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P48060 (GLIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glioma pathogenesis-related protein 1

Short name=GliPR 1
Alternative name(s):
Protein RTVP-1
Gene names
Name:GLIPR1
Synonyms:GLIPR, RTVP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

According to Ref.3, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to Ref.1 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.

Sequence similarities

Belongs to the CRISP family.

Contains 1 SCP domain.

Sequence caution

The sequence AAA82731.3 differs from that shown. Reason: Frameshift at position 3.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P48060-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P48060-2)

Also known as: RTVP-1b;

The sequence of this isoform differs from the canonical sequence as follows:
     142-266: VWADSYKVGC...HKYPNLVLLD → SQERGRDPNP...ISVLTDSETK
Note: Highly expressed in glioblastomas.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 266245Glioma pathogenesis-related protein 1
PRO_0000006270

Regions

Transmembrane233 – 25523Helical; Potential
Domain38 – 175138SCP

Natural variations

Alternative sequence142 – 266125VWADS…LVLLD → SQERGRDPNPKRGFLNLARE NPGLFGQIVTKLAAQFNFAL KFLALTLFPMEHILYATTDQ EGITQLGHIREEPPAVPAPI MTSVWTISVLTDSETK in isoform 2.
VSP_043902
Natural variant1631D → E.
Corresponds to variant rs28932170 [ dbSNP | Ensembl ].
VAR_061128
Natural variant2111R → Q.
Corresponds to variant rs3736392 [ dbSNP | Ensembl ].
VAR_048833

Experimental info

Sequence conflict2571H → L in CAA63005. Ref.3

Secondary structure

................................. 266
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 10, 2003. Version 3.
Checksum: C0466C085EFB2B7A

FASTA26630,366
        10         20         30         40         50         60 
MRVTLATIAW MVSFVSNYSH TANILPDIEN EDFIKDCVRI HNKFRSEVKP TASDMLYMTW 

        70         80         90        100        110        120 
DPALAQIAKA WASNCQFSHN TRLKPPHKLH PNFTSLGENI WTGSVPIFSV SSAITNWYDE 

       130        140        150        160        170        180 
IQDYDFKTRI CKKVCGHYTQ VVWADSYKVG CAVQFCPKVS GFDALSNGAH FICNYGPGGN 

       190        200        210        220        230        240 
YPTWPYKRGA TCSACPNNDK CLDNLCVNRQ RDQVKRYYSV VYPGWPIYPR NRYTSLFLIV 

       250        260 
NSVILILSVI ITILVQHKYP NLVLLD 

« Hide

Isoform 2 (RTVP-1b) [UniParc].

Checksum: 047EC17EE37A45C5
Show »

FASTA23726,919

References

« Hide 'large scale' references
[1]"The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors."
Murphy E.V., Zhang Y., Zhu W., Biggs J.
Gene 159:131-135(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]Murphy E.V.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin."
Rich T., Chen P., Furman F., Huynh N., Israel M.A.
Gene 180:125-130(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Glial tumor.
[4]"Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells."
Xiang C., Sarid R., Cazacu S., Finniss S., Lee H.K., Ziv-Av A., Mikkelsen T., Brodie C.
Biochem. Biophys. Res. Commun. 362:612-618(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Glial tumor.
[5]Wu J., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[7]"Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system."
Szyperski T., Fernandez C., Mumenthaler C., Wuethrich K.
Proc. Natl. Acad. Sci. U.S.A. 95:2262-2266(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U16307 mRNA. Translation: AAA82731.3. Frameshift.
X91911 mRNA. Translation: CAA63005.1.
AF400440 mRNA. Translation: AAK92489.1.
EF667354 mRNA. Translation: ABV21587.1.
BC012510 mRNA. Translation: AAH12510.1.
CCDSCCDS9011.1. [P48060-1]
PIRJC4131.
JC5308.
RefSeqNP_006842.2. NM_006851.2. [P48060-1]
UniGeneHs.205558.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q2RX-ray2.20A22-220[»]
3Q2UX-ray1.85A22-220[»]
ProteinModelPortalP48060.
SMRP48060. Positions 22-213.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP48060. 1 interaction.
STRING9606.ENSP00000266659.

PTM databases

PhosphoSiteP48060.

Polymorphism databases

DMDM27735198.

Proteomic databases

MaxQBP48060.
PaxDbP48060.
PRIDEP48060.

Protocols and materials databases

DNASU11010.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266659; ENSP00000266659; ENSG00000139278. [P48060-1]
GeneID11010.
KEGGhsa:11010.
UCSCuc001sxs.3. human. [P48060-1]

Organism-specific databases

CTD11010.
GeneCardsGC12P075800.
HGNCHGNC:17001. GLIPR1.
HPAHPA011014.
MIM602692. gene.
neXtProtNX_P48060.
PharmGKBPA134988403.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2340.
HOGENOMHOG000036879.
HOVERGENHBG072125.
InParanoidP48060.
OMAYYDFKTR.
OrthoDBEOG7F7WB4.
PhylomeDBP48060.
TreeFamTF316148.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressP48060.
BgeeP48060.
CleanExHS_GLIPR1.
GenevestigatorP48060.

Family and domain databases

Gene3D3.40.33.10. 1 hit.
InterProIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERPTHR10334. PTHR10334. 1 hit.
PfamPF00188. CAP. 1 hit.
[Graphical view]
PRINTSPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMSSF55797. SSF55797. 1 hit.
PROSITEPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP48060.
GeneWikiGLIPR1.
GenomeRNAi11010.
NextBio41823.
PROP48060.
SOURCESearch...

Entry information

Entry nameGLIP1_HUMAN
AccessionPrimary (citable) accession number: P48060
Secondary accession number(s): A7YET6 expand/collapse secondary AC list , F8VUC2, Q15409, Q969K2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 10, 2003
Last modified: July 9, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM