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Protein

Annexin A6

Gene

Anxa6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

Miscellaneous

Seems to bind one calcium ion with high affinity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A6
Alternative name(s):
Annexin VI
Annexin-6
Calcium-binding protein 65/67
Short name:
CBP 65/67
Gene namesi
Name:Anxa6
Synonyms:Anx6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621172 Anxa6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674962 – 673Annexin A6Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei30PhosphotyrosineBy similarity1
Modified residuei63N6-acetyllysineBy similarity1
Modified residuei68N6-acetyllysineBy similarity1
Modified residuei75N6-acetyllysineBy similarity1
Modified residuei81N6-acetyllysineBy similarity1
Modified residuei201PhosphotyrosineBy similarity1
Modified residuei306N6-acetyllysineBy similarity1
Modified residuei370N6-acetyllysineBy similarity1
Modified residuei418N6-acetyllysineBy similarity1
Modified residuei422PhosphoserineCombined sources1
Modified residuei483N6-acetyllysineBy similarity1
Modified residuei537PhosphoserineBy similarity1
Modified residuei620N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP48037
PRIDEiP48037

PTM databases

iPTMnetiP48037
PhosphoSitePlusiP48037

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP48037
IntActiP48037, 1 interactor
STRINGi10116.ENSRNOP00000014464

Structurei

3D structure databases

ProteinModelPortaliP48037
SMRiP48037
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 89Annexin 1Add BLAST61
Repeati101 – 161Annexin 2Add BLAST61
Repeati185 – 245Annexin 3Add BLAST61
Repeati260 – 320Annexin 4Add BLAST61
Repeati372 – 432Annexin 5Add BLAST61
Repeati444 – 504Annexin 6Add BLAST61
Repeati533 – 593Annexin 7Add BLAST61
Repeati608 – 668Annexin 8Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP48037
PhylomeDBiP48037

Family and domain databases

Gene3Di1.10.220.10, 8 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002393 ANX6
PANTHERiPTHR10502:SF19 PTHR10502:SF19, 2 hits
PfamiView protein in Pfam
PF00191 Annexin, 8 hits
PRINTSiPR00196 ANNEXIN
PR00202 ANNEXINVI
SMARTiView protein in SMART
SM00335 ANX, 8 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIAQGAMY RGSVHDFADF DANQDAEALY TAMKGFGSDK ESILELITSR
60 70 80 90 100
SNKQRQEICQ SYKSLYGKDL IADLKYELTG KFERLIVNLM RPLAYCDAKE
110 120 130 140 150
IKDAISGIGT DEKCLIEILA SRTNEQIHQL VAAYKDAYER DLESDIIGDT
160 170 180 190 200
SGHFQKMLVV LLQGTRENDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI
210 220 230 240 250
YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR
260 270 280 290 300
STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS
310 320 330 340 350
LYSMIKNDTS GEYKKALLKL CGGDDDAAGQ FFPEAAQVAY QMWELSAVSR
360 370 380 390 400
VELKGTVRAA NDFNPDADAK GLRKAMKGIG TDEATIIDII TQRSNVQRQQ
410 420 430 440 450
IRQTFKSHFG RDLMADLKSE ISGDLARLIL GLMMPPAHYD AKQLKKAMEG
460 470 480 490 500
AGTDEKALIE ILATRTNAEI RAINEAYKED YHKSLEDALS SDTSGHFKRI
510 520 530 540 550
LISLATGNRE EGGENRDQAQ EDAQVAAEIL EIADTPSGDK TSLETRFMTV
560 570 580 590 600
LCTRSYPHLR RVFQEFIKKT NYDIEHVIKK EMSGDVKDAF VAIVQSVKNK
610 620 630 640 650
PLFFADKLYK SMKGAGTDEK TLTRVMVSRS EIDLLNIRRE FIEKYDKSPH
660 670
QAIEGDTSGD FMKALLALCG GED
Length:673
Mass (Da):75,754
Last modified:January 23, 2007 - v2
Checksum:i03332E8E42E0DF6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86086 mRNA Translation: CAA60040.1
PIRiS65683 S52844
UniGeneiRn.204053

Genome annotation databases

UCSCiRGD:621172 rat

Similar proteinsi

Entry informationi

Entry nameiANXA6_RAT
AccessioniPrimary (citable) accession number: P48037
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health