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Protein

P2Y purinoceptor 1

Gene

P2RY1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for extracellular adenine nucleotides such as ATP and ADP.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-416476. G alpha (q) signalling events.
R-BTA-417957. P2Y receptors.
R-BTA-418592. ADP signalling through P2Y purinoceptor 1.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 1
Short name:
P2Y1
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RY1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularSequence analysisAdd
BLAST
Transmembranei53 – 7422Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini75 – 8713CytoplasmicSequence analysisAdd
BLAST
Transmembranei88 – 10922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini110 – 12617ExtracellularSequence analysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini148 – 16619CytoplasmicSequence analysisAdd
BLAST
Transmembranei167 – 18822Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini189 – 21830ExtracellularSequence analysisAdd
BLAST
Transmembranei219 – 23820Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini239 – 26527CytoplasmicSequence analysisAdd
BLAST
Transmembranei266 – 28520Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini286 – 30318ExtracellularSequence analysisAdd
BLAST
Transmembranei304 – 32825Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini329 – 37345CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373P2Y purinoceptor 1PRO_0000070004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence analysis
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48042.
PRIDEiP48042.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001919.

Structurei

3D structure databases

ProteinModelPortaliP48042.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP48042.
KOiK04270.
OMAiDYLRSYF.
OrthoDBiEOG7GFB51.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEVLWPAVP NGTDTAFLAD PGSPWGNSTV TSTAAVASPF KCALTKTGFQ
60 70 80 90 100
FYYLPAVYIL VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY
110 120 130 140 150
VLTLPALIFY YFNKTDWIFG DAMCKLQRFI FHVNLYGSIL FLTCISAHRY
160 170 180 190 200
SGVVYPLKSL GRLKKKNAVY ISVLVWLIVV VGISPILFYS GTGIRKNKTI
210 220 230 240 250
TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI VRALIYKDLD
260 270 280 290 300
NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPEMCAFND
310 320 330 340 350
RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL
360 370
QSKSEDMTLN ILSEFKQNGD TSL
Length:373
Mass (Da):42,288
Last modified:February 1, 1996 - v1
Checksum:i9270A7175C0BDA76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87628 mRNA. Translation: CAA60958.1.
U34041 mRNA. Translation: AAC78275.1.
PIRiJC4162.
RefSeqiNP_776835.1. NM_174410.3.
UniGeneiBt.303.

Genome annotation databases

EnsembliENSBTAT00000001919; ENSBTAP00000001919; ENSBTAG00000001465.
GeneIDi281963.
KEGGibta:281963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87628 mRNA. Translation: CAA60958.1.
U34041 mRNA. Translation: AAC78275.1.
PIRiJC4162.
RefSeqiNP_776835.1. NM_174410.3.
UniGeneiBt.303.

3D structure databases

ProteinModelPortaliP48042.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001919.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP48042.
PRIDEiP48042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001919; ENSBTAP00000001919; ENSBTAG00000001465.
GeneIDi281963.
KEGGibta:281963.

Organism-specific databases

CTDi5028.

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP48042.
KOiK04270.
OMAiDYLRSYF.
OrthoDBiEOG7GFB51.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-BTA-416476. G alpha (q) signalling events.
R-BTA-417957. P2Y receptors.
R-BTA-418592. ADP signalling through P2Y purinoceptor 1.

Miscellaneous databases

NextBioi20805835.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aortic endothelium.
  2. "Cloning and expression of a P2y purinoceptor from the adult bovine corpus callosum."
    Deng G., Matute C., Kumar C.K., Fogarty D.J., Miledi R.
    Neurobiol. Dis. 5:259-270(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Corpus callosum.

Entry informationi

Entry nameiP2RY1_BOVIN
AccessioniPrimary (citable) accession number: P48042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 9, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.