P48039 (MTR1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Melatonin receptor type 1A
Short name=Mel-1A-R
Short name=Mel1a receptor

Gene names

Name:

MTNR1A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement PubMed 9645677. Source: ProtInc circadian rhythm Traceable author statement PubMed 9645677. Source: ProtInc mating behavior Traceable author statement Ref.1. Source: ProtInc positive regulation of cGMP biosynthetic process Inferred from direct assay PubMed 10531408. Source: BHF-UCL
Cellular_component	integral to plasma membrane Inferred from direct assay PubMed 10531408. Source: BHF-UCL receptor complex Inferred from direct assay PubMed 10531408. Source: BHF-UCL
Molecular_function	hormone binding Inferred from physical interaction PubMed 10531408. Source: BHF-UCL melatonin receptor activity Traceable author statement PubMed 9645677. Source: ProtInc organic cyclic compound binding Inferred from physical interaction PubMed 10531408. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Melatonin receptor type 1A		PRO_0000069862
Regions
	Topological domain	1 – 29	29	Extracellular Potential
	Transmembrane	30 – 50	21	Helical; Name=1; Potential
	Topological domain	51 – 63	13	Cytoplasmic Potential
	Transmembrane	64 – 84	21	Helical; Name=2; Potential
	Topological domain	85 – 102	18	Extracellular Potential
	Transmembrane	103 – 123	21	Helical; Name=3; Potential
	Topological domain	124 – 142	19	Cytoplasmic Potential
	Transmembrane	143 – 163	21	Helical; Name=4; Potential
	Topological domain	164 – 187	24	Extracellular Potential
	Transmembrane	188 – 208	21	Helical; Name=5; Potential
	Topological domain	209 – 240	32	Cytoplasmic Potential
	Transmembrane	241 – 261	21	Helical; Name=6; Potential
	Topological domain	262 – 274	13	Extracellular Potential
	Transmembrane	275 – 295	21	Helical; Name=7; Potential
	Topological domain	296 – 350	55	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Disulfide bond	100 ↔ 177		By similarity
Natural variations
	Natural variant	54	1	R → W Exhibits significantly reduced B(max) and slightly enhanced affinity. Ref.2 Corresponds to variant rs1800885 [ dbSNP | Ensembl ].		VAR_009260
	Natural variant	157	1	A → V Similar binding characteristics compared to wild-type. Ref.2 Corresponds to variant rs1800884 [ dbSNP | Ensembl ].		VAR_009261
	Natural variant	212	1	I → T. Corresponds to variant rs7654853 [ dbSNP | Ensembl ].		VAR_049420

Sequences

	Sequence		Length	Mass (Da)
	P48039 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: DF7C67111D2386ED	FASTA	350	39,375
	10 20 30 40 50 60 MQGNGSALPN ASQPVLRGDG ARPSWLASAL ACVLIFTIVV DILGNLLVIL SVYRNKKLRN 70 80 90 100 110 120 AGNIFVVSLA VADLVVAIYP YPLVLMSIFN NGWNLGYLHC QVSGFLMGLS VIGSIFNITG 130 140 150 160 170 180 IAINRYCYIC HSLKYDKLYS SKNSLCYVLL IWLLTLAAVL PNLRAGTLQY DPRIYSCTFA 190 200 210 220 230 240 QSVSSAYTIA VVVFHFLVPM IIVIFCYLRI WILVLQVRQR VKPDRKPKLK PQDFRNFVTM 250 260 270 280 290 300 FVVFVLFAIC WAPLNFIGLA VASDPASMVP RIPEWLFVAS YYMAYFNSCL NAIIYGLLNQ 310 320 330 340 350 NFRKEYRRII VSLCTARVFF VDSSNDVADR VKWKPSPLMT NNNVVKVDSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses." Reppert S.M., Weaver D.R., Ebisawa T. Neuron 13:1177-1185(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders." Ebisawa T., Kajimura N., Uchiyama M., Katoh M., Sekimoto M., Watanabe T., Ozeki Y., Ikeda M., Jodoi T., Sugishita M., Iwase T., Kamei Y., Kim K., Shibui K., Kudo Y., Yamada N., Toyoshima R., Okawa M., Takahashi K., Yamauchi T. Biochem. Biophys. Res. Commun. 262:832-837(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TRP-54 AND VAL-157. Tissue: Leukocyte.
[3]	Huang Y.-H., Kaighin V.A., Martin A.L., Aronstam R.S. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hippocampus.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Web resources

Wikipedia

Melatonin receptor entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U14108 mRNA. Translation: AAB17720.1. AB029933 Genomic DNA. Translation: BAA85303.1. EU432127 mRNA. Translation: ABY87926.1. BC074946 mRNA. Translation: AAH74946.1. BC074947 mRNA. Translation: AAH74947.1. BC126297 mRNA. Translation: AAI26298.1. BC126299 mRNA. Translation: AAI26300.1.
IPI	IPI00007600.
PIR	I38848.
RefSeq	NP_005949.1. NM_005958.3.
UniGene	Hs.243467.
3D structure databases
ProteinModelPortal	P48039.
ModBase	Search...
Protein-protein interaction databases
IntAct	P48039. 21 interactions.
MINT	MINT-8087019.
STRING	9606.ENSP00000302811.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	1346544.
Proteomic databases
PaxDb	P48039.
PRIDE	P48039.
Protocols and materials databases
DNASU	4543.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307161; ENSP00000302811; ENSG00000168412.
GeneID	4543.
KEGG	hsa:4543.
UCSC	uc003izd.1. human.
Organism-specific databases
CTD	4543.
GeneCards	GC04M187347.
HGNC	HGNC:7463. MTNR1A.
MIM	600665. gene.
neXtProt	NX_P48039.
PharmGKB	PA31267.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG138016.
HOGENOM	HOG000037953.
HOVERGEN	HBG052528.
InParanoid	P48039.
KO	K04285.
OMA	RVKPDNK.
PhylomeDB	P48039.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
SignaLink	P48039.
Gene expression databases
Bgee	P48039.
CleanEx	HS_MTNR1A.
Genevestigator	P48039.
GermOnline	ENSG00000168412. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002278. Mel_1A_rcpt. IPR000025. Melatonin_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01149. MELATONIN1AR. PR00857. MELATONINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P48039.
ChEMBL	CHEMBL1945.
DrugBank	DB01065. Melatonin. DB00980. Ramelteon.
GenomeRNAi	4543.
NextBio	17521.
SOURCE	Search...

Entry information

Entry name

MTR1A_HUMAN

Accession

Primary (citable) accession number: P48039
Secondary accession number(s): A0AVC5, B0M0L2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 29, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.