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Protein

Melatonin receptor type 1A

Gene

MTNR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

  • hormone binding Source: BHF-UCL
  • melatonin receptor activity Source: ProtInc
  • organic cyclic compound binding Source: BHF-UCL

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • circadian rhythm Source: ProtInc
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • mating behavior Source: ProtInc
  • positive regulation of cGMP biosynthetic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168412-MONOMER.
ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-418594. G alpha (i) signalling events.
SignaLinkiP48039.

Protein family/group databases

TCDBi9.A.14.1.3. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1A
Short name:
Mel-1A-R
Short name:
Mel1a receptor
Gene namesi
Name:MTNR1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:7463. MTNR1A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 63CytoplasmicSequence analysisAdd BLAST13
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 102ExtracellularSequence analysisAdd BLAST18
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 142CytoplasmicSequence analysisAdd BLAST19
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 187ExtracellularSequence analysisAdd BLAST24
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 240CytoplasmicSequence analysisAdd BLAST32
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 274ExtracellularSequence analysisAdd BLAST13
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 350CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

  • integral component of plasma membrane Source: BHF-UCL
  • plasma membrane Source: Reactome
  • receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4543.
OpenTargetsiENSG00000168412.
PharmGKBiPA31267.

Chemistry databases

ChEMBLiCHEMBL1945.
DrugBankiDB06594. Agomelatine.
DB01065. Melatonin.
DB00980. Ramelteon.
DB09071. Tasimelteon.
GuidetoPHARMACOLOGYi287.

Polymorphism and mutation databases

BioMutaiMTNR1A.
DMDMi1346544.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698621 – 350Melatonin receptor type 1AAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi100 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48039.
PRIDEiP48039.

Expressioni

Tissue specificityi

Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.

Gene expression databases

BgeeiENSG00000168412.
CleanExiHS_MTNR1A.
GenevisibleiP48039. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MTNR1BP492862EBI-1188238,EBI-1188341
RGS20O760816EBI-1188238,EBI-1052678

Protein-protein interaction databases

BioGridi110639. 24 interactors.
IntActiP48039. 222 interactors.
MINTiMINT-8087019.
STRINGi9606.ENSP00000302811.

Chemistry databases

BindingDBiP48039.

Structurei

3D structure databases

ProteinModelPortaliP48039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
GeneTreeiENSGT00440000033318.
HOGENOMiHOG000037953.
HOVERGENiHBG052528.
InParanoidiP48039.
KOiK04285.
OMAiHFLVPMI.
OrthoDBiEOG091G0GO0.
PhylomeDBiP48039.
TreeFamiTF331693.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGNGSALPN ASQPVLRGDG ARPSWLASAL ACVLIFTIVV DILGNLLVIL
60 70 80 90 100
SVYRNKKLRN AGNIFVVSLA VADLVVAIYP YPLVLMSIFN NGWNLGYLHC
110 120 130 140 150
QVSGFLMGLS VIGSIFNITG IAINRYCYIC HSLKYDKLYS SKNSLCYVLL
160 170 180 190 200
IWLLTLAAVL PNLRAGTLQY DPRIYSCTFA QSVSSAYTIA VVVFHFLVPM
210 220 230 240 250
IIVIFCYLRI WILVLQVRQR VKPDRKPKLK PQDFRNFVTM FVVFVLFAIC
260 270 280 290 300
WAPLNFIGLA VASDPASMVP RIPEWLFVAS YYMAYFNSCL NAIIYGLLNQ
310 320 330 340 350
NFRKEYRRII VSLCTARVFF VDSSNDVADR VKWKPSPLMT NNNVVKVDSV
Length:350
Mass (Da):39,375
Last modified:February 1, 1996 - v1
Checksum:iDF7C67111D2386ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00926054R → W Exhibits significantly reduced B(max) and slightly enhanced affinity. 1 PublicationCorresponds to variant rs1800885dbSNPEnsembl.1
Natural variantiVAR_009261157A → V Similar binding characteristics compared to wild-type. 1 PublicationCorresponds to variant rs1800884dbSNPEnsembl.1
Natural variantiVAR_049420212I → T.Corresponds to variant rs7654853dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14108 mRNA. Translation: AAB17720.1.
AB029933 Genomic DNA. Translation: BAA85303.1.
EU432127 mRNA. Translation: ABY87926.1.
BC074946 mRNA. Translation: AAH74946.1.
BC074947 mRNA. Translation: AAH74947.1.
BC126297 mRNA. Translation: AAI26298.1.
BC126299 mRNA. Translation: AAI26300.1.
CCDSiCCDS3848.1.
PIRiI38848.
RefSeqiNP_005949.1. NM_005958.4.
UniGeneiHs.243467.

Genome annotation databases

EnsembliENST00000307161; ENSP00000302811; ENSG00000168412.
GeneIDi4543.
KEGGihsa:4543.
UCSCiuc003izd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Melatonin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14108 mRNA. Translation: AAB17720.1.
AB029933 Genomic DNA. Translation: BAA85303.1.
EU432127 mRNA. Translation: ABY87926.1.
BC074946 mRNA. Translation: AAH74946.1.
BC074947 mRNA. Translation: AAH74947.1.
BC126297 mRNA. Translation: AAI26298.1.
BC126299 mRNA. Translation: AAI26300.1.
CCDSiCCDS3848.1.
PIRiI38848.
RefSeqiNP_005949.1. NM_005958.4.
UniGeneiHs.243467.

3D structure databases

ProteinModelPortaliP48039.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110639. 24 interactors.
IntActiP48039. 222 interactors.
MINTiMINT-8087019.
STRINGi9606.ENSP00000302811.

Chemistry databases

BindingDBiP48039.
ChEMBLiCHEMBL1945.
DrugBankiDB06594. Agomelatine.
DB01065. Melatonin.
DB00980. Ramelteon.
DB09071. Tasimelteon.
GuidetoPHARMACOLOGYi287.

Protein family/group databases

TCDBi9.A.14.1.3. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiMTNR1A.
DMDMi1346544.

Proteomic databases

PaxDbiP48039.
PRIDEiP48039.

Protocols and materials databases

DNASUi4543.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307161; ENSP00000302811; ENSG00000168412.
GeneIDi4543.
KEGGihsa:4543.
UCSCiuc003izd.2. human.

Organism-specific databases

CTDi4543.
DisGeNETi4543.
GeneCardsiMTNR1A.
HGNCiHGNC:7463. MTNR1A.
MIMi600665. gene.
neXtProtiNX_P48039.
OpenTargetsiENSG00000168412.
PharmGKBiPA31267.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
GeneTreeiENSGT00440000033318.
HOGENOMiHOG000037953.
HOVERGENiHBG052528.
InParanoidiP48039.
KOiK04285.
OMAiHFLVPMI.
OrthoDBiEOG091G0GO0.
PhylomeDBiP48039.
TreeFamiTF331693.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168412-MONOMER.
ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-418594. G alpha (i) signalling events.
SignaLinkiP48039.

Miscellaneous databases

GeneWikiiMelatonin_receptor_1A.
GenomeRNAii4543.
PROiP48039.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168412.
CleanExiHS_MTNR1A.
GenevisibleiP48039. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTR1A_HUMAN
AccessioniPrimary (citable) accession number: P48039
Secondary accession number(s): A0AVC5, B0M0L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.