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P48066

- S6A11_HUMAN

UniProt

P48066 - S6A11_HUMAN

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Protein

Sodium- and chloride-dependent GABA transporter 3

Gene

SLC6A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

GO - Molecular functioni

  1. gamma-aminobutyric acid:sodium symporter activity Source: Ensembl
  2. neurotransmitter:sodium symporter activity Source: InterPro
  3. neurotransmitter binding Source: Ensembl

GO - Biological processi

  1. brain development Source: Ensembl
  2. neurotransmitter secretion Source: Reactome
  3. response to drug Source: Ensembl
  4. synaptic transmission Source: Reactome
  5. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_20506. Na+/Cl- dependent neurotransmitter transporters.
REACT_23910. Reuptake of GABA.
REACT_813. Creatine metabolism.

Protein family/group databases

TCDBi2.A.22.3.9. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent GABA transporter 3
Short name:
GAT-3
Alternative name(s):
Solute carrier family 6 member 11
Gene namesi
Name:SLC6A11
Synonyms:GABT3, GAT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11044. SLC6A11.

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. integral component of membrane Source: ProtInc
  4. integral component of plasma membrane Source: InterPro
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 632632Sodium- and chloride-dependent GABA transporter 3PRO_0000214784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP48066.
PaxDbiP48066.
PRIDEiP48066.

PTM databases

PhosphoSiteiP48066.

Expressioni

Tissue specificityi

Widespread distribution in the brain.

Gene expression databases

BgeeiP48066.
CleanExiHS_SLC6A11.
ExpressionAtlasiP48066. baseline and differential.
GenevestigatoriP48066.

Organism-specific databases

HPAiHPA037981.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000254488.

Structurei

3D structure databases

ProteinModelPortaliP48066.
SMRiP48066. Positions 49-593.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5858CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini152 – 22574ExtracellularSequence AnalysisAdd
BLAST
Topological domaini572 – 63261CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei59 – 7921Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei87 – 10620Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei131 – 15121Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei226 – 24419Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei253 – 27018Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei306 – 32318Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei335 – 35622Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei389 – 40820Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei438 – 45619Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei473 – 49321Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei514 – 53320Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei553 – 57119Helical; Name=12Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP48066.
KOiK05039.
OMAiNIYTYPA.
OrthoDBiEOG793B71.
PhylomeDBiP48066.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002982. Na/ntran_symport_GABA_GAT3.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01197. GAT3TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P48066-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAEKALPLG NGKAAEEARE SEAPGGGCSS GGAAPARHPR VKRDKAVHER
60 70 80 90 100
GHWNNKVEFV LSVAGEIIGL GNVWRFPYLC YKNGGGAFLI PYVVFFICCG
110 120 130 140 150
IPVFFLETAL GQFTSEGGIT CWRKVCPLFE GIGYATQVIE AHLNVYYIII
160 170 180 190 200
LAWAIFYLSN CFTTELPWAT CGHEWNTENC VEFQKLNVSN YSHVSLQNAT
210 220 230 240 250
SPVMEFWEHR VLAISDGIEH IGNLRWELAL CLLAAWTICY FCIWKGTKST
260 270 280 290 300
GKVVYVTATF PYIMLLILLI RGVTLPGASE GIKFYLYPDL SRLSDPQVWV
310 320 330 340 350
DAGTQIFFSY AICLGCLTAL GSYNNYNNNC YRDCIMLCCL NSGTSFVAGF
360 370 380 390 400
AIFSVLGFMA YEQGVPIAEV AESGPGLAFI AYPKAVTMMP LSPLWATLFF
410 420 430 440 450
MMLIFLGLDS QFVCVESLVT AVVDMYPKVF RRGYRRELLI LALSVISYFL
460 470 480 490 500
GLVMLTEGGM YIFQLFDSYA ASGMCLLFVA IFECICIGWV YGSNRFYDNI
510 520 530 540 550
EDMIGYRPPS LIKWCWMIMT PGICAGIFIF FLIKYKPLKY NNIYTYPAWG
560 570 580 590 600
YGIGWLMALS SMLCIPLWIC ITVWKTEGTL PEKLQKLTTP STDLKMRGKL
610 620 630
GVSPRMVTVN DCDAKLKSDG TIAAITEKET HF
Length:632
Mass (Da):70,606
Last modified:February 1, 1996 - v1
Checksum:iD75C5B988E983278
GO
Isoform 2 (identifier: P48066-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-632: Missing.

Note: No experimental confirmation available.

Show »
Length:208
Mass (Da):23,036
Checksum:i993E85CD5C8E2ACB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti284 – 2841F → L in BAG35593. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei209 – 632424Missing in isoform 2. 1 PublicationVSP_056539Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75989 mRNA. Translation: AAB33570.1.
AK312719 mRNA. Translation: BAG35593.1.
AC018495 Genomic DNA. No translation available.
AC027128 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64086.1.
BC036083 mRNA. Translation: AAH36083.1.
CCDSiCCDS2602.1. [P48066-1]
RefSeqiNP_055044.1. NM_014229.1.
UniGeneiHs.657405.

Genome annotation databases

EnsembliENST00000254488; ENSP00000254488; ENSG00000132164. [P48066-1]
ENST00000454147; ENSP00000404120; ENSG00000132164. [P48066-2]
GeneIDi6538.
KEGGihsa:6538.
UCSCiuc003bvz.3. human. [P48066-1]

Polymorphism databases

DMDMi1352531.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75989 mRNA. Translation: AAB33570.1 .
AK312719 mRNA. Translation: BAG35593.1 .
AC018495 Genomic DNA. No translation available.
AC027128 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64086.1 .
BC036083 mRNA. Translation: AAH36083.1 .
CCDSi CCDS2602.1. [P48066-1 ]
RefSeqi NP_055044.1. NM_014229.1.
UniGenei Hs.657405.

3D structure databases

ProteinModelPortali P48066.
SMRi P48066. Positions 49-593.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000254488.

Chemistry

BindingDBi P48066.
ChEMBLi CHEMBL5208.
DrugBanki DB00349. Clobazam.

Protein family/group databases

TCDBi 2.A.22.3.9. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSitei P48066.

Polymorphism databases

DMDMi 1352531.

Proteomic databases

MaxQBi P48066.
PaxDbi P48066.
PRIDEi P48066.

Protocols and materials databases

DNASUi 6538.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254488 ; ENSP00000254488 ; ENSG00000132164 . [P48066-1 ]
ENST00000454147 ; ENSP00000404120 ; ENSG00000132164 . [P48066-2 ]
GeneIDi 6538.
KEGGi hsa:6538.
UCSCi uc003bvz.3. human. [P48066-1 ]

Organism-specific databases

CTDi 6538.
GeneCardsi GC03P010857.
HGNCi HGNC:11044. SLC6A11.
HPAi HPA037981.
MIMi 607952. gene.
neXtProti NX_P48066.
PharmGKBi PA35907.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0733.
GeneTreei ENSGT00760000118857.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
InParanoidi P48066.
KOi K05039.
OMAi NIYTYPA.
OrthoDBi EOG793B71.
PhylomeDBi P48066.
TreeFami TF343812.

Enzyme and pathway databases

Reactomei REACT_20506. Na+/Cl- dependent neurotransmitter transporters.
REACT_23910. Reuptake of GABA.
REACT_813. Creatine metabolism.

Miscellaneous databases

GenomeRNAii 6538.
NextBioi 25439.
PROi P48066.
SOURCEi Search...

Gene expression databases

Bgeei P48066.
CleanExi HS_SLC6A11.
ExpressionAtlasi P48066. baseline and differential.
Genevestigatori P48066.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR002982. Na/ntran_symport_GABA_GAT3.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR01197. GAT3TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site."
    Borden L.A., Murali Dhar T.G., Smith K.E., Branchek T.A., Gluchowski C., Weinshank R.L.
    Recept. Channels 2:207-213(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiS6A11_HUMAN
AccessioniPrimary (citable) accession number: P48066
Secondary accession number(s): B2R6U6, Q8IYC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3