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Protein

ATP synthase subunit O, mitochondrial

Gene

ATP5O

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • drug binding Source: UniProtKB
  • proton-transporting ATP synthase activity, rotational mechanism Source: InterPro
  • transmembrane transporter activity Source: UniProtKB
  • transporter activity Source: ProtInc

GO - Biological processi

  • ATP biosynthetic process Source: Reactome
  • cristae formation Source: Reactome
  • mitochondrial ATP synthesis coupled proton transport Source: UniProtKB
  • proton transmembrane transport Source: UniProtKB

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit O, mitochondrial
Alternative name(s):
Oligomycin sensitivity conferral protein
Short name:
OSCP
Gene namesi
Name:ATP5O
Synonyms:ATPO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000241837.6
HGNCiHGNC:850 ATP5O
MIMi600828 gene
neXtProtiNX_P48047

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi162K → R: Increased ATP levels. 1 Publication1

Organism-specific databases

DisGeNETi539
OpenTargetsiENSG00000241837
PharmGKBiPA25144

Polymorphism and mutation databases

BioMutaiATP5O
DMDMi1352049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23Mitochondrion1 PublicationAdd BLAST23
ChainiPRO_000000264624 – 213ATP synthase subunit O, mitochondrialAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54N6-acetyllysineBy similarity1
Modified residuei60N6-acetyllysineBy similarity1
Modified residuei70N6-acetyllysineBy similarity1
Modified residuei73N6-acetyllysineBy similarity1
Modified residuei90N6-succinyllysineBy similarity1
Modified residuei158N6-acetyllysine; alternateBy similarity1
Modified residuei158N6-succinyllysine; alternateBy similarity1
Modified residuei162N6-acetyllysine; alternateCombined sources1 Publication1
Modified residuei162N6-succinyllysine; alternateBy similarity1
Modified residuei172N6-acetyllysineCombined sources1
Modified residuei176N6-acetyllysineBy similarity1
Modified residuei192N6-acetyllysineCombined sources1
Modified residuei199N6-succinyllysineBy similarity1

Post-translational modificationi

Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP48047
MaxQBiP48047
PaxDbiP48047
PeptideAtlasiP48047
PRIDEiP48047
TopDownProteomicsiP48047

2D gel databases

OGPiP48047
UCD-2DPAGEiP48047

PTM databases

iPTMnetiP48047
PhosphoSitePlusiP48047
SwissPalmiP48047

Expressioni

Gene expression databases

BgeeiENSG00000241837
CleanExiHS_ATP5O
ExpressionAtlasiP48047 baseline and differential
GenevisibleiP48047 HS

Organism-specific databases

HPAiCAB016209
HPA041394

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107021107 interactors.
CORUMiP48047
IntActiP48047 64 interactors.
MINTiP48047
STRINGi9606.ENSP00000290299

Structurei

3D structure databases

ProteinModelPortaliP48047
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase delta chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1662 Eukaryota
COG0712 LUCA
GeneTreeiENSGT00390000015060
HOGENOMiHOG000075825
HOVERGENiHBG004309
InParanoidiP48047
KOiK02137
OMAiMVDNIQD
OrthoDBiEOG091G0L4M
PhylomeDBiP48047
TreeFamiTF106241

Family and domain databases

Gene3Di1.10.520.201 hit
HAMAPiMF_01416 ATP_synth_delta_bact, 1 hit
InterProiView protein in InterPro
IPR026015 ATP_synth_OSCP/delta_N_sf
IPR020781 ATPase_OSCP/d_CS
IPR000711 ATPase_OSCP/dsu
PANTHERiPTHR11910 PTHR11910, 1 hit
PfamiView protein in Pfam
PF00213 OSCP, 1 hit
PRINTSiPR00125 ATPASEDELTA
SUPFAMiSSF47928 SSF47928, 1 hit
TIGRFAMsiTIGR01145 ATP_synt_delta, 1 hit
PROSITEiView protein in PROSITE
PS00389 ATPASE_DELTA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAVSGLS RQVRCFSTSV VRPFAKLVRP PVQVYGIEGR YATALYSAAS
60 70 80 90 100
KQNKLEQVEK ELLRVAQILK EPKVAASVLN PYVKRSIKVK SLNDITAKER
110 120 130 140 150
FSPLTTNLIN LLAENGRLSN TQGVVSAFST MMSVHRGEVP CTVTSASPLE
160 170 180 190 200
EATLSELKTV LKSFLSQGQV LKLEAKTDPS ILGGMIVRIG EKYVDMSVKT
210
KIQKLGRAMR EIV
Length:213
Mass (Da):23,277
Last modified:February 1, 1996 - v1
Checksum:i311F53576A31FC93
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01193098K → R2 PublicationsCorresponds to variant dbSNP:rs4842Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83218 mRNA Translation: CAA58219.1
BT019836 mRNA Translation: AAV38639.1
CR456822 mRNA Translation: CAG33103.1
AK222962 mRNA Translation: BAD96682.1
AK311796 mRNA Translation: BAG34739.1
CH471079 Genomic DNA Translation: EAX09802.1
BC021233 mRNA Translation: AAH21233.1
BC022865 mRNA Translation: AAH22865.1
CCDSiCCDS13634.1
RefSeqiNP_001688.1, NM_001697.2
UniGeneiHs.409140

Genome annotation databases

EnsembliENST00000290299; ENSP00000290299; ENSG00000241837
GeneIDi539
KEGGihsa:539
UCSCiuc002ytl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiATPO_HUMAN
AccessioniPrimary (citable) accession number: P48047
Secondary accession number(s): B2R4E2, Q5U042, Q6IBI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 25, 2018
This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome