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Protein

Sodium- and chloride-dependent betaine transporter

Gene

Slc6a12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular hyperosmotic response Source: RGD
  • cellular water homeostasis Source: RGD
  • chemical synaptic transmission Source: GO_Central
  • neurotransmitter transport Source: RGD
  • response to organic substance Source: RGD
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.
R-RNO-442660. Na+/Cl- dependent neurotransmitter transporters.
R-RNO-888593. Reuptake of GABA.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent betaine transporter
Alternative name(s):
Na(+)/Cl(-) betaine/GABA transporter
Solute carrier family 6 member 12
Gene namesi
Name:Slc6a12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620255. Slc6a12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444CytoplasmicSequence analysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei73 – 9220Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 21073ExtracellularSequence analysisAdd
BLAST
Transmembranei211 – 22919Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei238 – 25518Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei291 – 30818Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei320 – 34122Helical; Name=7Sequence analysisAdd
BLAST
Transmembranei374 – 39320Helical; Name=8Sequence analysisAdd
BLAST
Transmembranei423 – 44119Helical; Name=9Sequence analysisAdd
BLAST
Transmembranei458 – 47821Helical; Name=10Sequence analysisAdd
BLAST
Transmembranei499 – 51820Helical; Name=11Sequence analysisAdd
BLAST
Transmembranei538 – 55619Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini557 – 61458CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2111478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Sodium- and chloride-dependent betaine transporterPRO_0000214791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis
Modified residuei586 – 5861PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP48056.
PRIDEiP48056.

PTM databases

iPTMnetiP48056.
PhosphoSiteiP48056.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013547.
ExpressionAtlasiP48056. baseline and differential.
GenevisibleiP48056. RN.

Interactioni

Subunit structurei

Interacts with LIN7C.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018821.

Structurei

3D structure databases

ProteinModelPortaliP48056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP48056.
KOiK05039.
PhylomeDBiP48056.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002983. Na/ntran_symport_betaine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01198. BETTRANSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRKVTVHED GCPVVSWVPE EGEMMDQKDK DQVKDRGQWT NKMEFVLSVA
60 70 80 90 100
GEIIGLGNVW RFPYLCYKNG GGAFFIPYFI FFFSCGIPVF FLEVALGQYS
110 120 130 140 150
SQGSVTAWRK ICPLLQGIGM ASVVIESYLN IYYIIILAWA LFYLFSSFTW
160 170 180 190 200
ELPWTTCTNS WNTEHCVDFL NYSSTRAASY SENFTSPVME FWERRVLGIT
210 220 230 240 250
SGIHDLGSLR WELALCLLLA WIICYFCIWK GVKSTGKVVY FTATFPYLML
260 270 280 290 300
IILLIRGVTL PGAYQGIVFY LKPDLLRLKD PQVWMDAGTQ IFFSFAICQG
310 320 330 340 350
CLTALGSYNK YHNNCYRDSI ALCFLNSATS FVAGFVVFSI LGFMAQEQGV
360 370 380 390 400
PISEVAESGP GLAFIAFPKA VTMMPLSQLW SCLFFLMLLF LGLDSQFVCM
410 420 430 440 450
ECLVTASMDM FPQQLRKRGR RELLILAVAI VCYLMGLLLV TEGGMYIFQL
460 470 480 490 500
FDYYASSGIC LLFLSLFEVI CIGWVYGADR FYDNVEDMIG YRPWPLVKIS
510 520 530 540 550
WLFLTPGLCL ATFFFSLSKY TPLKYNNVYI YPSWGYSIGW LLAFSSMACV
560 570 580 590 600
PLFIIITLLK TQGSFKKRLQ RLITPDPSLP QPGRRSPQDG SSAQNCSTSP
610
VKQELIAWEK ETHL
Length:614
Mass (Da):69,749
Last modified:February 1, 1996 - v1
Checksum:i14C78DE5E1ED808B
GO

Sequence cautioni

The sequence AAC52867 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28927 mRNA. Translation: AAC52867.1. Different initiation.
RefSeqiNP_059031.1. NM_017335.1.
UniGeneiRn.11352.

Genome annotation databases

EnsembliENSRNOT00000089482; ENSRNOP00000071605; ENSRNOG00000013547.
GeneIDi50676.
KEGGirno:50676.
UCSCiRGD:620255. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28927 mRNA. Translation: AAC52867.1. Different initiation.
RefSeqiNP_059031.1. NM_017335.1.
UniGeneiRn.11352.

3D structure databases

ProteinModelPortaliP48056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018821.

Chemistry

ChEMBLiCHEMBL2111478.

PTM databases

iPTMnetiP48056.
PhosphoSiteiP48056.

Proteomic databases

PaxDbiP48056.
PRIDEiP48056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000089482; ENSRNOP00000071605; ENSRNOG00000013547.
GeneIDi50676.
KEGGirno:50676.
UCSCiRGD:620255. rat.

Organism-specific databases

CTDi6539.
RGDi620255. Slc6a12.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP48056.
KOiK05039.
PhylomeDBiP48056.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.
R-RNO-442660. Na+/Cl- dependent neurotransmitter transporters.
R-RNO-888593. Reuptake of GABA.

Miscellaneous databases

PROiP48056.

Gene expression databases

BgeeiENSRNOG00000013547.
ExpressionAtlasiP48056. baseline and differential.
GenevisibleiP48056. RN.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002983. Na/ntran_symport_betaine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01198. BETTRANSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS6A12_RAT
AccessioniPrimary (citable) accession number: P48056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.