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P48066

- S6A11_HUMAN

UniProt

P48066 - S6A11_HUMAN

Protein

Sodium- and chloride-dependent GABA transporter 3

Gene

SLC6A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

    GO - Molecular functioni

    1. gamma-aminobutyric acid:sodium symporter activity Source: Ensembl
    2. neurotransmitter:sodium symporter activity Source: InterPro
    3. neurotransmitter binding Source: Ensembl

    GO - Biological processi

    1. brain development Source: Ensembl
    2. neurotransmitter secretion Source: Reactome
    3. response to drug Source: Ensembl
    4. synaptic transmission Source: Reactome
    5. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_20506. Na+/Cl- dependent neurotransmitter transporters.
    REACT_23910. Reuptake of GABA.
    REACT_813. Creatine metabolism.

    Protein family/group databases

    TCDBi2.A.22.3.9. the neurotransmitter:sodium symporter (nss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent GABA transporter 3
    Short name:
    GAT-3
    Alternative name(s):
    Solute carrier family 6 member 11
    Gene namesi
    Name:SLC6A11
    Synonyms:GABT3, GAT3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11044. SLC6A11.

    Subcellular locationi

    GO - Cellular componenti

    1. cell projection Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. integral component of membrane Source: ProtInc
    4. integral component of plasma membrane Source: InterPro
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35907.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 632632Sodium- and chloride-dependent GABA transporter 3PRO_0000214784Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP48066.
    PaxDbiP48066.
    PRIDEiP48066.

    PTM databases

    PhosphoSiteiP48066.

    Expressioni

    Tissue specificityi

    Widespread distribution in the brain.

    Gene expression databases

    ArrayExpressiP48066.
    BgeeiP48066.
    CleanExiHS_SLC6A11.
    GenevestigatoriP48066.

    Organism-specific databases

    HPAiHPA037981.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000254488.

    Structurei

    3D structure databases

    ProteinModelPortaliP48066.
    SMRiP48066. Positions 49-593.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5858CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini152 – 22574ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini572 – 63261CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei59 – 7921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 10620Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei226 – 24419Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27018Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei306 – 32318Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei335 – 35622Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei389 – 40820Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei438 – 45619Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei473 – 49321Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei514 – 53320Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei553 – 57119Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiP48066.
    KOiK05039.
    OMAiNIYTYPA.
    OrthoDBiEOG793B71.
    PhylomeDBiP48066.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002982. Na/ntran_symport_GABA_GAT3.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR01197. GAT3TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P48066-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTAEKALPLG NGKAAEEARE SEAPGGGCSS GGAAPARHPR VKRDKAVHER    50
    GHWNNKVEFV LSVAGEIIGL GNVWRFPYLC YKNGGGAFLI PYVVFFICCG 100
    IPVFFLETAL GQFTSEGGIT CWRKVCPLFE GIGYATQVIE AHLNVYYIII 150
    LAWAIFYLSN CFTTELPWAT CGHEWNTENC VEFQKLNVSN YSHVSLQNAT 200
    SPVMEFWEHR VLAISDGIEH IGNLRWELAL CLLAAWTICY FCIWKGTKST 250
    GKVVYVTATF PYIMLLILLI RGVTLPGASE GIKFYLYPDL SRLSDPQVWV 300
    DAGTQIFFSY AICLGCLTAL GSYNNYNNNC YRDCIMLCCL NSGTSFVAGF 350
    AIFSVLGFMA YEQGVPIAEV AESGPGLAFI AYPKAVTMMP LSPLWATLFF 400
    MMLIFLGLDS QFVCVESLVT AVVDMYPKVF RRGYRRELLI LALSVISYFL 450
    GLVMLTEGGM YIFQLFDSYA ASGMCLLFVA IFECICIGWV YGSNRFYDNI 500
    EDMIGYRPPS LIKWCWMIMT PGICAGIFIF FLIKYKPLKY NNIYTYPAWG 550
    YGIGWLMALS SMLCIPLWIC ITVWKTEGTL PEKLQKLTTP STDLKMRGKL 600
    GVSPRMVTVN DCDAKLKSDG TIAAITEKET HF 632
    Length:632
    Mass (Da):70,606
    Last modified:February 1, 1996 - v1
    Checksum:iD75C5B988E983278
    GO
    Isoform 2 (identifier: P48066-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         209-632: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:208
    Mass (Da):23,036
    Checksum:i993E85CD5C8E2ACB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti284 – 2841F → L in BAG35593. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei209 – 632424Missing in isoform 2. 1 PublicationVSP_056539Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75989 mRNA. Translation: AAB33570.1.
    AK312719 mRNA. Translation: BAG35593.1.
    AC018495 Genomic DNA. No translation available.
    AC027128 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64086.1.
    BC036083 mRNA. Translation: AAH36083.1.
    CCDSiCCDS2602.1.
    RefSeqiNP_055044.1. NM_014229.1.
    UniGeneiHs.657405.

