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P48039

- MTR1A_HUMAN

UniProt

P48039 - MTR1A_HUMAN

Protein

Melatonin receptor type 1A

Gene

MTNR1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

    GO - Molecular functioni

    1. hormone binding Source: BHF-UCL
    2. melatonin receptor activity Source: ProtInc
    3. organic cyclic compound binding Source: BHF-UCL
    4. protein binding Source: IntAct

    GO - Biological processi

    1. circadian rhythm Source: ProtInc
    2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    3. mating behavior Source: ProtInc
    4. positive regulation of cGMP biosynthetic process Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.
    SignaLinkiP48039.

    Protein family/group databases

    TCDBi9.A.14.1.3. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melatonin receptor type 1A
    Short name:
    Mel-1A-R
    Short name:
    Mel1a receptor
    Gene namesi
    Name:MTNR1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:7463. MTNR1A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: BHF-UCL
    2. plasma membrane Source: Reactome
    3. receptor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31267.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Melatonin receptor type 1APRO_0000069862Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi100 ↔ 177PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP48039.
    PRIDEiP48039.

    Expressioni

    Tissue specificityi

    Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.

    Gene expression databases

    BgeeiP48039.
    CleanExiHS_MTNR1A.
    GenevestigatoriP48039.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MTNR1BP492862EBI-1188238,EBI-1188341
    RGS20O760816EBI-1188238,EBI-1052678

    Protein-protein interaction databases

    BioGridi110639. 23 interactions.
    IntActiP48039. 23 interactions.
    MINTiMINT-8087019.
    STRINGi9606.ENSP00000302811.

    Structurei

    3D structure databases

    ProteinModelPortaliP48039.
    SMRiP48039. Positions 39-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 6313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini85 – 10218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini124 – 14219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 18724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 24032CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 27413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini296 – 35055CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei64 – 8421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG138016.
    HOGENOMiHOG000037953.
    HOVERGENiHBG052528.
    InParanoidiP48039.
    KOiK04285.
    OMAiLMTNNNV.
    PhylomeDBiP48039.
    TreeFamiTF331693.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002278. Mel_1A_rcpt.
    IPR000025. Melatonin_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01149. MELATONIN1AR.
    PR00857. MELATONINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48039-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQGNGSALPN ASQPVLRGDG ARPSWLASAL ACVLIFTIVV DILGNLLVIL    50
    SVYRNKKLRN AGNIFVVSLA VADLVVAIYP YPLVLMSIFN NGWNLGYLHC 100
    QVSGFLMGLS VIGSIFNITG IAINRYCYIC HSLKYDKLYS SKNSLCYVLL 150
    IWLLTLAAVL PNLRAGTLQY DPRIYSCTFA QSVSSAYTIA VVVFHFLVPM 200
    IIVIFCYLRI WILVLQVRQR VKPDRKPKLK PQDFRNFVTM FVVFVLFAIC 250
    WAPLNFIGLA VASDPASMVP RIPEWLFVAS YYMAYFNSCL NAIIYGLLNQ 300
    NFRKEYRRII VSLCTARVFF VDSSNDVADR VKWKPSPLMT NNNVVKVDSV 350
    Length:350
    Mass (Da):39,375
    Last modified:February 1, 1996 - v1
    Checksum:iDF7C67111D2386ED
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541R → W Exhibits significantly reduced B(max) and slightly enhanced affinity. 1 Publication
    Corresponds to variant rs1800885 [ dbSNP | Ensembl ].
    VAR_009260
    Natural varianti157 – 1571A → V Similar binding characteristics compared to wild-type. 1 Publication
    Corresponds to variant rs1800884 [ dbSNP | Ensembl ].
    VAR_009261
    Natural varianti212 – 2121I → T.
    Corresponds to variant rs7654853 [ dbSNP | Ensembl ].
    VAR_049420

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14108 mRNA. Translation: AAB17720.1.
    AB029933 Genomic DNA. Translation: BAA85303.1.
    EU432127 mRNA. Translation: ABY87926.1.
    BC074946 mRNA. Translation: AAH74946.1.
    BC074947 mRNA. Translation: AAH74947.1.
    BC126297 mRNA. Translation: AAI26298.1.
    BC126299 mRNA. Translation: AAI26300.1.
    CCDSiCCDS3848.1.
    PIRiI38848.
    RefSeqiNP_005949.1. NM_005958.3.
    UniGeneiHs.243467.

    Genome annotation databases

    EnsembliENST00000307161; ENSP00000302811; ENSG00000168412.
    GeneIDi4543.
    KEGGihsa:4543.
    UCSCiuc003izd.1. human.

    Polymorphism databases

    DMDMi1346544.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Melatonin receptor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14108 mRNA. Translation: AAB17720.1 .
    AB029933 Genomic DNA. Translation: BAA85303.1 .
    EU432127 mRNA. Translation: ABY87926.1 .
    BC074946 mRNA. Translation: AAH74946.1 .
    BC074947 mRNA. Translation: AAH74947.1 .
    BC126297 mRNA. Translation: AAI26298.1 .
    BC126299 mRNA. Translation: AAI26300.1 .
    CCDSi CCDS3848.1.
    PIRi I38848.
    RefSeqi NP_005949.1. NM_005958.3.
    UniGenei Hs.243467.

    3D structure databases

    ProteinModelPortali P48039.
    SMRi P48039. Positions 39-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110639. 23 interactions.
    IntActi P48039. 23 interactions.
    MINTi MINT-8087019.
    STRINGi 9606.ENSP00000302811.

    Chemistry

    BindingDBi P48039.
    ChEMBLi CHEMBL2094268.
    DrugBanki DB01065. Melatonin.
    DB00980. Ramelteon.
    GuidetoPHARMACOLOGYi 287.

    Protein family/group databases

    TCDBi 9.A.14.1.3. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    Polymorphism databases

    DMDMi 1346544.

    Proteomic databases

    PaxDbi P48039.
    PRIDEi P48039.

    Protocols and materials databases

    DNASUi 4543.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307161 ; ENSP00000302811 ; ENSG00000168412 .
    GeneIDi 4543.
    KEGGi hsa:4543.
    UCSCi uc003izd.1. human.

    Organism-specific databases

    CTDi 4543.
    GeneCardsi GC04M187454.
    HGNCi HGNC:7463. MTNR1A.
    MIMi 600665. gene.
    neXtProti NX_P48039.
    PharmGKBi PA31267.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG138016.
    HOGENOMi HOG000037953.
    HOVERGENi HBG052528.
    InParanoidi P48039.
    KOi K04285.
    OMAi LMTNNNV.
    PhylomeDBi P48039.
    TreeFami TF331693.

    Enzyme and pathway databases

    Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.
    SignaLinki P48039.

    Miscellaneous databases

    GeneWikii Melatonin_receptor_1A.
    GenomeRNAii 4543.
    NextBioi 17521.
    PROi P48039.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48039.
    CleanExi HS_MTNR1A.
    Genevestigatori P48039.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002278. Mel_1A_rcpt.
    IPR000025. Melatonin_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01149. MELATONIN1AR.
    PR00857. MELATONINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses."
      Reppert S.M., Weaver D.R., Ebisawa T.
      Neuron 13:1177-1185(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TRP-54 AND VAL-157.
      Tissue: Leukocyte.
    3. Huang Y.-H., Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hippocampus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiMTR1A_HUMAN
    AccessioniPrimary (citable) accession number: P48039
    Secondary accession number(s): A0AVC5, B0M0L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3