Reviewed,
UniProtKB/Swiss-Prot P48051 (IRK6_HUMAN)
Last modified
June 16, 2009.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: G protein-activated inward rectifier potassium channel 2 Alternative name(s): GIRK2 Potassium channel, inwardly rectifying subfamily J member 6 Inward rectifier K(+) channel Kir3.2 KATP-2 BIR1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 423 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. |
| Subunit structure | Associates with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger By similarity. |
| Subcellular location | |
| Tissue specificity | Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas. |
| Sequence similarities | Belongs to the inward rectifier-type potassium channel family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Potassium transport Transport |
| Cellular component | Membrane |
| Domain | Transmembrane |
| Ligand | Potassium |
| Molecular function | Ionic channel Voltage-gated channel |
| Gene Ontology (GO) | |
| Biological process | potassium ion transport Ref.6 Traceable author statement. Source: ProtInc |
| Cellular component | Golgi apparatus Inferred from direct assay. Source: UniProtKB voltage-gated potassium channel complex Ref.6Traceable author statement. Source: ProtInc |
| Molecular function | G-protein activated inward rectifier potassium channel activity Traceable author statement. Source: ProtInc potassium ion bindingInferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 423 | 423 | G protein-activated inward rectifier potassium channel 2 | PRO_0000154942 | |||||
Regions | |||||||||
| Topological domain | 1 – 89 | 89 | Cytoplasmic By similarity | ||||||
| Transmembrane | 90 – 114 | 25 | M1 By similarity | ||||||
| Topological domain | 115 – 138 | 24 | Extracellular By similarity | ||||||
| Topological domain | 158 – 166 | 9 | Extracellular By similarity | ||||||
| Transmembrane | 167 – 188 | 22 | M2 By similarity | ||||||
| Topological domain | 189 – 423 | 235 | Cytoplasmic By similarity | ||||||
| Region | 139 – 150 | 12 | H5 (pore-forming helix) By similarity | ||||||
| Motif | 152 – 157 | 6 | Selectivity filter By similarity | ||||||
Sites | |||||||||
| Site | 182 | 1 | Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels." Ferrer J., Nichols C.G., Makhina E.N., Salkoff L., Bernstein J., Gerhard D., Wasson J., Ramanadham S., Permutt A. J. Biol. Chem. 270:26086-26091(1995) [PubMed: 7592809] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Insulinoma. |
| [2] | "Subunit interactions in the assembly of neuronal G protein-activated inwardly rectifying K+ channels." Dissmann E., Karschin A. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hippocampus. |
| [3] | "Gene identification in the 1.6 Mb of the Down syndrome region on chromosome 21." Ohira M., Seki N., Nagase T., Suzuki E., Nomura N., Ohara O., Saito T., Ichikawa H., Ohki M. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [4] | "Co-expression of human Kir3 subunits can yield channels with different functional properties." Schoots O., Wilson J.M., Ethier N., Bigras E., Hebert T.E., Van Tol H.H.M. Cell. Signal. 11:871-883(1999) [PubMed: 10659995] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cerebellum. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [6] | "Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit." Sakura H., Bond C., Warren-Perry M., Horsley S., Kearney L., Tucker S., Adelman J., Turner R., Ashcroft F.M. FEBS Lett. 367:193-197(1995) [PubMed: 7796919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-423. |
| [7] | "Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM." Tsaur M.-L., Menzel S., Lai F.-P., Espinosa R. III, Concannon P., Spielman R.S., Hanis C.L., Cox N.J., le Beau M.M., German M.S., Jan L.Y., Bell G.I., Stoffel M. Diabetes 44:592-596(1995) [PubMed: 7729621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 116-211. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U24660 mRNA. Translation: AAC50258.1. L78480 mRNA. Translation: AAB02277.1. D87327 mRNA. Translation: BAA13331.1. U52153 mRNA. Translation: AAB07044.1. BC101547 mRNA. Translation: AAI01548.1. S78685, S78684 Genomic DNA. Translation: AAB34738.2. G02354 Genomic DNA. No translation available. | |
| IPI | IPI00007627. |
| PIR | I38979. |
| RefSeq | NP_002231.1. |
| UniGene | Hs.658533 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1N9P based on UniProtKB P35562. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P48051. |
Proteomic databases | |
| PRIDE | P48051. |
Genome annotation databases | |
| Ensembl | ENSG00000157542. Homo sapiens. [Contig view] |
| GeneID | 3763. |
| KEGG | hsa:3763. |
Organism-specific databases | |
| GeneCards | GC21M037918. |
| H-InvDB | HIX0040889. |
| HGNC | HGNC:6267. KCNJ6. |
| HPA | CAB012452. |
| MIM | 600877. gene. |
| PharmGKB | PA30049. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P48051. |
| HOVERGEN | P48051. |
Gene expression databases | |
| ArrayExpress | P48051. |
| Bgee | P48051. |
| CleanEx | HS_KCNJ6. |
| GermOnline | ENSG00000157542. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016449. K_chnl_inward-rec_Kir. IPR001838. K_chnl_inward-rec_Kir-like. IPR003275. K_chnl_inward-rec_Kir3.2. IPR013521. K_chnl_inward-rec_Kir_Cr2. IPR013518. K_chnl_inward-rec_Kir_cyto. [Graphical view] |
| Gene3D | G3DSA:2.60.40.1400. IR_K+channel_cytopl. 1 hit. |
| PANTHER | PTHR11767. K+channel_IR. 1 hit. PTHR11767:SF19. KIR32_channel. 1 hit. |
| Pfam | PF01007. IRK. 1 hit. [Graphical view] |
| PIRSF | PIRSF005465. GIRK_kir. 1 hit. |
| PRINTS | PR01328. KIR32CHANNEL. PR01320. KIRCHANNEL. |
| ProDom | PD001103. K+channel_IR. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB01159. Halothane. |
| NextBio | 14755. |
| SOURCE | Search... |
Entry information
| Entry name | IRK6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P48051 Secondary accession number(s): Q3MJ74, Q53WW6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 21 Human chromosome 21: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


