##gff-version 3 P48061 UniProtKB Signal peptide 1 21 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P48061 UniProtKB Chain 22 93 . . . ID=PRO_0000005109;Note=Stromal cell-derived factor 1 P48061 UniProtKB Chain 24 93 . . . ID=PRO_0000005110;Note=SDF-1-beta(3-72) P48061 UniProtKB Chain 24 88 . . . ID=PRO_0000005111;Note=SDF-1-alpha(3-67) P48061 UniProtKB Region 29 33 . . . Note=Receptor and heparin binding;Ontology_term=ECO:0000305;evidence=ECO:0000305 P48061 UniProtKB Region 39 41 . . . Note=Receptor binding P48061 UniProtKB Region 48 50 . . . Note=Receptor binding P48061 UniProtKB Region 60 70 . . . Note=Receptor binding P48061 UniProtKB Motif 22 23 . . . Note=Receptor activation motif P48061 UniProtKB Binding site 41 51 . . . . P48061 UniProtKB Binding site 62 62 . . . . P48061 UniProtKB Binding site 69 69 . . . . P48061 UniProtKB Binding site 85 85 . . . . P48061 UniProtKB Site 45 45 . . . Note=Important for integrin interaction and activation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29301984;Dbxref=PMID:29301984 P48061 UniProtKB Site 46 46 . . . Note=Important for dimer formation P48061 UniProtKB Site 48 48 . . . Note=Important for integrin interaction and activation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29301984;Dbxref=PMID:29301984 P48061 UniProtKB Site 64 64 . . . Note=Important for integrin interaction and activation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29301984;Dbxref=PMID:29301984 P48061 UniProtKB Disulfide bond 30 55 . . . . P48061 UniProtKB Disulfide bond 32 71 . . . . P48061 UniProtKB Alternative sequence 39 93 . . . ID=VSP_054781;Note=In isoform 7. VARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM->YCTCLIRVSFHGATPLTQGSWVLYSLSCAGGETGLREPGPMVSPRVESHQEGRLGVPGPVNLGKA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16344560;Dbxref=PMID:16344560 P48061 UniProtKB Alternative sequence 89 93 . . . ID=VSP_042118;Note=In isoform Delta. KRFKM->NLISAAPAGKRVIAGARALHPSPPRACPTARALCEIRLWPPPEWSWPSPGDV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16626895;Dbxref=PMID:16626895 P48061 UniProtKB Alternative sequence 89 93 . . . ID=VSP_042119;Note=In isoform Epsilon. KRFKM->NC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16626895;Dbxref=PMID:16626895 P48061 UniProtKB Alternative sequence 90 93 . . . ID=VSP_001056;Note=In isoform Alpha. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7490086,ECO:0000303|Ref.4,ECO:0000303|Ref.6,ECO:0000303|Ref.7;Dbxref=PMID:14702039,PMID:15489334,PMID:7490086 P48061 UniProtKB Alternative sequence 90 93 . . . ID=VSP_041209;Note=In isoform Gamma. RFKM->GRREEKVGKKEKIGKKKRQKKRKAAQKRKN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16626895,ECO:0000303|Ref.5;Dbxref=PMID:16626895 P48061 UniProtKB Alternative sequence 90 93 . . . ID=VSP_042120;Note=In isoform Theta. RFKM->IWLYGNAETSR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16626895;Dbxref=PMID:16626895 P48061 UniProtKB Mutagenesis 22 23 . . . Note=Abolished CXCR4 activation ability%2C but only slightly impaired binding to the receptor. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9384579;Dbxref=PMID:9384579 P48061 UniProtKB Mutagenesis 22 22 . . . Note=Loss of chemotactic activity. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17357154,ECO:0000269|PubMed:9384579;Dbxref=PMID:17357154,PMID:9384579 P48061 UniProtKB Mutagenesis 22 22 . . . Note=Abolished CXCR4 activation ability%2C but only slightly impaired binding to the receptor. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17357154,ECO:0000269|PubMed:9384579;Dbxref=PMID:17357154,PMID:9384579 P48061 UniProtKB Mutagenesis 22 22 . . . Note=Abolished CXCR4 activation ability%2C but only slightly impaired binding to the receptor. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17357154,ECO:0000269|PubMed:9384579;Dbxref=PMID:17357154,PMID:9384579 P48061 UniProtKB Mutagenesis 23 23 . . . Note=Abolished CXCR4 activation ability%2C but only slightly impaired binding to the receptor. P->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9384579;Dbxref=PMID:9384579 P48061 UniProtKB Mutagenesis 25 27 . . . Note=Significantly impaired CXCR4 activation ability%2C but only slightly impaired binding to the receptor. SLS->AQA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9384579;Dbxref=PMID:9384579 P48061 UniProtKB Mutagenesis 28 28 . . . Note=Impaired CXCR4 activation ability%2C but only slightly impaired binding to the receptor. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9384579;Dbxref=PMID:9384579 P48061 UniProtKB Mutagenesis 28 28 . . . Note=No significant effect on CXCR4 binding or activation. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9384579;Dbxref=PMID:9384579 P48061 UniProtKB Mutagenesis 29 29 . . . Note=Slightly impaired binding and activation of CXCR4. R->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:9384579;Dbxref=PMID:17264079,PMID:9384579 P48061 UniProtKB Mutagenesis 29 29 . . . Note=Greatly impaired chemotactic activity and enhanced inhibition by heparin. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:9384579;Dbxref=PMID:17264079,PMID:9384579 P48061 UniProtKB Mutagenesis 33 38 . . . Note=Significantly decreased chemotactic activity. RFFESH->AAAAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10954912;Dbxref=PMID:10954912 P48061 UniProtKB Mutagenesis 33 33 . . . Note=Significantly decreased anti-HIV-1 and chemotactic activities. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10954912,ECO:0000269|PubMed:17264079;Dbxref=PMID:10954912,PMID:17264079 P48061 UniProtKB Mutagenesis 33 33 . . . Note=Slightly impaired chemotactic activity and enhanced inhibition by heparin. Greatly impaired chemotactic activity%3B when associated with Q-29. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10954912,ECO:0000269|PubMed:17264079;Dbxref=PMID:10954912,PMID:17264079 P48061 UniProtKB Mutagenesis 34 34 . . . Note=No effect on anti-HIV-1 and chemotactic activities. Slightly impaired chemotactic activity and no effect on inhibition by heparin%3B when associated with A-35. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10954912;Dbxref=PMID:10954912 P48061 UniProtKB Mutagenesis 35 35 . . . Note=No effect on anti-HIV-1 and chemotactic activities. Slightly impaired chemotactic activity and no effect on inhibition by heparin%3B when associated with A-34. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10954912;Dbxref=PMID:10954912 P48061 UniProtKB Mutagenesis 36 38 . . . Note=Slightly impaired chemotactic activity%2C no effect on inhibition by heparin. ESH->QSN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17264079;Dbxref=PMID:17264079 P48061 UniProtKB Mutagenesis 36 36 . . . Note=No effect on anti-HIV-1 and chemotactic activities. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10954912;Dbxref=PMID:10954912 P48061 UniProtKB Mutagenesis 37 37 . . . Note=No effect on anti-HIV-1 and chemotactic activities. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10954912;Dbxref=PMID:10954912 P48061 UniProtKB Mutagenesis 38 38 . . . Note=No effect on anti-HIV-1 and chemotactic activities. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10954912;Dbxref=PMID:10954912 P48061 UniProtKB Mutagenesis 41 41 . . . Note=No effect on CXCR4 activation. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799424;Dbxref=PMID:18799424 P48061 UniProtKB Mutagenesis 45 48 . . . Note=Loss of heparin-binding capacity. KHLK->SSLS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10446158;Dbxref=PMID:10446158 P48061 UniProtKB Mutagenesis 45 45 . . . Note=Loss of integrin activation%3B when associated with E-48 or E-64. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29301984;Dbxref=PMID:29301984 P48061 UniProtKB Mutagenesis 45 45 . . . Note=55-fold reduction in binding affinity for Link domain of TNFAIP6%3B when associated with S-46 and S-48. K->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27044744;Dbxref=PMID:27044744 P48061 UniProtKB Mutagenesis 46 46 . . . Note=Reduced dimerization in neutral pH. Eliminates the pH dependence of dimerization. H->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15741341,ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424;Dbxref=PMID:15741341,PMID:17264079,PMID:18799424 P48061 UniProtKB Mutagenesis 46 46 . . . Note=No significant effect on dimerization in neutral pH. Eliminates the pH dependence of dimerization. H->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15741341,ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424;Dbxref=PMID:15741341,PMID:17264079,PMID:18799424 P48061 UniProtKB Mutagenesis 46 46 . . . Note=Slightly impaired CXCR4 activation and clear resistance to inhibition by heparin%3B when associated with Q-48%3B Q-62%3B Q-68 and N-69. H->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15741341,ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424;Dbxref=PMID:15741341,PMID:17264079,PMID:18799424 P48061 UniProtKB Mutagenesis 46 46 . . . Note=No effect on CXCR4 activation. Impaired dimer formation%2C leading to increased chemotactic activity. Eliminates the pH dependence of dimerization. H->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15741341,ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424;Dbxref=PMID:15741341,PMID:17264079,PMID:18799424 P48061 UniProtKB Mutagenesis 46 46 . . . Note=55-fold reduction in binding affinity for Link domain of TNFAIP6%3B when associated with S-45 and S-48. H->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27044744;Dbxref=PMID:27044744 P48061 UniProtKB Mutagenesis 48 48 . . . Note=Impaired CXCR4 activation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424;Dbxref=PMID:17264079,PMID:18799424 P48061 UniProtKB Mutagenesis 48 48 . . . Note=Impaired CXCR4 activation. Loss of integrin activation%3B when associated with E-45 or E-64. K->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424,ECO:0000269|PubMed:29301984;Dbxref=PMID:17264079,PMID:18799424,PMID:29301984 P48061 UniProtKB Mutagenesis 48 48 . . . Note=Slightly impaired CXCR4 activation and clear resistance to inhibition by heparin%3B when associated with N-46%3B Q-62%3B Q-68 and N-69. K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424;Dbxref=PMID:17264079,PMID:18799424 P48061 UniProtKB Mutagenesis 48 48 . . . Note=55-fold reduction in binding affinity for Link domain of TNFAIP6%3B when associated with S-45 and S-46. K->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27044744;Dbxref=PMID:27044744 P48061 UniProtKB Mutagenesis 52 56 . . . Note=Slightly impaired chemotactic activity%2C no effect on inhibition by heparin. TPNCA->GPGCG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17264079;Dbxref=PMID:17264079 P48061 UniProtKB Mutagenesis 57 57 . . . Note=Formation of an intermolecular disulfide bond%2C leading to a locked dimer%3B when associated with C-86. No effect on CXCR4 activation%2C but loss of chemotactic activity%3B when associated with C-86. L->C P48061 UniProtKB Mutagenesis 60 60 . . . Note=Impaired CXCR4 activation. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799424;Dbxref=PMID:18799424 P48061 UniProtKB Mutagenesis 62 62 . . . Note=No effect on CXCR4 activation. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424;Dbxref=PMID:17264079,PMID:18799424 P48061 UniProtKB Mutagenesis 62 62 . . . Note=Slightly impaired CXCR4 activation and clear resistance to inhibition by heparin%3B when associated with N-46%3B Q-48%3B Q-68 and N-69. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424;Dbxref=PMID:17264079,PMID:18799424 P48061 UniProtKB Mutagenesis 64 64 . . . Note=Loss of integrin activation%3B when associated with E-45 or E-48. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29301984;Dbxref=PMID:29301984 P48061 UniProtKB Mutagenesis 68 68 . . . Note=Impaired CXCR4 activation. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424;Dbxref=PMID:17264079,PMID:18799424 P48061 UniProtKB Mutagenesis 68 68 . . . Note=Greatly impaired CXCR4 activation. R->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424;Dbxref=PMID:17264079,PMID:18799424 P48061 UniProtKB Mutagenesis 68 68 . . . Note=Slightly impaired CXCR4 activation and clear resistance to inhibition by heparin%3B when associated with N-46%3B Q-48%3B Q-62 and N-69. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17264079,ECO:0000269|PubMed:18799424;Dbxref=PMID:17264079,PMID:18799424 P48061 UniProtKB Mutagenesis 69 69 . . . Note=Slightly impaired CXCR4 activation and clear resistance to inhibition by heparin%3B when associated with N-46%3B Q-48%3B Q-62 and Q-68. Q->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17264079;Dbxref=PMID:17264079 P48061 UniProtKB Mutagenesis 70 70 . . . Note=Impaired CXCR4 activation. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799424;Dbxref=PMID:18799424 P48061 UniProtKB Mutagenesis 81 81 . . . Note=No effect on CXCR4 activation. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799424;Dbxref=PMID:18799424 P48061 UniProtKB Mutagenesis 84 84 . . . Note=No effect on CXCR4 activation. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799424;Dbxref=PMID:18799424 P48061 UniProtKB Mutagenesis 85 85 . . . Note=No effect on CXCR4 activation. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18799424;Dbxref=PMID:18799424 P48061 UniProtKB Mutagenesis 86 86 . . . Note=Formation of an intermolecular disulfide bond%2C leading to a locked dimer%3B when associated with C-57. No effect on CXCR4 activation%2C but loss of chemotactic activity%3B when associated with C-57. A->C P48061 UniProtKB Helix 24 26 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4UAI P48061 UniProtKB Beta strand 27 29 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2K01 P48061 UniProtKB Beta strand 31 34 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3HP3 P48061 UniProtKB Beta strand 36 38 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1VMC P48061 UniProtKB Helix 41 43 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GV3 P48061 UniProtKB Beta strand 44 49 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GV3 P48061 UniProtKB Turn 53 55 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QG7 P48061 UniProtKB Beta strand 59 63 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GV3 P48061 UniProtKB Turn 64 66 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GV3 P48061 UniProtKB Beta strand 69 72 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GV3 P48061 UniProtKB Helix 79 86 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GV3