Glioma pathogenesis-related protein 1 precursor

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Natural variations

Experimental info

Secondary structure

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Preferred order of sections

Molecule processing

Regions

Natural variations

Experimental info

Secondary structure

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

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P48060 (GLIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 117. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Protein names

Recommended name:
Glioma pathogenesis-related protein 1
Short name=GliPR 1

Alternative name(s):
Protein RTVP-1

Gene names

Name:	GLIPR1
Synonyms:	GLIPR, RTVP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	According to Ref.3, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to Ref.1 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.
Sequence similarities	Belongs to the CRISP family. Contains 1 SCP domain.
Sequence caution	The sequence AAA82731.3 differs from that shown. Reason: Frameshift at position 3.

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular lipid metabolic process Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	extracellular region Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Signal peptide

1 – 21

Potential

Chain

22 – 266

245

Glioma pathogenesis-related protein 1

PRO_0000006270

Transmembrane

233 – 255

Helical; Potential

Domain

38 – 175

138

SCP

Alternative sequence

142 – 266

125

VWADS…LVLLD → SQERGRDPNPKRGFLNLARE NPGLFGQIVTKLAAQFNFAL KFLALTLFPMEHILYATTDQ EGITQLGHIREEPPAVPAPI MTSVWTISVLTDSETK in isoform 2.

VSP_043902

Natural variant

163

D → E.
Corresponds to variant rs28932170 [ dbSNP | Ensembl ].

VAR_061128

Natural variant

211

R → Q.
Corresponds to variant rs3736392 [ dbSNP | Ensembl ].

VAR_048833

Sequence conflict

257

H → L in CAA63005. Ref.3

266

Helix Strand Turn

Details...

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified January 10, 2003. Version 3. Checksum: C0466C085EFB2B7A Show »	FASTA	266	30,366
10 20 30 40 50 60 MRVTLATIAW MVSFVSNYSH TANILPDIEN EDFIKDCVRI HNKFRSEVKP TASDMLYMTW 70 80 90 100 110 120 DPALAQIAKA WASNCQFSHN TRLKPPHKLH PNFTSLGENI WTGSVPIFSV SSAITNWYDE 130 140 150 160 170 180 IQDYDFKTRI CKKVCGHYTQ VVWADSYKVG CAVQFCPKVS GFDALSNGAH FICNYGPGGN 190 200 210 220 230 240 YPTWPYKRGA TCSACPNNDK CLDNLCVNRQ RDQVKRYYSV VYPGWPIYPR NRYTSLFLIV 250 260 NSVILILSVI ITILVQHKYP NLVLLD « Hide
Isoform 2 (RTVP-1b) [UniParc]. Checksum: 047EC17EE37A45C5 Show »	FASTA	237	26,919
10 20 30 40 50 60 MRVTLATIAW MVSFVSNYSH TANILPDIEN EDFIKDCVRI HNKFRSEVKP TASDMLYMTW 70 80 90 100 110 120 DPALAQIAKA WASNCQFSHN TRLKPPHKLH PNFTSLGENI WTGSVPIFSV SSAITNWYDE 130 140 150 160 170 180 IQDYDFKTRI CKKVCGHYTQ VSQERGRDPN PKRGFLNLAR ENPGLFGQIV TKLAAQFNFA 190 200 210 220 230 LKFLALTLFP MEHILYATTD QEGITQLGHI REEPPAVPAP IMTSVWTISV LTDSETK « Hide

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors." Murphy E.V., Zhang Y., Zhu W., Biggs J. Gene 159:131-135(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	Murphy E.V. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin." Rich T., Chen P., Furman F., Huynh N., Israel M.A. Gene 180:125-130(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Glial tumor.
[4]	"Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells." Xiang C., Sarid R., Cazacu S., Finniss S., Lee H.K., Ziv-Av A., Mikkelsen T., Brodie C. Biochem. Biophys. Res. Commun. 362:612-618(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Glial tumor.
[5]	Wu J., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[7]	"Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system." Szyperski T., Fernandez C., Mumenthaler C., Wuethrich K. Proc. Natl. Acad. Sci. U.S.A. 95:2262-2266(1998) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

EMBL
GenBank
DDBJ

U16307 mRNA. Translation: AAA82731.3. Frameshift.
X91911 mRNA. Translation: CAA63005.1.
AF400440 mRNA. Translation: AAK92489.1.
EF667354 mRNA. Translation: ABV21587.1.
BC012510 mRNA. Translation: AAH12510.1.

IPI

IPI00296936.
IPI00868942.

PIR

JC4131.
JC5308.

RefSeq

NP_006842.2. NM_006851.2.

UniGene

Hs.205558.

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3Q2R	X-ray	2.20	A	22-220	[»]
3Q2U	X-ray	1.85	A	22-220	[»]

ProteinModelPortal

P48060.

ModBase

Search...

IntAct

P48060. 1 interaction.

STRING

9606.ENSP00000266659.

PhosphoSite

P48060.

DMDM

27735198.

PaxDb

P48060.

PRIDE

P48060.

DNASU

11010.

StructuralBiologyKnowledgebase

Search...

Ensembl

ENST00000266659; ENSP00000266659; ENSG00000139278.

GeneID

11010.

KEGG

hsa:11010.

UCSC

uc001sxs.3. human.

CTD

11010.

GeneCards

GC12P075800.

HGNC

HGNC:17001. GLIPR1.

HPA

HPA011014.

MIM

602692. gene.

neXtProt

NX_P48060.

PharmGKB

PA134988403.

GenAtlas

Search...

eggNOG

COG2340.

HOGENOM

HOG000036879.

HOVERGEN

HBG072125.

InParanoid

P48060.

OMA

YYDFKTR.

OrthoDB

EOG4K9BD9.

PhylomeDB

P48060.

Reactome

REACT_111217. Metabolism.

ArrayExpress

P48060.

Bgee

P48060.

CleanEx

HS_GLIPR1.

Genevestigator

P48060.

GermOnline

ENSG00000139278. Homo sapiens.

Gene3D

3.40.33.10. 1 hit.

InterPro

IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]

PANTHER

PTHR10334. PTHR10334. 1 hit.

Pfam

PF00188. CAP. 1 hit.
[Graphical view]

PRINTS

PR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.

SMART

SM00198. SCP. 1 hit.
[Graphical view]

SUPFAM

SSF55797. SCP-like_extracellular. 1 hit.

PROSITE

PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

ProtoNet

Search...

EvolutionaryTrace

P48060.

GenomeRNAi

11010.

NextBio

41823.

SOURCE

Search...

Entry name

GLIP1_HUMAN

Accession

Primary (citable) accession number: P48060
Secondary accession number(s): A7YET6

Q969K2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 10, 2003
Last modified:	May 1, 2013
This is version 117 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P48060-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P48060-2)

Also known as: RTVP-1b;

The sequence of this isoform differs from the canonical sequence as follows:
142-266: VWADSYKVGC...HKYPNLVLLD → SQERGRDPNP...ISVLTDSETK

Note: Highly expressed in glioblastomas.