Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vasopressin V2 receptor

Gene

AVPR2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin (PubMed:7698346, PubMed:8257689). The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei102Implicated in agonist binding1
Sitei106Implicated in agonist binding1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-388479. Vasopressin-like receptors.
R-BTA-418555. G alpha (s) signalling events.
R-BTA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-BTA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-BTA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene namesi
Name:AVPR2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 77CytoplasmicSequence analysisAdd BLAST14
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 113ExtracellularSequence analysisAdd BLAST15
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 159CytoplasmicSequence analysisAdd BLAST24
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 199ExtracellularSequence analysisAdd BLAST19
Transmembranei200 – 219Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini220 – 270CytoplasmicSequence analysisAdd BLAST51
Transmembranei271 – 292Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini293 – 307ExtracellularSequence analysisAdd BLAST15
Transmembranei308 – 327Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini328 – 370CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702061 – 370Vasopressin V2 receptorAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Lipidationi340S-palmitoyl cysteineBy similarity1
Lipidationi341S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP48044.
PRIDEiP48044.

Expressioni

Gene expression databases

BgeeiENSBTAG00000047138.
ExpressionAtlasiP48044. differential.

Interactioni

Subunit structurei

Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055744.

Chemistry databases

BindingDBiP48044.

Structurei

3D structure databases

ProteinModelPortaliP48044.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOVERGENiHBG105710.
InParanoidiP48044.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG091G0DB6.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFMASTTSAV PWHLSQPTPA GNGSEGELLT ARDPLLAQAE LALLSTVFVA
60 70 80 90 100
VALSNGLVLG ALVRRGRRGR WAPMHVFIGH LCLADLAVAL FQVLPQLAWD
110 120 130 140 150
ATDRFRGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAHRH
160 170 180 190 200
GGGTHWNRPV LLAWAFSLLF SLPQLFIFAQ RDVDGSGVLD CWARFAEPWG
210 220 230 240 250
LRAYVTWIAL MVFVAPALGI AACQVLIFRE IHASLGPGPV PRAGGPRRGC
260 270 280 290 300
RPGSPAEGAR VSAAVAKTVK MTLVIVIVYV LCWAPFFLVQ LWAAWDPEAP
310 320 330 340 350
REGPPFVLLM LLASLNSCTN PWIYASFSSS ISSELRSLLC CTWRRAPPSP
360 370
GPQEESCATA SSFLAKDTPS
Length:370
Mass (Da):40,236
Last modified:February 1, 1996 - v1
Checksum:i5FDCCC2CD21DD4AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83741 mRNA. Translation: CAA58709.1.
PIRiS68777.
RefSeqiNP_776671.1. NM_174246.2.
UniGeneiBt.98.

Genome annotation databases

EnsembliENSBTAT00000065044; ENSBTAP00000055744; ENSBTAG00000047138.
GeneIDi281642.
KEGGibta:281642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83741 mRNA. Translation: CAA58709.1.
PIRiS68777.
RefSeqiNP_776671.1. NM_174246.2.
UniGeneiBt.98.

3D structure databases

ProteinModelPortaliP48044.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055744.

Chemistry databases

BindingDBiP48044.
ChEMBLiCHEMBL2344.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP48044.
PRIDEiP48044.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000065044; ENSBTAP00000055744; ENSBTAG00000047138.
GeneIDi281642.
KEGGibta:281642.

Organism-specific databases

CTDi554.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOVERGENiHBG105710.
InParanoidiP48044.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG091G0DB6.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-BTA-388479. Vasopressin-like receptors.
R-BTA-418555. G alpha (s) signalling events.
R-BTA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-BTA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-BTA-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiP48044.

Gene expression databases

BgeeiENSBTAG00000047138.
ExpressionAtlasiP48044. differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV2R_BOVIN
AccessioniPrimary (citable) accession number: P48044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.