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Protein

Glioma pathogenesis-related protein 1

Gene

GLIPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139278-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glioma pathogenesis-related protein 1
Short name:
GliPR 1
Alternative name(s):
Protein RTVP-1
Gene namesi
Name:GLIPR1
Synonyms:GLIPR, RTVP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:17001. GLIPR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei233 – 255HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

  • extracellular region Source: InterPro
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11010.
OpenTargetsiENSG00000139278.
PharmGKBiPA134988403.

Polymorphism and mutation databases

BioMutaiGLIPR1.
DMDMi27735198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000627022 – 266Glioma pathogenesis-related protein 1Add BLAST245

Proteomic databases

EPDiP48060.
MaxQBiP48060.
PaxDbiP48060.
PeptideAtlasiP48060.
PRIDEiP48060.

PTM databases

iPTMnetiP48060.
PhosphoSitePlusiP48060.

Expressioni

Tissue specificityi

According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.

Gene expression databases

BgeeiENSG00000139278.
CleanExiHS_GLIPR1.
ExpressionAtlasiP48060. baseline and differential.
GenevisibleiP48060. HS.

Organism-specific databases

HPAiHPA011014.

Interactioni

Protein-protein interaction databases

BioGridi116200. 2 interactors.
IntActiP48060. 7 interactors.
STRINGi9606.ENSP00000266659.

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi31 – 46Combined sources16
Beta strandi52 – 54Combined sources3
Helixi62 – 72Combined sources11
Beta strandi76 – 78Combined sources3
Beta strandi97 – 104Combined sources8
Turni105 – 107Combined sources3
Helixi110 – 118Combined sources9
Helixi119 – 123Combined sources5
Turni126 – 129Combined sources4
Beta strandi130 – 133Combined sources4
Helixi136 – 141Combined sources6
Beta strandi148 – 157Combined sources10
Beta strandi167 – 177Combined sources11
Beta strandi188 – 190Combined sources3
Turni191 – 194Combined sources4
Beta strandi200 – 202Combined sources3
Beta strandi205 – 207Combined sources3
Helixi209 – 212Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q2RX-ray2.20A22-220[»]
3Q2UX-ray1.85A22-220[»]
ProteinModelPortaliP48060.
SMRiP48060.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48060.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 175SCPAdd BLAST138

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000036879.
HOVERGENiHBG072125.
InParanoidiP48060.
OMAiKPPYKLH.
OrthoDBiEOG091G048D.
PhylomeDBiP48060.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P48060-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVTLATIAW MVSFVSNYSH TANILPDIEN EDFIKDCVRI HNKFRSEVKP
60 70 80 90 100
TASDMLYMTW DPALAQIAKA WASNCQFSHN TRLKPPHKLH PNFTSLGENI
110 120 130 140 150
WTGSVPIFSV SSAITNWYDE IQDYDFKTRI CKKVCGHYTQ VVWADSYKVG
160 170 180 190 200
CAVQFCPKVS GFDALSNGAH FICNYGPGGN YPTWPYKRGA TCSACPNNDK
210 220 230 240 250
CLDNLCVNRQ RDQVKRYYSV VYPGWPIYPR NRYTSLFLIV NSVILILSVI
260
ITILVQHKYP NLVLLD
Length:266
Mass (Da):30,366
Last modified:January 10, 2003 - v3
Checksum:iC0466C085EFB2B7A
GO
Isoform 2 (identifier: P48060-2) [UniParc]FASTAAdd to basket
Also known as: RTVP-1b

The sequence of this isoform differs from the canonical sequence as follows:
     142-266: VWADSYKVGC...HKYPNLVLLD → SQERGRDPNP...ISVLTDSETK

Note: Highly expressed in glioblastomas.
Show »
Length:237
Mass (Da):26,919
Checksum:i047EC17EE37A45C5
GO

Sequence cautioni

The sequence AAA82731 differs from that shown. Reason: Frameshift at position 3.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257H → L in CAA63005 (PubMed:8973356).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061128163D → E.Corresponds to variant rs28932170dbSNPEnsembl.1
Natural variantiVAR_048833211R → Q.Corresponds to variant rs3736392dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043902142 – 266VWADS…LVLLD → SQERGRDPNPKRGFLNLARE NPGLFGQIVTKLAAQFNFAL KFLALTLFPMEHILYATTDQ EGITQLGHIREEPPAVPAPI MTSVWTISVLTDSETK in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16307 mRNA. Translation: AAA82731.3. Frameshift.
X91911 mRNA. Translation: CAA63005.1.
AF400440 mRNA. Translation: AAK92489.1.
EF667354 mRNA. Translation: ABV21587.1.
BC012510 mRNA. Translation: AAH12510.1.
CCDSiCCDS9011.1. [P48060-1]
PIRiJC4131.
JC5308.
RefSeqiNP_006842.2. NM_006851.2. [P48060-1]
UniGeneiHs.205558.

Genome annotation databases

EnsembliENST00000266659; ENSP00000266659; ENSG00000139278. [P48060-1]
GeneIDi11010.
KEGGihsa:11010.
UCSCiuc001sxs.4. human. [P48060-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16307 mRNA. Translation: AAA82731.3. Frameshift.
X91911 mRNA. Translation: CAA63005.1.
AF400440 mRNA. Translation: AAK92489.1.
EF667354 mRNA. Translation: ABV21587.1.
BC012510 mRNA. Translation: AAH12510.1.
CCDSiCCDS9011.1. [P48060-1]
PIRiJC4131.
JC5308.
RefSeqiNP_006842.2. NM_006851.2. [P48060-1]
UniGeneiHs.205558.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q2RX-ray2.20A22-220[»]
3Q2UX-ray1.85A22-220[»]
ProteinModelPortaliP48060.
SMRiP48060.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116200. 2 interactors.
IntActiP48060. 7 interactors.
STRINGi9606.ENSP00000266659.

PTM databases

iPTMnetiP48060.
PhosphoSitePlusiP48060.

Polymorphism and mutation databases

BioMutaiGLIPR1.
DMDMi27735198.

Proteomic databases

EPDiP48060.
MaxQBiP48060.
PaxDbiP48060.
PeptideAtlasiP48060.
PRIDEiP48060.

Protocols and materials databases

DNASUi11010.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266659; ENSP00000266659; ENSG00000139278. [P48060-1]
GeneIDi11010.
KEGGihsa:11010.
UCSCiuc001sxs.4. human. [P48060-1]

Organism-specific databases

CTDi11010.
DisGeNETi11010.
GeneCardsiGLIPR1.
HGNCiHGNC:17001. GLIPR1.
HPAiHPA011014.
MIMi602692. gene.
neXtProtiNX_P48060.
OpenTargetsiENSG00000139278.
PharmGKBiPA134988403.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000036879.
HOVERGENiHBG072125.
InParanoidiP48060.
OMAiKPPYKLH.
OrthoDBiEOG091G048D.
PhylomeDBiP48060.
TreeFamiTF316148.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139278-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiP48060.
GeneWikiiGLIPR1.
GenomeRNAii11010.
PROiP48060.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139278.
CleanExiHS_GLIPR1.
ExpressionAtlasiP48060. baseline and differential.
GenevisibleiP48060. HS.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLIP1_HUMAN
AccessioniPrimary (citable) accession number: P48060
Secondary accession number(s): A7YET6
, F8VUC2, Q15409, Q969K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 10, 2003
Last modified: November 30, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.