100        110        120 
LSVAGEIIGL GNVWRFPYLC YKNGGGAFLI PYVVFFICCG IPVFFLETAL GQFTSEGGIT 

       130        140        150        160        170        180 
CWRKVCPLFE GIGYATQVIE AHLNVYYIII LAWAIFYLSN CFTTELPWAT CGHEWNTENC 

       190        200        210        220        230        240 
VEFQKLNVSN YSHVSLQNAT SPVMEFWEHR VLAISDGIEH IGNLRWELAL CLLAAWTICY 

       250        260        270        280        290        300 
FCIWKGTKST GKVVYVTATF PYIMLLILLI RGVTLPGASE GIKFYLYPDL SRLSDPQVWV 

       310        320        330        340        350        360 
DAGTQIFFSY AICLGCLTAL GSYNNYNNNC YRDCIMLCCL NSGTSFVAGF AIFSVLGFMA 

       370        380        390        400        410        420 
YEQGVPIAEV AESGPGLAFI AYPKAVTMMP LSPLWATLFF MMLIFLGLDS QFVCVESLVT 

       430        440        450        460        470        480 
AVVDMYPKVF RRGYRRELLI LALSVISYFL GLVMLTEGGM YIFQLFDSYA ASGMCLLFVA 

       490        500        510        520        530        540 
IFECICIGWV YGSNRFYDNI EDMIGYRPPS LIKWCWMIMT PGICAGIFIF FLIKYKPLKY 

       550        560        570        580        590        600 
NNIYTYPAWG YGIGWLMALS SMLCIPLWIC ITVWKTEGTL PEKLQKLTTP STDLKMRGKL 

       610        620        630 
GVSPRMVTVN DCDAKLKSDG TIAAITEKET HF 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site."
Borden L.A., Murali Dhar T.G., Smith K.E., Branchek T.A., Gluchowski C., Weinshank R.L.
Recept. Channels 2:207-213(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S75989 mRNA. Translation: AAB33570.1.
AK312719 mRNA. Translation: BAG35593.1.
CCDSCCDS2602.1.
RefSeqNP_055044.1. NM_014229.1.
UniGeneHs.657405.

3D structure databases

ProteinModelPortalP48066.
SMRP48066. Positions 49-593.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000254488.

Chemistry

BindingDBP48066.
ChEMBLCHEMBL5208.

Protein family/group databases

TCDB2.A.22.3.9. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteP48066.

Polymorphism databases

DMDM1352531.

Proteomic databases

MaxQBP48066.
PaxDbP48066.
PRIDEP48066.

Protocols and materials databases

DNASU6538.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254488; ENSP00000254488; ENSG00000132164.
GeneID6538.
KEGGhsa:6538.
UCSCuc003bvz.3. human.

Organism-specific databases

CTD6538.
GeneCardsGC03P010857.
HGNCHGNC:11044. SLC6A11.
HPAHPA037981.
MIM607952. gene.
neXtProtNX_P48066.
PharmGKBPA35907.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0733.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidP48066.
KOK05039.
OMANIYTYPA.
OrthoDBEOG793B71.
PhylomeDBP48066.
TreeFamTF343812.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_13685. Neuronal System.
REACT_15518. Transmembrane transport of small molecules.
REACT_20679. Amine compound SLC transporters.

Gene expression databases

ArrayExpressP48066.
BgeeP48066.
CleanExHS_SLC6A11.
GenevestigatorP48066.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR002982. Na/ntran_symport_GABA_GAT3.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR01197. GAT3TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi6538.
NextBio25439.
PROP48066.
SOURCESearch...

Entry information

Entry nameS6A11_HUMAN
AccessionPrimary (citable) accession number: P48066
Secondary accession number(s): B2R6U6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM