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P48060

- GLIP1_HUMAN

UniProt

P48060 - GLIP1_HUMAN

Protein

Glioma pathogenesis-related protein 1

Gene

GLIPR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cellular lipid metabolic process Source: Reactome
    2. small molecule metabolic process Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glioma pathogenesis-related protein 1
    Short name:
    GliPR 1
    Alternative name(s):
    Protein RTVP-1
    Gene namesi
    Name:GLIPR1
    Synonyms:GLIPR, RTVP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:17001. GLIPR1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134988403.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 266245Glioma pathogenesis-related protein 1PRO_0000006270Add
    BLAST

    Proteomic databases

    MaxQBiP48060.
    PaxDbiP48060.
    PRIDEiP48060.

    PTM databases

    PhosphoSiteiP48060.

    Expressioni

    Tissue specificityi

    According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.

    Gene expression databases

    ArrayExpressiP48060.
    BgeeiP48060.
    CleanExiHS_GLIPR1.
    GenevestigatoriP48060.

    Organism-specific databases

    HPAiHPA011014.

    Interactioni

    Protein-protein interaction databases

    IntActiP48060. 1 interaction.
    STRINGi9606.ENSP00000266659.

    Structurei

    Secondary structure

    1
    266
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi31 – 4616
    Beta strandi52 – 543
    Helixi62 – 7211
    Beta strandi76 – 783
    Beta strandi97 – 1048
    Turni105 – 1073
    Helixi110 – 1189
    Helixi119 – 1235
    Turni126 – 1294
    Beta strandi130 – 1334
    Helixi136 – 1416
    Beta strandi148 – 15710
    Beta strandi167 – 17711
    Beta strandi188 – 1903
    Turni191 – 1944
    Beta strandi200 – 2023
    Beta strandi205 – 2073
    Helixi209 – 2124

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3Q2RX-ray2.20A22-220[»]
    3Q2UX-ray1.85A22-220[»]
    ProteinModelPortaliP48060.
    SMRiP48060. Positions 22-213.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP48060.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei233 – 25523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 175138SCPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRISP family.Curated
    Contains 1 SCP domain.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2340.
    HOGENOMiHOG000036879.
    HOVERGENiHBG072125.
    InParanoidiP48060.
    OMAiYYDFKTR.
    OrthoDBiEOG7F7WB4.
    PhylomeDBiP48060.
    TreeFamiTF316148.

    Family and domain databases

    Gene3Di3.40.33.10. 1 hit.
    InterProiIPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR002413. V5_allergen.
    [Graphical view]
    PANTHERiPTHR10334. PTHR10334. 1 hit.
    PfamiPF00188. CAP. 1 hit.
    [Graphical view]
    PRINTSiPR00838. V5ALLERGEN.
    PR00837. V5TPXLIKE.
    SMARTiSM00198. SCP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55797. SSF55797. 1 hit.
    PROSITEiPS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P48060-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRVTLATIAW MVSFVSNYSH TANILPDIEN EDFIKDCVRI HNKFRSEVKP    50
    TASDMLYMTW DPALAQIAKA WASNCQFSHN TRLKPPHKLH PNFTSLGENI 100
    WTGSVPIFSV SSAITNWYDE IQDYDFKTRI CKKVCGHYTQ VVWADSYKVG 150
    CAVQFCPKVS GFDALSNGAH FICNYGPGGN YPTWPYKRGA TCSACPNNDK 200
    CLDNLCVNRQ RDQVKRYYSV VYPGWPIYPR NRYTSLFLIV NSVILILSVI 250
    ITILVQHKYP NLVLLD 266
    Length:266
    Mass (Da):30,366
    Last modified:January 10, 2003 - v3
    Checksum:iC0466C085EFB2B7A
    GO
    Isoform 2 (identifier: P48060-2) [UniParc]FASTAAdd to Basket

    Also known as: RTVP-1b

    The sequence of this isoform differs from the canonical sequence as follows:
         142-266: VWADSYKVGC...HKYPNLVLLD → SQERGRDPNP...ISVLTDSETK

    Note: Highly expressed in glioblastomas.

    Show »
    Length:237
    Mass (Da):26,919
    Checksum:i047EC17EE37A45C5
    GO

    Sequence cautioni

    The sequence AAA82731.3 differs from that shown. Reason: Frameshift at position 3.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti257 – 2571H → L in CAA63005. (PubMed:8973356)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti163 – 1631D → E.
    Corresponds to variant rs28932170 [ dbSNP | Ensembl ].
    VAR_061128
    Natural varianti211 – 2111R → Q.
    Corresponds to variant rs3736392 [ dbSNP | Ensembl ].
    VAR_048833

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei142 – 266125VWADS…LVLLD → SQERGRDPNPKRGFLNLARE NPGLFGQIVTKLAAQFNFAL KFLALTLFPMEHILYATTDQ EGITQLGHIREEPPAVPAPI MTSVWTISVLTDSETK in isoform 2. 1 PublicationVSP_043902Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U16307 mRNA. Translation: AAA82731.3. Frameshift.
    X91911 mRNA. Translation: CAA63005.1.
    AF400440 mRNA. Translation: AAK92489.1.
    EF667354 mRNA. Translation: ABV21587.1.
    BC012510 mRNA. Translation: AAH12510.1.
    CCDSiCCDS9011.1. [P48060-1]
    PIRiJC4131.
    JC5308.
    RefSeqiNP_006842.2. NM_006851.2. [P48060-1]
    UniGeneiHs.205558.

    Genome annotation databases

    GeneIDi11010.
    KEGGihsa:11010.
    UCSCiuc001sxs.3. human. [P48060-1]

    Polymorphism databases

    DMDMi27735198.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U16307 mRNA. Translation: AAA82731.3 . Frameshift.
    X91911 mRNA. Translation: CAA63005.1 .
    AF400440 mRNA. Translation: AAK92489.1 .
    EF667354 mRNA. Translation: ABV21587.1 .
    BC012510 mRNA. Translation: AAH12510.1 .
    CCDSi CCDS9011.1. [P48060-1 ]
    PIRi JC4131.
    JC5308.
    RefSeqi NP_006842.2. NM_006851.2. [P48060-1 ]
    UniGenei Hs.205558.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3Q2R X-ray 2.20 A 22-220 [» ]
    3Q2U X-ray 1.85 A 22-220 [» ]
    ProteinModelPortali P48060.
    SMRi P48060. Positions 22-213.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P48060. 1 interaction.
    STRINGi 9606.ENSP00000266659.

    PTM databases

    PhosphoSitei P48060.

    Polymorphism databases

    DMDMi 27735198.

    Proteomic databases

    MaxQBi P48060.
    PaxDbi P48060.
    PRIDEi P48060.

    Protocols and materials databases

    DNASUi 11010.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11010.
    KEGGi hsa:11010.
    UCSCi uc001sxs.3. human. [P48060-1 ]

    Organism-specific databases

    CTDi 11010.
    GeneCardsi GC12P075800.
    HGNCi HGNC:17001. GLIPR1.
    HPAi HPA011014.
    MIMi 602692. gene.
    neXtProti NX_P48060.
    PharmGKBi PA134988403.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2340.
    HOGENOMi HOG000036879.
    HOVERGENi HBG072125.
    InParanoidi P48060.
    OMAi YYDFKTR.
    OrthoDBi EOG7F7WB4.
    PhylomeDBi P48060.
    TreeFami TF316148.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.

    Miscellaneous databases

    EvolutionaryTracei P48060.
    GeneWikii GLIPR1.
    GenomeRNAii 11010.
    NextBioi 41823.
    PROi P48060.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48060.
    Bgeei P48060.
    CleanExi HS_GLIPR1.
    Genevestigatori P48060.

    Family and domain databases

    Gene3Di 3.40.33.10. 1 hit.
    InterProi IPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR002413. V5_allergen.
    [Graphical view ]
    PANTHERi PTHR10334. PTHR10334. 1 hit.
    Pfami PF00188. CAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00838. V5ALLERGEN.
    PR00837. V5TPXLIKE.
    SMARTi SM00198. SCP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55797. SSF55797. 1 hit.
    PROSITEi PS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors."
      Murphy E.V., Zhang Y., Zhu W., Biggs J.
      Gene 159:131-135(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Murphy E.V.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin."
      Rich T., Chen P., Furman F., Huynh N., Israel M.A.
      Gene 180:125-130(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Glial tumor.
    4. "Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells."
      Xiang C., Sarid R., Cazacu S., Finniss S., Lee H.K., Ziv-Av A., Mikkelsen T., Brodie C.
      Biochem. Biophys. Res. Commun. 362:612-618(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Glial tumor.
    5. Wu J., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    7. "Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system."
      Szyperski T., Fernandez C., Mumenthaler C., Wuethrich K.
      Proc. Natl. Acad. Sci. U.S.A. 95:2262-2266(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiGLIP1_HUMAN
    AccessioniPrimary (citable) accession number: P48060
    Secondary accession number(s): A7YET6
    , F8VUC2, Q15409, Q969K2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3