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P48039

- MTR1A_HUMAN

UniProt

P48039 - MTR1A_HUMAN

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Protein

Melatonin receptor type 1A

Gene

MTNR1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

  1. hormone binding Source: BHF-UCL
  2. melatonin receptor activity Source: ProtInc
  3. organic cyclic compound binding Source: BHF-UCL

GO - Biological processi

  1. circadian rhythm Source: ProtInc
  2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  3. mating behavior Source: ProtInc
  4. positive regulation of cGMP biosynthetic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.
SignaLinkiP48039.

Protein family/group databases

TCDBi9.A.14.1.3. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1A
Short name:
Mel-1A-R
Short name:
Mel1a receptor
Gene namesi
Name:MTNR1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:7463. MTNR1A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 6313CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei64 – 8421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini85 – 10218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini124 – 14219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei143 – 16321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini164 – 18724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 24032CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini262 – 27413ExtracellularSequence AnalysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini296 – 35055CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: BHF-UCL
  2. plasma membrane Source: Reactome
  3. receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31267.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Melatonin receptor type 1APRO_0000069862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi100 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48039.
PRIDEiP48039.

Expressioni

Tissue specificityi

Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.

Gene expression databases

BgeeiP48039.
CleanExiHS_MTNR1A.
GenevestigatoriP48039.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MTNR1BP492862EBI-1188238,EBI-1188341
RGS20O760816EBI-1188238,EBI-1052678

Protein-protein interaction databases

BioGridi110639. 23 interactions.
IntActiP48039. 23 interactions.
MINTiMINT-8087019.
STRINGi9606.ENSP00000302811.

Structurei

3D structure databases

ProteinModelPortaliP48039.
SMRiP48039. Positions 39-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG138016.
GeneTreeiENSGT00440000033318.
HOGENOMiHOG000037953.
HOVERGENiHBG052528.
InParanoidiP48039.
KOiK04285.
OMAiLMTNNNV.
PhylomeDBiP48039.
TreeFamiTF331693.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48039-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQGNGSALPN ASQPVLRGDG ARPSWLASAL ACVLIFTIVV DILGNLLVIL
60 70 80 90 100
SVYRNKKLRN AGNIFVVSLA VADLVVAIYP YPLVLMSIFN NGWNLGYLHC
110 120 130 140 150
QVSGFLMGLS VIGSIFNITG IAINRYCYIC HSLKYDKLYS SKNSLCYVLL
160 170 180 190 200
IWLLTLAAVL PNLRAGTLQY DPRIYSCTFA QSVSSAYTIA VVVFHFLVPM
210 220 230 240 250
IIVIFCYLRI WILVLQVRQR VKPDRKPKLK PQDFRNFVTM FVVFVLFAIC
260 270 280 290 300
WAPLNFIGLA VASDPASMVP RIPEWLFVAS YYMAYFNSCL NAIIYGLLNQ
310 320 330 340 350
NFRKEYRRII VSLCTARVFF VDSSNDVADR VKWKPSPLMT NNNVVKVDSV
Length:350
Mass (Da):39,375
Last modified:February 1, 1996 - v1
Checksum:iDF7C67111D2386ED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541R → W Exhibits significantly reduced B(max) and slightly enhanced affinity. 1 Publication
Corresponds to variant rs1800885 [ dbSNP | Ensembl ].
VAR_009260
Natural varianti157 – 1571A → V Similar binding characteristics compared to wild-type. 1 Publication
Corresponds to variant rs1800884 [ dbSNP | Ensembl ].
VAR_009261
Natural varianti212 – 2121I → T.
Corresponds to variant rs7654853 [ dbSNP | Ensembl ].
VAR_049420

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14108 mRNA. Translation: AAB17720.1.
AB029933 Genomic DNA. Translation: BAA85303.1.
EU432127 mRNA. Translation: ABY87926.1.
BC074946 mRNA. Translation: AAH74946.1.
BC074947 mRNA. Translation: AAH74947.1.
BC126297 mRNA. Translation: AAI26298.1.
BC126299 mRNA. Translation: AAI26300.1.
CCDSiCCDS3848.1.
PIRiI38848.
RefSeqiNP_005949.1. NM_005958.3.
UniGeneiHs.243467.

Genome annotation databases

EnsembliENST00000307161; ENSP00000302811; ENSG00000168412.
GeneIDi4543.
KEGGihsa:4543.
UCSCiuc003izd.1. human.

Polymorphism databases

DMDMi1346544.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Melatonin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14108 mRNA. Translation: AAB17720.1 .
AB029933 Genomic DNA. Translation: BAA85303.1 .
EU432127 mRNA. Translation: ABY87926.1 .
BC074946 mRNA. Translation: AAH74946.1 .
BC074947 mRNA. Translation: AAH74947.1 .
BC126297 mRNA. Translation: AAI26298.1 .
BC126299 mRNA. Translation: AAI26300.1 .
CCDSi CCDS3848.1.
PIRi I38848.
RefSeqi NP_005949.1. NM_005958.3.
UniGenei Hs.243467.

3D structure databases

ProteinModelPortali P48039.
SMRi P48039. Positions 39-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110639. 23 interactions.
IntActi P48039. 23 interactions.
MINTi MINT-8087019.
STRINGi 9606.ENSP00000302811.

Chemistry

BindingDBi P48039.
ChEMBLi CHEMBL1945.
DrugBanki DB06594. Agomelatine.
DB01065. Melatonin.
DB00980. Ramelteon.
GuidetoPHARMACOLOGYi 287.

Protein family/group databases

TCDBi 9.A.14.1.3. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

Polymorphism databases

DMDMi 1346544.

Proteomic databases

PaxDbi P48039.
PRIDEi P48039.

Protocols and materials databases

DNASUi 4543.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307161 ; ENSP00000302811 ; ENSG00000168412 .
GeneIDi 4543.
KEGGi hsa:4543.
UCSCi uc003izd.1. human.

Organism-specific databases

CTDi 4543.
GeneCardsi GC04M187454.
HGNCi HGNC:7463. MTNR1A.
MIMi 600665. gene.
neXtProti NX_P48039.
PharmGKBi PA31267.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG138016.
GeneTreei ENSGT00440000033318.
HOGENOMi HOG000037953.
HOVERGENi HBG052528.
InParanoidi P48039.
KOi K04285.
OMAi LMTNNNV.
PhylomeDBi P48039.
TreeFami TF331693.

Enzyme and pathway databases

Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.
SignaLinki P48039.

Miscellaneous databases

GeneWikii Melatonin_receptor_1A.
GenomeRNAii 4543.
NextBioi 17521.
PROi P48039.
SOURCEi Search...

Gene expression databases

Bgeei P48039.
CleanExi HS_MTNR1A.
Genevestigatori P48039.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses."
    Reppert S.M., Weaver D.R., Ebisawa T.
    Neuron 13:1177-1185(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TRP-54 AND VAL-157.
    Tissue: Leukocyte.
  3. Huang Y.-H., Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMTR1A_HUMAN
AccessioniPrimary (citable) accession number: P48039
Secondary accession number(s): A0AVC5, B0M0L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3