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P48060

- GLIP1_HUMAN

UniProt

P48060 - GLIP1_HUMAN

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Protein

Glioma pathogenesis-related protein 1

Gene

GLIPR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cellular lipid metabolic process Source: Reactome
  2. small molecule metabolic process Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Glioma pathogenesis-related protein 1
Short name:
GliPR 1
Alternative name(s):
Protein RTVP-1
Gene namesi
Name:GLIPR1
Synonyms:GLIPR, RTVP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:17001. GLIPR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei233 – 25523HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 266245Glioma pathogenesis-related protein 1PRO_0000006270Add
BLAST

Proteomic databases

MaxQBiP48060.
PaxDbiP48060.
PRIDEiP48060.

PTM databases

PhosphoSiteiP48060.

Expressioni

Tissue specificityi

According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.

Gene expression databases

BgeeiP48060.
CleanExiHS_GLIPR1.
ExpressionAtlasiP48060. baseline and differential.
GenevestigatoriP48060.

Organism-specific databases

HPAiHPA011014.

Interactioni

Protein-protein interaction databases

BioGridi116200. 2 interactions.
IntActiP48060. 1 interaction.
STRINGi9606.ENSP00000266659.

Structurei

Secondary structure

1
266
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi31 – 4616Combined sources
Beta strandi52 – 543Combined sources
Helixi62 – 7211Combined sources
Beta strandi76 – 783Combined sources
Beta strandi97 – 1048Combined sources
Turni105 – 1073Combined sources
Helixi110 – 1189Combined sources
Helixi119 – 1235Combined sources
Turni126 – 1294Combined sources
Beta strandi130 – 1334Combined sources
Helixi136 – 1416Combined sources
Beta strandi148 – 15710Combined sources
Beta strandi167 – 17711Combined sources
Beta strandi188 – 1903Combined sources
Turni191 – 1944Combined sources
Beta strandi200 – 2023Combined sources
Beta strandi205 – 2073Combined sources
Helixi209 – 2124Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q2RX-ray2.20A22-220[»]
3Q2UX-ray1.85A22-220[»]
ProteinModelPortaliP48060.
SMRiP48060. Positions 22-213.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48060.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 175138SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2340.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000036879.
HOVERGENiHBG072125.
InParanoidiP48060.
OMAiYYDFKTR.
OrthoDBiEOG7F7WB4.
PhylomeDBiP48060.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P48060-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVTLATIAW MVSFVSNYSH TANILPDIEN EDFIKDCVRI HNKFRSEVKP
60 70 80 90 100
TASDMLYMTW DPALAQIAKA WASNCQFSHN TRLKPPHKLH PNFTSLGENI
110 120 130 140 150
WTGSVPIFSV SSAITNWYDE IQDYDFKTRI CKKVCGHYTQ VVWADSYKVG
160 170 180 190 200
CAVQFCPKVS GFDALSNGAH FICNYGPGGN YPTWPYKRGA TCSACPNNDK
210 220 230 240 250
CLDNLCVNRQ RDQVKRYYSV VYPGWPIYPR NRYTSLFLIV NSVILILSVI
260
ITILVQHKYP NLVLLD
Length:266
Mass (Da):30,366
Last modified:January 10, 2003 - v3
Checksum:iC0466C085EFB2B7A
GO
Isoform 2 (identifier: P48060-2) [UniParc]FASTAAdd to Basket

Also known as: RTVP-1b

The sequence of this isoform differs from the canonical sequence as follows:
     142-266: VWADSYKVGC...HKYPNLVLLD → SQERGRDPNP...ISVLTDSETK

Note: Highly expressed in glioblastomas.

Show »
Length:237
Mass (Da):26,919
Checksum:i047EC17EE37A45C5
GO

Sequence cautioni

The sequence AAA82731.3 differs from that shown. Reason: Frameshift at position 3. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571H → L in CAA63005. (PubMed:8973356)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631D → E.
Corresponds to variant rs28932170 [ dbSNP | Ensembl ].
VAR_061128
Natural varianti211 – 2111R → Q.
Corresponds to variant rs3736392 [ dbSNP | Ensembl ].
VAR_048833

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 266125VWADS…LVLLD → SQERGRDPNPKRGFLNLARE NPGLFGQIVTKLAAQFNFAL KFLALTLFPMEHILYATTDQ EGITQLGHIREEPPAVPAPI MTSVWTISVLTDSETK in isoform 2. 1 PublicationVSP_043902Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16307 mRNA. Translation: AAA82731.3. Frameshift.
X91911 mRNA. Translation: CAA63005.1.
AF400440 mRNA. Translation: AAK92489.1.
EF667354 mRNA. Translation: ABV21587.1.
BC012510 mRNA. Translation: AAH12510.1.
CCDSiCCDS9011.1. [P48060-1]
PIRiJC4131.
JC5308.
RefSeqiNP_006842.2. NM_006851.2. [P48060-1]
UniGeneiHs.205558.

Genome annotation databases

EnsembliENST00000266659; ENSP00000266659; ENSG00000139278. [P48060-1]
GeneIDi11010.
KEGGihsa:11010.
UCSCiuc001sxs.3. human. [P48060-1]

Polymorphism databases

DMDMi27735198.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16307 mRNA. Translation: AAA82731.3 . Frameshift.
X91911 mRNA. Translation: CAA63005.1 .
AF400440 mRNA. Translation: AAK92489.1 .
EF667354 mRNA. Translation: ABV21587.1 .
BC012510 mRNA. Translation: AAH12510.1 .
CCDSi CCDS9011.1. [P48060-1 ]
PIRi JC4131.
JC5308.
RefSeqi NP_006842.2. NM_006851.2. [P48060-1 ]
UniGenei Hs.205558.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3Q2R X-ray 2.20 A 22-220 [» ]
3Q2U X-ray 1.85 A 22-220 [» ]
ProteinModelPortali P48060.
SMRi P48060. Positions 22-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116200. 2 interactions.
IntActi P48060. 1 interaction.
STRINGi 9606.ENSP00000266659.

PTM databases

PhosphoSitei P48060.

Polymorphism databases

DMDMi 27735198.

Proteomic databases

MaxQBi P48060.
PaxDbi P48060.
PRIDEi P48060.

Protocols and materials databases

DNASUi 11010.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266659 ; ENSP00000266659 ; ENSG00000139278 . [P48060-1 ]
GeneIDi 11010.
KEGGi hsa:11010.
UCSCi uc001sxs.3. human. [P48060-1 ]

Organism-specific databases

CTDi 11010.
GeneCardsi GC12P075800.
HGNCi HGNC:17001. GLIPR1.
HPAi HPA011014.
MIMi 602692. gene.
neXtProti NX_P48060.
PharmGKBi PA134988403.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2340.
GeneTreei ENSGT00760000119004.
HOGENOMi HOG000036879.
HOVERGENi HBG072125.
InParanoidi P48060.
OMAi YYDFKTR.
OrthoDBi EOG7F7WB4.
PhylomeDBi P48060.
TreeFami TF316148.

Enzyme and pathway databases

Reactomei REACT_116145. PPARA activates gene expression.

Miscellaneous databases

EvolutionaryTracei P48060.
GeneWikii GLIPR1.
GenomeRNAii 11010.
NextBioi 41823.
PROi P48060.
SOURCEi Search...

Gene expression databases

Bgeei P48060.
CleanExi HS_GLIPR1.
ExpressionAtlasi P48060. baseline and differential.
Genevestigatori P48060.

Family and domain databases

Gene3Di 3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
[Graphical view ]
PRINTSi PR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTi SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
PROSITEi PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors."
    Murphy E.V., Zhang Y., Zhu W., Biggs J.
    Gene 159:131-135(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Murphy E.V.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin."
    Rich T., Chen P., Furman F., Huynh N., Israel M.A.
    Gene 180:125-130(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Glial tumor.
  4. "Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells."
    Xiang C., Sarid R., Cazacu S., Finniss S., Lee H.K., Ziv-Av A., Mikkelsen T., Brodie C.
    Biochem. Biophys. Res. Commun. 362:612-618(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Glial tumor.
  5. Wu J., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  7. "Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system."
    Szyperski T., Fernandez C., Mumenthaler C., Wuethrich K.
    Proc. Natl. Acad. Sci. U.S.A. 95:2262-2266(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiGLIP1_HUMAN
AccessioniPrimary (citable) accession number: P48060
Secondary accession number(s): A7YET6
, F8VUC2, Q15409, Q969K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 10, 2003
Last modified: November 26, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3