    Genome annotation databases

    EnsembliENST00000254488; ENSP00000254488; ENSG00000132164.
    ENST00000454147; ENSP00000404120; ENSG00000132164.
    GeneIDi6538.
    KEGGihsa:6538.
    UCSCiuc003bvz.3. human.

    Polymorphism databases

    DMDMi1352531.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75989 mRNA. Translation: AAB33570.1 .
    AK312719 mRNA. Translation: BAG35593.1 .
    AC018495 Genomic DNA. No translation available.
    AC027128 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64086.1 .
    BC036083 mRNA. Translation: AAH36083.1 .
    CCDSi CCDS2602.1.
    RefSeqi NP_055044.1. NM_014229.1.
    UniGenei Hs.657405.

    3D structure databases

    ProteinModelPortali P48066.
    SMRi P48066. Positions 49-593.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000254488.

    Chemistry

    BindingDBi P48066.
    ChEMBLi CHEMBL5208.

    Protein family/group databases

    TCDBi 2.A.22.3.9. the neurotransmitter:sodium symporter (nss) family.

    PTM databases

    PhosphoSitei P48066.

    Polymorphism databases

    DMDMi 1352531.

    Proteomic databases

    MaxQBi P48066.
    PaxDbi P48066.
    PRIDEi P48066.

    Protocols and materials databases

    DNASUi 6538.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254488 ; ENSP00000254488 ; ENSG00000132164 .
    ENST00000454147 ; ENSP00000404120 ; ENSG00000132164 .
    GeneIDi 6538.
    KEGGi hsa:6538.
    UCSCi uc003bvz.3. human.

    Organism-specific databases

    CTDi 6538.
    GeneCardsi GC03P010857.
    HGNCi HGNC:11044. SLC6A11.
    HPAi HPA037981.
    MIMi 607952. gene.
    neXtProti NX_P48066.
    PharmGKBi PA35907.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0733.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi P48066.
    KOi K05039.
    OMAi NIYTYPA.
    OrthoDBi EOG793B71.
    PhylomeDBi P48066.
    TreeFami TF343812.

    Enzyme and pathway databases

    Reactomei REACT_20506. Na+/Cl- dependent neurotransmitter transporters.
    REACT_23910. Reuptake of GABA.
    REACT_813. Creatine metabolism.

    Miscellaneous databases

    GenomeRNAii 6538.
    NextBioi 25439.
    PROi P48066.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48066.
    Bgeei P48066.
    CleanExi HS_SLC6A11.
    Genevestigatori P48066.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR002982. Na/ntran_symport_GABA_GAT3.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01197. GAT3TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site."
      Borden L.A., Murali Dhar T.G., Smith K.E., Branchek T.A., Gluchowski C., Weinshank R.L.
      Recept. Channels 2:207-213(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiS6A11_HUMAN
    AccessioniPrimary (citable) accession number: P48066
    Secondary accession number(s): B2R6U6, Q8IYC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3