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P48039 (MTR1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melatonin receptor type 1A

Short name=Mel-1A-R
Short name=Mel1a receptor
Gene names
Name:MTNR1A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Melatonin receptor type 1A
PRO_0000069862

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 6313Cytoplasmic Potential
Transmembrane64 – 8421Helical; Name=2; Potential
Topological domain85 – 10218Extracellular Potential
Transmembrane103 – 12321Helical; Name=3; Potential
Topological domain124 – 14219Cytoplasmic Potential
Transmembrane143 – 16321Helical; Name=4; Potential
Topological domain164 – 18724Extracellular Potential
Transmembrane188 – 20821Helical; Name=5; Potential
Topological domain209 – 24032Cytoplasmic Potential
Transmembrane241 – 26121Helical; Name=6; Potential
Topological domain262 – 27413Extracellular Potential
Transmembrane275 – 29521Helical; Name=7; Potential
Topological domain296 – 35055Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Disulfide bond100 ↔ 177 By similarity

Natural variations

Natural variant541R → W Exhibits significantly reduced B(max) and slightly enhanced affinity. Ref.2
Corresponds to variant rs1800885 [ dbSNP | Ensembl ].
VAR_009260
Natural variant1571A → V Similar binding characteristics compared to wild-type. Ref.2
Corresponds to variant rs1800884 [ dbSNP | Ensembl ].
VAR_009261
Natural variant2121I → T.
Corresponds to variant rs7654853 [ dbSNP | Ensembl ].
VAR_049420

Sequences

Sequence LengthMass (Da)Tools
P48039 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: DF7C67111D2386ED

FASTA35039,375
        10         20         30         40         50         60 
MQGNGSALPN ASQPVLRGDG ARPSWLASAL ACVLIFTIVV DILGNLLVIL SVYRNKKLRN 

        70         80         90        100        110        120 
AGNIFVVSLA VADLVVAIYP YPLVLMSIFN NGWNLGYLHC QVSGFLMGLS VIGSIFNITG 

       130        140        150        160        170        180 
IAINRYCYIC HSLKYDKLYS SKNSLCYVLL IWLLTLAAVL PNLRAGTLQY DPRIYSCTFA 

       190        200        210        220        230        240 
QSVSSAYTIA VVVFHFLVPM IIVIFCYLRI WILVLQVRQR VKPDRKPKLK PQDFRNFVTM 

       250        260        270        280        290        300 
FVVFVLFAIC WAPLNFIGLA VASDPASMVP RIPEWLFVAS YYMAYFNSCL NAIIYGLLNQ 

       310        320        330        340        350 
NFRKEYRRII VSLCTARVFF VDSSNDVADR VKWKPSPLMT NNNVVKVDSV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses."
Reppert S.M., Weaver D.R., Ebisawa T.
Neuron 13:1177-1185(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders."
Ebisawa T., Kajimura N., Uchiyama M., Katoh M., Sekimoto M., Watanabe T., Ozeki Y., Ikeda M., Jodoi T., Sugishita M., Iwase T., Kamei Y., Kim K., Shibui K., Kudo Y., Yamada N., Toyoshima R., Okawa M., Takahashi K., Yamauchi T.
Biochem. Biophys. Res. Commun. 262:832-837(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TRP-54 AND VAL-157.
Tissue: Leukocyte.
[3]Huang Y.-H., Kaighin V.A., Martin A.L., Aronstam R.S.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hippocampus.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Web resources

Wikipedia

Melatonin receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U14108 mRNA. Translation: AAB17720.1.
AB029933 Genomic DNA. Translation: BAA85303.1.
EU432127 mRNA. Translation: ABY87926.1.
BC074946 mRNA. Translation: AAH74946.1.
BC074947 mRNA. Translation: AAH74947.1.
BC126297 mRNA. Translation: AAI26298.1.
BC126299 mRNA. Translation: AAI26300.1.
PIRI38848.
RefSeqNP_005949.1. NM_005958.3.
UniGeneHs.243467.

3D structure databases

ProteinModelPortalP48039.
SMRP48039. Positions 29-323.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110639. 23 interactions.
IntActP48039. 23 interactions.
MINTMINT-8087019.
STRING9606.ENSP00000302811.

Chemistry

BindingDBP48039.
ChEMBLCHEMBL1945.
DrugBankDB01065. Melatonin.
DB00980. Ramelteon.
GuidetoPHARMACOLOGY287.

Protein family/group databases

TCDB9.A.14.1.3. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

Polymorphism databases

DMDM1346544.

Proteomic databases

PaxDbP48039.
PRIDEP48039.

Protocols and materials databases

DNASU4543.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307161; ENSP00000302811; ENSG00000168412.
GeneID4543.
KEGGhsa:4543.
UCSCuc003izd.1. human.

Organism-specific databases

CTD4543.
GeneCardsGC04M187454.
HGNCHGNC:7463. MTNR1A.
MIM600665. gene.
neXtProtNX_P48039.
PharmGKBPA31267.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG138016.
HOGENOMHOG000037953.
HOVERGENHBG052528.
InParanoidP48039.
KOK04285.
OMAMIIVIFC.
PhylomeDBP48039.
TreeFamTF331693.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP48039.

Gene expression databases

BgeeP48039.
CleanExHS_MTNR1A.
GenevestigatorP48039.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMelatonin_receptor_1A.
GenomeRNAi4543.
NextBio17521.
PROP48039.
SOURCESearch...

Entry information

Entry nameMTR1A_HUMAN
AccessionPrimary (citable) accession number: P48039
Secondary accession number(s): A0AVC5, B0M0L2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries